The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index; 1 of the 52 sources its claims cite were checked for support.
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice
Open accessAbstract
Deficits in social interaction are important early markers for autism and related neurodevelopmental disorders with strong genetic components. Standardized behavioral assays that measure the preference of mice for initiating social interactions with novel conspecifics would be of great value for mutant mouse models of autism. We developed a new procedure to assess sociability and the preference for social novelty in mice. To quantitate sociability, each mouse was scored on measures of exploration in a central habituated area, a side chamber containing an unfamiliar conspecific (stranger 1) in a wire cage, or an empty side chamber. In a secondary test, preference for social novelty was quantitated by presenting the test mouse with a choice between the first, now‐familiar, conspecific (stranger 1) in one side chamber, and a second unfamiliar mouse (stranger 2) in the other side chamber. Parameters scored included time spent in each chamber and number of entries into the chambers. Five inbred strains of mice were tested, C57BL/6J, DBA/2J, FVB/NJ, A/J and B6129PF2/J hybrids. Four strains showed significant levels of sociability (spend‐ ing more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now‐familiar stranger 1). These social preferences were observed in both male and female mice, and in juveniles and adults. The exception was A/J, a strain that demonstrated a preference for the central chamber. Results are discussed in terms of potential applications of the new methods, and the proper controls for the interpretation of social behavior data, including assays for health, relevant sensory abilities and motor functions. This new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.
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63 Own result · 16 No full text of the sources · 15 Own method · 6 Not checked yet · 6 Own interpretation · 5 Sources not found · 2 No basis given · 1 Partly supported · accuracy not yet measured
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Four strains showed significant levels of sociability (spending more time in the chamber containing stranger 1 than in the empty chamber)”
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In the paper
“Four strains showed significant levels of sociability (spending more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now-familiar stranger 1).”
plain- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The exception was A/J, a strain that demonstrated a preference for the central chamber.”
boosted- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Overall, four of the five inbred and hybrid strains tested spent more time in the side of the social test box containing the unfamiliar stranger, vs. time in the empty side.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“DBA/2 mice tended to have lower numbers of entries than the C57BL/6J mice (Fig. 10b; significant main effect of strain, F 1,9 ¼ 16.156, P ¼ 0.003; retest, F 1,9 ¼ 36.215,P ¼ 0.0002; and side, F 1,9 ¼ 8.723, P ¼ 0.0161).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“Finally, the adult C57BL/6J and DBA/2 mice had higher numbers of entries into the side of the chamber containing the unfamiliar conspecific in the sociability test.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plainn = 2- Asserted: passes — The authors put it forward as true.
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In the paper
“Adult A/J males failed to show a significant preference for the side containing stranger 1, as compared to the empty side.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“The low number of entries observed in the A/J mice was significantly different from both of the other inbred strains (post hoc tests following repeated measures ANOVA, F-values above).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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- It may state two separate claims as one. 24
- The quote only partly states this claim. 1
- Probably not a substantial claim. 32
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Higher numbers of sniffs were directed toward stranger 1 than towards the empty wire cage, and towards the novel stranger 2 vs. the now-familiar stranger 1, in C57BL/6J, DBA/2J and FVB/NJ male mice (Nadler et al. 2004).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Partly supportedcites Nadler et al. 2004 sourceExperimental — accuracy not yet measured
The “Social behavior tasks in three inbred strains” section reports that males of all three named strains spent more time sniffing the cage containing stranger 1 than the empty cage, and more time sniffing stranger 2 than stranger 1. The “Sociability test” section specifies that sniffing was scored as cumulative duration in seconds, not as a number of sniffs; that measurement in the claim is unsupported. Page numbers are unavailable in our copy. (LLM, conf=0.86)
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“General health, neurological reflexes, activity levels, motor functions and sensory abilities were normal in most regards for the strains tested.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Similar levels of sociability were clearly evident in a group of young female C57BL/6J mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
boosted- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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The quote only partly states this claim.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“A/J was the only strain tested that failed to spend more time with a conspecific, and spent most of its time in the central chamber after the initial 5-minute habituation session.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“All of the inbred strains were able to locate buried food, supporting an interpretation that none were anosmic, which could have severely impacted social behaviors by blocking detection of olfactory cues emitted by the stranger mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“For the olfactory test, the majority of the subjects successfully located and retrieved the buried food.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > General health, home cage behavior, neurophysiological reflexes and sensory and motor function
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As shown in Fig. 9, the A/J group did show significant increases in time spent in the side regions (Fig. 9a, significant main effect of retest, F 1,9 ¼ 11.343, P ¼ 0.0083) and in number of entries (Fig. 9b, significant main effect of retest, F 1,9 ¼ 13.302, P ¼ 0.0053) when the openings between chambers were more accessible.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Sociability procedure with modified social test box
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the significantly higher locomotor scores observed in the FVB/NJ strain, in comparison to the other two groups, were not reflected in an overall higher number of entries.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The FVB/NJ mice demonstrated a significantly shorter latency for locating the buried food,”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
boosted- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“A significant interaction was found between side of chamber and test condition (F 1,57 ¼ 67.634, P < 0.0001), reflecting the finding that preference was for the stranger 1 side during the first half of the session (the sociability condition), but switched to the stranger 2 side during the last part of the session (the social novelty condition).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Social behavior
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Arguing against an artifactual interpretation that hypolocomotion caused the social deficit in the A/J group are the data of Fig. 8. Repeated testing of A/J in the modified apparatus increased the number of entries, but did not yield significant sociability scores.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The A/J mice spent significantly more time in the center chamber, indicating a strong preference for the start box that was not seen in the other strains.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the second group of juvenile C57BL/6J mice, both males and females made equal numbers of entries into each side of the social test box during the assay for sociability, but showed an increased number of entries into the side of the social box containing the second, 'novel' unfamiliar stranger during the test for social novelty.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There were no significant differences between the strains in body weight or rotarod performance (see Table 1 for mean latency to fall on the second trial).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > General health, home cage behavior, neurophysiological reflexes and sensory and motor function
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, for the juvenile male mice, number of entries did not reflect the trends for social preference seen in the duration measures, and only partially correlated with their locomotor activity independently quantitated in the open field.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In addition, low locomotor scores in DBA/2J and high locomotor scores in FVB/NJ appeared to be unrelated to amount of time spent in the chamber with stranger 1 and stranger 2.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Significant preferences for sociability (Fig. 3a) or preference for social novelty (Fig. 3b) were not observed for number of chamber entries in any of the inbred strains.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Social behavior
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the present study, the juvenile male mice made nests and huddled together while sleeping.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Autistic individuals may further avoid unfamiliar social partners and display diminished interest in novelty (American Psychiatric Association 1994).”
What the sources say
- Not matchedcites American Psychiatric Association 1994
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
hedgedconditional- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. It may state two separate claims as one.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“This modification focuses the task on social approach tendencies, relevant to the social approach deficit in autism, while avoiding potential confounds resulting from aggressive or sexual interactions.”
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Rests on an assumption: Most autistic individuals demonstrate reduced or unusual social approach.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“To ensure that differences in social behaviors were not artifacts of other aspects of mouse behaviors, a series of independent control experiments was conducted to evaluate potential confounding factors.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The number of times that the mouse exited from the habituated empty central chamber into the novel empty chamber provided a general measure of locomotor function.”
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Social behaviors have been explored in mice with mutations in candidate genes such as oxytocin (Winslow & Insel 2002;Young et al. 2002), monoamine oxidase-A (Shih & Chen 1999), fragile X (Churchill et al. 2002;Mineur et al. 2002) and dishevelled-1 (Lijam et al. 1997).”
What the sources say
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Further controls were designed to detect additional symptoms relevant to autism, such as abnormalities in locomotion or motor coordination (Hallett et al. 1993;Piven et al. 1997), that could directly affect performance of the social task.”
What the sources say
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
In the paper
“Measures of general health, home cage behavior and neurological reflexes were conducted to rule out gross physical abnormalities (Crawley 2000).”
What the sources say
- Not checked — no full text of the sourcecites Crawley 2000
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Retrieval of food buried in cage bedding was quantitated in a 15-minute olfactory test, to ensure that the subject mice were not grossly impaired in olfaction abilities.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
None of the sources cited for this claim have been checked yet.
In the paper
“A large body of evidence from twin and family studies supports the important role of genetic factors in the etiology of autism (Bailey et al. 1995;Ritvo et al. 1989;Szatmari et al. 1998).”
What the sources say
boostedcorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present mouse tasks were designed to maximize face validity to some of the core symptoms of autism.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, the A/J mice were given a second test one week later, with the dividing walls between the chamber sides partially retracted to facilitate exploration.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Test for sociability in adult male mice
plainn = 10- Asserted: passes — The authors put it forward as true.
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- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Given the primacy of social impairment in autism, we considered this symptom to be fundamental to a mouse model of autism (Insel 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
What the sources say
- Not matchedcites Insel 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
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Probably not a substantial claim.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Several additional behavioral assays were performed in the initial set of juvenile male mice (C57BL/6J, DBA/2J and FVB/ NJ).These assays were designed as controls for sensory and motor abilities, etc., to ensure that the test mice were physically able to perform the procedures necessary for the social tasks described above.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The chambers of the social apparatus were cleaned and fresh paper chip bedding was added between trials.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The location of stranger 1 in the left vs. right side chamber was systematically alternated between trials.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“In our experience to date with the present procedures, human observers attain a high level of proficiency after only one or two practice sessions, with high rates (greater than 95%) of interrater reliability between trained observers.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present protocol used a small wire cage to enclose the stimulus mouse, which allowed visual, auditory and olfactory contact between the mice, but prevented the occurrence of aggressive and other responses.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
In the paper
“From an early age, autistic children show low levels of eye contact and affective responses, less orientation toward others and language deficits, with a concomitant paucity of speech and social communication (for review, see Tager-Flusberg et al. 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
What the sources say
- Not checked — no full text of the sourcecites Tager-Flusberg et al. 2001 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The stranger mouse was enclosed in a small, round wire cage (Galaxy Cup, Spectrum Diversified Designs, Inc., Streetsboro, OH), which allowed nose contact between the bars, but prevented fighting.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Previous work in social recognition has shown that mice show both habituation of olfactory responses directed toward an unfamiliar conspecific, and dishabituation, with a reinstatement of social sniffing, when a novel stimulus animal is presented (Bluthe et al. 1993;Dluzen & Kreutzberg 1993;Ferguson et al. 2000;Kogan et al. 2000;Winslow & Camacho 1995).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Alternatively, these data may reflect the low levels of open field exploratory behaviors and high levels of anxiety-like behaviors in the light/dark transitions test reported for A/J mice in other studies (Bouwknecht & Paylor 2002;Mathis et al. 1994Mathis et al. , 1995;;Thifault et al. 2002;Wahlsten et al. 2003) and reflected in the low number of entries in the present study.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present procedures for the sociability and social novelty tests are designed to be simple, quantitative and easily mastered by investigators.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. It may be too vague to check against evidence. The paper’s conclusions may not depend on it. The paper may give no reason why it holds. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, the present methods were designed to quantitate levels of sociability, i.e. tendency to initiate social contact, and preference for social novelty, i.e. tendency to initiate social contacts with a new individual as compared to someone familiar from past experience, using a simple scoring approach for laboratory mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“For example, some autistic patients demonstrate aberrant motor responses, including repeated hand flapping, jumping and other repetitive and stereotyped behaviors (Bodfish et al. 2000;Tager-Flusberg et al. 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Altered sensory responses have been reported, including both hypo-and hyper-reactivity to environmental stimuli (Baranek 2002).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Baranek 2002 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Observational findings in some of these behavioral domains have been reported in some targeted gene mutations, e.g.deficits in social interaction within the home cage have been reported for mice deficient in the dishevelled-1 gene (Lijam et al. 1997) or the NMDA NR1 subunit (Mohn et al. 1999).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Use of the three-chambered apparatus for demonstrating social preference (Insel 2001) was adapted by Brodkin et al. (2004) to investigate social approach and avoidance in female mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not matchedcites Insel 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites Brodkin et al. 2004 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Observations of mice in these settings have shown that exposure to an unfamiliar stranger typically evokes a period of intense social sniffing, which may be followed by escalating aggressive responses or sexual behavior, dependent upon such factors as age and sex of the unfamiliar conspecific (Bluthe et al. 1993;Kogan et al. 2000;Winslow & Camacho 1995).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“and the mouse model of fragile X syndrome has been characterized by changes in activity (Bakker et al. 1994;Peier et al. 2000) and reactivity to acoustic stimuli (Chen & Toth 2001;Nielson et al. 2002).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not matchedcites Bakker et al. 1994
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites Peier et al. 2000
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites Chen & Toth 2001 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
In the paper
“Children with fragile X syndrome often show autistic behavior (Hagerman et al. 1986),”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Hagerman et al. 1986 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“As noted by Winslow (2003), the analysis of the full behavioral series that can occur in social tests demands familiarity with the mouse ethogram, extensive training and the ability to discern the sometimes rapid and fleeting responses that mice can emit.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Winslow 2003 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Methods are based on procedures examining pair-bonding in voles (Dean, S.M. & Vandenbergh, J.G. as above), as well as many other elegant tests for social behavior in rodents (Bluthe et al. 1993;Carter et al. 1995;Dluzen & Kreutzberg 1993;Gheusi et al. 1994;Insel and Young 2001;Kogan et al. 2000;Winslow & Camacho 1995;Winslow 2003).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
Most autistic individuals demonstrate reduced or unusual social approach.
“We reasoned that most autistic individuals demonstrate reduced or unusual social approach.”
The paper relies on this without support.
Behavioral models of autistic-like responses in mice have received little attention.
“However, to date, behavioral models of autistic-like responses in mice have received little attention.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Studies aimed at modeling, in animals, the core phenotypes associated with ASDs have focused on studying social and repetitive behaviors in mice [530-532] and pair-bonding behaviors in the prairie vole (Microtus ochrogaster) [533,534].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [530]
In the citing paper
“There is compelling evidence that some strains are more”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [9]
In the citing paper
“However, almost all of them display some level of sociability (ie, preference to explore other mice over inanimate objects 9 ).”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [9]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Test for sociability in adult male mice
“the social novelty test was not conducted”
Citations
Cites
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Hu, R. J. (2003) · Elsevier eBooks · doi:10.1016/b0-12-226870-9/01070-4 · Cited by 9,168
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Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520
Autism as a strongly genetic disorder: evidence from a British twin study
Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., & Rutter, M. (1995) · Psychological Medicine · doi:10.1017/s0033291700028099 · Cited by 2,461
Epidemiological Surveys of Autism and Other Pervasive Developmental Disorders: An Update
Fombonne, E. (2003) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1025054610557 · Cited by 1,505
Varieties of Repetitive Behavior in Autism: Comparisons to Mental Retardation
Bodfish, J. W., Symons, F. J., Parker, D. E., & Lewis, M. H. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005596502855 · Cited by 1,223
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
A Comparison of the Social Postures of Some Common Laboratory Rodents
Grant, E. C., & Mackintosh, J. H. (1963) · Behaviour · doi:10.1163/156853963x00185 · Cited by 1,167
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
Fmr1 knockout mice: A model to study fragile X mental retardation
THEDUTCHBELGIANFRAGILEXCONSOR (1994) · Cell · doi:10.1016/0092-8674(94)90569-x · Cited by 1,108
Research works printed but not linked: 1
- Bachevalier J., 1991, Advances in Neuropsychiatry and Psychopharmacology, 129
Cited by
Sorted by citations
Items 201–300 of 1,472
Comprehensive behavioral analysis of heterozygous Syngap1 knockout mice
Nakajima, R., Takao, K., Hattori, S., Shoji, H., Komiyama, N. H., Grant, S. G. N., & Miyakawa, T. (2019) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12073 · Cited by 92
Scopolamine-induced deficits in social memory in mice: Reversal by donepezil
Riedel, G., Kang, S. H., Choi, D.-Y., & Platt, B. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.06.012 · Cited by 97
Estrogen receptors in the medial amygdala inhibit the expression of male prosocial behavior
Cushing, B. S., Perry, A., Musatov, S., Ogawa, S., & Papademetriou, E. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1928-08.2008 · Cited by 95
“This result is similar to observations of male mice in that after spending time with a nonreceptive female, males prefer a novel female when given a choice (Moy et al., 2004).”
ResultAbbas, M. G., Shoji, H., Soya, S., Hondo, M., Miyakawa, T., & Sakurai, T. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00324 · Cited by 99
“We used an apparatus consisting of transparent plastic cylinders (20 cm height × 10 cm diameter) (Miyakawa et al., 2003).”
MethodFound in translation: Understanding the biology and behavior of experimental traumatic brain injury
Bondi, C. O., Semple, B. D., Noble‐Haeusslein, L. J., Osier, N. D., Carlson, S. W., Dixon, C. E., Giza, C. C., & Kline, A. E. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.004 · Cited by 94
Social dysfunction after pediatric traumatic brain injury: A translational perspective
Ryan, N. P., Catroppa, C., Godfrey, C., Noble‐Haeusslein, L. J., Shultz, S. R., O'Brien, T. J., Anderson, V. A., & Semple, B. D. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.020 · Cited by 102
“In this task, the test animal is presented with a choice between chambers containing either the stimulus animal or an empty cup, with preferential proximity and investigative sniffing of the stimulus considered to be an indicator of sociability (Moy et al., 2004; Moy et al., 2007).”
BackgroundMaternal diet disrupts the placenta-brain axis in a sex-specific manner
Ceasrine, A. M., Devlin, B. A., Bolton, J. L., Green, L. A., Jo, Y. C., Huynh, C., Patrick, B., Washington, K., Sánchez, C., Joo, F., et al. (2022) · Nature Metabolism · doi:10.1016/j.bbi.2022.07.117 · Cited by 104
Autism Spectrum Disorders: Translating human deficits into mouse behavior
Pasciuto, E., Borrie, S. C., Kanellopoulos, A. K., Santos, A. R. S., Cappuyns, E., D’Andrea, L., Pacini, L., & Bagni, C. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.07.013 · Cited by 103
Autism‐Related Neuroligin‐3 Mutation Alters Social Behavior and Spatial Learning
Jaramillo, T. C., Liu, S., Pettersen, A., Birnbaum, S. G., & Powell, C. M. (2014) · Autism Research · doi:10.1002/aur.1362 · Cited by 97
“, 2007], NL3R451C mutants on a 129S2/SvPasCrl genetic background show decreased sociability in a three-chamber task of sociability [Moy et al., 2004].”
BackgroundMethodResultInfluentialRyan, B. C., Young, N. B., Moy, S. S., & Crawley, J. N. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.06.002 · Cited by 95
Self-citationLiu, T., Ma, Y., Zhang, R., Zhong, H., Wang, L., Zhao, J., Yang, L., & Fan, X. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5148-5 · Cited by 97
Cerebellar dopamine D2 receptors regulate social behaviors
Cutando, L., Puighermanal, E., Castell, L., Tarot, P., Belle, M., Bertaso, F., Arango-Lievano, M., Ango, F., Rubinstein, M., Quintana, A., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01092-8 · Cited by 78
Zhao, Y., Fung, C., Shin, D., Shin, B.-C., Thamotharan, S., Sankar, R., Ehninger, D., Silva, A., & Devaskar, S. U. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.51 · Cited by 88
“The impaired social behavior detected in glut3+/− mice is similar to that reported in the BTBR T +tf/J mouse relevant to autism (26, 27).”
MethodResultInfluentialDeficits in Social Behavior Emerge during Development after Pediatric Traumatic Brain Injury in Mice
Semple, B. D., Canchola, S. A., & Noble‐Haeusslein, L. J. (2012) · Journal of Neurotrauma · doi:10.1089/neu.2012.2595 · Cited by 97
“also been conducted using a repeated study design, testing mice as juveniles and again as adults.(60)”
Sams, D. S., Nardone, S., Getselter, D., Raz, D., Tal, M., Rayi, P. R., Kaphzan, H., Hakim, O., & Elliott, E. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.004 · Cited by 92
“Sociability and social novelty recognition were examined in the three chambered social test (Moy et al., 2004).”
Bøttger, P., Glerup, S., Gesslein, B., Illarionova, N. B., Isaksen, T. J., Heuck, A., Clausen, B. H., Füchtbauer, E., Gramsbergen, J. B., Gunnarson, E., et al. (2016) · Scientific Reports · doi:10.1038/srep22047 · Cited by 92
“Notably, female and male C57BL/6J mice were social, which was in agreement with previous findings 41 .”
ResultAllen, M., Huang, B. S., Notaras, M. J., Lodhi, A., Barrio-Alonso, E., Lituma, P. J., Wolujewicz, P., Witztum, J., Longo, F., Chen, M., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01486-x · Cited by 96
“To score sociability, a three-chamber social interaction paradigm was used as previously described [15, 65, 66].”
MethodBabovic, D., O’Tuathaigh, C. M. P., O'Connor, A. M., O'Sullivan, G. J., Tighe, O., Croke, D. T., Karayiorgou, M., Gogos, J. A., Cotter, D., & Waddington, J. L. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.006 · Cited by 90
The role of neurotrophic factors in autism
Nickl‐Jockschat, T., & Michel, T. M. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.103 · Cited by 96
Peartree, N. A., Hood, L. E., Thiel, K. J., Sanabria, F., Pentkowski, N. S., Chandler, K. N., & Neisewander, J. L. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.10.001 · Cited by 90
“In fact, rodents will inherently prefer a novel conspecific compared to a novel object in initial testing [54-56], similar to our day 1 of conditioning where mesh screen contacts are higher with an initially unfamiliar partner behind the screen than with a novel ball.”
BackgroundNollet, M., Hicks, H., McCarthy, A. P., Wu, H., Möller‐Levet, C. S., Laing, E., Malki, K., Lawless, N., Wafford, K. A., Dijk, D., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816456116 · Cited by 95
“Body weight, coat state, self-centered behavior (grooming test), motivation (nest building test), anhedonia (reward-driven exploratory test), social preference (social novelty preference test), aggressiveness (resident-intruder test), anxiety (novelty-suppressed feeding test), and despair behavior (forced swim test) w…”
MethodDougherty, J. D., Maloney, S. E., Wozniak, D. F., Rieger, M. A., Sonnenblick, L. I., Coppola, G., Mahieu, N. G., Zhang, J., Cai, J., Patti, G. J., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4762-12.2013 · Cited by 88
Disturbed neurotransmitter homeostasis in ether lipid deficiency
Dorninger, F., König, T., Scholze, P., Berger, M. L., Zeitler, G., Wiesinger, C., Gundacker, A., Pollak, D. D., Huck, S., Just, W. W., et al. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz040 · Cited by 91
“Furthermore, autism-like behavior in mice is often characterized by impaired sociability (70), as demonstrated here for Gnpat KO mice.”
Bellisario, V., Panetta, P., Balsevich, G., Baumann, V., Noble, J., Raggi, C., Nathan, O., Berry, A., Seckl, J., Schmidt, M., et al. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.06.012 · Cited by 88
“Two days before the expected delivery date (G17) dams underwent a modified version of the sociability test as described by Crawley (Moy et al., 2004).”
MethodMechanisms for Interferon-α-Induced Depression and Neural Stem Cell Dysfunction
Zheng, L.-S., Hitoshi, S., Kaneko, N., Takao, K., Miyakawa, T., Tanaka, Y., Xia, H., Kalinke, U., Kudo, K., Kanba, S., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.05.015 · Cited by 90
“familiar mouse in the social novelty preference test (Moy et al., 2004).”
BackgroundMoon, J., Beaudin, A. E., Verosky, S. C., Driscoll, L. L., Weiskopf, M., Levitsky, D. A., Crnic, L. S., & Strupp, B. J. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.6.1367 · Cited by 91
Visual social preferences of lone zebrafish in a novel environment: strain and anxiolytic effects
Barba-Escobedo, P. A., & Gould, G. G. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00770.x · Cited by 91
“Initially, we compared performance among different zebrafish lines, paralleling screening of mouse strains for social behavior (Moy et al. 2004).”
ResultARAKAWA, H., BLANCHARD, D., & BLANCHARD, R. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.027 · Cited by 86
“This suggests that detailed description of social behaviors in strains of mice specifically relevant to genetic models of autism are needed for both initial and maintenance phases of social relationships [12,15,50,55].”
BackgroundTNF-α and its receptors modulate complex behaviours and neurotrophins in transgenic mice
Camara, M. L., Corrigan, F., Jaehne, E. J., Jawahar, M. C., Anscomb, H., Körner, H., & Baune, B. T. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.010 · Cited by 86
Eltokhi, A., Kurpiers, B., & Pitzer, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-67758-0 · Cited by 90
Tzanoulinou, S., Riccio, O., de Boer, M. W., & Sandi, C. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.54 · Cited by 87
Tsuda, M. C., & Ogawa, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033028 · Cited by 86
Santos, A. R., Kanellopoulos, A. K., & Bagni, C. (2014) · Learning & Memory · doi:10.1101/lm.035956.114 · Cited by 91
“The numbers of approaches and the time spent in proximity with each mouse are scored (Moy et al. 2004).”
BackgroundDeletion of α-neurexin II results in autism-related behaviors in mice
Dachtler, J., Glasper, J., Cohen, R. N., Ivorra, J. L., Swiffen, D. J., Jackson, A. J., Harte, M. K., Rodgers, R. J., & Clapcote, S. J. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.123 · Cited by 84
Bracko, O., Vinarcsik, L. K., Cruz Hernández, J. C., Ruiz-Uribe, N. E., Haft-Javaherian, M., Falkenhain, K., Ramanauskaite, E. M., Ali, M., Mohapatra, A., Swallow, M. A., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-65908-y · Cited by 85
Kang, J., & Kim, E. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00017 · Cited by 82
Understanding Mammalian Genetic Systems: The Challenge of Phenotyping in the Mouse
Brown, S. D. M., Hancock, J. M., & Gates, H. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020118 · Cited by 88
Okuda, K., Takao, K., Watanabe, A., Miyakawa, T., Mizuguchi, M., & Tanaka, T. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196587 · Cited by 84
Ritzel, R. M., He, J., Li, Y., Cao, T., Khan, N., Shim, B., Sabirzhanov, B. E., Aubrecht, T. G., Stoica, B. A., Faden, A. I., et al. (2020) · Glia · doi:10.1002/glia.23926 · Cited by 83
“Social interaction was performed at 72 days postinjury with the sociability and preference test originally designed by (Moy et al., 2004), using a three-chambered rectangular apparatus made of Plexiglas with each chamber equally divided at 20 (width) × 40 (length) ∣ 23 (height) cm.”
Hattori, S., Takao, K., Tanda, K., Toyama, K., Shintani, N., Baba, A., Hashimoto, H., & Miyakawa, T. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00058 · Cited by 85
“We modified the method described by Moy et al. (2004) as follows: a habituation session was not performed in the apparatus, and the wire cages in the lateral compartments were located in a corner.”
MethodPaine, T. A., Swedlow, N., & Swetschinski, L. R. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.10.012 · Cited by 83
Yu, F., Shukla, D. K., Armstrong, R. C., Marion, C. M., Radomski, K. L., Selwyn, R. G., & Dardzinski, B. J. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2016.4569 · Cited by 85
“The three-chambered task has been widely used to evaluate social interactions in mice.(39,70,71) In TBI”
MethodMini-review: polybrominated diphenyl ether (PBDE) flame retardants as potential autism risk factors
Messer, A. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.01.011 · Cited by 81
Sagheer, T. A., Haïda, O., Balbous, A., Francheteau, M., Matas, E., Fernagut, P., & Jaber, M. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy043 · Cited by 88
“Test (P35–P45) Social interaction was assessed using the 3-chambers test (Moy et al., 2004).”
MethodModels of Neurodevelopmental Abnormalities in Schizophrenia
Powell, S. B. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_57 · Cited by 87
“In this paradigm, test mice are placed in a three-chambered arena, in one chamber, a “stranger” mouse is placed under a wire cup, and in the opposite chamber there is an empty wire container (Crawley 2007; Moy et al. 2004).”
MethodDachtler, J., Ivorra, J. L., Rowland, T. E., Lever, C., Rodgers, R. J., & Clapcote, S. J. (2015) · Behavioral Neuroscience · doi:10.1037/bne0000108 · Cited by 83
“However, extensive validation using the same apparatus found no biasing effect of using male conspecifics; specifically there were “no confounding sexual or aggressive behaviors, because the strangers were contained within the wire cages” (Moy et al., 2004).”
BackgroundMethodInfluentialYasui, D. H., Gonzales, M. L., Aflatooni, J. O., Crary-Dooley, F. K., Hu, D. J., Gavino, B. J., Golub, M. S., Vincent, J. B., Schanen, N. C., Olson, C. O., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt640 · Cited by 86
“The sociability preference test was performed using a threechamber assay as established in previous studies (39,40).”
MethodLatapy, C., Rioux, V., Guitton, M. J., & Beaulieu, J. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0094 · Cited by 84
Homberg, J. R., Kyzar, E. J., Nguyen, M., Norton, W., Pittman, J. T., Poudel, M. K., Gaikwad, S., Nakamura, S., Koshiba, M., Yamanouchi, H., et al. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.013 · Cited by 86
Activation of Entorhinal Cortical Projections to the Dentate Gyrus Underlies Social Memory Retrieval
Leung, C., Cao, F., Nguyen, R., Joshi, K., Aqrabawi, A. J., Xia, S., Cortez, M. A., Snead, O. C., Kim, J. C., & Jia, Z. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.073 · Cited by 84
Arakawa, H., Arakawa, K., Blanchard, D. C., & Blanchard, R. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.009 · Cited by 80
Li, K., Yan, L., Zhang, Y., Yang, Z., Zhang, C., Li, Y., Kalueff, A. V., Li, W., & Song, C. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112487 · Cited by 80
Ritzel, R. M., Li, Y., He, J., Khan, N., Doran, S. J., Faden, A. I., & Wu, J. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104713 · Cited by 76
“Social interaction was assessed with the sociability and preference test originally designed by Crawley et al. (Moy et al., 2004), using a three-chambered rectangular apparatus made of Plexiglas with each chamber equally divided at 20 (width) × 40 (length) × 23 (height) cm.”
Ueno, H., Takahashi, Y., Suemitsu, S., Murakami, S., Kitamura, N., Wani, K., Matsumoto, Y., Okamoto, M., & Ishihara, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-60530-4 · Cited by 80
Liu, L., Xu, H., Wang, J., Li, J., Tian, Y., Zheng, J., He, M., Xu, T., Wu, Z., Li, W., et al. (2020) · Science Advances · doi:10.1126/sciadv.aay4073 · Cited by 85
“PV INs and SST INs respond differentially to social interaction We next measured the spiking activity of prefrontal neurons in mice subjected to a three-chambered social approach task, which is widely used for testing social behavior in rodents (22).”
MethodJiang-Xie, L.-F., Liao, H., Chen, C., Chen, Y.-T., Ho, S., Lu, D., Lee, L., Liou, H., Fu, W., & Gau, S. S. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-32 · Cited by 84
“001 from a two-t behaviors of the mutant mice [29,30].”
BackgroundMethodEissa, N., Jayaprakash, P., Azimullah, S., Ojha, S. K., Al‐Houqani, M., Jalal, F. Y., Łażewska, D., Kieć‐Kononowicz, K., & Sadek, B. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-31385-7 · Cited by 80
REM sleep-active hypothalamic neurons may contribute to hippocampal social-memory consolidation
Qin, H., Fu, L., Jian, T., Jin, W., Liang, M., Li, J., Chen, Q., Yang, X., Du, H., Liao, X., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.09.004 · Cited by 78
Oxytocin during Development: Possible Organizational Effects on Behavior
Miller, T. V., & Caldwell, H. K. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00076 · Cited by 79
Christian, D. L., Wu, D. Y., Martin, J. R., Moore, J. R., Liu, Y. R., Clemens, A. W., Nettles, S. A., Kirkland, N. M., Papouin, T., Hill, C. A., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108416 · Cited by 84
C57BL/6J mice fail to exhibit preference for social novelty in the three-chamber apparatus
Pearson, B. L., Defensor, E. B., Blanchard, D. C., & Blanchard, R. J. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.04.054 · Cited by 78
Ruskin, D. N., Fortin, J. A., Bisnauth, S. N., & Masino, S. A. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.10.023 · Cited by 82
“After 30 min habituation to the testing room mice were tested in the three chamber sociability test [60].”
Modeling autism-relevant behavioral phenotypes in rats and mice: Do ‘autistic’ rodents exist?
Servadio, M., Vanderschuren, L. J. M. J., & Trezza, V. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000163 · Cited by 76
“During the second session, ‘preference for social novelty’ is defined as propensity to spend time with a new stimulus rather than with the same stimulus encountered in the first session (Moy et al., 2004).”
Bell, J. J. L., Rakhade, S. N., Klein, P., Obeid, M., Jackson, M. C., Joseph, A., & Jensen, F. E. (2013) · Epilepsia · doi:10.1111/epi.12378 · Cited by 79
“S1C) as described previously (Moy et al., 2004; Silverman et al., 2011; Talos et al., 2012).”
Yang, M., Lewis, F. C., Sarvi, M. S., Foley, G. M., & Crawley, J. N. (2015) · Learning & Memory · doi:10.1101/lm.039602.115 · Cited by 70
“Preference for social novelty was tested in the three-chamber apparatus, using methods previously described (Moy et al. 2004; Silverman et al. 2011; Yang et al. 2011, 2012, 2015a).”
MethodSelf-citationAçıkgöz, B., Dalkiran, B., & Dayı, A. (2022) · Behavioural Processes · doi:10.1016/j.beproc.2022.104670 · Cited by 82
Social Novelty Investigation in the Juvenile Rat: Modulation by the μ‐Opioid System
Smith, C. J. W., Wilkins, K. B., Mogavero, J. N., & Veenema, A. H. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12301 · Cited by 77
Oliver, P. L., & Davies, K. E. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp425 · Cited by 78
“(5) Sociability and preference for social novelty behaviour was assessed based on a previously described method (42).”
MethodSynaptic P-Rex1 signaling regulates hippocampal long-term depression and autism-like social behavior
Li, J., Chai, A., Wang, L., Ma, Y., Wu, Z., Yu, H., Mei, L., Lu, L., Zhang, C., Yue, W., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512913112 · Cited by 75
“First, we used a three-chamber social interaction assay (15) to investigate animals’ voluntary initiation of social interaction and their ability to discriminate social novelty (Fig.”
MethodMcGill, B. E., Barve, R. A., Maloney, S. E., Strickland, A. M., Rensing, N. R., Wang, P. L., Wong, M., Head, R. D., Wozniak, D. F., & Milbrandt, J. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0936-17.2017 · Cited by 74
“, 2013), which were adapted from earlier works (Moy et al., 2004; Silverman et al., 2011).”
MethodResultSargin, D., El-Kordi, A., Agarwal, A., et al. (2011) · BMC Biology · doi:10.1186/1741-7007-9-27 · Cited by 74
“Sociability and social memory were tested as described in detail elsewhere (for example [54]).”
MethodHäring, M., Kaiser, N., Monory, K., & Lutz, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026617 · Cited by 73
Schizophrenia‐related endophenotypes in heterozygous neuregulin‐1 ‘knockout’ mice
O’Tuathaigh, C. M. P., Harte, M., O’Leary, C., O'Sullivan, G., Blau, C., Lai, D., Harvey, R. P., Tighe, O., Fagan, A. J., Kerskens, C., et al. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.07069.x · Cited by 76
“Social approach ⁄ avoidance behaviour was assessed using a previously described measure of affiliative behaviour and social novelty preference in mice (Moy et al., 2004; Sankoorikal et al., 2006; O’Tuathaigh et al., 2007b).”
MethodCortical network dysfunction caused by a subtle defect of myelination
Poggi, G., Boretius, S., Möbius, W., Moschny, N., Baudewig, J., Ruhwedel, T., Hassouna, I. A., Wieser, G. L., Werner, H. B., Goebbels, S., et al. (2016) · Glia · doi:10.1002/glia.23039 · Cited by 76
“All tests were conducted as published in detail (Bodda et al., 2013; Dere et al., 2014; El-Kordi et al., 2013; Moy et al., 2004; Radyushkin et al., 2010).”
MethodDisease‐modifying effects of ganglioside GM1 in Huntington's disease models
Alpaugh, M., Galleguillos, D., Forero, J. P., Morales, L. C., Lackey, S. W. K., Kar, P., Pardo, A. D., Holt, A., Kerr, B. J., Todd, K. G., et al. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201707763 · Cited by 74
“In the Crawley’s social approach test (Moy et al, 2004; Crawley, 2007), all mice showed similar sociability, but YAC128 mice spent more time with a familiar mouse rather than a new mouse (Fig 7A, preference for social novelty), a behaviour that is also observed in AD mouse models (Faizi et al,…”
The planar polarity protein Scribble1 is essential for neuronal plasticity and brain function
Moreau, M. M., Piguel, N., Papouin, T., Koehl, M., Durand, C. M., Rubio, M. E., Loll, F., Richard, E. M., Mazzocco, C., Racca, C., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6007-09.2010 · Cited by 69
“Miceweretestedinatransparentplasticcagedividedintothreechambers (each20 (cid:5) 40 (cid:5) 22 cm) as previously described (Nadler et al., 2004; Jamainetal.,2008).”
InfluentialHernan, A. E., Alexander, A., Jenks, K. R., Barry, J., Lenck-Santini, P.-P., Isaeva, E., Holmes, G. L., & Scott, R. C. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.11.012 · Cited by 73
“The sociability experiment was based on a previously described mouse sociability task (Moy et al., 2004).”
A circuit-based mechanism underlying familiarity signaling and the preference for novelty
Molas, S., Zhao-Shea, R., Liu, L., DeGroot, S. R., Gardner, P. D., & Tapper, A. R. (2017) · Nature Neuroscience · doi:10.1038/nn.4607 · Cited by 78
“To address the behavioral and neural responses to familiar and novel stimuli, we adapted a paradigm of social interaction using a three-chamber interaction context 11 .”
Vanderplow, A. M., Eagle, A. L., Kermath, B. A., Bjornson, K. J., Robison, A. J., & Cahill, M. E. (2021) · Neuron · doi:10.1016/j.neuron.2021.03.008 · Cited by 74
Kerr, B., Alvarez-Saavedra, M., Sáez, M., Saona, A., & Young, J. I. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn061 · Cited by 73
“Afterwards, a second unfamiliar mouse (stranger 2) was introduced into the empty-wired cage to allow the subject mouse to choose which mouse to interact with, the now familiar stranger 1 or the unfamiliar stranger 2, for an extra 10 min period to measure social novelty preferences ( 32 ).”
BackgroundSpecificity in Sociality: Mice and Prairie Voles Exhibit Different Patterns of Peer Affiliation
Beery, A. K., Christensen, J. D., Lee, N. S., & Blandino, K. L. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00050 · Cited by 81
“In contrast, laboratory mice typically prefer novel individuals in brief tests of social interaction (Moy et al., 2004).”
BackgroundMethodInfluentialBraunschweig, D., Golub, M. S., Koenig, C. M., Qi, L., Pessah, I. N., Van de Water, J., & Berman, R. F. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.08.002 · Cited by 71
“Sociability and preference for social noveltywere tested using previously developed techniques (Moy et al., 2004).”
MethodEffects of sex and gonadectomy on social investigation and social recognition in mice
Karlsson, S. A., Haziri, K., Hansson, E., Kettunen, P., & Westberg, L. (2015) · BMC Neuroscience · doi:10.1186/s12868-015-0221-z · Cited by 72
“, [22] to screen for sociability in mice and measure preference for a novel conspecific vs.”
BackgroundCrescenzo, A. H. D., Panoutsopoulos, A. A., Tat, L., Schaaf, Z. A., Racherla, S., Henderson, L., Leung, K., Greene, N. D. E., Green, R., & Zarbalis, K. S. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa248 · Cited by 79
“5) The “marble bury test” indirectly measures anxiety and/or obsessive compulsive behaviors (Njung’e and Handley 1991; Thomas et al. 2009).”
Puścian, A., Łęski, S., Kasprowicz, G., Winiarski, M., Borowska, J., Nikolaev, T., Boguszewski, P. M., Lipp, H.-P., & Knapska, E. (2016) · eLife · doi:10.7554/elife.19532 · Cited by 69
“Conventional tests of social phenotyping have repeatedly proven inefficient in differentiating certain genotypes and replicating these differences across laboratories and protocol conditions (Chadman et al., 2008; Moy et al., 2004; Pearson et al., 2010; Tabuchi et al., 2007).”
BackgroundSexual rejection via a vomeronasal receptor-triggered limbic circuit
Osakada, T., Ishii, K. K., Mori, H., Eguchi, R., Ferrero, D. M., Yoshihara, Y., Liberles, S. D., Miyamichi, K., & Touhara, K. (2018) · Nature Communications · doi:10.1038/s41467-018-07003-5 · Cited by 78
Ben-Yehuda, H., Matcovitch-Natan, O., Kertser, A., Spinrad, A., Prinz, M., Amit, I., & Schwartz, M. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0604-0 · Cited by 73
Ethological concepts enhance the translational value of animal models
Peters, S. M., Pothuizen, H. H. J., & Spruijt, B. M. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.043 · Cited by 70
Langley, E. A., Krykbaeva, M., Blusztajn, J. K., & Mellott, T. J. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.09.043 · Cited by 71
Mutant Mouse Models: Genotype-Phenotype Relationships to Negative Symptoms in Schizophrenia
O’Tuathaigh, C. M. P., Kirby, B. P., Moran, P. M., & Waddington, J. L. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp125 · Cited by 73
“This task has now been well characterized in terms of mouse strain differences.(26,27) It has also been shown that sociability in this task correlates well with frequency of social investigative behaviors in free social interaction assays.”
BackgroundNeural circuits regulating prosocial behaviors
Walsh, J. J., Christoffel, D. J., & Malenka, R. C. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01348-8 · Cited by 72
“Three-chamber sociability assay Unlike the direct contact that occurs in the juvenile interaction assay, the three-chamber sociability task assesses the preference a test mouse has for a “social chamber,” housing a novel conspecific (either age-matched or juvenile) under a wired cup versus an “empty chamber” with an e…”
BackgroundYang, Y., Arsenault, J., Bah, A., Krzeminski, M., Fekete, Á., Chao, O. Y.-H., Pacey, L. K. K., Wang, A. B., Forman-Kay, J. D., Hampson, D. R., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0240-0 · Cited by 72
Novel role for mineralocorticoid receptors in control of a neuronal phenotype
McCann, K. E., Lustberg, D. J., Shaughnessy, E. K., Carstens, K. E., Farris, S., Alexander, G. M., Radzicki, D., Zhao, M., & Dudek, S. M. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0598-7 · Cited by 74
RFID-supported video tracking for automated analysis of social behaviour in groups of mice
Peleh, T., Bai, X., Kas, M. J., & Hengerer, B. (2019) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.108323 · Cited by 74
“For instance, in the three-chamber social approach task the test subject is given the choice to approach a locally restricted conspecific or an empty container (Crawley, 2007; Moy et al., 2004; Nadler et al., 2004).”
Dougnon, G., & Matsui, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147550 · Cited by 76
Loureiro, M., Renard, J., Zunder, J. S., & Laviolette, S. R. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.329 · Cited by 73
“Male Sprague-Dawley rats (300–350 g; Charles River) were used in compliance with the regulations approved by the Canadian Council for Animal Care and the University of Western Ontario Animal Care and Use committee.”
MethodVeenit, V., Cordero, M. I., Tzanoulinou, S., & Sandi, C. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00026 · Cited by 68
“The social preference test was adapted from the protocol described by Crawley and collaborators to investigate social affiliation in male mice (Moy et al., 2004) and following the same conditions as in our previous peripuberty stress study (Márquez et al., 2013).”
MethodYin, J., & Schaaf, C. P. (2016) · Prenatal Diagnosis · doi:10.1002/pd.4942 · Cited by 78
Whissell, P. D., Bang, J. Y., Khan, I., Xie, Y., Parfitt, G. M., Grenon, M. B., Plummer, N. W., Jensen, P., Bonin, R. P., & Kim, J. C. (2019) · eNeuro · doi:10.1523/eneuro.0360-18.2019 · Cited by 68
“Accordingly, we next examined the effects of activating CCK-GABA neurons in the three-chambered social interaction test (Moy et al., 2004).”
BackgroundJones, K. L., Smith, R. M., Edwards, K. S., Givens, B. S., Tilley, M. R., & Beversdorf, D. Q. (2010) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.05.002 · Cited by 67
“Decreased total time spent with the novel stranger as compared to the familiar stranger can be interpreted as decreased social novelty seeking as well as decreased recognition of social cues (Crawley, 2004), and less time spent in the chamber with a novel mouse in comparison to a novel object is indicative of decrease…”
Background
Metadata
- Authors
- Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- National Institute of Mental Health (US)
- Corresponding author
- Moy, S. S.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2004-04-29
- Volume
- 3
- Issue
- 5
- Pages
- 287-302
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- OpenAlex
- W2109091674
- Cited by
- 1,522
- References
- 80
- Citations by year
- 2026: 93 · 2025: 99 · 2024: 99 · 2023: 98 · 2022: 121 · 2021: 110 · 2020: 109 · 2019: 114 · 2018: 98 · 2017: 65 · 2016: 83 · 2015: 72 · 2014: 65 · 2013: 53 · 2012: 57
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- North Carolina State University
- National Institute for Health and Care Research
- National Institutes of Health (5u54mh066418-05)
- National Institute of Mental Health (U54 MH 66418, MH66418)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD003110)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- sociability, autism spectrum disorder, mouse models of autism, inbred mouse strains, social interaction deficits, social avoidance, C57BL/6J mice, DBA/2J, A/J, sex differences, age differences
- MeSH terms
- Age Factors, Analysis of Variance, Animals, Autistic Disorder, Disease Models, Animal, Exploratory Behavior, Female, Locomotion, Male, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Inbred Strains, Sex Factors, Social Behavior, Species Specificity, Reproducibility of Results, Rotarod Performance Test, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-12, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-12 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Cited sources are checked with a language model’s help (gpt-6-sol).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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