GAMBLINGLESS: for LIFE study protocol: a pragmatic randomised trial of an online cognitive-behavioural programme for disordered gambling
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INTRODUCTION: The prevalence of disordered gambling worldwide has been estimated at 2.3%. Only a small minority of disordered gamblers seek specialist face-to-face treatment, and so a need for alternative treatment delivery models that capitalise on advances in communication technology, and use self-directed activity that can complement existing services has been identified. As such, the primary aim of this study is to evaluate an online self-directed cognitive-behavioural programme for disordered gambling (GamblingLess: For Life). METHODS AND ANALYSIS: The study will be a 2-arm, parallel group, pragmatic randomised trial. Participants will be randomly allocated to a pure self-directed (PSD) or guided self-directed (GSD) intervention. Participants in both groups will be asked to work through the 4 modules of the GamblingLess programme over 8 weeks. Participants in the GSD intervention will also receive weekly emails of guidance and support from a gambling counsellor. A total of 200 participants will be recruited. Participants will be eligible if they reside in Australia, are aged 18 years and over, have access to the internet, have adequate knowledge of the English language, are seeking help for their own gambling problems and are willing to take part in the intervention and associated assessments. Assessments will be conducted at preintervention, and at 2, 3 and 12 months from preintervention. The primary outcome is gambling severity, assessed using the Gambling Symptom Assessment Scale. Secondary outcomes include gambling frequency, gambling expenditure, psychological distress, quality of life and additional help-seeking. Qualitative interviews will also be conducted with a subsample of participants and the Guides (counsellors). ETHICS AND DISSEMINATION: The study has been approved by the Deakin University Human Research and Eastern Health Human Research Ethics Committees. Findings will be disseminated via report, peer-reviewed publications and conference presentations. TRIAL REGISTRATION NUMBER: ACTRN12615000864527; results.
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The study's sample size was determined a priori by a power calculation assuming a moderate interaction effect (f = 0.25), 5% significance, 95% power, and pre-post correlation 0.5, requiring 54 participants, then increased to 134 to allow for 60% attrition.
“Assuming an effect size of moderate magnitude (f = 0.25), (Cohen, 1988) a significance level of 5%, a statistical power of 95%, and a correlation between pre-treatment and post-treatment measures of 0.5, a total of 54 participants are needed.”
From Efficacy of an internet-based psychological intervention for problem gambling and gambling disorder: Study protocol for a randomized controlled trial (2021) · cites this paper as Merkouris et al. (2017)
The Methods > Sample size section gives a different calculation: 100 participants at postintervention to detect Cohen’s d = 0.55 with 80% power at p < 0.05, increased to 200 for anticipated 50% dropout. It does not give 54 participants, 95% power, or an increase to 134 for 60% attrition. (LLM, conf=0.91)
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Cunningham, J. A., Godinho, A., & Hodgins, D. C. (2019) · Addictive Behaviors Reports · doi:10.1016/j.abrep.2019.100175 · Cited by 16 · see citing works
Self-citationDowling, N. A., Merkouris, S., & Spence, K. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081709 · Cited by 14 · see citing works
Self-citationHumphrey, G., Chu, J. T. W., Ruwhiu-Collins, R., Erick-Peleti, S., Dowling, N. A., Merkouris, S., Newcombe, D. A. L., Rodda, S. N., Ho, E., Nosa, V. H., et al. (2022) · JMIR Formative Research · doi:10.2196/32940 · Cited by 13 · see citing works
Self-citationMide, M., Mattiasson, J., Norlin, D., Sehlin, H., Rasmusson, J., Ljung, S., Lindskog, A., Petersson, J., Saavedra, F., & Gordh, A. S. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1243826 · Cited by 12 · see citing works
Hawker, C. O., Merkouris, S., Thomas, A. C., Rodda, S. N., Cowlishaw, S., & Dowling, N. A. (2025) · Journal of Gambling Studies · doi:10.1007/s10899-024-10373-9 · Cited by 10 · see citing works
Self-citationSelf-directed interventions for gambling disorder
Abbott, M. (2019) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000515 · Cited by 10 · see citing works
Diaz-Sanahuja, L., Campos, D., Mira, A., Castilla, D., García-Palacios, A., & Bretón-López, J. M. (2021) · Internet Interventions · doi:10.1016/j.invent.2021.100466 · Cited by 10 · see citing works
Cunningham, J. A., Hodgins, D. C., Keough, M. T., Hendershot, C. S., Bennett, K., Bennett, A., & Godinho, A. (2018) · Trials · doi:10.1186/s13063-018-2672-x · Cited by 4 · see citing works
Self-citationSong, J., Ma, R., Zhao, X., Zhang, X., Wang, Y., Ling, M., & Zhou, Y.-Q. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06872-7 · Cited by 2 · see citing works
Dowling, N. A. (2022) · doi:10.2196/preprints.38958 · Cited by 1 · see citing works
Self-citationLópez, C. V., Díaz Aguilar, E., & del Peral, J. A. M. (2022) · Revista Española de Drogodependencias · doi:10.54108/10015
Dowling, N. A., Merkouris, S., Greenwood, C. J., Youssef, G. J., Thomas, A. C., Hawker, C. O., Lubman, D. I., & Rodda, S. N. (2025) · Journal of Medical Internet Research · doi:10.2196/79852
Self-citation
- Authors
- Merkouris, S. S., Rodda, S. N., Austin, D., Lubman, D. I., Harvey, P., Battersby, M., Cunningham, J., Lavis, T., Smith, D., & Dowling, N. A.
- Affiliations
- Deakin University (AU)
- Eastern Health (AU)
- Flinders University (AU)
- Australian National University (AU)
- Corresponding author
- Merkouris, S S
- ORCID
- Venue
- BMJ Open
- Publisher
- BMJ
- Published
- 2017-02
- Volume
- 7
- Issue
- 2
- Pages
- e014226
- ISSN
- 2044-6055 (ISSN-L)
- PMC
- PMC5337748
- OpenAlex
- W2589557221
- Cited by
- 21
- References
- 85
- Citations by year
- 2025: 3 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 2
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- BMJ Open (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- HighWire Press Open Archive (acceptedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc)
- Flinders Academic Commons (Flinders University) (submittedVersion)
- Flinders Academic Commons (Flinders University) (submittedVersion, cc-by-nc)
- Figshare (submittedVersion, cc-by-nc)
- ANU Open Research (Australian National University) (submittedVersion, cc-by-nc)
- ResearchSpace (University of Auckland) (submittedVersion, cc-by-nc)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- gambling addiction, self-guided intervention, gambling severity, psychological distress, quality of life, help-seeking, online therapy
- MeSH terms
- Adolescent, Adult, Aged, Australia, Female, Gambling, Humans, Male, Middle Aged, Quality of Life, Research Design, Cognitive Behavioral Therapy, Logistic Models, Internet, Young Adult
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