Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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Crystal Structure at 2.8 Å of an FcRn/Heterodimeric Fc Complex

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Molecular basis for LDL receptor recognition by PCSK9

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Crystal Structure of the CSL-Notch-Mastermind Ternary Complex Bound to DNA

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XPD Helicase Structures and Activities: Insights into the Cancer and Aging Phenotypes from XPD Mutations

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A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates

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Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

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Molecular Mechanisms of HipA-Mediated Multidrug Tolerance and Its Neutralization by HipB

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Architecture of the synaptotagmin–SNARE machinery for neuronal exocytosis

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Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins

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Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system

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Structure of the Autoinhibited Kinase Domain of CaMKII and SAXS Analysis of the Holoenzyme

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Architecture of a protein central to iron homeostasis: crystal structure and spectroscopic analysis of the ferric uptake regulator

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Structural aspects of messenger RNA reading frame maintenance by the ribosome

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Ultrahigh resolution drug design I: Details of interactions in human aldose reductase–inhibitor complex at 0.66 Å

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Molecular recognition of p53 and MDM2 by USP7/HAUSP.

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Structural basis for recruitment of glycogen synthase kinase 3β to the axin—APC scaffold complex

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Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids

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Crystal structure of HIV-1 Tat complexed with human P-TEFb

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Binding of the Respiratory Chain Inhibitor Antimycin to the Mitochondrial bc1 Complex: A New Crystal Structure Reveals an Altered Intramolecular Hydrogen-bonding Pattern

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Crystal Structures of MAP Kinase p38 Complexed to the Docking Sites on Its Nuclear Substrate MEF2A and Activator MKK3b

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Crystal structure of a Rad51 filament

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A chiroselective peptide replicator

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Structural basis for ATP-dependent DnaA assembly and replication-origin remodeling

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Structure of Internalin, a Major Invasion Protein of Listeria monocytogenes, in Complex with Its Human Receptor E-Cadherin

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Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases

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The Mad2 spindle checkpoint protein has two distinct natively folded states

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Crystal structure of protoporphyrinogen IX oxidase: a key enzyme in haem and chlorophyll biosynthesis

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First Structures of an Active Bacterial Tyrosinase Reveal Copper Plasticity

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Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase

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Structural and Computational Analysis of the Quinone-binding Site of Complex II (Succinate-Ubiquinone Oxidoreductase)

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The crystal structure of xanthine oxidoreductase during catalysis: Implications for reaction mechanism and enzyme inhibition

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A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo

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Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats

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Docking Motif Interactions in MAP Kinases Revealed by Hydrogen Exchange Mass Spectrometry

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Structure of a voltage-dependent K+ channel β subunit

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Secreted amyloid-β precursor protein functions as a GABA B R1a ligand to modulate synaptic transmission

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Structure of the Cand1-Cul1-Roc1 Complex Reveals Regulatory Mechanisms for the Assembly of the Multisubunit Cullin-Dependent Ubiquitin Ligases

Goldenberg, S. J., Cascio, T. C., Shumway, S. D., Garbutt, K. C., Liu, J., Xiong, Y., & Zheng, N. (2004) · Cell · doi:10.1016/j.cell.2004.10.019 · Cited by 280

Comparison of Crystal Structures of Human Androgen Receptor Ligand-Binding Domain Complexed with Various Agonists Reveals Molecular Determinants Responsible for Binding Affinity

Pereira de Jésus‐Tran, K., Côté, P., Cantin, L., Blanchet, J., Labrie, F., & Breton, R. (2006) · Protein Science · doi:10.1110/ps.051905906 · Cited by 278

Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125

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Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression

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Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes

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Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein

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Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53–MDM2 Pathway

Hu, M., Gu, L., Li, M., Jeffrey, P. D., Gu, W., & Shi, Y. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040027 · Cited by 251

Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release

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Structural basis for Duffy recognition by the malaria parasite Duffy-binding-like domain

Singh, S. K., Hora, R., Belrhali, H., Chitnis, C. E., & Sharma, A. (2006) · Nature · doi:10.1038/nature04443 · Cited by 247

Siderocalin (Lcn 2) Also Binds Carboxymycobactins, Potentially Defending against Mycobacterial Infections through Iron Sequestration

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Structures of D 14 and D 14 L in the strigolactone and karrikin signaling pathways

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The modular architecture of protein–protein binding interfaces

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Crystal structures of EF-G-ribosome complexes trapped in intermediate states of translocation

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Crystal structure of a β-catenin/Axin complex suggests a mechanism for the β-catenin destruction complex

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Molecular driving forces determining potassium channel slow inactivation

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Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

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Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

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Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70

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Structural basis for recognition of AU-rich element RNA by the HuD protein.

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Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor

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Crystallographic Analysis of Primary Visual Photochemistry

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All-trans retinoic acid is a ligand for the orphan nuclear receptor RORβ

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Teaching an Old Scaffold New Tricks: Monobodies Constructed Using Alternative Surfaces of the FN3 Scaffold

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The 2.0 A structure of human ferrochelatase, the terminal enzyme of heme biosynthesis.

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Structural insight into the unique properties of adeno-associated virus serotype 9

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Crystal Structure of Human Frataxin

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Predicting the structure of large protein complexes using AlphaFold and Monte Carlo tree search

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The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation

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Structural mechanism of ergosterol regulation by fungal sterol transcription factor Upc2

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A crystallographic view of interactions between Dbs and Cdc42: PH domain‐assisted guanine nucleotide exchange

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Replication of a cis–syn thymine dimer at atomic resolution

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Crystal Structure and Thermodynamic Analysis of Human Brain Fatty Acid-binding Protein

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Structural mechanism of demethylation and inactivation of protein phosphatase 2A

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Structural and Thermodynamic Analysis of Human PCNA with Peptides Derived from DNA Polymerase-δ p66 Subunit and Flap Endonuclease-1

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Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

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Structurally mapping the diverse phenotype of adeno-associated virus serotype 4

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The Acidic Transcription Activator Gcn4 Binds the Mediator Subunit Gal11/Med15 Using a Simple Protein Interface Forming a Fuzzy Complex

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Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C‐shaped scaffold

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Structural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors,

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Structure of factor-inhibiting hypoxia-inducible factor 1: an asparaginyl hydroxylase involved in the hypoxic response pathway

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Crystal structure of JNK3: a kinase implicated in neuronal apoptosis

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DNA stretching by bacterial initiators promotes replication origin opening

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Structure of a Lipid Droplet Protein

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Electron crystallography of ultrathin 3D protein crystals: atomic model with charges

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Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor

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Crystal structure of a soluble CD28-Fab complex

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Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils

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X-ray structure of a native calicivirus: Structural insights into antigenic diversity and host specificity

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Crystal Structure of the Human Cytosolic Sialidase Neu2

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Solution structure of p53 core domain: Structural basis for its instability

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Structural Basis for Endosomal Targeting by the Bro1 Domain

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Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX

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Docking Interactions Induce Exposure of Activation Loop in the MAP Kinase ERK2

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Sialic acid recognition by Vibrio cholerae neuraminidase

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