Orbitofrontal cortex, associative learning and expectancies
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Orbitofrontal cortex is characterized by its unique pattern of connections with subcortical areas, such as basolateral amygdala. Here we distinguish between the critical role of these areas in associative learning and the pivotal contribution of OFC to the manipulation of this information to control behavior. This contribution reflects the ability of OFC to signal the desirability of expected outcomes, which requires the integration of associative information with information concerning internal states and goals in representational memory.
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Recent models of OFC function emphasize involvement in constructing expected values based on multimodal inputs that drive behavior.
“Recent models of a general OFC function emphasize involvement in constructing expected values based on multimodal inputs (including current internal states) that drive behavior (Schoenbaum and Roesch, 2005; Murray et al., 2007; Schoenbaum et al., 2009; Rudebeck and Murray, 2014).”
From Top-Down Dysregulation—From ADHD to Emotional Instability (2016) · cites this paper as Schoenbaum and Roesch, 2005
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- Authors
- Schoenbaum, G., & Roesch, M.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Schoenbaum, Geoffrey
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 47
- Issue
- 5
- Pages
- 633-636
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2628809
- OpenAlex
- W2027368063
- Cited by
- 404
- References
- 28
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 12 · 2023: 14 · 2022: 11 · 2021: 12 · 2020: 11 · 2019: 19 · 2018: 15 · 2017: 19 · 2016: 31 · 2015: 22 · 2014: 29 · 2013: 21 · 2012: 20
- FWCI
- 14.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2912 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (T32-NS07375)
- National Institute of Development Administration (R01-DA015718)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- orbitofrontal cortex, associative learning, expectancy, basolateral amygdala, internal state, goal-directed behavior, subcortical connections
- MeSH terms
- Amygdala, Animals, Association Learning, Behavior, Humans, Orbit, Prefrontal Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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