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Cited by 844

The DOI matches its Crossref record.

Prokaryotic Regulation of Epithelial Responses by Inhibition of IκB-α Ubiquitination

Neish, Andrew S., Gewirtz, Andrew T., Zeng, Hui, Young, Andrew N., Hobert, Michael E., Karmali, Vinit, Rao, Anjali S., Madara, James L.·2000·Science
DOI 10.1126/science.289.5484.1560
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Abstract

Epithelia of the vertebrate intestinal tract characteristically maintain an inflammatory hyporesponsiveness toward the lumenal prokaryotic microflora. We report the identification of enteric organisms (nonvirulent Salmonella strains) whose direct interaction with model human epithelia attenuate synthesis of inflammatory effector molecules elicited by diverse proinflammatory stimuli. This immunosuppressive effect involves inhibition of the inhibitor κB/nuclear factor κB (IκB/NF-κB) pathway by blockade of IκB-α degradation, which prevents subsequent nuclear translocation of active NF-κB dimer. Although phosphorylation of IκB-α occurs, subsequent polyubiquitination necessary for regulated IκB-α degradation is completely abrogated. These data suggest that prokaryotic determinants could be responsible for the unique tolerance of the gastrointestinal mucosa to proinflammatory stimuli.

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Metadata

Authors
Neish, A. S., Gewirtz, A. T., Zeng, H., Young, A. N., Hobert, M. E., Karmali, V., Rao, A. S., & Madara, J. L.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2000-09
Volume
289
Issue
5484
Pages
1560-1563
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.289.5484.1560
OpenAlex
W1511823445
Cited by
844
References
0
FWCI
22.03
Type
journal article
Language
en
Open access
closed

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