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Cited by 4,786Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationMesenchymal stem cell research

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Mammalian neural stem cells.

Gage, Fred H.·2000·Science
DOI 10.1126/science.287.5457.1433
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Abstract

Neural stem cells exist not only in the developing mammalian nervous system but also in the adult nervous system of all mammalian organisms, including humans. Neural stem cells can also be derived from more primitive embryonic stem cells. The location of the adult stem cells and the brain regions to which their progeny migrate in order to differentiate remain unresolved, although the number of viable locations is limited in the adult. The mechanisms that regulate endogenous stem cells are poorly understood. Potential uses of stem cells in repair include transplantation to repair missing cells and the activation of endogenous cells to provide “self-repair.” Before the full potential of neural stem cells can be realized, we need to learn what controls their proliferation, as well as the various pathways of differentiation available to their daughter cells.

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Metadata

Authors
Gage, F. H.
Affiliations
Salk Institute for Biological Studies (US)
Corresponding author
Gage, Fred H.
ORCID
Gage, Fred H.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2000-02-25
Volume
287
Issue
5457
Pages
1433-1438
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.287.5457.1433
OpenAlex
W2084652820
Cited by
4,786
References
4
Citations by year
2026: 43 · 2025: 75 · 2024: 85 · 2023: 87 · 2022: 85 · 2021: 117 · 2020: 113 · 2019: 139 · 2018: 184 · 2017: 191 · 2016: 187 · 2015: 231 · 2014: 218 · 2013: 248 · 2012: 240
FWCI
11.42
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • DigitalGeorgetown (Georgetown University Library) (submittedVersion)
Funders
National Institute of Neurological Disorders and Stroke (N01 NS 62348)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords
neural stem cells, adult nervous system, embryonic stem cells, stem cell transplantation, self-healing, stem cell proliferation, neuronal differentiation, stem cell regulation, brain regions
MeSH terms
Animals, Brain, Cell Differentiation, Cell Division, Cell Movement, Cell Separation, Embryo, Mammalian, Humans, Neurons, Spinal Cord, Stem Cells, Cell Death, Stem Cell Transplantation

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