The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index; 1 of the 52 sources its claims cite were checked for support.
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice
Open accessAbstract
Deficits in social interaction are important early markers for autism and related neurodevelopmental disorders with strong genetic components. Standardized behavioral assays that measure the preference of mice for initiating social interactions with novel conspecifics would be of great value for mutant mouse models of autism. We developed a new procedure to assess sociability and the preference for social novelty in mice. To quantitate sociability, each mouse was scored on measures of exploration in a central habituated area, a side chamber containing an unfamiliar conspecific (stranger 1) in a wire cage, or an empty side chamber. In a secondary test, preference for social novelty was quantitated by presenting the test mouse with a choice between the first, now‐familiar, conspecific (stranger 1) in one side chamber, and a second unfamiliar mouse (stranger 2) in the other side chamber. Parameters scored included time spent in each chamber and number of entries into the chambers. Five inbred strains of mice were tested, C57BL/6J, DBA/2J, FVB/NJ, A/J and B6129PF2/J hybrids. Four strains showed significant levels of sociability (spend‐ ing more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now‐familiar stranger 1). These social preferences were observed in both male and female mice, and in juveniles and adults. The exception was A/J, a strain that demonstrated a preference for the central chamber. Results are discussed in terms of potential applications of the new methods, and the proper controls for the interpretation of social behavior data, including assays for health, relevant sensory abilities and motor functions. This new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.
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63 Own result · 16 No full text of the sources · 15 Own method · 6 Not checked yet · 6 Own interpretation · 5 Sources not found · 2 No basis given · 1 Partly supported · accuracy not yet measured
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Four strains showed significant levels of sociability (spending more time in the chamber containing stranger 1 than in the empty chamber)”
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In the paper
“Four strains showed significant levels of sociability (spending more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now-familiar stranger 1).”
plain- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The exception was A/J, a strain that demonstrated a preference for the central chamber.”
boosted- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Overall, four of the five inbred and hybrid strains tested spent more time in the side of the social test box containing the unfamiliar stranger, vs. time in the empty side.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“DBA/2 mice tended to have lower numbers of entries than the C57BL/6J mice (Fig. 10b; significant main effect of strain, F 1,9 ¼ 16.156, P ¼ 0.003; retest, F 1,9 ¼ 36.215,P ¼ 0.0002; and side, F 1,9 ¼ 8.723, P ¼ 0.0161).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“Finally, the adult C57BL/6J and DBA/2 mice had higher numbers of entries into the side of the chamber containing the unfamiliar conspecific in the sociability test.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plainn = 2- Asserted: passes — The authors put it forward as true.
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In the paper
“Adult A/J males failed to show a significant preference for the side containing stranger 1, as compared to the empty side.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“The low number of entries observed in the A/J mice was significantly different from both of the other inbred strains (post hoc tests following repeated measures ANOVA, F-values above).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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- It may state two separate claims as one. 24
- The quote only partly states this claim. 1
- Probably not a substantial claim. 32
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Higher numbers of sniffs were directed toward stranger 1 than towards the empty wire cage, and towards the novel stranger 2 vs. the now-familiar stranger 1, in C57BL/6J, DBA/2J and FVB/NJ male mice (Nadler et al. 2004).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Partly supportedcites Nadler et al. 2004 sourceExperimental — accuracy not yet measured
The “Social behavior tasks in three inbred strains” section reports that males of all three named strains spent more time sniffing the cage containing stranger 1 than the empty cage, and more time sniffing stranger 2 than stranger 1. The “Sociability test” section specifies that sniffing was scored as cumulative duration in seconds, not as a number of sniffs; that measurement in the claim is unsupported. Page numbers are unavailable in our copy. (LLM, conf=0.86)
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“General health, neurological reflexes, activity levels, motor functions and sensory abilities were normal in most regards for the strains tested.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Similar levels of sociability were clearly evident in a group of young female C57BL/6J mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
boosted- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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The quote only partly states this claim.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“A/J was the only strain tested that failed to spend more time with a conspecific, and spent most of its time in the central chamber after the initial 5-minute habituation session.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“All of the inbred strains were able to locate buried food, supporting an interpretation that none were anosmic, which could have severely impacted social behaviors by blocking detection of olfactory cues emitted by the stranger mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“For the olfactory test, the majority of the subjects successfully located and retrieved the buried food.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > General health, home cage behavior, neurophysiological reflexes and sensory and motor function
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As shown in Fig. 9, the A/J group did show significant increases in time spent in the side regions (Fig. 9a, significant main effect of retest, F 1,9 ¼ 11.343, P ¼ 0.0083) and in number of entries (Fig. 9b, significant main effect of retest, F 1,9 ¼ 13.302, P ¼ 0.0053) when the openings between chambers were more accessible.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Sociability procedure with modified social test box
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the significantly higher locomotor scores observed in the FVB/NJ strain, in comparison to the other two groups, were not reflected in an overall higher number of entries.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The FVB/NJ mice demonstrated a significantly shorter latency for locating the buried food,”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
boosted- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“A significant interaction was found between side of chamber and test condition (F 1,57 ¼ 67.634, P < 0.0001), reflecting the finding that preference was for the stranger 1 side during the first half of the session (the sociability condition), but switched to the stranger 2 side during the last part of the session (the social novelty condition).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Social behavior
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Arguing against an artifactual interpretation that hypolocomotion caused the social deficit in the A/J group are the data of Fig. 8. Repeated testing of A/J in the modified apparatus increased the number of entries, but did not yield significant sociability scores.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The A/J mice spent significantly more time in the center chamber, indicating a strong preference for the start box that was not seen in the other strains.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the second group of juvenile C57BL/6J mice, both males and females made equal numbers of entries into each side of the social test box during the assay for sociability, but showed an increased number of entries into the side of the social box containing the second, 'novel' unfamiliar stranger during the test for social novelty.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There were no significant differences between the strains in body weight or rotarod performance (see Table 1 for mean latency to fall on the second trial).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > General health, home cage behavior, neurophysiological reflexes and sensory and motor function
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, for the juvenile male mice, number of entries did not reflect the trends for social preference seen in the duration measures, and only partially correlated with their locomotor activity independently quantitated in the open field.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In addition, low locomotor scores in DBA/2J and high locomotor scores in FVB/NJ appeared to be unrelated to amount of time spent in the chamber with stranger 1 and stranger 2.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Significant preferences for sociability (Fig. 3a) or preference for social novelty (Fig. 3b) were not observed for number of chamber entries in any of the inbred strains.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Social behavior
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the present study, the juvenile male mice made nests and huddled together while sleeping.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Autistic individuals may further avoid unfamiliar social partners and display diminished interest in novelty (American Psychiatric Association 1994).”
What the sources say
- Not matchedcites American Psychiatric Association 1994
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
hedgedconditional- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. It may state two separate claims as one.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“This modification focuses the task on social approach tendencies, relevant to the social approach deficit in autism, while avoiding potential confounds resulting from aggressive or sexual interactions.”
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Rests on an assumption: Most autistic individuals demonstrate reduced or unusual social approach.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“To ensure that differences in social behaviors were not artifacts of other aspects of mouse behaviors, a series of independent control experiments was conducted to evaluate potential confounding factors.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The number of times that the mouse exited from the habituated empty central chamber into the novel empty chamber provided a general measure of locomotor function.”
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Social behaviors have been explored in mice with mutations in candidate genes such as oxytocin (Winslow & Insel 2002;Young et al. 2002), monoamine oxidase-A (Shih & Chen 1999), fragile X (Churchill et al. 2002;Mineur et al. 2002) and dishevelled-1 (Lijam et al. 1997).”
What the sources say
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Further controls were designed to detect additional symptoms relevant to autism, such as abnormalities in locomotion or motor coordination (Hallett et al. 1993;Piven et al. 1997), that could directly affect performance of the social task.”
What the sources say
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
In the paper
“Measures of general health, home cage behavior and neurological reflexes were conducted to rule out gross physical abnormalities (Crawley 2000).”
What the sources say
- Not checked — no full text of the sourcecites Crawley 2000
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Retrieval of food buried in cage bedding was quantitated in a 15-minute olfactory test, to ensure that the subject mice were not grossly impaired in olfaction abilities.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
None of the sources cited for this claim have been checked yet.
In the paper
“A large body of evidence from twin and family studies supports the important role of genetic factors in the etiology of autism (Bailey et al. 1995;Ritvo et al. 1989;Szatmari et al. 1998).”
What the sources say
boostedcorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present mouse tasks were designed to maximize face validity to some of the core symptoms of autism.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, the A/J mice were given a second test one week later, with the dividing walls between the chamber sides partially retracted to facilitate exploration.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Test for sociability in adult male mice
plainn = 10- Asserted: passes — The authors put it forward as true.
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- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Given the primacy of social impairment in autism, we considered this symptom to be fundamental to a mouse model of autism (Insel 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
What the sources say
- Not matchedcites Insel 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
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Probably not a substantial claim.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Several additional behavioral assays were performed in the initial set of juvenile male mice (C57BL/6J, DBA/2J and FVB/ NJ).These assays were designed as controls for sensory and motor abilities, etc., to ensure that the test mice were physically able to perform the procedures necessary for the social tasks described above.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The chambers of the social apparatus were cleaned and fresh paper chip bedding was added between trials.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The location of stranger 1 in the left vs. right side chamber was systematically alternated between trials.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“In our experience to date with the present procedures, human observers attain a high level of proficiency after only one or two practice sessions, with high rates (greater than 95%) of interrater reliability between trained observers.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present protocol used a small wire cage to enclose the stimulus mouse, which allowed visual, auditory and olfactory contact between the mice, but prevented the occurrence of aggressive and other responses.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
In the paper
“From an early age, autistic children show low levels of eye contact and affective responses, less orientation toward others and language deficits, with a concomitant paucity of speech and social communication (for review, see Tager-Flusberg et al. 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
What the sources say
- Not checked — no full text of the sourcecites Tager-Flusberg et al. 2001 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The stranger mouse was enclosed in a small, round wire cage (Galaxy Cup, Spectrum Diversified Designs, Inc., Streetsboro, OH), which allowed nose contact between the bars, but prevented fighting.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Previous work in social recognition has shown that mice show both habituation of olfactory responses directed toward an unfamiliar conspecific, and dishabituation, with a reinstatement of social sniffing, when a novel stimulus animal is presented (Bluthe et al. 1993;Dluzen & Kreutzberg 1993;Ferguson et al. 2000;Kogan et al. 2000;Winslow & Camacho 1995).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Alternatively, these data may reflect the low levels of open field exploratory behaviors and high levels of anxiety-like behaviors in the light/dark transitions test reported for A/J mice in other studies (Bouwknecht & Paylor 2002;Mathis et al. 1994Mathis et al. , 1995;;Thifault et al. 2002;Wahlsten et al. 2003) and reflected in the low number of entries in the present study.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present procedures for the sociability and social novelty tests are designed to be simple, quantitative and easily mastered by investigators.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. It may be too vague to check against evidence. The paper’s conclusions may not depend on it. The paper may give no reason why it holds. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, the present methods were designed to quantitate levels of sociability, i.e. tendency to initiate social contact, and preference for social novelty, i.e. tendency to initiate social contacts with a new individual as compared to someone familiar from past experience, using a simple scoring approach for laboratory mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“For example, some autistic patients demonstrate aberrant motor responses, including repeated hand flapping, jumping and other repetitive and stereotyped behaviors (Bodfish et al. 2000;Tager-Flusberg et al. 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Altered sensory responses have been reported, including both hypo-and hyper-reactivity to environmental stimuli (Baranek 2002).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Baranek 2002 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Observational findings in some of these behavioral domains have been reported in some targeted gene mutations, e.g.deficits in social interaction within the home cage have been reported for mice deficient in the dishevelled-1 gene (Lijam et al. 1997) or the NMDA NR1 subunit (Mohn et al. 1999).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Use of the three-chambered apparatus for demonstrating social preference (Insel 2001) was adapted by Brodkin et al. (2004) to investigate social approach and avoidance in female mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not matchedcites Insel 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites Brodkin et al. 2004 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Observations of mice in these settings have shown that exposure to an unfamiliar stranger typically evokes a period of intense social sniffing, which may be followed by escalating aggressive responses or sexual behavior, dependent upon such factors as age and sex of the unfamiliar conspecific (Bluthe et al. 1993;Kogan et al. 2000;Winslow & Camacho 1995).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“and the mouse model of fragile X syndrome has been characterized by changes in activity (Bakker et al. 1994;Peier et al. 2000) and reactivity to acoustic stimuli (Chen & Toth 2001;Nielson et al. 2002).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not matchedcites Bakker et al. 1994
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites Peier et al. 2000
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites Chen & Toth 2001 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
In the paper
“Children with fragile X syndrome often show autistic behavior (Hagerman et al. 1986),”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Hagerman et al. 1986 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“As noted by Winslow (2003), the analysis of the full behavioral series that can occur in social tests demands familiarity with the mouse ethogram, extensive training and the ability to discern the sometimes rapid and fleeting responses that mice can emit.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Winslow 2003 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Methods are based on procedures examining pair-bonding in voles (Dean, S.M. & Vandenbergh, J.G. as above), as well as many other elegant tests for social behavior in rodents (Bluthe et al. 1993;Carter et al. 1995;Dluzen & Kreutzberg 1993;Gheusi et al. 1994;Insel and Young 2001;Kogan et al. 2000;Winslow & Camacho 1995;Winslow 2003).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
Most autistic individuals demonstrate reduced or unusual social approach.
“We reasoned that most autistic individuals demonstrate reduced or unusual social approach.”
The paper relies on this without support.
Behavioral models of autistic-like responses in mice have received little attention.
“However, to date, behavioral models of autistic-like responses in mice have received little attention.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Studies aimed at modeling, in animals, the core phenotypes associated with ASDs have focused on studying social and repetitive behaviors in mice [530-532] and pair-bonding behaviors in the prairie vole (Microtus ochrogaster) [533,534].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [530]
In the citing paper
“There is compelling evidence that some strains are more”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [9]
In the citing paper
“However, almost all of them display some level of sociability (ie, preference to explore other mice over inanimate objects 9 ).”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [9]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Test for sociability in adult male mice
“the social novelty test was not conducted”
Citations
Cites
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The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
A Comparison of the Social Postures of Some Common Laboratory Rodents
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Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
Fmr1 knockout mice: A model to study fragile X mental retardation
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Cited by
Sorted by citations
Items 101–200 of 1,472
Lin, Y.-T., Hsieh, T.-Y., Tsai, T.-C., Chen, C.-C., Huang, C.-C., & Hsu, K.-S. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1896-17.2017 · Cited by 165
“The three-chamber tests for sociability, response to social novelty and SRM were performed as previously described (Moy et al., 2004) with minor modifications.”
MethodIntegrins in synapse regulation
Park, Y. K., & Goda, Y. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.138 · Cited by 167
Kctd13 deletion reduces synaptic transmission via increased RhoA
Escamilla, C. O., Filonova, I., Walker, A. K., Xuan, Z. X., Holehonnur, R., Espinosa, F., Liu, S., Thyme, S. B., López-García, I. A., Mendoza, D. B., et al. (2017) · Nature · doi:10.1038/nature24470 · Cited by 165
Distinct and Dynamic ON and OFF Neural Ensembles in the Prefrontal Cortex Code Social Exploration
Liang, B., Zhang, L., Barbera, G., Fang, W., Zhang, J., Chen, X., Chen, R., Li, Y., & Lin, D. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.043 · Cited by 174
Social Behavior Is Modulated by Valence-Encoding mPFC-Amygdala Sub-circuitry
Huang, W., Zucca, A., Levy, J., & Page, D. T. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107899 · Cited by 171
“…either the PL-BLA or IL-BLA circuit to probe their function in social approach-avoidance behavior by using the three-chamber social approach assay to assess social interaction, as mice innately prefer to engage with a social rather than a non-social stimulus in this test (Moy et al., 2004).”
Ankrd11 Is a Chromatin Regulator Involved in Autism that Is Essential for Neural Development
Gallagher, D., Voronova, A., Zander, M. A., Cancino, G. I., Bramall, A. N., Krause, M. P., Abad, C., Tekin, M., Neilsen, P. M., Callen, D. F., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.031 · Cited by 171
Kosel, F., Pelley, J. M. S., & Franklin, T. B. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.012 · Cited by 173
Autism-Relevant Social Abnormalities and Cognitive Deficits in Engrailed-2 Knockout Mice
Brielmaier, J. M., Matteson, P. G., Silverman, J. L., Senerth, J. M., Kelly, S., Genestine, M., Millonig, J. H., DiCicco-Bloom, E. M., & Crawley, J. N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040914 · Cited by 162
“[77,146,161–163]).”
Self-citationMicrobiota influence the development of the brain and behaviors in C57BL/6J mice
Lu, J., Synowiec, S., Lu, L., Yu, Y., Bretherick, T., Takada, S., Yarnykh, V., Caplan, J., Caplan, M., Claud, E. C., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201829 · Cited by 159
Trainor, B. C., Pride, M. C., Villalon Landeros, R., Knoblauch, N. W., Takahashi, E. Y., Silva, A. L., & Crean, K. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017405 · Cited by 157
“Social interaction testing has become prevalent in various forms [8,51,52,53], and the vast majority of studies are conducted in a novel environment.”
BackgroundDiCarlo, G. E., Aguilar, J. I., Matthies, H. J. G., Harrison, F. E., Bundschuh, K. E., West, A. M., Hashemi, P., Herborg, F., Rickhag, M., Chen, H., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci127411 · Cited by 150
Yang, L., Zou, B., Xiong, X., Pascual, C., Xie, J., Malik, A., Xie, J., Sakurai, T., & Xie, X. (. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3200-12.2013 · Cited by 153
“The three-chamber apparatus and testing procedure have been used commonly to assess rodents’ sociability, social novelty, and social memory (Crawley, 2004; Moy et al., 2004; Deng et al., 2007).”
MethodBicks, L. K., Yamamuro, K., Flanigan, M. E., Kim, J. M., Kato, D., Lucas, E. K., Koike, H., Peng, M. S., Brady, D. M., Chandrasekaran, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14740-z · Cited by 150
Optogenetic insights on the relationship between anxiety-related behaviors and social deficits
Allsop, S. A., Vander Weele, C. M., Wichmann, R., & Tye, K. M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00241 · Cited by 150
“While impairments in social function are found in a variety of psychiatric disorders (Ormel et al., 1993; Wohlfarth et al., 1993; American Psychiatric Association, 2013), the prevalence of social anxiety disorder and the high rate of co-morbidity between anxiety and autism spectrum disorders…”
BackgroundERK2 Contributes to the Control of Social Behaviors in Mice
Satoh, Y., Endo, S., Nakata, T., Kobayashi, Y., Yamada, K., Ikeda, T., Takeuchi, A., Hiramoto, T., Watanabe, Y., & Kazama, T. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2349-11.2011 · Cited by 145
“Social preference for novelty was performed in a three-room chamber as previously described (Moy et al., 2004).”
MethodVasopressin 1b Receptor Knock-Out Impairs Memory for Temporal Order
DeVito, L. M., Konigsberg, R., Lykken, C., Sauvage, M., Young, W. S., & Eichenbaum, H. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5488-08.2009 · Cited by 147
“The social recognition paradigm was adapted from that of Moy et al. (2004).”
BackgroundMethodLow stress reactivity and neuroendocrine factors in the BTBR T+tf/J mouse model of autism
Silverman, J. L., Yang, M., Turner, S. M., Katz, A. M., Bell, D. B., Koenig, J. I., & Crawley, J. N. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.059 · Cited by 146
Self-citationRodent tests of depression and anxiety: Construct validity and translational relevance
Gencturk, S., & Ünal, G. (2024) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-024-01171-2 · Cited by 160
“The three-chambered social approach test apparatus comprises a central compartment, where the test animal is positioned, and two side compartments adjacent to the center (Landauer & Balster, 1982; Moy et al., 2004; Nadler et al., 2004).”
BackgroundMethodInfluentialSamaco, R. C., Mandel‐Brehm, C., McGraw, C. M., Shaw, C. A., McGill, B. E., & Zoghbi, H. Y. (2012) · Nature Genetics · doi:10.1038/ng.1066 · Cited by 148
“We therefore chose to further characterize the social behavior abnormalities of MECP2 -TG1 mice by subjecting these animals to the three-chamber test for sociabilit”
MethodPham, M., Raymond, J., Hester, J., Kyzar, E. J., Gaikwad, S., Bruce, I., Fryar, C., Chanin, S., Enriquez, J., Bagawandoss, S., et al. (2012) · Neuromethods · doi:10.1007/978-1-61779-597-8_17 · Cited by 155
“Based on a similar rodent paradigm [13, 42, 43], it assesses zebrafish sociability by observing the interactions between several fish, and assessing zebrafish preference for conspecifics.”
BackgroundKane, M. J., Angoa‐Pérez, M., Briggs, D. I., Sykes, C. E., Francescutti, D. M., Rosenberg, D. R., & Kuhn, D. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048975 · Cited by 145
“Moy and colleagues [63] were followed for this test.”
BackgroundThe neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation
Lee, C. R., Chen, A., & Tye, K. M. (2021) · Cell · doi:10.1016/j.cell.2021.02.028 · Cited by 148
“Familiarity of a social agent provides context for an interaction, and while some species may prefer interacting with familiar individuals, others, such as mice, prefer to interact with unfamiliar individuals over familiar individuals (Moy et al., 2004).”
BackgroundFaizi, M., Bader, P. L., Tun, C., Encarnacion, A., Kleschevnikov, A. M., Belichenko, P. V., Saw, N. L., Priestley, M., Tsien, R. W., Mobley, W. C., et al. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.04.011 · Cited by 141
“In the 3-chamber test, we found no deficits in Ts65Dn mice both in session B (test for sociability), as well as in session C (test for preference for social novelty) (Crawley, 2007; Moy et al., 2004; Moy et al., 2007).”
MethodSpeed, H. E., Kouser, M., Xuan, Z., Reimers, J. M., Ochoa, C. F., Gupta, N. M., Liu, S., & Powell, C. M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3125-14.2015 · Cited by 148
“, 2009) and based to a large extent on the original descriptions (Moy et al., 2004; Nadler et al., 2004).”
BackgroundMethodTSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons
Caubit, X., Gubellini, P., Andrieux, J., Roubertoux, P. L., Metwaly, M., Jacq, B., Fatmi, A., Had‐Aissouni, L., Kwan, K. Y., Salin, P., et al. (2016) · Nature Genetics · doi:10.1038/ng.3681 · Cited by 139
“…social novelty (increased number of interactions towards an unknown conspecific, i.e a new arrival) were measured in the Tshz3 +/lacZ and wild-type male mice according to the principles of the three-chamber test 45,46 but in a different two-chamber set up 43,44 , with opaque walls, as shown in Fig.”
InfluentialLabrie, V., Lipina, T. V., & Roder, J. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1196-6 · Cited by 141
“Social affiliations The social affiliations task was adapted from previously described studies (Brodkin et al. 2004; Moy et al. 2004).”
MethodGould, G. G., Hensler, J. G., Burke, T. F., Benno, R. H., Onaivi, E. S., & Daws, L. C. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07104.x · Cited by 141
Ecological validity of social interaction tests in rats and mice
Kondrakiewicz, K., Kostecki, M., Szadzińska, W., & Knapska, E. (2019) · Genes, Brain and Behavior · doi:10.1111/gbb.12525 · Cited by 136
“Some tend to group together more than others(1) and/or engage in more social interactions.(9) However, almost all of them display some level of sociability (ie, preference to explore other mice over inanimate objects(9)).”
BackgroundWu, H., Wang, X., Gao, J., Liang, S., Hao, Y., Sun, C., Xia, W., Cao, Y., & Wu, L. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.01.012 · Cited by 137
Defensor, E. B., Pearson, B. L., Pobbe, R. L. H., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.033 · Cited by 136
“A combination of social interaction tests have been used to identify low social responsiveness in inbred candidate strains [4],[11],[12],[18],[19], [20],[41],[45],[46],[48],[54],[70].”
BackgroundMouse models of autism spectrum disorders: The challenge for behavioral genetics
Moy, S. S., Nadler, J. J., Magnuson, T., & Crawley, J. N. (2006) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.30081 · Cited by 141
“…a behavioral testing screen with measures relevant to the clinical syndrome is crucial for the development and evaluation of appropriate animal models [Rodier, 1996; Insel, 2001;Murcia et al., 2004], few mouse tests have been targeted toward the constellation of symptoms characteristic of the ASDs.”
BackgroundMethodSelf-citationThe role of the microbiome in the neurobiology of social behaviour
Sarkar, A., Harty, S., Johnson, K. V. ‐., Moeller, A. H., Carmody, R. N., Lehto, S. M., Erdman, S. E., Dunbar, R. I. M., & Burnet, P. W. J. (2020) · Biological Reviews · doi:10.1111/brv.12603 · Cited by 135
Behavioral and Neuroanatomical Phenotypes in Mouse Models of Autism
Ellegood, J., & Crawley, J. N. (2015) · Neurotherapeutics · doi:10.1007/s13311-015-0360-z · Cited by 137
Self-citationSocial deficits in BTBR T + tf/J mice are unchanged by cross‐fostering with C57BL/6J mothers
Yang, M., Zhodzishsky, V., & Crawley, J. N. (2007) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2007.09.008 · Cited by 132
“Social approach behaviors were tested in an automated three-chambered apparatus using methods similar to those previously described (Moy et al., 2004, 2007; Nadler et al., 2004; Crawley et al., 2007; McFarlane et al., 2007).”
MethodSelf-citationEhrlichman, R. S., Luminais, S. N., White, S., Rudnick, N. D., Ma, N., Dow, H. C., Kreibich, A. S., Abel, T. G., Brodkin, E. S., Hahn, C.-G., et al. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.065 · Cited by 134
“, 2003), sociability (Brodkin, 2007; Fairless et al., 2008; Moy et al., 2004; Moy et al., 2007; Yang et al., 2007) as well as novel object recognition and fear conditioning (Orsini et al.”
BackgroundTanda, K., Nishi, A., Matsuo, N., Nakanishi, K., Yamasaki, N., Sugimoto, T., Toyama, K., Takao, K., & Miyakawa, T. (2009) · Molecular Brain · doi:10.1186/1756-6606-2-19 · Cited by 136
“The test for sociability and preference for social novelty was conducted as previously described [50,51].”
MethodSex-dependent behavioral deficits and neuropathology in a maternal immune activation model of autism
Haïda, O., Sagheer, T. A., Balbous, A., Francheteau, M., Matas, E., Soria, F. N., Fernagut, P., & Jaber, M. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0457-y · Cited by 139
Banerjee, S., Wang, Y., Solt, L. A., Griffett, K., Kazantzis, M., Amador, A., Elgendy, B., Huitrón‐Reséndiz, S., Roberts, A. J., Shin, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms6759 · Cited by 133
El-Kordi, A., Winkler, D., Hammerschmidt, K., Kästner, A., Krueger‐Burg, D., Ronnenberg, A., Ritter, C., Jatho, J., Radyushkin, K., Bourgeron, T., et al. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.11.016 · Cited by 134
Al-Amin, M. M., Rahman, M., Khan, F. R., Zaman, F., & Reza, H. M. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.041 · Cited by 135
A myelin gene causative of a catatonia‐depression syndrome upon aging
Hagemeyer, N., Goebbels, S., Papiol, S., Kästner, A., Hofer, S., Begemann, M., Gerwig, U. C., Boretius, S., Wieser, G. L., Ronnenberg, A., et al. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200230 · Cited by 131
Wilson, C., & Koenig, J. I. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.11.008 · Cited by 136
“Another version of the task utilizes an arena divided into several chambers and the time the rodent (typically mice) spends in the chamber with a caged unfamiliar conspecific and the empty chambers is scored (Moy et al., 2004).”
BackgroundZhou, X., Sun, L., Bracko, O., Choi, J. W., Jia, Y., Nana, A. L., Brady, O. A., Hernández, J. C. C., Nishimura, N., Seeley, W. W., et al. (2017) · Nature Communications · doi:10.1038/ncomms15277 · Cited by 132
Gestational exposure to bisphenol A and cross-fostering affect behaviors in juvenile mice.
Cox, K. H., Gatewood, J. D., Howeth, C., & Rissman, E. F. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.07.008 · Cited by 127
“N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript The time spent in each chamber, the time spent sniffing each jail cell, and the numbers of entries into each side were all scored (adapted from (Moy et al., 2004; Moy et al., 2009).”
MethodChoi, C. S., Gonzales, E. L., Kim, K. C., Yang, S. M., Kim, J., Mabunga, D. F. N., Cheong, J. H., Han, S., Bahn, G. H., & Shin, C. Y. (2016) · Scientific Reports · doi:10.1038/srep36250 · Cited by 136
Ultrasonic signals associated with different types of social behavior of mice
Sangiamo, D. T., Warren, M. R., & Neunuebel, J. P. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0584-z · Cited by 134
“For instance, tube tests assess social dominance 42 , three-chamber tests evaluate sociability 43 , and discrimination tasks probe decision making 44 .”
Adenylosuccinate lyase deficiency
Spiegel, E. K., Colman, R. F., & PATTERSON, D. (2006) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2006.04.018 · Cited by 126
Yang, M. (2007) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.001.2007 · Cited by 124
Deletion of Glutamate Delta-1 Receptor in Mouse Leads to Aberrant Emotional and Social Behaviors
Yadav, R., Gupta, S. C., Hillman, B. G., Bhatt, J. M., Stairs, D. J., & Dravid, S. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032969 · Cited by 129
Pobbe, R. L. H., Pearson, B. L., Defensor, E. B., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.06.025 · Cited by 124
“The use of inbred strains of mice provides valuable translational tools to assess the interplay of genetic and environmental factors in neurodevelopmental disorders [13,32,34,35,37].”
BackgroundMethodLewis, A. S., Vaidya, S. P., Blaiss, C. A., Liu, Z., Stoub, T. R., Brager, D. H., Chen, X., Bender, R. A., Estep, C. M., Popov, A. B., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0936-11.2011 · Cited by 129
“The test of social interaction with an adult caged conspecific, modified from the study by Moy et al. (2004), was conducted essentially as described previously (Kwon et al., 2006; Tabuchi et al., 2007; Blundell et al., 2009; Etherton et al., 2009), and TopScan videotracking software (version 2.00;…”
MethodInfluentialFemale mice are protected from space radiation-induced maladaptive responses
Krukowski, K., Grue, K. A., Frias, E. S., Pietrykowski, J., Jones, T., Nelson, G. A., & Rosi, S. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.08.008 · Cited by 126
“These observed deficits in social functions could be due to a lack of motivation, anxiety and/or diminished response to novelty (Moy, 2004; Sobota et al., 2015; Allsop et al., 2014).”
BackgroundCriteria for validating mouse models of psychiatric diseases
Chadman, K. K., Yang, M., & Crawley, J. N. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30777 · Cited by 131
“Our automated three chambered social approach task assays aspects of sociability in mice that are most relevant to the first diagnostic symptom of autism, and can be used repeatedly in the same animals for longitudinal analyses of neurodevelopmental models [Moy et al., 2004; Nadler et al., 2004; Crawley, 2007a; Moy et…”
BackgroundMethodSelf-citationOverproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice
Fang, W.-Q., Chen, W.-W., Jiang, L., Liu, K., Yung, W.-H., Fu, A. K. Y., & Ip, N. Y. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.003 · Cited by 114
Jaramillo, T. C., Speed, H. E., Xuan, Z., Reimers, J. M., Escamilla, C. O., Weaver, T. P., Liu, S., Filonova, I., & Powell, C. M. (2017) · Autism Research · doi:10.1002/aur.1664 · Cited by 119
“Three-chamber social approach, social preference and social novelty was tested using a three-chambered box as described previously [Blundell et al., 2009] and based to a large extent on the original descriptions [Moy et al., 2004; Nadler et al., 2004].”
Zhang, H., Kang, E., Wang, Y., Yang, C., Yu, H., Wang, Q., Chen, Z.-Y., Zhang, C., Christian, K. M., Song, H., et al. (2016) · Nature Communications · doi:10.1038/ncomms11773 · Cited by 119
Distinct neural mechanisms for the prosocial and rewarding properties of MDMA
Heifets, B. D., Salgado, J. S., Taylor, M. D., Hoerbelt, P., Cardozo Pinto, D. F., Steinberg, E. E., Walsh, J. J., Sze, J. Y., & Malenka, R. C. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw6435 · Cited by 120
“Social approach testing was performed similar to previously described methods (17).”
MethodJeans, A. F., Oliver, P. L., Johnson, R., Capogna, M., Vikman, J., Molnár, Z., Babbs, A., Partridge, C. J., Salehi, A. A., Bengtsson, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610222104 · Cited by 122
Ehninger, D., Sano, Y., de Vries, P. J., Dies, K., Franz, D., Geschwind, D. H., Kaur, M., Lee, Y.-S., Li, W., Lowe, J. K., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2010.115 · Cited by 120
Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability
Yang, M., Clarke, A. M., & Crawley, J. N. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06714.x · Cited by 117
“Forward genetic approaches identify inbred strains of mice with phenotypes relevant to autism, and explore mechanisms responsible for the phenotypes (Brodkin, 2007; Moy et al., 2004, 2007; Panksepp & Lahvis, 2007; McFarlane et al., Correspondence: Dr M. Yang, as above.”
BackgroundSelf-citationNapoli, E., Ross‐Inta, C., Wong, S., Hung, C., Fujisawa, Y., Sakaguchi, D., Angelastro, J. M., Omanska-Klusek, A., Schoenfeld, R. A., & Giulivi, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042504 · Cited by 116
“Sociability (the tendency to spend time with another conspecific), preference for social novelty, and the ability to discriminate and choose between familiar and new conspecifics were tested in Het and HET-CRE mice [30,31].”
BackgroundMethodNikolopoulos, D., Manolakou, T., Polissidis, A., Filia, A., Bertsias, G. K., Koutmani, Y., & Boumpas, D. T. (2023) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2022-223506 · Cited by 121
“…and nephritic stage: novel object recognition (NOR), novel object location (NOL) tasks, 19 elevated plus maze, 20 rotarod, 21 tail suspension test, 22 prepulse inhibition (PPI), 23 sociability (social novelty and social preference) 24 and sucrose preference test (SPT) 25 as previously described.”
Serine racemase deletion disrupts memory for order and alters cortical dendritic morphology
DeVito, L. M., Balu, D. T., Kanter, B. R., Lykken, C., Basu, A. C., COYLE, J. T., & Eichenbaum, H. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00656.x · Cited by 114
“Social recognition: sociability and preference for social novelty A social recognition paradigm was adapted from Moy et al. (2004).”
MethodSingle prolonged stress impairs social and object novelty recognition in rats
Eagle, A. L., Fitzpatrick, C. J., & Perrine, S. A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.09.014 · Cited by 117
“This test was conducted using a previously established behavioral paradigm for social discrimination [21] and autism-like sociability and social novelty preference impairments in mice [22], which uses wire mesh to eliminate tactile social interaction.”
Tartaglione, A. M., Schiavi, S., Calamandrei, G., & Trezza, V. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.12.024 · Cited by 117
Arac, A., Zhao, P., Dobkin, B. H., Carmichael, S. T., & Golshani, P. (2019) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2019.00020 · Cited by 112
General and social anxiety in the BTBR T+ tf/J mouse strain
Pobbe, R. L. H., Defensor, E. B., Pearson, B. L., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.08.039 · Cited by 121
“In the second experiment, we used an extensively investigated three-chambered test [41] to verify the effect of systemic administration of an anxiolytic compound, diazepam, on B6 and BTBR social preferences.”
MethodYu, W., Pati, D., Pina, M. M., Schmidt, K. T., Boyt, K. M., Hunker, A. C., Zweifel, L. S., McElligott, Z. A., & Kash, T. L. (2021) · Neuron · doi:10.1016/j.neuron.2021.03.001 · Cited by 112
Carter, M. D., Shah, C. R., Muller, C. L., Crawley, J. N., Carneiro, A. M. D., & Veenstra-VanderWeele, J. M. (2011) · Autism Research · doi:10.1002/aur.180 · Cited by 113
“Three-chamber sociability and preference for social novelty test [Moy et al., 2004; Yang et al., 2007; Chadman et al., 2008; Silverman et al., 2010].”
BackgroundSelf-citationBrunner, D., Kabitzke, P., He, D., Cox, K., Thiede, L., Hanania, T., Sabath, E., Alexandrov, V., Saxe, M., Peles, E., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0134572 · Cited by 111
“The three-chamber test is a widely-used behavioral test to assess sociability and social recognition [56].”
MethodHCN2 Channels in Cholinergic Interneurons of Nucleus Accumbens Shell Regulate Depressive Behaviors
Cheng, J., Umschweif, G., Leung, J., Sagi, Y., & Greengard, P. (2019) · Neuron · doi:10.1016/j.neuron.2018.12.018 · Cited by 110
Liang, J., Xu, W., Hsu, Y.-T., Yee, A. X., Chen, L., & Südhof, T. C. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.31 · Cited by 110
Sakurai, T., Dorr, N. P., Takahashi, N., McInnes, L. A., Elder, G. A., & Buxbaum, J. D. (2011) · Autism Research · doi:10.1002/aur.169 · Cited by 108
Park, G., Ryu, C., Kim, S., Jeong, S. J., Koo, J. W., Lee, Y., & Kim, S. J. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109104 · Cited by 109
Bertoni, A., Schaller, F., Tyzio, R., Gaillard, S., Santini, F., Xolin, M., Diabira, D., Vaidyanathan, R., Matarazzo, V. A., Medina, I., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01227-6 · Cited by 110
Jabarin, R., Netser, S., & Wagner, S. (2022) · Molecular Autism · doi:10.1186/s13229-022-00521-6 · Cited by 119
Long-lived epigenetic interactions between perinatal PBDE exposure and Mecp2308 mutation
Woods, R., Vallero, R. O., Golub, M. S., Suarez, J., Ta, T. A., Yasui, D. H., Chi, L.-H., Kostyniak, P. J., Pessah, I. N., Berman, R. F., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds046 · Cited by 107
Reduced fear and aggression and altered serotonin metabolism in Gtf2ird1‐targeted mice
Young, E. J., Lipina, T. V., Tam, E., Mandel, A., Clapcote, S. J., Bechard, A. R., Chambers, J., Mount, H. T. J., Fletcher, P. J., Roder, J., et al. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00343.x · Cited by 109
“This was carried out as described previously, by measuring the time it took for eachmouse to find food buried in bedding (Moy et al. 2004).”
BackgroundMethodDong, Z., Chen, W., Chen, C., Wang, H., Cui, W., Tan, Z., Robinson, H., Gao, N., Luo, B., Zhang, L., et al. (2020) · Neuron · doi:10.1016/j.neuron.2019.10.035 · Cited by 109
Ricceri, L., Moles, A., & Crawley, J. N. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.024 · Cited by 113
Self-citationDere, E., Dahm, L., Lu, D. S., Hammerschmidt, K., Ju, A., Tantra, M., Kästner, A., Chowdhury, K., & Ehrenreich, H. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00181 · Cited by 107
Evidence supporting the match/mismatch hypothesis of psychiatric disorders
Santarelli, S., Lesuis, S. L., Wang, X., Wagner, K. V., Hartmann, J., Labermaier, C., Scharf, S. H., Müller, M. B., Holsboer, F., & Schmidt, M. V. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.02.002 · Cited by 115
“The sociability test was performed on PND93 as previously described (Moy et al., 2004; Sankoorikal et al., 2006), with slight modifications.”
MethodSocial peers rescue autism‐relevant sociability deficits in adolescent mice
Yang, M., Perry, K., Weber, M. D., Katz, A. M., & Crawley, J. N. (2011) · Autism Research · doi:10.1002/aur.163 · Cited by 106
“…to social cues as adults, and high repetitive selfgrooming that persists throughout development [Bolivar et al., 2007; McFarlane et al., 2008; Moy et al., 2004, 2008; Scattoni, Ricceri, & Crawley, 2010; Silverman et al., 2009; Wöhr, Roullet, & Crawley, 2010; Yang, Clarke, & Crawley, 2009;…”
BackgroundSelf-citationRDoC-based categorization of amygdala functions and its implications in autism
Hennessey, T., Andari, E., & Rainnie, D. G. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.04.007 · Cited by 107
“The autism phenotype is heterogeneous and not restricted to a lack of social approach, the gold standard measure in the majority of animal studies (Moy et al., 2004; Tordjman et al., 2007).”
Fluoxetine but not risperidone increases sociability in the BTBR mouse model of autism
Chadman, K. K. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.09.012 · Cited by 105
“…test has been developed to identify deficits in social interaction, whereby a subject mouse has the choice between a social and a non-social environment (Moy et al., 2004, 2007, 2009; Nadler et al., 2004; Yang et al., 2007a,b; McFarlane et al., 2008; Scattoni et al., 2008a; Chadman et al., 2008).”
Ketogenic diet improves behaviors in a maternal immune activation model of autism spectrum disorder
Ruskin, D. N., Murphy, M. I., Slade, S. L., & Masino, S. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171643 · Cited by 107
O’Tuathaigh, C. M. P., Hryniewiecka, M., Behan, Á. T., Tighe, O., Coughlan, C. A., Desbonnet, L., Cannon, M. D., Karayiorgou, M., Gogos, J. A., Cotter, D., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.100 · Cited by 103
“Sociability and social novelty preference This task has been used to provide an easily quantifiable measure of affiliative behavior and behavioral response to social novelty (”
MethodGuo, D., Peng, Y., Wang, L., Sun, X., Wang, X., Liang, C., Yang, X., Li, S., Xu, J., Ye, W.-C., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-019-0472-7 · Cited by 102
“Finally, social approach and social preference behaviors were assessed using the Three-chamber test 36 .”
Giusti, S. A., Vercelli, C. A., Vogl, A. M., Kolarz, A., Pino, N. S., Deussing, J. M., & Refojo, D. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.04.002 · Cited by 104
“The sociability test was performed using a three chamber apparatus, as previously described (Nadler et al., 2004; Hartmann et al., 2012; Moy et al., 2004).”
BackgroundMethodValproic acid exposure sequentially activates Wnt and mTOR pathways in rats
Qin, L., Dai, X., & Yin, Y. (2016) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2016.06.004 · Cited by 101
Wang, X., Lu, J., Xie, W., Lu, X., Liang, Y., Li, M., Wang, Z., Huang, X., Tang, M., Pfaff, D. W., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1912625116 · Cited by 103
Kim, B. B., Colon, E., Chawla, S., Vandenberg, L. N., & Suvorov, A. (2015) · Environmental Health · doi:10.1186/s12940-015-0051-6 · Cited by 107
“To assess sociability and the preference for social novelty in male mice, we used the Three-Chamber Social Approach Test described elsewhere [32, 33].”
MethodSala, M., Braida, D., Donzelli, A., Martucci, R., Busnelli, M., Bulgheroni, E., Rubino, T., Parolaro, D., Nishimori, K., & Chini, B. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02385.x · Cited by 104
Prosocial effects of oxytocin in two mouse models of autism spectrum disorders
Teng, B. L., Nonneman, R. J., Agster, K. L., Nikolova, V. D., Davis, T. T., Riddick, N. V., Baker, L. K., Pedersen, C. A., Jarstfer, M. B., & Moy, S. S. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.038 · Cited by 98
Self-citationA Conserved Role for Serotonergic Neurotransmission in Mediating Social Behavior in Octopus
Edsinger, E., & Dölen, G. (2018) · Current Biology · doi:10.1016/j.cub.2018.07.061 · Cited by 104
“In order to experimentally quantify octopus social behaviors, next we adapted the three-chambered social approach assay routinely used in rodents [25, 26] for use in O.”
MethodCox, K. H., & Rissman, E. F. (2011) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2011.00688.x · Cited by 97
“Juvenile social behaviors have been examined in several ways: preference for social novelty (Mcnaughton et al. 2008; Moy et al. 2004; Moy et al. 2009), conditioned place preference (Panksepp & Lahvis 2007) and direct social encounters with peers (McFarlane et al.”
BackgroundMouse models of frontotemporal dementia
Roberson, E. D. (2012) · Annals of Neurology · doi:10.1002/ana.23722 · Cited by 103
Nguyen, R., Morrissey, M. D., Mahadevan, V., Cajanding, J. D., Woodin, M. A., Yeomans, J. S., Takehara‐Nishiuchi, K., & Kim, J. C. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2204-14.2014 · Cited by 100
“Last, to determine whether vHPC PV neuron inhibition affects behaviors associated with negative symptoms of schizophrenia, we measured social interaction in Crawley’s three-chamber sociability test (Moy et al., 2004; Arguello and Gogos, 2006).”
MethodJohnson, A. W., Jaaro-Peled, H., Shahani, N., Sedlak, T. W., Zoubovsky, S., Burruss, D., Emiliani, F., Sawa, A., & Gallagher, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307925110 · Cited by 96
“In this task a stranger mouse is introduced into the enclosure of one side of the chamber (37).”
BackgroundBehavioral effects of space radiation: A comprehensive review of animal studies
Kiffer, F. C., Boerma, M., & Allen, A. R. (2019) · Life Sciences in Space Research · doi:10.1016/j.lssr.2019.02.004 · Cited by 95
Metadata
- Authors
- Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- National Institute of Mental Health (US)
- Corresponding author
- Moy, S. S.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2004-04-29
- Volume
- 3
- Issue
- 5
- Pages
- 287-302
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- OpenAlex
- W2109091674
- Cited by
- 1,522
- References
- 80
- Citations by year
- 2026: 93 · 2025: 99 · 2024: 99 · 2023: 98 · 2022: 121 · 2021: 110 · 2020: 109 · 2019: 114 · 2018: 98 · 2017: 65 · 2016: 83 · 2015: 72 · 2014: 65 · 2013: 53 · 2012: 57
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- North Carolina State University
- National Institute for Health and Care Research
- National Institutes of Health (5u54mh066418-05)
- National Institute of Mental Health (U54 MH 66418, MH66418)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD003110)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- sociability, autism spectrum disorder, mouse models of autism, inbred mouse strains, social interaction deficits, social avoidance, C57BL/6J mice, DBA/2J, A/J, sex differences, age differences
- MeSH terms
- Age Factors, Analysis of Variance, Animals, Autistic Disorder, Disease Models, Animal, Exploratory Behavior, Female, Locomotion, Male, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Inbred Strains, Sex Factors, Social Behavior, Species Specificity, Reproducibility of Results, Rotarod Performance Test, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-12, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-12 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Cited sources are checked with a language model’s help (gpt-6-sol).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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