The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Widespread Changes in Synaptic Markers as a Function of Sleep and Wakefulness in Drosophila
Open accessAbstract
Sleep is universal, strictly regulated, and necessary for cognition. Why this is so remains a mystery, although recent work suggests that sleep, memory, and plasticity are linked. However, little is known about how wakefulness and sleep affect synapses. Using Western blots and confocal microscopy in Drosophila , we found that protein levels of key components of central synapses were high after waking and low after sleep. These changes were related to behavioral state rather than time of day and occurred in all major areas of the Drosophila brain. The decrease of synaptic markers during sleep was progressive, and sleep was necessary for their decline. Thus, sleep may be involved in maintaining synaptic homeostasis altered by waking activities.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The outcome that better “content-relevant sleep” leads to improved performance is supported by previous controlled studies on the role of sleep in memory consolidation.14,15”
From Sleep quality, duration, and consistency are associated with better academic performance in college students (2019) · cites this paper as [14]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“the general understanding is that specific synaptic connections that were active during awake-periods are strengthened during sleep, allowing for the consolidation of memory, and synaptic connections that were inactive are weakened.5,14,15”
From Sleep quality, duration, and consistency are associated with better academic performance in college students (2019) · cites this paper as [14]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Suppressing expression of LTP-related genes in rats by chronic lesion of the noradrenergic system produced a strong reduction in the homeostatic SWA response (see, e.g., Refs.205 and 457, for similar results in flies).”
From About Sleep's Role in Memory (2013) · cites this paper as [457]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Sleep is thought to play a crucial and specific role in memory consolidation.”
From Sleep quality, duration, and consistency are associated with better academic performance in college students (2019) · cites this paper as [14]
The cited source says what the claim attributes to it.
In the citing paper
“The answer that emerges from the above arguments is that sleep is an optimization process that is disclosed by the nightly removal of sensory perturbations; in other words, the brain can take itself off-line with impunity, so that synaptic plasticity and homoeostasis (Gilestro et al., 2009) can reduce the complexity it has accrued during wakefulness.”
From Virtual reality and consciousness inference in dreaming (2014) · cites this paper as Gilestro et al., 2009
In the citing paper
“Thus, mechanisms of synaptic homeostasis [62] and plasticity to maintain the number of synapses in check (including the decrease of synaptic markers during sleep [63]), as well as sparse coding, with only a small proportion of neurons firing at high frequencies at any moment [49], [64], [65], may be direct consequences to brain function of a limiting and size-invariant, fixed energy budget per”
From Scaling of Brain Metabolism with a Fixed Energy Budget per Neuron: Implications for Neuronal Activity, Plasticity and Evolution (2011) · cites this paper as [63]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151
Self-citationHuber, R., Felice Ghilardi, M., Massimini, M., & Tononi, G. (2004) · Nature · doi:10.1038/nature02663 · Cited by 1,854
Self-citationPSD-95 Involvement in Maturation of Excitatory Synapses
El-Husseini, A. E.-D., Schnell, E., Chetkovich, D. M., Nicoll, R. A., & Bredt, D. S. (2000) · Science · doi:10.1126/science.290.5495.1364 · Cited by 1,303
Correlates of Sleep and Waking in Drosophila melanogaster
Shaw, P. J., Cirelli, C., Greenspan, R. J., & Tononi, G. (2000) · Science · doi:10.1126/science.287.5459.1834 · Cited by 1,300
Self-citationRest in Drosophila is a sleep-like state
Hendricks, J. C., Finn, S. M., Panckeri, K. A., Chavkin, J., Williams, J. A., Sehgal, A., & Pack, A. I. (2000) · Neuron · doi:10.1016/s0896-6273(00)80877-6 · Cited by 1,050
Wagh, D. A., Rasse, T. M., Asan, E., Hofbauer, A., Schwenkert, I., Dürrbeck, H., Buchner, S., Dabauvalle, M.-C., Schmidt, M., Qin, G., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.008 · Cited by 908
Woods, D. F., & Bryant, P. J. (1991) · Cell · doi:10.1016/0092-8674(81)90009-x · Cited by 898
Vyazovskiy, V. V., Cirelli, C., Pfister-Genskow, M., Faraguna, U., & Tononi, G. (2008) · Nature Neuroscience · doi:10.1038/nn2035 · Cited by 837
Self-citationCirelli, C., & Tononi, G. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060216 · Cited by 646
Self-citationEhrlich, I., & Malinow, R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4733-03.2004 · Cited by 567
Cited by
Sorted by citations
The free-energy principle: a unified brain theory?
Friston, K. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2787 · Cited by 8,120
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783
“As discussed in section IVB, several studies show an increase in extracellular glutamate concentrations as well as molecular markers of LTP across wake periods and a decrease after sleep periods, particularly after SWS (204, 205, 207, 257, 457, 607, 940, 1264), suggesting that the induction of new LTP is more likely d…”
BackgroundTononi, G., & Cirelli, C. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.025 · Cited by 2,356
Self-citationAmyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477
From the genetic architecture to synaptic plasticity in autism spectrum disorder
Bourgeron, T. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3992 · Cited by 975
Neuronal activity regulates the regional vulnerability to amyloid-β deposition
Bero, A. W., Yan, P., Roh, J. H., Cirrito, J. R., Stewart, F. R., Raichle, M. E., Lee, J.-M., & Holtzman, D. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2801 · Cited by 880
Cortical firing and sleep homeostasis
Vyazovskiy, V. V., Olcese, U., Lazimy, Y. M., Faraguna, U., Esser, S. K., Williams, J. C., Cirelli, C., & Tononi, G. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.024 · Cited by 740
Self-citationHerculano-Houzel, S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201895109 · Cited by 726
Herculano‐Houzel, S. (2014) · Glia · doi:10.1002/glia.22683 · Cited by 731
Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut
Vaccaro, A., Kaplan Dor, Y., Nambara, K., Pollina, E. A., Lin, C., Greenberg, M. E., & Rogulja, D. (2020) · Cell · doi:10.1016/j.cell.2020.04.049 · Cited by 541
Ooms, S., Overeem, S., Besse, K., Rikkert, M. O., Verbeek, M., & Claassen, J. A. H. R. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.1173 · Cited by 438
Circadian Rhythms and Sleep in Drosophila melanogaster
Dubowy, C., & Sehgal, A. (2017) · Genetics · doi:10.1534/genetics.115.185157 · Cited by 432
Genetics of Sleep and Sleep Disorders
Sehgal, A., & Mignot, E. J.-M. (2011) · Cell · doi:10.1016/j.cell.2011.07.004 · Cited by 416
Advances in visual perceptual learning and plasticity
Sasaki, Y., Náñez, J. E., & Watanabe, T. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2737 · Cited by 400
Changes in the composition of brain interstitial ions control the sleep-wake cycle
Ding, F., O’Donnell, J., Xu, Q., Kang, N., Goldman, N., & Nedergaard, M. (2016) · Science · doi:10.1126/science.aad4821 · Cited by 393
The genetic and molecular regulation of sleep: from fruit flies to humans
Cirelli, C. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2683 · Cited by 388
Self-citationInducing Sleep by Remote Control Facilitates Memory Consolidation in Drosophila
Donlea, J. M., Thimgan, M. S., Suzuki, Y., Gottschalk, L., & Shaw, P. J. (2011) · Science · doi:10.1126/science.1202249 · Cited by 378
Sleep and Synaptic Homeostasis: Structural Evidence in Drosophila
Bushey, D., Tononi, G., & Cirelli, C. (2011) · Science · doi:10.1126/science.1202839 · Cited by 357
Self-citationGlucocorticoids are critical regulators of dendritic spine development and plasticity in vivo
Liston, C., & Gan, W.-B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110444108 · Cited by 352
Okano, K., Kaczmarzyk, J. R., Dave, N., Gabrieli, J. D. E., & Grossman, J. C. (2019) · npj Science of Learning · doi:10.1038/s41539-019-0055-z · Cited by 335
“The outcome that better “content-relevant sleep” leads to improved performance is supported by previous controlled studies on the role of sleep in memory consolidation.(14,15) Consistent with some previous research(45,46) female students tended to experience better quality sleep and with more consistency than male stu…”
BackgroundResultHerculano-Houzel, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017514 · Cited by 343
Sleep Drive Is Encoded by Neural Plastic Changes in a Dedicated Circuit
Liu, S., Liu, Q., Tabuchi, M., & Wu, M. N. (2016) · Cell · doi:10.1016/j.cell.2016.04.013 · Cited by 317
Identification of a dopamine pathway that regulates sleep and arousal in Drosophila
Ueno, T., Tomita, J., Tanimoto, H., Endo, K., Ito, K., Kume, S., & Kume, K. (2012) · Nature Neuroscience · doi:10.1038/nn.3238 · Cited by 289
Fundamental Elements in Autism: From Neurogenesis and Neurite Growth to Synaptic Plasticity
Gilbert, J. P., & Man, H. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00359 · Cited by 286
Effects of Age and Amyloid Deposition on Aβ Dynamics in the Human Central Nervous System
Huang, Y. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.235 · Cited by 291
A Dynamic Deep Sleep Stage inDrosophila
van Alphen, B., Yap, M., Kirszenblat, L., Kottler, B., & van Swinderen, B. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0061-13.2013 · Cited by 246
Evolutionary Convergence on Sleep Loss in Cavefish Populations
Duboué, E. R., Keene, A. C., & Borowsky, R. L. (2011) · Current Biology · doi:10.1016/j.cub.2011.03.020 · Cited by 236
Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states
Ehmann, N., van de Linde, S., Alon, A., Ljaschenko, D., Keung, X. Z., Holm, T., Rings, A., DiAntonio, A., Hallermann, S., Ashery, U., et al. (2014) · Nature Communications · doi:10.1038/ncomms5650 · Cited by 233
Waking and dreaming consciousness: neurobiological and functional considerations.
Hobson, J. A., & Friston, K. J. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.05.003 · Cited by 287
Unraveling the evolutionary determinants of sleep
Joiner, W. J. (2016) · Current Biology · doi:10.1016/j.cub.2016.08.068 · Cited by 232
Liu, Z.-W., Faraguna, U., Cirelli, C., Tononi, G., & Gao, X.-B. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1409-10.2010 · Cited by 248
Self-citationLocal Experience-Dependent Changes in the Wake EEG after Prolonged Wakefulness
Hung, C., Sarasso, S., Ferrarelli, F., Riedner, B. A., Ghilardi, M. F., Cirelli, C., & Tononi, G. (2012) · SLEEP · doi:10.5665/sleep.2302 · Cited by 233
Self-citationKarabanov, A. N., Ziemann, U., Hamada, M., George, M. S., Quartarone, A., Claßen, J., Massimini, M., Rothwell, J. C., & Siebner, H. R. (2015) · Brain stimulation · doi:10.1016/j.brs.2015.01.404 · Cited by 236
Lifespan brain activity, β-amyloid, and Alzheimer's disease
Jagust, W. J., & Mormino, E. C. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.09.004 · Cited by 221
“These results parallel known fluctuations in synaptic strength during sleep/wake cycles that may reflect synaptic activity [6].”
ResultInformation and efficiency in the nervous system-a synthesis.
Sengupta, B., Stemmler, M. B., & Friston, K. J. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003157 · Cited by 212
Virtual reality and consciousness inference in dreaming
Hobson, J. A., Hong, C. C.-H., & Friston, K. J. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01133 · Cited by 197
“This is exactly consistent with the synaptic homoeostasis hypothesis and the role of sleep in pruning unnecessary and exuberant synaptic connections (Gilestro et al., 2009).”
BackgroundResultSentience and the Origins of Consciousness: From Cartesian Duality to Markovian Monism
Friston, K. J., Wiese, W., & Hobson, J. A. (2020) · Entropy · doi:10.3390/e22050516 · Cited by 186
Scullin, M. K. (2013) · Psychology and Aging · doi:10.1037/a0028830 · Cited by 181
Circadian and Homeostatic Regulation of Structural Synaptic Plasticity in Hypocretin Neurons
Appelbaum, L., Wang, G. X., Yokogawa, T., Skariah, G. M., Smith, S. J., Mourrain, P., & Mignot, E. J.-M. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.006 · Cited by 174
Circadian clocks: genes, sleep, and cognition
Kyriacou, C. P., & Hastings, M. H. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.03.007 · Cited by 179
The consequences of sleep deprivation on cognitive performance
Khan, M., & Al-Jahdali, H. H. (2023) · Neurosciences · doi:10.17712/nsj.2023.2.20220108 · Cited by 218
Bayer, T. A., & Wirths, O. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1287-x · Cited by 170
Canto, C. B., Onuki, Y., Bruinsma, B., van der Werf, Y. D., & Zeeuw, C. I. D. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.03.001 · Cited by 175
Apolipoprotein E, not fibrillar β-amyloid, reduces cerebral glucose metabolism in normal aging
Jagust, W. J., Landau, S. M., & Initiative, F. T. A. D. N. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3266-12.2012 · Cited by 162
Long-term sleep disturbances in children: A cause of neuronal loss
Jan, J. E., Reiter, R. J., Bax, M. C. O., Ribary, U., Freeman, R. D., & Wasdell, M. B. (2010) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2010.05.001 · Cited by 172
Karabanov, A. N., Ziemann, U., Hamada, M., George, M. S., Quartarone, A., Claßen, J., Massimini, M., Rothwell, J. C., & Siebner, H. R. (2015) · Brain stimulation · doi:10.1016/j.brs.2015.06.017 · Cited by 166
CLOCK gene variants associate with sleep duration in two independent populations
Allebrandt, K. V., Teder-Laving, M., Akyol, M., Pichler, I., Müller-Myhsok, B., Pramstaller, P., Merrow, M., Meitinger, T., Metspalu, A., & Roenneberg, T. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.026 · Cited by 159
Carew, T. J., & Magsamen, S. H. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.028 · Cited by 156
Genetic analysis of sleepPreprint
Crocker, A. J., & Sehgal, A. (2010) · Genes & Development · doi:10.1101/gad.1913110 · Cited by 156
Molecular Mechanisms of Sleep Homeostasis in Flies and MammalsPreprint
Allada, R., Cirelli, C., & Sehgal, A. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a027730 · Cited by 160
Self-citationDaily Oscillation of the Excitation-Inhibition Balance in Visual Cortical Circuits
Bridi, M., Zong, F., Min, X., Luo, N., Tran, T., Qiu, J., Severín, D., Zhang, X., Wang, G., Zhu, Z., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.11.011 · Cited by 146
The Unrested Resting Brain: Sleep Deprivation Alters Activity within the Default-mode Network
Gujar, N., Yoo, S., Hu, P. T., & Walker, M. P. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21331 · Cited by 156
Sleep Restores Behavioral Plasticity to Drosophila Mutants
Dissel, S., Angadi, V., Kirszenblat, L., Suzuki, Y., Donlea, J. M., Klose, M. K., Koch, Z., English, D., Winsky‐Sommerer, R., van Swinderen, B., et al. (2015) · Current Biology · doi:10.1016/j.cub.2015.03.027 · Cited by 151
Synaptic plasticity in sleep: learning, homeostasis and disease
Wang, G., Grone, B., Colas, D., Appelbaum, L., & Mourrain, P. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.07.005 · Cited by 172
REM sleep promotes experience-dependent dendritic spine elimination in the mouse cortex
Zhou, Y., Lai, C. S. W., Bai, Y., Li, W., Zhao, R., Yang, G., Frank, M. G., & Gan, W. (2020) · Nature Communications · doi:10.1038/s41467-020-18592-5 · Cited by 139
Developmental aspects of sleep slow waves
Ringli, M., & Huber, R. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53839-0.00005-3 · Cited by 143
Kurth, S., Ringli, M., LeBourgeois, M. K., Geiger, A., Buchmann, A., Jenni, O. G., & Huber, R. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.053 · Cited by 136
Yang, G., & Gan, W. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20996 · Cited by 131
Yurgel, M. E., Kakad, P. P., Zandawala, M., Nässel, D. R., Godenschwege, T. A., & Keene, A. C. (2019) · PLoS Biology · doi:10.1371/journal.pbio.2006409 · Cited by 135
Hippocampal memory consolidation during sleep: a comparison of mammals and birds
Rattenborg, N. C., Martínez-González, D., Roth, T. C., & Витальевич, П. В. (2010) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2010.00165.x · Cited by 128
Sleep, clocks, and synaptic plasticity
Frank, M. G., & Cantera, R. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.06.005 · Cited by 125
Electrophysiological correlates of sleep homeostasis in freely behaving rats
Vyazovskiy, V. V., Cirelli, C., & Tononi, G. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53839-0.00002-8 · Cited by 117
Self-citationTime to Be SHY? Some Comments on Sleep and Synaptic Homeostasis
Tononi, G., & Cirelli, C. (2012) · Neural Plasticity · doi:10.1155/2012/415250 · Cited by 124
Self-citationPfeiffenberger, C., & Allada, R. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003003 · Cited by 112
Gupta, V., Pech, U., Bhukel, A., Fulterer, A., Ender, A., Mauermann, S. F., Andlauer, T. F. M., Antwi-Adjei, E., Beuschel, C. B., Thriene, K., et al. (2016) · PLoS Biology · doi:10.1371/journal.pbio.1002563 · Cited by 114
Sleep and Synaptic Renormalization: A Computational Study
Olcese, U., Esser, S. K., & Tononi, G. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00593.2010 · Cited by 117
Self-citationOrbán, C., Kong, R., Li, J., Chee, M. W. L., & Yeo, B. T. T. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000602 · Cited by 104
Kuo, T., Pike, D. H., Beizaeipour, Z., & Williams, J. A. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-17 · Cited by 110
Morning-evening variation in human brain metabolism and memory circuits
Shannon, B., Dosenbach, R. A. T., Su, Y., Vlassenko, A. G., Larson‐Prior, L. J., Nolan, T. S., Snyder, A. Z., & Raichle, M. E. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00651.2012 · Cited by 108
Long-term sleep disturbances in children: A cause of neuronal loss
Nolan, B. (2011) · Yearbook of Neurology and Neurosurgery · doi:10.1016/j.yneu.2010.12.031 · Cited by 101
Cerebral blood flow changes after a day of wake, sleep, and sleep deprivation
Elvsåshagen, T., Mutsaerts, H. J. M. M., Zak, N., Norbom, L. B., Quraishi, S. H., Pedersen, P. Ø., Malt, U. F., Westlye, L. T., Someren, E. J. W. V., Bjørnerud, A., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.11.032 · Cited by 100
The Steroid Molting Hormone Ecdysone Regulates Sleep in Adult Drosophila melanogaster
Ishimoto, H., & Kitamoto, T. (2010) · Genetics · doi:10.1534/genetics.110.114587 · Cited by 102
Local sleep homeostasis in the avian brain: convergence of sleep function in mammals and birds?
Lesku, J. A., Vyssotski, A. L., Martinez-Gonzalez, D., Wilzeck, C., & Rattenborg, N. C. (2011) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2010.2316 · Cited by 112
Circadian Pacemaker Neurons Change Synaptic Contacts across the Day
Gorostiza, E. A., Depetris-Chauvin, A., Frenkel, L., Pírez, N., & Ceriani, M. F. (2014) · Current Biology · doi:10.1016/j.cub.2014.07.063 · Cited by 103
Erasing Synapses in Sleep: Is It Time to Be SHY?
Frank, M. G. (2012) · Neural Plasticity · doi:10.1155/2012/264378 · Cited by 117
Bellesi, M., Bushey, D., Chini, M., Tononi, G., & Cirelli, C. (2016) · Scientific Reports · doi:10.1038/srep36804 · Cited by 99
Self-citationRaccuglia, D., Huang, S., Ender, A., Heim, M. ‐., Laber, D., Suárez-Grimalt, R., Liotta, A., Sigrist, S. J., Geiger, J. R. P., & Owald, D. (2019) · Current Biology · doi:10.1016/j.cub.2019.08.070 · Cited by 89
Video tracking and analysis of sleep in Drosophila melanogaster
Gilestro, G. F. (2012) · Nature Protocols · doi:10.1038/nprot.2012.041 · Cited by 94
Self-citationA Paradoxical Kind of Sleep in Drosophila melanogaster
Heap, L. A., Kirszenblat, L., Notaras, E., Grabowska, M. J., Jeans, R., Feng, K., Shaw, P. J., & van Swinderen, B. (2020) · Current Biology · doi:10.1016/j.cub.2020.10.081 · Cited by 92
Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish
Elbaz, I., Foulkes, N. S., Gothilf, Y., & Appelbaum, L. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00009 · Cited by 93
Sleep in Drosophila and Its Context
Beckwith, E. J., & French, A. S. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01167 · Cited by 94
Circadian rhythms and memory: not so simple as cogs and gears
Eckel‐Mahan, K. L., & Storm, D. R. (2009) · EMBO Reports · doi:10.1038/embor.2009.123 · Cited by 99
Helfrich‐Förster, C. (2017) · Annual Review of Entomology · doi:10.1146/annurev-ento-020117-043201 · Cited by 89
Sleep Deprivation Specifically Impairs Short-term Olfactory Memory in Drosophila
Li, X., Yu, F., & Guo, A. (2009) · SLEEP · doi:10.1093/sleep/32.11.1417 · Cited by 92
The neurobiological basis of sleep: Insights from Drosophila
Ly, S., Pack, A. I., & Naidoo, N. N. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.01.015 · Cited by 85
Gorgoni, M., D’Atri, A., Lauri, G., Rossini, P. M., Ferlazzo, F., & Gennaro, L. D. (2013) · Neural Plasticity · doi:10.1155/2013/103949 · Cited by 95
Ortega, F. B., Chillón, P., Ruiz, J. R., Delgado‐Fernández, M., Albers, U., Alvarez-Granda, J. L., Marcos, A., Moreno, L. A., & Castillo, M. J. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1536-1 · Cited by 89
Embodied inference: or "I think therefore I am, if I am what I think"
Friston, K. J. (2011) · Cited by 84
Pistollato, F., Cano, S. S., Elío, I., Vergara, M. M., Giampieri, F., & Battino, M. A. (2016) · Advances in Nutrition · doi:10.3945/an.115.011775 · Cited by 85
Ion channels to inactivate neurons in Drosophila
Hodge, J. J. L. (2009) · Frontiers in Molecular Neuroscience · doi:10.3389/neuro.02.013.2009 · Cited by 82
Late bedtimes weaken school performance and predispose adolescents to health hazards
Merikanto, I., Lahti, T., Puusniekka, R., & Partonen, T. (2013) · Sleep Medicine · doi:10.1016/j.sleep.2013.06.009 · Cited by 79
Regulation of sleep homeostasis by sexual arousal
Beckwith, E. J., Geissmann, Q., French, A. S., & Gilestro, G. F. (2017) · eLife · doi:10.7554/elife.27445 · Cited by 79
Self-citationThe why and how of sleep-dependent synaptic down-selection
Cirelli, C., & Tononi, G. (2022) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2021.02.007 · Cited by 74
Self-citationChristensen, J., Li, C. N., & Mychasiuk, R. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221082786 · Cited by 78
Drosophila strategies to study psychiatric disorders
van Alphen, B., & van Swinderen, B. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.09.007 · Cited by 77
ThreeDrosophilaLiprins Interact to Control Synapse Formation
Astigarraga, S., Hofmeyer, K., Farajian, R., & Treisman, J. E. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1862-10.2010 · Cited by 76
Sleep as a Therapeutic Target in the Aging Brain
Bah, T. M., Goodman, J. R., & Iliff, J. J. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00769-6 · Cited by 76
Regulation of sleep by the short neuropeptide F (sNPF) in Drosophila melanogaster
Chen, W., Shi, W., Li, L., Zheng, Z., Li, T., Bai, W., & Zhao, Z. (2013) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2013.06.003 · Cited by 73
Acosta-Peña, E., Camacho‐Abrego, I., Melgarejo-Gutiérrez, M. A., Flores, G., Drucker-Colı́n, R., & García‐García, F. (2014) · Synapse · doi:10.1002/syn.21779 · Cited by 73
Metadata
- Authors
- Gilestro, G. F., Tononi, G., & Cirelli, C.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Tononi, Giulio
- Cirelli, Chiara
- Venue
- Science
- Published
- 2009-04-03
- Volume
- 324
- Issue
- 5923
- Pages
- 109-112
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2715914
- OpenAlex
- W2015113576
- Cited by
- 360
- References
- 29
- Citations by year
- 2026: 14 · 2025: 23 · 2024: 16 · 2023: 14 · 2022: 17 · 2021: 8 · 2020: 15 · 2019: 20 · 2018: 11 · 2017: 22 · 2016: 19 · 2015: 18 · 2014: 22 · 2013: 24 · 2012: 26
- FWCI
- 18.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (DP1OD000579)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- sleep, wakefulness, synaptic markers, synaptic homeostasis, Drosophila, behavioral state, memory consolidation, neuroplasticity
- MeSH terms
- Animals, Biological Clocks, Brain, Circadian Rhythm, Drosophila melanogaster, Female, Homeostasis, Male, Sleep, Sleep Deprivation, Synapses, Wakefulness, Blotting, Western, Synapsins, Microscopy, Confocal, Models, Animal, Tumor Suppressor Proteins, Drosophila Proteins, Qa-SNARE Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
