The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index; 1 of the 52 sources its claims cite were checked for support.
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice
Open accessAbstract
Deficits in social interaction are important early markers for autism and related neurodevelopmental disorders with strong genetic components. Standardized behavioral assays that measure the preference of mice for initiating social interactions with novel conspecifics would be of great value for mutant mouse models of autism. We developed a new procedure to assess sociability and the preference for social novelty in mice. To quantitate sociability, each mouse was scored on measures of exploration in a central habituated area, a side chamber containing an unfamiliar conspecific (stranger 1) in a wire cage, or an empty side chamber. In a secondary test, preference for social novelty was quantitated by presenting the test mouse with a choice between the first, now‐familiar, conspecific (stranger 1) in one side chamber, and a second unfamiliar mouse (stranger 2) in the other side chamber. Parameters scored included time spent in each chamber and number of entries into the chambers. Five inbred strains of mice were tested, C57BL/6J, DBA/2J, FVB/NJ, A/J and B6129PF2/J hybrids. Four strains showed significant levels of sociability (spend‐ ing more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now‐familiar stranger 1). These social preferences were observed in both male and female mice, and in juveniles and adults. The exception was A/J, a strain that demonstrated a preference for the central chamber. Results are discussed in terms of potential applications of the new methods, and the proper controls for the interpretation of social behavior data, including assays for health, relevant sensory abilities and motor functions. This new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.
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63 Own result · 16 No full text of the sources · 15 Own method · 6 Not checked yet · 6 Own interpretation · 5 Sources not found · 2 No basis given · 1 Partly supported · accuracy not yet measured
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Four strains showed significant levels of sociability (spending more time in the chamber containing stranger 1 than in the empty chamber)”
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In the paper
“Four strains showed significant levels of sociability (spending more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now-familiar stranger 1).”
plain- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The exception was A/J, a strain that demonstrated a preference for the central chamber.”
boosted- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Overall, four of the five inbred and hybrid strains tested spent more time in the side of the social test box containing the unfamiliar stranger, vs. time in the empty side.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“DBA/2 mice tended to have lower numbers of entries than the C57BL/6J mice (Fig. 10b; significant main effect of strain, F 1,9 ¼ 16.156, P ¼ 0.003; retest, F 1,9 ¼ 36.215,P ¼ 0.0002; and side, F 1,9 ¼ 8.723, P ¼ 0.0161).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“Finally, the adult C57BL/6J and DBA/2 mice had higher numbers of entries into the side of the chamber containing the unfamiliar conspecific in the sociability test.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plainn = 2- Asserted: passes — The authors put it forward as true.
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In the paper
“Adult A/J males failed to show a significant preference for the side containing stranger 1, as compared to the empty side.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“The low number of entries observed in the A/J mice was significantly different from both of the other inbred strains (post hoc tests following repeated measures ANOVA, F-values above).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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- It may state two separate claims as one. 24
- The quote only partly states this claim. 1
- Probably not a substantial claim. 32
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Higher numbers of sniffs were directed toward stranger 1 than towards the empty wire cage, and towards the novel stranger 2 vs. the now-familiar stranger 1, in C57BL/6J, DBA/2J and FVB/NJ male mice (Nadler et al. 2004).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Partly supportedcites Nadler et al. 2004 sourceExperimental — accuracy not yet measured
The “Social behavior tasks in three inbred strains” section reports that males of all three named strains spent more time sniffing the cage containing stranger 1 than the empty cage, and more time sniffing stranger 2 than stranger 1. The “Sociability test” section specifies that sniffing was scored as cumulative duration in seconds, not as a number of sniffs; that measurement in the claim is unsupported. Page numbers are unavailable in our copy. (LLM, conf=0.86)
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“General health, neurological reflexes, activity levels, motor functions and sensory abilities were normal in most regards for the strains tested.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Similar levels of sociability were clearly evident in a group of young female C57BL/6J mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
boosted- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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The quote only partly states this claim.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“A/J was the only strain tested that failed to spend more time with a conspecific, and spent most of its time in the central chamber after the initial 5-minute habituation session.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“All of the inbred strains were able to locate buried food, supporting an interpretation that none were anosmic, which could have severely impacted social behaviors by blocking detection of olfactory cues emitted by the stranger mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“For the olfactory test, the majority of the subjects successfully located and retrieved the buried food.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > General health, home cage behavior, neurophysiological reflexes and sensory and motor function
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As shown in Fig. 9, the A/J group did show significant increases in time spent in the side regions (Fig. 9a, significant main effect of retest, F 1,9 ¼ 11.343, P ¼ 0.0083) and in number of entries (Fig. 9b, significant main effect of retest, F 1,9 ¼ 13.302, P ¼ 0.0053) when the openings between chambers were more accessible.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Sociability procedure with modified social test box
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the significantly higher locomotor scores observed in the FVB/NJ strain, in comparison to the other two groups, were not reflected in an overall higher number of entries.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The FVB/NJ mice demonstrated a significantly shorter latency for locating the buried food,”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
boosted- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“A significant interaction was found between side of chamber and test condition (F 1,57 ¼ 67.634, P < 0.0001), reflecting the finding that preference was for the stranger 1 side during the first half of the session (the sociability condition), but switched to the stranger 2 side during the last part of the session (the social novelty condition).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Social behavior
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Arguing against an artifactual interpretation that hypolocomotion caused the social deficit in the A/J group are the data of Fig. 8. Repeated testing of A/J in the modified apparatus increased the number of entries, but did not yield significant sociability scores.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The A/J mice spent significantly more time in the center chamber, indicating a strong preference for the start box that was not seen in the other strains.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the second group of juvenile C57BL/6J mice, both males and females made equal numbers of entries into each side of the social test box during the assay for sociability, but showed an increased number of entries into the side of the social box containing the second, 'novel' unfamiliar stranger during the test for social novelty.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There were no significant differences between the strains in body weight or rotarod performance (see Table 1 for mean latency to fall on the second trial).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > General health, home cage behavior, neurophysiological reflexes and sensory and motor function
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, for the juvenile male mice, number of entries did not reflect the trends for social preference seen in the duration measures, and only partially correlated with their locomotor activity independently quantitated in the open field.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In addition, low locomotor scores in DBA/2J and high locomotor scores in FVB/NJ appeared to be unrelated to amount of time spent in the chamber with stranger 1 and stranger 2.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Significant preferences for sociability (Fig. 3a) or preference for social novelty (Fig. 3b) were not observed for number of chamber entries in any of the inbred strains.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Social behavior
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the present study, the juvenile male mice made nests and huddled together while sleeping.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Autistic individuals may further avoid unfamiliar social partners and display diminished interest in novelty (American Psychiatric Association 1994).”
What the sources say
- Not matchedcites American Psychiatric Association 1994
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
hedgedconditional- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. It may state two separate claims as one.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“This modification focuses the task on social approach tendencies, relevant to the social approach deficit in autism, while avoiding potential confounds resulting from aggressive or sexual interactions.”
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Rests on an assumption: Most autistic individuals demonstrate reduced or unusual social approach.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“To ensure that differences in social behaviors were not artifacts of other aspects of mouse behaviors, a series of independent control experiments was conducted to evaluate potential confounding factors.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The number of times that the mouse exited from the habituated empty central chamber into the novel empty chamber provided a general measure of locomotor function.”
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Social behaviors have been explored in mice with mutations in candidate genes such as oxytocin (Winslow & Insel 2002;Young et al. 2002), monoamine oxidase-A (Shih & Chen 1999), fragile X (Churchill et al. 2002;Mineur et al. 2002) and dishevelled-1 (Lijam et al. 1997).”
What the sources say
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Further controls were designed to detect additional symptoms relevant to autism, such as abnormalities in locomotion or motor coordination (Hallett et al. 1993;Piven et al. 1997), that could directly affect performance of the social task.”
What the sources say
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
In the paper
“Measures of general health, home cage behavior and neurological reflexes were conducted to rule out gross physical abnormalities (Crawley 2000).”
What the sources say
- Not checked — no full text of the sourcecites Crawley 2000
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Retrieval of food buried in cage bedding was quantitated in a 15-minute olfactory test, to ensure that the subject mice were not grossly impaired in olfaction abilities.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
None of the sources cited for this claim have been checked yet.
In the paper
“A large body of evidence from twin and family studies supports the important role of genetic factors in the etiology of autism (Bailey et al. 1995;Ritvo et al. 1989;Szatmari et al. 1998).”
What the sources say
boostedcorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present mouse tasks were designed to maximize face validity to some of the core symptoms of autism.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, the A/J mice were given a second test one week later, with the dividing walls between the chamber sides partially retracted to facilitate exploration.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Test for sociability in adult male mice
plainn = 10- Asserted: passes — The authors put it forward as true.
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- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Given the primacy of social impairment in autism, we considered this symptom to be fundamental to a mouse model of autism (Insel 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
What the sources say
- Not matchedcites Insel 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
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Probably not a substantial claim.
- Not matched
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Several additional behavioral assays were performed in the initial set of juvenile male mice (C57BL/6J, DBA/2J and FVB/ NJ).These assays were designed as controls for sensory and motor abilities, etc., to ensure that the test mice were physically able to perform the procedures necessary for the social tasks described above.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The chambers of the social apparatus were cleaned and fresh paper chip bedding was added between trials.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The location of stranger 1 in the left vs. right side chamber was systematically alternated between trials.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“In our experience to date with the present procedures, human observers attain a high level of proficiency after only one or two practice sessions, with high rates (greater than 95%) of interrater reliability between trained observers.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present protocol used a small wire cage to enclose the stimulus mouse, which allowed visual, auditory and olfactory contact between the mice, but prevented the occurrence of aggressive and other responses.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
In the paper
“From an early age, autistic children show low levels of eye contact and affective responses, less orientation toward others and language deficits, with a concomitant paucity of speech and social communication (for review, see Tager-Flusberg et al. 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
What the sources say
- Not checked — no full text of the sourcecites Tager-Flusberg et al. 2001 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The stranger mouse was enclosed in a small, round wire cage (Galaxy Cup, Spectrum Diversified Designs, Inc., Streetsboro, OH), which allowed nose contact between the bars, but prevented fighting.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Tests for sociability and social novelty preference
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Previous work in social recognition has shown that mice show both habituation of olfactory responses directed toward an unfamiliar conspecific, and dishabituation, with a reinstatement of social sniffing, when a novel stimulus animal is presented (Bluthe et al. 1993;Dluzen & Kreutzberg 1993;Ferguson et al. 2000;Kogan et al. 2000;Winslow & Camacho 1995).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Alternatively, these data may reflect the low levels of open field exploratory behaviors and high levels of anxiety-like behaviors in the light/dark transitions test reported for A/J mice in other studies (Bouwknecht & Paylor 2002;Mathis et al. 1994Mathis et al. , 1995;;Thifault et al. 2002;Wahlsten et al. 2003) and reflected in the low number of entries in the present study.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The present procedures for the sociability and social novelty tests are designed to be simple, quantitative and easily mastered by investigators.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
plain- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. It may be too vague to check against evidence. The paper’s conclusions may not depend on it. The paper may give no reason why it holds. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Therefore, the present methods were designed to quantitate levels of sociability, i.e. tendency to initiate social contact, and preference for social novelty, i.e. tendency to initiate social contacts with a new individual as compared to someone familiar from past experience, using a simple scoring approach for laboratory mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“For example, some autistic patients demonstrate aberrant motor responses, including repeated hand flapping, jumping and other repetitive and stereotyped behaviors (Bodfish et al. 2000;Tager-Flusberg et al. 2001).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Altered sensory responses have been reported, including both hypo-and hyper-reactivity to environmental stimuli (Baranek 2002).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Baranek 2002 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Observational findings in some of these behavioral domains have been reported in some targeted gene mutations, e.g.deficits in social interaction within the home cage have been reported for mice deficient in the dishevelled-1 gene (Lijam et al. 1997) or the NMDA NR1 subunit (Mohn et al. 1999).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Use of the three-chambered apparatus for demonstrating social preference (Insel 2001) was adapted by Brodkin et al. (2004) to investigate social approach and avoidance in female mice.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not matchedcites Insel 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites Brodkin et al. 2004 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Observations of mice in these settings have shown that exposure to an unfamiliar stranger typically evokes a period of intense social sniffing, which may be followed by escalating aggressive responses or sexual behavior, dependent upon such factors as age and sex of the unfamiliar conspecific (Bluthe et al. 1993;Kogan et al. 2000;Winslow & Camacho 1995).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“and the mouse model of fragile X syndrome has been characterized by changes in activity (Bakker et al. 1994;Peier et al. 2000) and reactivity to acoustic stimuli (Chen & Toth 2001;Nielson et al. 2002).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not matchedcites Bakker et al. 1994
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites Peier et al. 2000
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not checked — no full text of the sourcecites Chen & Toth 2001 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
In the paper
“Children with fragile X syndrome often show autistic behavior (Hagerman et al. 1986),”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Hagerman et al. 1986 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“As noted by Winslow (2003), the analysis of the full behavioral series that can occur in social tests demands familiarity with the mouse ethogram, extensive training and the ability to discern the sometimes rapid and fleeting responses that mice can emit.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
- Not checked — no full text of the sourcecites Winslow 2003 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Methods are based on procedures examining pair-bonding in voles (Dean, S.M. & Vandenbergh, J.G. as above), as well as many other elegant tests for social behavior in rodents (Bluthe et al. 1993;Carter et al. 1995;Dluzen & Kreutzberg 1993;Gheusi et al. 1994;Insel and Young 2001;Kogan et al. 2000;Winslow & Camacho 1995;Winslow 2003).”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Mouse sociability tasks
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
Most autistic individuals demonstrate reduced or unusual social approach.
“We reasoned that most autistic individuals demonstrate reduced or unusual social approach.”
The paper relies on this without support.
Behavioral models of autistic-like responses in mice have received little attention.
“However, to date, behavioral models of autistic-like responses in mice have received little attention.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Studies aimed at modeling, in animals, the core phenotypes associated with ASDs have focused on studying social and repetitive behaviors in mice [530-532] and pair-bonding behaviors in the prairie vole (Microtus ochrogaster) [533,534].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [530]
In the citing paper
“There is compelling evidence that some strains are more”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [9]
In the citing paper
“However, almost all of them display some level of sociability (ie, preference to explore other mice over inanimate objects 9 ).”
From Ecological validity of social interaction tests in rats and mice (2019) · cites this paper as [9]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
“These social preferences were observed in both male and female mice, and in juveniles and adults.”
§ Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice > Test for sociability in adult male mice
“the social novelty test was not conducted”
Citations
Cites
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Social amnesia in mice lacking the oxytocin gene
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Fmr1 knockout mice: A model to study fragile X mental retardation
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Cited by
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Items 301–400 of 1,472
Outbred CD1 mice are as suitable as inbred C57BL/6J mice in performing social tasks
Hsieh, L. S., Wen, J. H., Miyares, L. C., Lombroso, P. J., & Bordey, A. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.11.035 · Cited by 64
Watt, G., Shang, K., Zieba, J., Olaya, J. C., Li, H., Garner, B., & Karl, T. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191242 · Cited by 70
Oxytocin: Parallel Processing in the Social Brain?
Dölen, G. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12284 · Cited by 65
de León-Reyes, N. S., Díaz, P. S., Nogueira, R., Ruiz-Pino, A., Nomura, Y., de Solis, C. A., Schulkin, J. A., Asok, A., & Leroy, F. (2023) · Cell · doi:10.1016/j.cell.2023.08.010 · Cited by 67
“In addition to innate factors (e.g., kin, strain, and sex), social preference is also influenced by social memory 10 , social hierarchy 9,11,12 and the affective state of the conspecific 13 .”
Comprehensive analysis of two Shank3 and the Cacna1c mouse models of autism spectrum disorder
Kabitzke, P., Brunner, D., He, D., Fazio, P. A., Cox, K., Sutphen, J. C., Thiede, L., Sabath, E. V., Hanania, T., Alexandrov, V., et al. (2017) · Genes Brain & Behavior · doi:10.1111/gbb.12405 · Cited by 68
“Tests of social behavior Three-chamber test The three-chamber test is one of the most widely used behavioral tests to assess social behavior (Moy et al. 2004).”
BackgroundSymeonides, C., Vacy, K., Thomson, S., Tanner, S., Chua, H. K., Dixit, S., Mansell, T., O’Hely, M., Novakovic, B., Herbstman, J. B., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48897-8 · Cited by 66
Williamson, C. M., Franks, B., & Curley, J. P. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00152 · Cited by 64
The effects of prenatal PCBs on adult social behavior in rats
Reilly, M. P., Weeks, C. D., Topper, V. Y., Thompson, L. M., Crews, D., & Gore, A. C. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.06.002 · Cited by 65
“1) was used as the testing arena (Crews et al., 2012; Moy et al., 2004).”
Mohapatra, A. N., & Wagner, S. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1205199 · Cited by 71
“, sniffing) a novel stimulus as opposed to a familiar cage-mate or a recently encountered conspecific to control for aggression due to male pheromones and general social motivation (110).”
BackgroundYasumura, M., Yoshida, T., Yamazaki, M., Abe, M., Natsume, R., Kanno, K., Uemura, T., Takao, K., Sakimura, K., Kikusui, T., et al. (2014) · Scientific Reports · doi:10.1038/srep06613 · Cited by 69
Effects of Environmental Enrichment on Repetitive Behaviors in the BTBR T+tf/J Mouse Model of Autism
Reynolds, S., Urruela, M., & Devine, D. P. (2013) · Autism Research · doi:10.1002/aur.1298 · Cited by 65
Reichelt, A. C., Gibson, G. D., Abbott, K. N., & Hare, D. J. (2019) · Food & Function · doi:10.1039/c8fo02118j · Cited by 65
Kambali, M., Anshu, K., Kutty, B. M., Muddashetty, R. S., & Laxmi, T. R. (2019) · Experimental Brain Research · doi:10.1007/s00221-019-05567-2 · Cited by 68
Mouse Models of Autism: Testing Hypotheses About Molecular Mechanisms
Roullet, F., & Crawley, J. N. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_113 · Cited by 67
“…compares the time that the subject mouse spends with a novel mouse versus the time that the subject mouse time spent with a nonsocial novel object (Moy et al. 2004, 2007, 2008b; Nadler et al. 2004; Kwon et al. 2006; Mineur et al. 2006; Crawley et al. 2007; Yang et al. 2007a, b, 2009; Chadman et…”
BackgroundMethodSelf-citationCognitive and social functions and growth factors in a mouse model of Rett syndrome
Schaevitz, L. R., Moriuchi, J. M., Nag, N., Mellott, T. J., & Berger-Sweeney, J. E. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.12.025 · Cited by 65
Perspectives on Zebrafish Models of Hallucinogenic Drugs and Related Psychotropic Compounds
Neelkantan, N., Mikhaylova, A., Stewart, A., Arnold, R., Gjeloshi, V., Kondaveeti, D., Poudel, M. K., & Kalueff, A. V. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400090q · Cited by 67
Lukas, M., & Neumann, I. D. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.03.013 · Cited by 65
Novel behavioural characteristics of the APPSwe/PS1ΔE9 transgenic mouse model of Alzheimer's disease
Cheng, D., Logge, W., Low, J. K., Garner, B., & Karl, T. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.02.008 · Cited by 69
“While control mice exhibited a clear preference for the novel opponent as expected [30], APPxPS1 males did not differentiate between the novel and familiar opponent mouse”
Contrasting characteristic behaviours among common laboratory mouse strains
Sultana, R., Ogundele, O. M., & Lee, C. C. (2019) · Royal Society Open Science · doi:10.1098/rsos.190574 · Cited by 62
Long, L. E., Chesworth, R., Arnold, J. C., & Karl, T. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1896-6 · Cited by 67
“The social interaction opponents used by O’Tuathaigh and colleagues were C57BL/6 mice, which are a less passive and more socially interactive strain than the A/J mice used in our study (Moy et al. 2004) and accordingly may have elicited different social interaction patterns.”
MethodHowell, K. R., Floyd, K., & Law, A. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175993 · Cited by 67
Singh, K., Loreth, D., Pöttker, B., Hefti, K., Innos, J., Schwald, K., Hengstler, H., Menzel, L., Sommer, C., Radyushkin, K., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00030 · Cited by 65
“Negr1-deficiency Impairs Social Behavior We next studied social interaction as a behavioral marker for neurodevelopmental disorders (Moy et al., 2004).”
BackgroundMcNamara, E. H., Grillakis, A., Tucker, L. B., & McCabe, J. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113409 · Cited by 61
“A popular test for the study of social interaction in mice is the three-chambered sociability test, which allows the study of simple social interaction, social memory, and preference for social novelty (Moy et al., 2004).”
Mesic, I., Guzmán, Y. F., Guedea, A. L., Jovasevic, V., Corcoran, K. A., Leaderbrand, K., Nishimori, K., Contractor, A., & Radulović, J. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.81 · Cited by 64
“Social Interaction Paradigm To assess sociability and social novelty, we used a threecompartment social behavior chamber (Moy et al, 2004; Sankoorikal et al, 2006).”
MethodWurzman, R. P., Forcelli, P. A., Griffey, C. J., & Kromer, L. F. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.09.012 · Cited by 66
“As performance on many common behavioral assays can vary between inbred strains [33-35], genetic drift between the DKOs and WTs was minimized by interbreeding these mice and then limiting the number of subsequent breeding cycles for each genotype to a Wurzman et al.”
BackgroundMethodAqrabawi, A. J., Browne, C. J., Dargaei, Z., Garand, D., Khademullah, C. S., Woodin, M. A., & Kim, J. C. (2016) · Nature Communications · doi:10.1038/ncomms13721 · Cited by 64
Opendak, M., Offit, L., Monari, P., Schoenfeld, T. J., Sonti, A. N., Cameron, H. A., & Gould, E. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4435-15.2016 · Cited by 61
“Social recognition and novelty preference were tested using an apparatus based on previous social behavior studies done in mice, with dimensions scaled up to accommodate rats (Engelmann et al., 1995; Moy et al., 2004; Crawley, 2007; Eagle et al., 2013).”
MethodBlanchard, D. C., Summers, C. H., & Blanchard, R. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.06.008 · Cited by 60
Adinolfi, A., Zelli, S., Leo, D., Carbone, C., Mus, L., Illiano, P., Alleva, E., Gainetdinov, R. R., & Adriani, W. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.11.028 · Cited by 61
“created by Crawley in mice [36], our rats did undergo evaluation of sociability.”
BackgroundRey, C. C., Robert, V., Bouisset, G., Loisy, M., Lopez, S., Cattaud, V., Lejards, C., Piskorowski, R. A., Rampon, C., Chevaleyre, V., et al. (2022) · iScience · doi:10.1016/j.isci.2022.103895 · Cited by 66
“Moreover, PV cells in area CA2 express a unique form of plasticity in the hippocampus: they undergo a long-term depression of GABA release (iLTD) (Piskorowski and Chevaleyre, 2013), that results in disinhibition of CA2 pyramidal cells (Nasrallah et al., 2015).”
BackgroundJang, Y., Lee, S., Lee, B., Jung, S., Khalid, A., Uchida, K., Tominaga, M., Jeon, D., & Oh, U. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5251-14.2015 · Cited by 62
“This experiment was based on a previously described protocol (Moy et al., 2004; Nadler et al., 2004).”
MethodSociability and brain development in BALB/cJ and C57BL/6J mice
Fairless, A. H., Dow, H. C., Kreibich, A. S., Torre, M., Kuruvilla, M., Gordon, E., Morton, E. A., Tan, J., Berrettini, W. H., Li, H., et al. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.12.001 · Cited by 64
Characterization of Rett Syndrome-like phenotypes in Mecp2-knockout rats
Wu, Y., Zhong, W., Cui, N., Johnson, C. M., Xing, H., Zhang, S., & Jiang, C. L. (2016) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-016-9156-7 · Cited by 61
“Consistent with previous reports [29, 30], the WT animals showed a clear tendency of social novelty by spending a longer time with the stranger animal than with the familiar one (363.”
ResultEltokhi, A., Rappold, G., & Sprengel, R. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00240 · Cited by 63
What we can learn from a genetic rodent model about autism
Möhrle, D., Fernández, M. C., Peñagarikano, O., Frick, A., Allman, B. L., & Schmid, S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.015 · Cited by 60
Scott, K. E., Kazazian, K., Mann, R. S., Möhrle, D., Schormans, A. L., Schmid, S., & Allman, B. L. (2020) · Autism Research · doi:10.1002/aur.2364 · Cited by 62
“Each rat’s preference for a conspecific over an inanimate object (sociability), as well as its preference for a stranger rat over a familiar rat (social novelty) was assessed using previously established 3-chamber assays [Crawley, 2007; Moy et al., 2004].”
MethodExposure to silver impairs learning and social behaviors in adult zebrafish
Fu, C.-W., Horng, J., Tong, S., Cherng, B., Liao, B., Lin, L., & Chou, M. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124031 · Cited by 59
Models of hypoxia and ischemia-induced seizures
Sun, H., Juul, H. M., & Jensen, F. E. (2015) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2015.09.023 · Cited by 61
Reversible Behavioral Phenotypes in a Conditional Mouse Model of TDP-43 Proteinopathies
Alfieri, J. A., Pino, N. S., & Igaz, L. M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1918-14.2014 · Cited by 60
“We tested the social behavior of TDP-43- NLS mice at 1 month after induction using a 3-chamber social interaction test (Moy et al., 2004).”
MethodLight phase testing of social behaviors: not a problem
Yang, M. (2008) · Frontiers in Neuroscience · doi:10.3389/neuro.01.029.2008 · Cited by 62
“In our three-chambered social approach test (Chadman et al., 2008; Crawley et al., 2007; McFarlane et al., 2008; Moy et al., 2004, 2007, 2008; Nadler et al., 2004; Ryan et al., 2008; Stack et al., 2008; Yang et al., 2007a,b), more time spent in the chamber containing a novel mouse than in the…”
Foote, M. M., Qiao, H., Graham, K., Wu, Y., & Zhou, Y. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.02.015 · Cited by 60
“Next, we utilized a three-chamber social interaction test to assess the social behaviors of the 14-3-3 FKO mice, as social withdrawal is a symptom of schizophrenia (31, 44).”
MethodCannabidiol (CBD) reduces anxiety-related behavior in mice via an FMRP-independent mechanism
Zieba, J., Sinclair, D., Sebree, T. B., Bonn‐Miller, M. O., Gutterman, D. L., Siegel, S. J., & Karl, T. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.05.002 · Cited by 65
Cardoso, C. V., Barros, M. P., Bachi, A. L. L., Bernardi, M. M., Kirsten, T. B., Martins, M. D. F. M., Rocha, P. R. D., Rodrigues, P., & Bondan, E. F. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112233 · Cited by 64
Holmes, G. L., Tian, C., Hernan, A. E., Flynn, S. P., Camp, D., & Barry, J. M. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.02.015 · Cited by 61
“Sociability and social novelty tests The three chamber sociability test was used to test social behavior in the seizure and control rats (Nadler et al., 2004;Moy et al., 2004, 2007).”
MethodThe Functional Annotation of Mammalian Genomes: The Challenge of Phenotyping
Brown, S. D. M., Wurst, W., Kühn, R., & Hancock, J. M. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134143 · Cited by 59
Veeraragavan, S., Wan, Y.-W., Connolly, D. R., Hamilton, S. M., Ward, C. S., Soriano, S., Pitcher, M. R., McGraw, C. M., Huang, S. G., Green, J. R., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw178 · Cited by 59
“As a modification of the original apparatus (61) to accommodate the juvenile rats, inverted cups were replaced by creating two small chambers within the side chambers as previously described (62).”
MethodNetser, S., Haskal, S., Magalnik, H., & Wagner, S. (2017) · Molecular Autism · doi:10.1186/s13229-017-0169-1 · Cited by 65
Cinque, C., Pondiki, S., Oddi, D., Certo, M. G. D., Marinelli, S., Troisi, A., Moles, A., & D'Amato, F. R. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.83 · Cited by 59
“Animals were tested immediately before weaning in a gray Plexiglas rectangular box (60 40 24 cm(3)) consisting of three interconnected chambers.(22,23) Two identical clear Plexiglas cylinders (8 cm in diameter) with multiple small holes were placed, one in each end chamber of the apparatus.”
BackgroundMethodBrain innate immune response via miRNA-TLR7 sensing in polymicrobial sepsis
Zou, L., He, J., Gu, L., Shahror, R. A., Li, Y., Cao, T., Wang, S., Zhu, J., Huang, H., Chen, F., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.11.007 · Cited by 58
“This task is based on rodent’s innate tendency to investigate a novel congener over a familiar one (Moy et al., 2004).”
BackgroundVenerosi, A., Cutuli, D., Colonnello, V., Cardona, D., Ricceri, L., & Calamandrei, G. (2008) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2008.07.002 · Cited by 57
“This test measures the propensity of mice to spend time in contact with an unfamiliar same sex conspecific rather thanwith an inanimate novel object, and to recognize a familiar partner from an unfamiliar one [11,29].”
BackgroundImpaired nitric oxide synthase signaling dissociates social investigation and aggression.
Trainor, B. C., Workman, J. L., Jessen, R., & Nelson, R. J. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.2.362 · Cited by 57
“Supporting this hypothesis are studies reporting that nNOS signaling increases dopamine release in the medial preoptic area ( Lorrain, Matuszewich, Howard, Du, & Hull, 1996 ), increases sexual motivation (Lagoda, Muschamp, Vigdorchik, & Hull, 2004), and facilitates social memory (Bohme et al., 1993).”
BackgroundDecreased cohesin in the brain leads to defective synapse development and anxiety-related behavior
Fujita, Y., Masuda, K., Bando, M., Nakato, R., Katou, Y., Tanaka, T., Nakayama, M., Takao, K., Miyakawa, T., Tanaka, T., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20161517 · Cited by 60
modCHIMERA: a novel murine closed-head model of moderate traumatic brain injury
Sauerbeck, A. D., Fanizzi, C., Kim, J. H., Gangolli, M., Bayly, P. V., Wellington, C. L., Brody, D. L., & Kummer, T. T. (2018) · Scientific Reports · doi:10.1038/s41598-018-25737-6 · Cited by 57
Social Interaction Test in Home Cage as a Novel and Ethological Measure of Social Behavior in Mice
Kim, D. G., Gonzales, E. L., Kim, S., Kim, Y., Adil, K. J., Jeon, S. J., Cho, K. S., Kwon, K. J., & Shin, C. Y. (2019) · Experimental Neurobiology · doi:10.5607/en.2019.28.2.247 · Cited by 63
Olfactory modulation of the medial prefrontal cortex circuitry: Implications for social cognition
Bhattarai, J. P., Etyemez, S., Jaaro-Peled, H., Janke, E., Tolosa, U. D. L., Kamiya, A., Gottfried, J. A., Sawa, A., & Ma, M. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.03.022 · Cited by 57
Paw preferences in mice and rats: Meta-analysis
Manns, M., Basbasse, Y. E., Freund, N., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.05.011 · Cited by 56
Alkam, T., Kim, H., Hiramatsu, M., Mamiya, T., Aoyama, Y., Nitta, A., Yamada, K., & Nabeshima, T. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.058 · Cited by 56
Tzanoulinou, S., García-Mompó, C., Castillo-Gómez, E., Veenit, V., Nacher, J., & Sandi, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094666 · Cited by 56
“The social preference test was adapted from the protocol described by Crawley and collaborators to investigate social affiliation in male mice [63] and followed the same conditions previously described [9,62].”
MethodMice lacking cyclin-dependent kinase-like 5 manifest autistic and ADHD-like behaviors
Jhang, C.-L., Huang, T., Hsueh, Y., & Liao, W. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx279 · Cited by 58
“Three-chamber social test Male mice at 4–5 weeks of age were tested for the sociability and social preference as previously described (74).”
MethodNolan, A., Hennessy, E., Krukowski, K., Guglielmetti, C., Chaumeil, M. M., Sohal, V. S., & Rosi, S. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2018.5731 · Cited by 53
Age-related changes in social behaviours in the 5xFAD mouse model of Alzheimer’s disease
Kosel, F., Muñoz, P., Yang, J., Wong, A. A., & Franklin, T. B. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.01.029 · Cited by 57
“The apparatus was a three-chamber box similar to that described by Moy et al [31].”
MethodInfluentialBerger, S., Gureczny, S., Reisinger, S. N., Horvath, O., & Pollak, D. D. (2019) · Cells · doi:10.3390/cells8091018 · Cited by 56
“In the social interaction test where the time spent in the zone near a stranger mouse in a three-compartment arena is a reliable parameter indicating sociability [32], a decrease in time spent with the stranger mouse has been associated with depression-like behavior in other animal models [33] but not yet evaluated in…”
BackgroundThe trajectory of gait development in mice
Akula, S. K., McCullough, K. B., Weichselbaum, C. T., Dougherty, J. D., & Maloney, S. E. (2020) · Brain and Behavior · doi:10.1002/brb3.1636 · Cited by 58
Ike, K. G. O., de Boer, S. F., Buwalda, B., & Kas, M. J. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.06.030 · Cited by 64
Macrı̀, S., Biamonte, F., Romano, E., Marino, R., Keller, F., & Laviola, G. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.03.012 · Cited by 55
“In order to quantify levels of sociability in mice, we performed a social interaction test, evaluating the preference for a novel unfamiliar subject over a familiar one (Moy et al., 2004).”
Novel behavioural characteristics of female APPSwe/PS1ΔE9 double transgenic mice
Cheng, D., Low, J. K., Logge, W., Garner, B., & Karl, T. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.11.046 · Cited by 61
Disruption of social approach by MK-801, amphetamine, and fluoxetine in adolescent C57BL/6J mice
Moy, S. S., Nonneman, R. J., Shafer, G. O., Nikolova, V. D., Riddick, N. V., Agster, K. L., Baker, L. K., & Knapp, D. J. (2012) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.07.007 · Cited by 60
“2.3 Testing procedures 2.3.1 Three-chamber social choice test—Mice were tested in an automated 3- chamber box, using our published methods (Moy et al. 2004, Moy et al. 2007, Nadler et al. 2004).”
MethodInfluentialSelf-citationGenetic loss of D‐amino acid oxidase activity reverses schizophrenia‐like phenotypes in mice
Labrie, V., Wang, W., Barger, S. W., Baker, G. B., & Roder, J. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00529.x · Cited by 56
“Social affiliation The social affiliation task was conducted similarly to previously described studies (Labrie et al. 2008c; Moy et al. 2004), using a clear Plexiglas box (61.”
MethodLópez‐Cruz, L., Carbo‐Gas, M., Pardo, M., Bayarri, P., Valverde, O., Ledent, C. A., Salamone, J. D., & Correa, M. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.12.020 · Cited by 56
Zarif, H., Nicolas, S., Guyot, M., Hosseiny, S., Lazzari, A., Canali, M. M., Cazareth, J., Brau, F., Golzné, V., Dourneau, E., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.11.016 · Cited by 56
“The test was videotaped and the time spent in each chamber of the apparatus during the two 5-min sessions was measured (Moy et al., 2004).”
MethodGromova, K. V., Muhia, M., Rothammer, N., Gee, C. E., Thies, E., Schaefer, I., Kress, S., Kilimann, M. W., Shevchuk, O., Oertner, T. G., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.112 · Cited by 55
Mohammadi, S., Asadi‐Shekaari, M., Basiri, M., Parvan, M., Shabani, M., & Nozari, M. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05357-2 · Cited by 57
BTBR T+tf/J mice: Autism-relevant behaviors and reduced fractone-associated heparan sulfate
Blanchard, D. C., Defensor, E. B., Meyza, K. Z., Pobbe, R. L. H., Pearson, B. L., Bolivar, V. J., & Blanchard, R. J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.06.008 · Cited by 56
Fukumitsu, K., Kaneko, M., Maruyama, T., Yoshihara, C., Huang, A. J. Y., McHugh, T. J., Itohara, S., Tanaka, M., & Kuroda, K. O. (2022) · Nature Communications · doi:10.1038/s41467-022-28131-z · Cited by 56
Yang, E.-J., Ahn, S., Lee, K., Mahmood, U., & Kim, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153298 · Cited by 56
A Neuroscientist’s Guide to the Vole
Kenkel, W. M., Gustison, M. L., & Beery, A. K. (2021) · Current Protocols · doi:10.1002/cpz1.175 · Cited by 52
“For example, mice and rats often prefer social novelty (Moy et al., 2004; Smith et al., 2015; Hackenberg et al., 2021), whereas voles typically prefer familiar social partners.”
Social defeat interacts with Disc1 mutations in the mouse to affect behavior
Haque, F. N., Lipina, T. V., Roder, J., & Wong, A. H. C. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.037 · Cited by 54
Communication, interventions, and scientific advances in autism: A commentary
Llaneza, D. C., DeLuke, S. V., Batista, M., Crawley, J. N., Christodulu, K. V., & Frye, C. A. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.01.003 · Cited by 62
Self-citationInositol hexakisphosphate kinase-1 regulates behavioral responses via GSK3 signaling pathways
Chakraborty, A., Latapy, C., Xu, J., Snyder, S. H., & Beaulieu, J. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.21 · Cited by 55
MicroRNA-155 deletion reduces anxiety- and depressive-like behaviors in mice
Fonken, L. K., Gaudet, A. D., Gaier, K. R., Nelson, R. J., & Popovich, P. G. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.10.019 · Cited by 56
Zakirova, Z., Crynen, G. C., Hassan, S., Abdullah, L. I., Horne, L., Mathura, V. S., Crawford, F., & Ait‐Ghezala, G. (2016) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2015.00071 · Cited by 53
Simmons, D. H., Titley, H. K., Hansel, C., & Mason, P. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.05.010 · Cited by 57
Hyperactivity and lack of social discrimination in the adolescent Fmr1 knockout mouse
Sørensen, E. M., Bertelsen, F., Weikop, P., Skovborg, M. M., Banke, T. G., Drasbek, K. R., & Scheel‐Krüger, J. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000152 · Cited by 59
“The three-chamber test of social behaviour was adapted with minor modifications from the original test by Moy et al. (2004).”
MethodStack, C. M., Lim, M. A., Cuasay, K., Stone, M. M., Seibert, K. M., Spivak-Pohis, I., Crawley, J. N., Waschek, J. A., & Hill, J. M. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.01.003 · Cited by 54
“Social behavior was examined with the recently designed social approach task that was created to test potential mouse models of autism (Crawley, 2004; Moy et al., 2004; Nadler et al., 2004; Crawley et al., 2007).”
BackgroundMethodInfluentialSelf-citationPapaleo, F., Yang, F., Paterson, C., Palumbo, S., Carr, G. V., Wang, Y., Floyd, K., Huang, W., Thomas, C. J., Chen, J., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4632-15.2016 · Cited by 55
“Social approach was tested in an automated threechambered apparatus using methods described previously for sociability and preference for social novelty (Moy et al., 2004; Paterson and Law, 2014).”
MethodInfluentialBaroncelli, L., Molinaro, A., Cacciante, F., Alessandri, M., Napoli, D., Putignano, E., Tola, J., Leuzzi, V., Cioni, G., & Pizzorusso, T. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw252 · Cited by 51
Mortimer, N., Ganster, T., O’Leary, A., Popp, S., Freudenberg, F., Reif, A., Artigas, M. S., Marta Ribasés, A., Ramos‐Quiroga, J. A., Lesch, K., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.02.039 · Cited by 53
Early Pharmacological Treatment of Autism: A Rationale for Developmental Treatment
Bethea, T. C., & Sikich, L. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.021 · Cited by 55
“…FRAX knockouts (Galvez and Greenough 2005), inducible Smith Lemli Opitz Syndrome (SLOS) knockouts (Waage-Baudet et al 2003), mice that have low rates of brain serotonin synthesis (Zhang et al 2004) inbred strains that show impaired sociability (Moy et al 2004), or Garner’s set shifting mouse.”
BackgroundBerman, R. F., Pessah, I. N., Mouton, P. R., Mav, D., & Harry, J. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm265 · Cited by 52
Comparative Assessment of Familiarity/Novelty Preferences in Rodents
Beery, A. K., & Shambaugh, K. L. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.648830 · Cited by 50
“This is in line with prior work demonstrating that in 10min social preference tests, prairie voles did not exhibit novelty preferences (Beery et al., 2018) as other rodents such as mice and rats often do (Moy et al., 2004; Smith et al., 2017).”
BackgroundResultPimpinella, D., Mastrorilli, V., Giorgi, C., Coemans, S., Lecca, S., Lalive, A. L., Ostermann, H., Fuchs, E. C., Monyer, H., Mele, A., et al. (2021) · eLife · doi:10.7554/elife.65580 · Cited by 54
“Counting of MSDB c- Fos nuclei was evaluated in home- caged control (HCC) mice or in animals exposed to social interaction (SI) by performing sociability and social novelty discrimination tasks in the three- chamber test (Moy et al., 2004).”
Pair housing reverses post-stroke depressive behavior in mice
Verma, R., Friedler, B. D., Harris, N., & McCullough, L. D. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.04.044 · Cited by 52
Zhang, M. Q., Ji, M., Zhao, Q., Jia, M., Qiu, L. L., Yang, J., Peng, Y., Yang, J. J., & Martynyuk, A. E. (2015) · British Journal of Anaesthesia · doi:10.1093/bja/aev339 · Cited by 51
“At P50, the rats were studied in the modified social interaction test, as previously described.(10) In brief, the cage was 70 cm long and 30 cm wide, with three communicating compartments.”
MethodChao, O. Y.-H., Yunger, R., & Yang, Y. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.03.014 · Cited by 52
“Sociability test The sociability test was composed of three sessions: habituation, sociability and social novelty, which evaluated sociable behavior and recognition of social novelty [25].”
Sidhu, H., Kreifeldt, M., & Contet, C. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13760 · Cited by 52
Vyas, Y., Lee, K., Jung, Y., & Montgomery, J. M. (2020) · Molecular Brain · doi:10.1186/s13041-020-00650-0 · Cited by 51
“The three-chamber social interaction test enabled evaluation of two critical and distinguishable aspects of social behaviours – social affiliation/motivation (sociability), as well as a social memory for novelty (social novelty recognition) as shown by previous studies [21, 46, 50].”
ResultDrew, C. J. G., Kyd, R. J., & Morton, A. J. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm181 · Cited by 51
“The tests for sociability and social novelty were conducted as described in reference (33).”
BackgroundMethodInfluentialLoss of Adenylyl Cyclase Type-5 in the Dorsal Striatum Produces Autistic-Like Behaviors
Kim, H., Lee, Y., Park, J.-Y., Kim, J.-E., Kim, T.-K., Choi, J., Lee, J.-E., Lee, E.-H., Kim, D., Kim, K.-S., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0256-x · Cited by 50
Gyles, T. M., Nestler, E. J., & Parise, E. M. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01625-0 · Cited by 55
Pedersen, C. S., Sørensen, D. B., Parachikova, A. I., & Plath, N. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.023 · Cited by 50
Metadata
- Authors
- Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- National Institute of Mental Health (US)
- Corresponding author
- Moy, S. S.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2004-04-29
- Volume
- 3
- Issue
- 5
- Pages
- 287-302
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- OpenAlex
- W2109091674
- Cited by
- 1,522
- References
- 80
- Citations by year
- 2026: 93 · 2025: 99 · 2024: 99 · 2023: 98 · 2022: 121 · 2021: 110 · 2020: 109 · 2019: 114 · 2018: 98 · 2017: 65 · 2016: 83 · 2015: 72 · 2014: 65 · 2013: 53 · 2012: 57
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- North Carolina State University
- National Institute for Health and Care Research
- National Institutes of Health (5u54mh066418-05)
- National Institute of Mental Health (U54 MH 66418, MH66418)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD003110)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- sociability, autism spectrum disorder, mouse models of autism, inbred mouse strains, social interaction deficits, social avoidance, C57BL/6J mice, DBA/2J, A/J, sex differences, age differences
- MeSH terms
- Age Factors, Analysis of Variance, Animals, Autistic Disorder, Disease Models, Animal, Exploratory Behavior, Female, Locomotion, Male, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Inbred Strains, Sex Factors, Social Behavior, Species Specificity, Reproducibility of Results, Rotarod Performance Test, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-12, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-12 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Cited sources are checked with a language model’s help (gpt-6-sol).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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