Exercise training modifies gut microbiota in normal and diabetic mice
Abstract
Cecal microbiota from type 2 diabetic (db/db) and control (db/+) mice was obtained following 6 weeks of sedentary or exercise activity. qPCR analysis revealed a main effect of exercise, with greater abundance of select Firmicutes species and lower Bacteroides/Prevotella spp. in both normal and diabetic exercised mice compared with sedentary counterparts. Conversely, Bifidobacterium spp. was greater in exercised normal but not diabetic mice (exercise × diabetes interaction). How exercise influences gut microbiota requires further investigation.
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Animal models have shown that exercise impacts microbial abundance.
“Recently, animal models have shown that exercise impacts microbial abundance (Lambert et al., 2015; Welly et al., 2016)”
From Six-Week Endurance Exercise Alters Gut Metagenome That Is not Reflected in Systemic Metabolism in Over-weight Women (2018) · cites this paper as Lambert et al., 2015
Exercised mice presented a greater abundance of Firmicutes species and lower Bacteroides/Prevotella genera compared with sedentary mice.
“Lambert et al. [75] described that exercised mice presented a greater abundance of Firmicutes species and lower Bacteroides/Prevotella genera compared with sedentary mice.”
From The athletic gut microbiota (2020) · cites this paper as [75]
Daily wheel running exercise may improve some aspects of unhealthy states, such as diet-induced obesity, diabetes, and toxicity, by impacting gut microbial composition in mice.
“Other animal studies demonstrated that daily wheel running exercise may improve some aspects of unhealthy states, such as diet-induced obesity, diabetes, and toxicity, by impacting the gut microbial composition in mice [73–75].”
From The athletic gut microbiota (2020) · cites this paper as [75]
Alterations to the microbiota exerted by exercise in rats following a high-fat diet were different to rats on a normal diet, and alterations in diabetic mice were different to their control counterparts.
“Alterations to the microbiota exerted by exercise in rats following a high-fat diet were different to rats on a normal diet [89], as well as the alterations produced in diabetic mice were different to their control counterparts [75].”
From The athletic gut microbiota (2020) · cites this paper as [75]
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The gut microbiome and heart failure: A better gut for a better heart
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The Association between Gut Microbiota and Osteoarthritis: Does the Disease Begin in the Gut?
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Gut microbiome approaches to treat obesity in humans
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Effects of Probiotics on Anxiety, Stress, Mood and Fitness of Badminton Players
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Gut microbiota and its metabolites: Bridge of dietary nutrients and obesity-related diseases
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Gut Microbiota Modulation as a Novel Therapeutic Strategy in Cardiometabolic Diseases
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Early-life effects of juvenile Western diet and exercise on adult gut microbiome composition in mice
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Interactions between Gut Microbiota and Polyphenols: New Insights into the Treatment of Fatigue
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Update on gut microbiota in cardiovascular diseases
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Ginseng ameliorates exercise-induced fatigue potentially by regulating the gut microbiota
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Type 2 diabetes, gut microbiome, and systems biology: A novel perspective for a new era
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The roles of gut microbiota and its metabolites in diabetic nephropathy
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The Microbiome and Mental Health: Looking Back, Moving Forward with Lessons from Allergic Diseases
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Diagnostics and therapeutic implications of gut microbiota alterations in cardiometabolic diseases
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Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD
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Home-based exercise training influences gut bacterial levels in multiple sclerosis
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Self-citation
- Authors
- Lambert, J. E., Myslicki, J. P., Bomhof, M. R., Belke, D. D., Shearer, J., & Reimer, R. A.
- Affiliations
- University of Calgary (CA)
- Corresponding author
- Shearer, Jane
- Reimer, Raylene A.
- Venue
- Applied Physiology, Nutrition, and Metabolism
- Publisher
- Canadian Science Publishing
- Published
- 2015-07
- Volume
- 40
- Issue
- 7
- Pages
- 749-752
- ISSN
- 1715-5312 (ISSN-L)
- 1715-5320
- OpenAlex
- W2135952951
- Cited by
- 214
- References
- 27
- Citations by year
- 2026: 9 · 2025: 20 · 2024: 16 · 2023: 19 · 2022: 26 · 2021: 27 · 2020: 25 · 2019: 27 · 2018: 18 · 2017: 9 · 2016: 15 · 2015: 2
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Applied Physiology, Nutrition, and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (MOP115076)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- exercise training, gut microbiota, type 2 diabetes, db/db mice, sedentary behavior, Firmicutes, Bacteroides, Prevotella, Bifidobacterium, cecal microbiota
- MeSH terms
- Gastrointestinal Microbiome, Animals, Diabetes Mellitus, Experimental, Disease Models, Animal, Male, Mice, Inbred C57BL, Physical Conditioning, Animal, Mice
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