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The Role of Sirtuins in the Control of Metabolic Homeostasis

Yu, Jiujiu, Auwerx, Johan·2009·Annals of the New York Academy of Sciences
DOI 10.1111/j.1749-6632.2009.04952.xPMC PMC3620552
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Abstract

Recently the function of the sirtuin family, named after their homology to the Saccharomyces cerevisiae gene silent information regulator 2 (Sir2), has received a lot of attention, as their beneficial impact on longevity was linked to their effects on metabolic control. All sirtuins require nicotinamide adenine dinucleotide (NAD+) for their deacetylase or ADP‐ribosyl transferase activity, linking their function tightly to cellular energy levels. SIRT1, the founding member of the sirtuin family, modulates many aspects of glucose and lipid homeostasis in almost all key metabolic tissues. Other members including SIRT2, SIRT3, and SIRT4 are also implicated in various metabolic processes. Here, we review the recent data related to the role of sirtuins in the control of metabolic homeostasis and possible underlying molecular mechanisms.

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Metadata

Authors
Yu, J., & Auwerx, J.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2009-09
Volume
1173
Issue
s1
ISSN
  • 0077-8923
  • 1749-6632
DOI
10.1111/j.1749-6632.2009.04952.x
PMC
PMC3620552
Cited by
145
References
13
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 10 d)

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