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Cited by 1,094Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersFamily and Disability Support Research

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

A case-control family history study of autism

Bolton, P., Macdonald, H., Pickles, A., Rios, P., Goode, S., Crowson, M., Bailey, A., Rutter, M.·1994·Journal of Child Psychology and Psychiatry
DOI 10.1111/j.1469-7610.1994.tb02300.x
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Abstract

Family history data on 99 autistic and 36 Down's syndrome probands are reported. They confirmed a raised familial loading for both autism and more broadly defined pervasive developmental disorders in siblings (2.9% and 2.9%, respectively, vs 0% in the Down's group) and also evidence for the familial aggregation of a lsser'variant of autism, comprising more subtle communication/social impairments or stereotypic behaviours, but not mental retardation alone. Between 12.4 and 20.4% of the autism siblings and 1.6% and 3.2% of the Down's siblings exhibited this lesser variant, depending on the stringency of its definition. Amongst autistic probands with speech, various features of their disorder (increased number of autistic symptoms; reduced verbal and performance ability) as well as a history of obstetric complications, indexed an elevation in familial loading. No such association was seen in the probands without speech, even though familial loading for the lesser variant in this subgroup, was significantly higher than in the Down's controls. The findings suggest that the autism phenotype extends beyond autism as traditionally diagnosed; that aetiology involves several genes; that autism is genetically heterogeneous; and that obstetric abnormalities in autistic subjects may derive from abnormality in the foetus.

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Crossref · 10.1111/j.1469-7610.1994.tb02300.x

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Show all 40 references

Research works printed but not linked: 18

  1. Bailey A., 1993, British twin study of autism. Paper presented at the 3rd World Congress of Psychiatric Genetics, New Orleans, 2–5 October 1993, Psychiatric Genetics, 3, 129
  2. Bolton P., 1993, Obstetric complications in Autism. Paper presented at the 3rd World Congress of Psychiatric Genetics, New Orleans, 2–5 October 1993, Psychiatric Genetics, 3, 178
  3. Bolton P., 1992, Genetic aspects of autism: family data and the broader phenotype, 11
  4. Bolton P., 1991, Genetic findings and heterogeneity in autism. Paper presented at the second world congress of psychiatric genetics, London 1991, Psychiatric Genetics, 2, 49
  5. Breslow N., 1989, Proceedings of Statistical Modelling, Trenta, Lecture Notes in Statistics
  6. Dunn L. M., 1982, British Picture Vocabulary Scale (Manual for long and short forms)
  7. EGRET, 1990, EGRET Manual
  8. Gray W., 1963, Gray Oral Reading Test
  9. Le Couteur A., 1989, An cpidemiologically based twin study of autism, 3
  10. Macdonald H., 1989, Cognitive and social abnormalities in the siblings of autistic and Down's syndrome probands, 3
  11. Raven J. C, 1982, Manual for Raven's progressive matrices and vocabulary scales: research and references
  12. Rutter M., 1988, Preventative and curative interventions in mental retardation, 265
  13. Stutsman R., 1948, Merrill‐Palmer scale of mental tests. Reprint of Part III, mental measurement of preschool children
  14. University of Edinburgh, 1977, The Edinburgh reading tests stages 1–4
  15. Waldrop M., 1971, Exceptional infant
  16. Wechsler D., 1974, Wechsler intelligence scale for children‐revised
  17. Wechsler D., 1981, Wechsler adult intelligence scale‐revised
  18. World Health Organization, 1992, ICD‐10. Categories F00‐F99 mental and behavioural disorders (including disorders of psychological development)

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Metadata

Authors
Bolton, P., Macdonald, H., Pickles, A., Rios, P., Goode, S., Crowson, M., Bailey, A., & Rutter, M.
Corresponding author
Bolton, P.
ORCID
Venue
Journal of Child Psychology and Psychiatry
Publisher
Wiley
Published
1994-07
Volume
35
Issue
5
Pages
877-900
ISSN
  • 0021-9630 (ISSN-L)
  • 1469-7610
DOI
10.1111/j.1469-7610.1994.tb02300.x
OpenAlex
W2142343384
Cited by
1,094
References
40
Citations by year
2026: 11 · 2025: 14 · 2024: 14 · 2023: 22 · 2022: 29 · 2021: 35 · 2020: 19 · 2019: 22 · 2018: 29 · 2017: 33 · 2016: 35 · 2015: 55 · 2014: 50 · 2013: 42 · 2012: 50
FWCI
11.26
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4542 d)
Locations
  • Journal of Child Psychology and Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Social Sciences › Psychology › Clinical Psychology › Family and Disability Support Research
Keywords
autism spectrum disorder, familial aggregation, pervasive developmental disorders, Down syndrome, siblings, stereotypy, communication disorders, pregnancy complications, genetic heterogeneity, autism phenotype, speech disorders, genetic aetiology
MeSH terms
Congenital Abnormalities, Adolescent, Adult, Autistic Disorder, Child, Child, Preschool, Down Syndrome, Female, Humans, Intelligence, Male, Models, Genetic, Personality Assessment, Phenotype, Risk Factors, Case-Control Studies

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