CoChat
Sign Up
Cited by 4,786Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationMesenchymal stem cell research

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Mammalian neural stem cells.

Gage, Fred H.·2000·Science
DOI 10.1126/science.287.5457.1433
Open this paper in CoChat — free account

Abstract

Neural stem cells exist not only in the developing mammalian nervous system but also in the adult nervous system of all mammalian organisms, including humans. Neural stem cells can also be derived from more primitive embryonic stem cells. The location of the adult stem cells and the brain regions to which their progeny migrate in order to differentiate remain unresolved, although the number of viable locations is limited in the adult. The mechanisms that regulate endogenous stem cells are poorly understood. Potential uses of stem cells in repair include transplantation to repair missing cells and the activation of endogenous cells to provide “self-repair.” Before the full potential of neural stem cells can be realized, we need to learn what controls their proliferation, as well as the various pathways of differentiation available to their daughter cells.

Overview

Integrity signals

Registry

Crossref · 10.1126/science.287.5457.1433

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 4 references

Research works printed but not linked: 83

  1. 10.1126/science.282.5391.1145 · DOI
  2. 10.1073/pnas.95.23.13726 · DOI
  3. Doe C. Q., Fuerstenberg S., Peng C.-Y., J. Neurobiol. 36, 111 (1998). · DOI
  4. Alvarado A. S., Newmark P. A., Wound Repair Regen. 6, 413 (1998). · DOI
  5. Gensburger C., Labourdette G., Sensenbrenner M., FEBS Lett. 217, 1 (1987); · DOI
  6. Richards L. J., Kilpatrick T. J., Bartlett P. F., Proc. Natl. Acad. Sci. U.S.A. 89, 8591 (1992); · DOI
  7. Ray J., Peterson D. A., Schinstine M., Gage F. H., Proc. Natl. Acad. Sci. U.S.A. 90, 3602 (1993); · DOI
  8. Davis A. A., Temple S., Nature 372, 263 (1994). · DOI
  9. 10.1126/science.1553558 · DOI
  10. Reynolds B. A., Tetzlaff W., Weiss S., J. Neurosci. 12, 4565 (1992). · DOI
  11. Reynolds B. A., Weiss S., Dev. Biol. 175, 1 (1996); · DOI
  12. Gritti A., et al., J. Neurosci. 16, 1091 (1996); · DOI
  13. 10.1101/gad.10.24.3129 · DOI
  14. Kalyani A., Hobson K., Rao M. S., Dev. Biol. 186, 202 (1997). · DOI
  15. Palmer T. D., Takahashi J., Gage F. H., Mol. Cell. Neurosci. 8, 389 (1997). · DOI
  16. Noble M., Methods Mol. Biol. 97, 139 (1999).
  17. Hoshimaru M., Ray J., Sah D. W. Y., Gage F. H., Proc. Natl. Acad. Sci. U.S.A. 93, 1518 (1996). · DOI
  18. 10.1038/3473 · DOI
  19. Vescovi A. L., Gritti A., Galli R., Parati E. A., J. Neurotrauma 16, 689 (1999); · DOI
  20. Carpenter M. K., et al., Exp. Neurol. 158, 265 (1999); · DOI
  21. Gritti A., et al., J. Neurosci. 19, 3287 (1999); · DOI
  22. Kukekov V. G., et al., Exp. Neurol. 156, 333 (1999); · DOI
  23. Kirschenbaum B., et al., Cereb. Cortex 4, 576 (1994). · DOI
  24. 10.1126/science.287.5457.1439 · DOI
  25. Gaiano N., Fishell G., J. Neurobiol. 36, 152 (1998); · DOI
  26. Fricker R. A., et al., J. Neurosci. 19, 5990 (1999). · DOI
  27. Brüstle O., et al., Proc. Natl. Acad. Sci. U.S.A. 94, 14809 (1997); · DOI
  28. Olsson M., et al., Eur. J. Neurosci. 10, 71 (1998); · DOI
  29. Brüstle O., et al., Nature Biotechnol. 16, 1040 (1998); · DOI
  30. Wichterle H., Garcia-Verdugo J. M., Herrere D. G., Alvarez-Buylla A., Nature Neurosci. 2, 461 (1999) . · DOI · Paper page
  31. Snyder E. Y., Yoon C., Flax J. D., Macklis J. D., Proc. Natl. Acad. Sci. U.S.A. 94, 11663 (1997); · DOI
  32. Yandava B. D., Billinghurst L. L., Snyder E. Y., Proc. Natl. Acad. Sci. U.S.A. 96, 7029 (1999). · DOI
  33. Gage F. H., et al., Proc. Natl. Acad. Sci. U.S.A. 92, 11879 (1995). · DOI
  34. 10.1038/383624a0 · DOI
  35. 10.1126/science.283.5401.534 · DOI
  36. Overturf K. M., Am. J. Pathol. 151, 1078 (1997).
  37. 10.1523/JNEUROSCI.19-19-08487.1999 · DOI
  38. 10.1016/S0092-8674(00)80583-8 · DOI
  39. 10.1126/science.287.5457.1442 · DOI
  40. Brüstle O., et al., Science 285, 754 (1999). · DOI
  41. McDonald J. W., et al., Nature Med. 5, 1410 (1999). · DOI
  42. 10.1073/pnas.96.19.10711 · DOI
  43. Walsh C., Cepko C. L., Science 241, 1342 (1988); · DOI
  44. Price J., Thurlow L., Development 104, 473 (1988). · DOI
  45. 10.1126/science.135.3509.1127 · DOI
  46. Kuhn H. G., Winkler J., Kempermann G., Thal L. J., Gage F. H., J. Neurosci. 17, 5820 (1997). · DOI
  47. J. Altman and S. A. Bayer Atlas of Prenatal Rat Brain Development (CRC Press Boca Raton FL 1995).
  48. Goldman S. A., Nottebohm F., Proc. Natl. Acad. Sci. U.S.A. 80, 2390 (1983). · DOI
  49. 10.1126/science.6474166 · DOI
  50. Alvarez-Buylla A., Kirn J., J. Neurobiol. 33, 585 (1997). · DOI
  51. Cameron H. A., Gould E., Neuroscience 61, 203 (1994); · DOI
  52. Erickson P. S., et al., Nature Med. 4, 1313 (1998); · DOI · Paper page
  53. Gould E., et al., Proc. Natl. Acad. Sci. U.S.A. 96, 5263 (1999); · DOI
  54. Kornack D. R., Rakic P., Proc. Natl. Acad. Sci. U.S.A. 96, 5768 (1999). · DOI
  55. 10.1016/S0092-8674(00)80956-3 · DOI
  56. Chiasson B. J., Tropepe V., Morshead C. M., van der Kooy D., J. Neurosci. 19, 4462 (1999). · DOI
  57. 10.1126/science.287.5457.1427 · DOI
  58. 10.1073/pnas.90.5.2074 · DOI
  59. Luskin M. B., Neuron 11, 173 (1993). · DOI
  60. 10.1126/science.271.5251.978 · DOI · Paper page
  61. Alvarez-Buylla A., Neuron 18, 779 (1997). · DOI
  62. Bonfanti L., Theodosis D. T., Neuroscience 62, 291 (1994); · DOI
  63. Ono K., Tomasiewicz H., Magnuson T., Rutishauser U., Neuron 13, 595 (1994). · DOI
  64. Tomasiewicz H., et al., Neuron 11, 1163 (1993); · DOI
  65. Cremer H., et al., Nature 367, 455 (1994). · DOI
  66. 10.1126/science.286.5439.548 · DOI
  67. Kempermann G., Kuhn H. G., Gage F. H., Proc. Natl. Acad. Sci. U.S.A. 94, 10409 (1997). · DOI
  68. ___, Nature 386, 493 (1997). · DOI
  69. Kempermann G., Brandon E. P., Gage F. H., Curr. Biol. 8, 939 (1998); · DOI
  70. Gould E., Beylin A., Tanapat P., Reeves A., Shors T. J., Nature Neurosci. 2, 260 (1999). · DOI · Paper page
  71. Van Praag H., Christie B. R., Sejnowski T. J., Gage F. H., Proc. Natl. Acad. Sci. U.S.A. 96, 13427 (1999). · DOI · Paper page
  72. Gould E., Cameron H. A., Daniels D. C., Woolley C. S., McEwen B. S., J. Neurosci. 12, 3642 (1992); · DOI
  73. Gould E., Tanapat P., McEwen B. S., Flugge G., Fuchs E., Proc. Natl. Acad. Sci. U.S.A. 95, 3168 (1998). · DOI · Paper page
  74. Gould E., Tanapat P., Neuroscience 80, 427 (1997). · DOI
  75. Parent J. M., et al., J. Neurosci. 17, 3727 (1997). · DOI
  76. Stanfield B. B., Trice J. E., Exp. Brain Res. 72, 399 (1988);
  77. Markakis E., Gage F. H., J. Comp. Neurol. 406, 449 (1999). · DOI
  78. 10.1523/JNEUROSCI.16-08-02649.1996 · DOI
  79. Y. Tao I. B. Black E. DiCicco-Bloom J. Comp. Neurol. 376 653 (1996); · DOI
  80. Wagner J. P., Black I. B., DiCicco-Bloom E., J. Neurosci. 19, 6006 (1999). · DOI
  81. Luskin M. B., Zigova T., Soteres B. J., Stewart R. R., Mol. Cell. Neurosci. 8, 351 (1997). · DOI
  82. Brasted P. J., Watts C., Robbins T. W., Dunnett S. B., Proc. Natl. Acad. Sci. U.S.A. 96, 10524 (1999). · DOI
  83. 10.1002/(SICI)1097-4695(199808)36:2<234::AID-NEU10>3.0.CO;2-E · DOI

Cited by

Sorted by citations

Items 101–122 of 122

Metadata

Authors
Gage, F. H.
Affiliations
Salk Institute for Biological Studies (US)
Corresponding author
Gage, Fred H.
ORCID
Gage, Fred H.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2000-02-25
Volume
287
Issue
5457
Pages
1433-1438
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.287.5457.1433
OpenAlex
W2084652820
Cited by
4,786
References
4
Citations by year
2026: 43 · 2025: 75 · 2024: 85 · 2023: 87 · 2022: 85 · 2021: 117 · 2020: 113 · 2019: 139 · 2018: 184 · 2017: 191 · 2016: 187 · 2015: 231 · 2014: 218 · 2013: 248 · 2012: 240
FWCI
11.42
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • DigitalGeorgetown (Georgetown University Library) (submittedVersion)
Funders
National Institute of Neurological Disorders and Stroke (N01 NS 62348)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords
neural stem cells, adult nervous system, embryonic stem cells, stem cell transplantation, self-healing, stem cell proliferation, neuronal differentiation, stem cell regulation, brain regions
MeSH terms
Animals, Brain, Cell Differentiation, Cell Division, Cell Movement, Cell Separation, Embryo, Mammalian, Humans, Neurons, Spinal Cord, Stem Cells, Cell Death, Stem Cell Transplantation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review