Early neglect is associated with alterations in white matter integrity and cognitive functioning
Open accessAbstract
Cognitive deficits have been reported in children who experienced early neglect, especially children raised in institutionalized settings. Previous research suggests that early neglect may differentially affect the directional organization of white matter in the prefrontal cortex (PFC). This may be one mechanism to explain cognitive deficits associated with neglect. To test this idea, properties of white matter and neurocognitive performance were assessed in children who suffered early neglect and those raised in typical environments (n = 63, Mage = 11.75 years). As predicted, prefrontal white matter microstructure was affected, consistent with more diffuse organization, in children that suffered early neglect and this was related to neurocognitive deficits. Such findings underscore how early adversity may affect the PFC and explain cognitive deficits associated with neglect.
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Reduced integrity of white matter tracts connecting the temporal lobe and prefrontal cortex is associated with poorer neurocognitive functioning among neglected children.
“Reduced integrity of white matter tracts connecting the temporal lobe and prefrontal cortex is associated with poorer neurocognitive functioning among neglected children (31).”
From Long-term effects of institutional rearing, foster care, and brain activity on memory and executive functioning (2019) · cites this paper as [31]
Experimental — accuracy not yet measuredThese white matter alterations predicted lower cognitive functioning at ages 9-14 years.
“and these alterations predicted lower cognitive functioning at ages 9–14 years (Hanson et al., 2013).”
From Resting brain activity in early childhood predicts IQ at 18 years (2023) · cites this paper as Hanson et al., 2013
Children with a history of institutional rearing showed lower white matter directional organization in the prefrontal cortex (PFC) and in white matter tracts connecting the PFC and temporal lobe.
“Children with a history of institutional rearing also showed lower white matter directional organization in the prefrontal cortex (PFC) and in white matter tracts connecting the PFC and temporal lobe”
From Resting brain activity in early childhood predicts IQ at 18 years (2023) · cites this paper as Hanson et al., 2013
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- Authors
- Hanson, J. L., Adluru, N., Chung, M. K., Alexander, A. L., Davidson, R. J., & Pollak, S. D.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Hanson, Jamie L
- Venue
- Child Development
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-09-01
- Volume
- 84
- Issue
- 5
- Pages
- 1566-1578
- ISSN
- 0009-3920 (ISSN-L)
- 1467-8624
- PMC
- PMC3690164
- OpenAlex
- W2149579330
- Cited by
- 276
- References
- 64
- Citations by year
- 2026: 13 · 2025: 19 · 2024: 30 · 2023: 14 · 2022: 17 · 2021: 21 · 2020: 28 · 2019: 43 · 2018: 14 · 2017: 29 · 2016: 15 · 2015: 21 · 2014: 8 · 2013: 4
- FWCI
- 17.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Child Development (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- US National Institute of Mental Health (MH61285, MH68858, MH84051)
- US National Institute of Drug Abuse Fellowship (DA028087)
- University of Wisconsin
- National Institute of Child Health and Human Development (P30-HD03352)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Safety Research › Child Welfare and Adoption
- Life Sciences › Neuroscience › Cognitive Neuroscience › Spatial Neglect and Hemispheric Dysfunction
- Keywords
- institutionalized children, white matter microstructure, prefrontal cortex, white matter organization, cognitive impairment, childhood adversity, neuropsychological performance, children
- MeSH terms
- Adolescent, Brain Mapping, Child, Child Abuse, Cognition Disorders, Female, Humans, Male, Organ Size, Prefrontal Cortex, Diffusion Tensor Imaging, Leukoencephalopathies
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