Cited by 404Neural and Behavioral Psychology StudiesMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

Orbitofrontal cortex, associative learning and expectancies

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Schoenbaum, Geoffrey, Roesch, Matthew·2005·Neuron

Abstract

Orbitofrontal cortex is characterized by its unique pattern of connections with subcortical areas, such as basolateral amygdala. Here we distinguish between the critical role of these areas in associative learning and the pivotal contribution of OFC to the manipulation of this information to control behavior. This contribution reflects the ability of OFC to signal the desirability of expected outcomes, which requires the integration of associative information with information concerning internal states and goals in representational memory.

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Crossref · 10.1016/j.neuron.2005.07.018

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  • Recent models of OFC function emphasize involvement in constructing expected values based on multimodal inputs that drive behavior.

    “Recent models of a general OFC function emphasize involvement in constructing expected values based on multimodal inputs (including current internal states) that drive behavior (Schoenbaum and Roesch, 2005; Murray et al., 2007; Schoenbaum et al., 2009; Rudebeck and Murray, 2014).”

    From Top-Down Dysregulation—From ADHD to Emotional Instability (2016) · cites this paper as Schoenbaum and Roesch, 2005

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Authors
Schoenbaum, G., & Roesch, M.
Affiliations
University of Maryland, Baltimore (US)
Corresponding author
Schoenbaum, Geoffrey
Venue
Neuron
Publisher
Elsevier BV
Published
2005-09
Volume
47
Issue
5
Pages
633-636
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2027368063
Cited by
404
References
28
Citations by year
2026: 2 · 2025: 6 · 2024: 12 · 2023: 14 · 2022: 11 · 2021: 12 · 2020: 11 · 2019: 19 · 2018: 15 · 2017: 19 · 2016: 31 · 2015: 22 · 2014: 29 · 2013: 21 · 2012: 20
FWCI
14.56
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Neurological Disorders and Stroke (T32-NS07375)
  • National Institute of Development Administration (R01-DA015718)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
orbitofrontal cortex, associative learning, expectancy, basolateral amygdala, internal state, goal-directed behavior, subcortical connections
MeSH terms
Amygdala, Animals, Association Learning, Behavior, Humans, Orbit, Prefrontal Cortex

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