Retinal prosthesis.
Open accessAbstract
Retinal prosthesis has been translated from the laboratory to the clinic over the past two decades. Currently, two devices have regulatory approval for the treatment of retinitis pigmentosa. These devices provide partial sight restoration and patients use this improved vision in their everyday lives. Improved mobility and object detection are some of the more notable findings from the clinical trials. However, significant vision restoration will require both better technology and improved understanding of the interaction between electrical stimulation and the retina. This paper reviews the recent clinical trials and highlights technology breakthroughs that will contribute to next generation of retinal prostheses.
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Polyimide absorbs moisture, causing hydrolytic attack of the substrate material.
“However, polyimide is known to absorb moisture, causing hydrolytic attack of the substrate material, and resulting in stresses associated with delamination between metal/polyimide and polyimide/polyimide interfaces [7] [21] [22].”
From Flexible Nerve Stimulation Electrode With Iridium Oxide Sputtered on Liquid Crystal Polymer (2009) · cites this paper as [7]
Moisture absorption in polyimide results in stresses associated with delamination between metal/polyimide and polyimide/polyimide interfaces.
“However, polyimide is known to absorb moisture, causing hydrolytic attack of the substrate material, and resulting in stresses associated with delamination between metal/polyimide and polyimide/polyimide interfaces [7] [21] [22].”
From Flexible Nerve Stimulation Electrode With Iridium Oxide Sputtered on Liquid Crystal Polymer (2009) · cites this paper as [7]
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Self-citationEnd-to-end optimization of prosthetic vision
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“These neural interfaces can functionally replace the eye with a camera that is connected to the retina (Weiland, Liu, & Humayun, 2005; Zrenner et al., 2011), thalamus (Pezaris & Reid, 2007), or visual cortex (Beauchamp & Yoshor, 2020; Chen et al., 2020; Dobelle, Mladejovsky, & Girvin, 1974;…”
Background
- Authors
- Weiland, J. D., & Humayun, M. S.
- Affiliations
- University of Southern California (US)
- Venue
- IEEE Transactions on Biomedical Engineering
- Published
- 2014-05
- Volume
- 61
- Issue
- 5
- Pages
- 1412-1424
- ISSN
- 0018-9294 (ISSN-L)
- 1558-2531
- PMC
- PMC4356127
- OpenAlex
- W4240629939
- Cited by
- 186
- References
- 7
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 11 · 2023: 11 · 2022: 12 · 2021: 18 · 2020: 22 · 2019: 19 · 2018: 22 · 2017: 20 · 2016: 17 · 2015: 14 · 2014: 4
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- IEEE Transactions on Biomedical Engineering (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation (EEC-0310723)
- Office of Science (BER) U.S. Department of Energy (DE-FC02-04ER63735)
- National Eye Institute (5R01EY022931)
- The W.M. Keck Foundation
- Research to Prevent Blindness
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- retinal prosthesis, retinitis pigmentosa, vision restoration, clinical trials, regulatory approval, mobility (physical function), object detection
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