The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation
Open accessAbstract
In this paper we demonstrate in the intact human the possibility of a non-invasive modulation of motor cortex excitability by the application of weak direct current through the scalp. Excitability changes of up to 40 %, revealed by transcranial magnetic stimulation, were accomplished and lasted for several minutes after the end of current stimulation. Excitation could be achieved selectively by anodal stimulation, and inhibition by cathodal stimulation. By varying the current intensity and duration, the strength and duration of the after-effects could be controlled. The effects were probably induced by modification of membrane polarisation. Functional alterations related to post-tetanic potentiation, short-term potentiation and processes similar to postexcitatory central inhibition are the likely candidates for the excitability changes after the end of stimulation. Transcranial electrical stimulation using weak current may thus be a promising tool to modulate cerebral excitability in a non-invasive, painless, reversible, selective and focal way.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“The principal mechanism of action involves a subtle alteration of a neuron’s resting membrane potential affecting the neuron’s probability of firing [22].”
From Primary outcome from the augmenting cognitive training in older adults study (ACT): A tDCS and cognitive training randomized clinical trial (2023) · cites this paper as [22]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
What's wrong with Bonferroni adjustments
Perneger, T. V. (1998) · BMJ · doi:10.1136/bmj.316.7139.1236 · Cited by 5,900
Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729
Induction of plasticity in the human motor cortex by paired associative stimulation
Stefan, K. (2000) · Brain · doi:10.1093/brain/123.3.572 · Cited by 1,484
Bindman, L. J., Lippold, O. C. J., & Redfearn, J. W. T. (1964) · The Journal of Physiology · doi:10.1113/jphysiol.1964.sp007425 · Cited by 969
Artola, A., Bröcher, S., & Singer, W. (1990) · Nature · doi:10.1038/347069a0 · Cited by 880
INTRACELLULAR ACTIVITIES AND EVOKED POTENTIAL CHANGES DURING POLARIZATION OF MOTOR CORTEX.
Purpura, D., & McMurtry, J. G. (1965) · Journal of Neurophysiology · doi:10.1152/jn.1965.28.1.166 · Cited by 875
Polarization of the human motor cortex through the scalp
Priori, A., Berardelli, A., Rona, S., Accornero, N., & Manfredi, M. (1998) · Neuroreport · doi:10.1097/00001756-199807130-00020 · Cited by 568
Influence of transcortical d-c currents on cortical neuronal activity
Creutzfeldt, O. D., Fromm, G. H., & Kapp, H. (1962) · Experimental Neurology · doi:10.1016/0014-4886(62)90056-0 · Cited by 555
Long-term reorganization of human motor cortex driven by short-term sensory stimulation
Hamdy, S., Rothwell, J. C., Aziz, Q., Singh, K. D., & Thompson, D. G. (1998) · Nature Neuroscience · doi:10.1038/264 · Cited by 494
Mechanisms of Deafferentation-Induced Plasticity in Human Motor Cortex
Ziemann, U., Hallett, M., & Cohen, L. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-17-07000.1998 · Cited by 408
Cited by
Sorted by citations
Items 1,001–1,029 of 1,029
Senço, N. M., Huang, Y., D’Urso, G., Parra, L. C., Bikson, M., Mantovani, A., Shavitt, R. G., Hoexter, M. Q., Miguel, E. C., & Brunoni, A. R. (2015) · Expert Review of Medical Devices · doi:10.1586/17434440.2015.1037832 · Cited by 67
Groppa, S., Bergmann, T. O., Siems, C., Mölle, M., Marshall, L., & Siebner, H. R. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.01.019 · Cited by 67
Why is working memory performance unstable? A review of 21 factors
Blasiman, R. N., & Was, C. A. (2018) · Europe’s Journal of Psychology · doi:10.5964/ejop.v14i1.1472 · Cited by 65
Indahlastari, A., Hardcastle, C., Albizu, A., Alvarez-Alvarado, S., Boutzoukas, E. M., Evangelista, N. D., Hausman, H. K., Kraft, J., Langer, K., & Woods, A. J. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s259499 · Cited by 64
Nissim, N. R., O’Shea, A., Indahlastari, A., Telles, R., Richards, L., Porges, E., Cohen, R., & Woods, A. J. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00051 · Cited by 63
Plewnia, C., Schroeder, P. A., Kunze, R., Faehling, F., & Wolkenstein, L. (2015) · PLOS ONE · doi:10.1371/journal.pone.0122578 · Cited by 61
Brunoni, A. R., Machado-Vieira, R., Zarate, C. A., Vieira, E. L. M., Vanderhasselt, M.-A., Nitsche, M. A., Valiengo, L., Benseñor, I. M., Lotufo, P. A., Gattaz, W. F., et al. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.03.006 · Cited by 60
Self-citationKhalighinejad, N., Di Costa, S., & Haggard, P. (2016) · Brain Stimulation · doi:10.1016/j.brs.2016.01.005 · Cited by 58
Genetic Modulation of Transcranial Direct Current Stimulation Effects on Cognition
Wiegand, A., Nieratschker, V., & Plewnia, C. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00651 · Cited by 52
Leffa, D. T., de Souza, A., Scarabelot, V. L., Medeiros, L. F., de Oliveira, C., Grevet, E. H., Caumo, W., de Souza, D. O., Rohde, L. A. P., & Torres, I. L. S. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.11.012 · Cited by 50
Systems Neuroengineering: Understanding and Interacting with the Brain
Edelman, B. J., Johnson, N., Sohrabpour, A., Tong, S., Thakor, N., & He, B. (2015) · Engineering · doi:10.15302/j-eng-2015078 · Cited by 45
Meyer, B., Mann, C., Götz, M., Gerlicher, A., Saase, V., Yuen, K. S. L., Aedo-Jury, F., Gonzalez-Escamilla, G., Stroh, A., & Kalisch, R. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.3128-18.2019 · Cited by 43
Chesters, J., Watkins, K. E., & Möttönen, R. (2017) · Brain and Language · doi:10.1016/j.bandl.2016.10.003 · Cited by 39
Stephens, J. A., Jones, K. T., & Berryhill, M. E. (2017) · Scientific Reports · doi:10.1038/s41598-017-14030-7 · Cited by 43
Neuromodulation of OCD: a review of invasive and non-invasive methods
Kammen, A., Cavaleri, J., Lam, J., Frank, A. C., Mason, X., Choi, W., Penn, M., Brasfield, K., Van Noppen, B., Murray, S. B., et al. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.909264 · Cited by 38
Ghasemian-Shirvan, E., Mosayebi-Samani, M., Farnad, L., Kuo, M.-F., Meesen, R. L. J., & Nitsche, M. A. (2022) · Brain Stimulation · doi:10.1016/j.brs.2022.01.011 · Cited by 34
Self-citationTranscranial direct current stimulation: a new treatment for depression?
Nitsche, M. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.4.s1.43.x · Cited by 32
Self-citationtDCS Over DLPFC Leads to Less Utilitarian Response in Moral-Personal Judgment
Zheng, H., Lu, X., & Huang, D. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00193 · Cited by 31
Jongkees, B. J. (2020) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-020-00783-8 · Cited by 28
Teixeira-Santos, A. C., Moreira, C. S., Pereira, D. R., Pinal, D., Fregni, F., Leite, J., Carvalho, S., & Sampaio, A. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.827188 · Cited by 27
Neurostimulation techniques in the treatment of nicotine dependence: a review
Rachid, F. (2016) · The American Journal on Addictions · doi:10.1111/ajad.12405 · Cited by 24
Transcranial direct current stimulation: considerations for research in adolescent depression
Lee, J. C., Lewis, C. P., Daskalakis, Z. J., & Croarkin, P. E. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00091 · Cited by 22
Jongkees, B. J., Sellaro, R., Beste, C., Nitsche, M. A., Kühn, S., & Colzato, L. S. (2017) · Cortex · doi:10.1016/j.cortex.2017.02.014 · Cited by 21
Self-citationRetractedGendron, M., Mesquita, B., & Barrett, L. F. (2020) · Culture, Mind, and Brain · doi:10.1017/9781108695374.010 · Cited by 20
Moein, N., Mohamadi, R., Rostami, R., Nitsche, M., Zomorrodi, R., & Ostadi, A. (2022) · Journal of Fluency Disorders · doi:10.1016/j.jfludis.2022.105907 · Cited by 16
Self-citationA quantum–classical model of brain dynamics
Sergi, A., Messina, A., Vicario, C. M., & Martino, G. (2023) · Entropy · doi:10.3390/e25040592 · Cited by 16
Neurochemical mechanisms underlying serotonergic modulation of neuroplasticity in humans
Melo, L., Beaupain, M. C., Ghanavati, E., Kuo, M.-F., & Nitsche, M. A. (2024) · Brain Stimulation · doi:10.1016/j.brs.2024.04.001 · Cited by 15
Self-citationTseng, P., Zeng, B., Wang, H., Zeng, B., Liang, C., Chen, Y. B., Stubbs, B., Carvalho, A. F., Brunoni, A. R., Su, K., et al. (2024) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13688 · Cited by 14
Hausman, H. K., Alexander, G. E., Cohen, R., Marsiske, M., DeKosky, S. T., Hishaw, G. A., O'Shea, A., Kraft, J. N., Dai, Y., Wu, S., et al. (2023) · Brain Stimulation · doi:10.1016/j.brs.2023.05.021 · Cited by 13
Metadata
- Authors
- Nitsche, M. A., & Paulus, W.
- Affiliations
- University of Göttingen (DE)
- Corresponding author
- Nitsche, M. A.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2000-09
- Volume
- 527
- Issue
- 3
- Pages
- 633-639
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC2270099
- OpenAlex
- W2097273459
- Cited by
- 5,656
- References
- 29
- Citations by year
- 2026: 264 · 2025: 352 · 2024: 344 · 2023: 329 · 2022: 354 · 2021: 455 · 2020: 449 · 2019: 426 · 2018: 361 · 2017: 357 · 2016: 380 · 2015: 315 · 2014: 263 · 2013: 274 · 2012: 195
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- GRO (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- transcranial direct current stimulation, motor cortex excitability, non-invasive brain stimulation, anodal stimulation, cathodal stimulation, aftereffects, post-tetanic potentiation, short-term potentiation, membrane polarization, transcranial magnetic stimulation
- MeSH terms
- Adult, Electric Stimulation, Electromagnetic Fields, Female, Humans, Male, Motor Cortex, Evoked Potentials, Motor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
