Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 420

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

Divergent SARS-CoV-2 Omicron–reactive T and B cell responses in COVID-19 vaccine recipients

Open access
GeurtsvanKessel, Corine H., Geers, Daryl, Schmitz, Katharina S., Mykytyn, Anna Z., Lamers, Mart M., Bogers, Susanne, Scherbeijn, Sandra, Gommers, Lennert, Sablerolles, Roos S. G., Nieuwkoop, Nella N., Rijsbergen, Laurine C., van Dijk, Laura L. A., de Wilde, Janet, Alblas, Kimberley, Breugem, Tim I., Rijnders, Bart J. A., de Jager, Herbert, Weiskopf, Daniela, van der Kuy, P. Hugo M., Sette, Alessandro, Koopmans, Marion P. G., Grifoni, Alba, Haagmans, Bart L., de Vries, Rory D.·2022·Science Immunology
DOI 10.1126/sciimmunol.abo2202
Open this paper in CoChat — free account

Abstract

The severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) Omicron variant is spreading rapidly, even in vaccinated individuals, raising concerns about immune escape. Here, we studied neutralizing antibodies and T cell responses targeting SARS-CoV-2 D614G [wild type (WT)] and the Beta, Delta, and Omicron variants of concern in a cohort of 60 health care workers after immunization with ChAdOx-1 S, Ad26.COV2.S, mRNA-1273, or BNT162b2. High binding antibody levels against WT SARS-CoV-2 spike (S) were detected 28 days after vaccination with both mRNA vaccines (mRNA-1273 or BNT162b2), which substantially decreased after 6 months. In contrast, antibody levels were lower after Ad26.COV2.S vaccination but did not wane. Neutralization assays showed consistent cross-neutralization of the Beta and Delta variants, but neutralization of Omicron was significantly lower or absent. BNT162b2 booster vaccination after either two mRNA-1273 immunizations or Ad26.COV2 priming partially restored neutralization of the Omicron variant, but responses were still up to 17-fold decreased compared with WT. SARS-CoV-2–specific T cells were detected up to 6 months after all vaccination regimens, with more consistent detection of specific CD4 + than CD8 + T cells. No significant differences were detected between WT- and variant-specific CD4 + or CD8 + T cell responses, including Omicron, indicating minimal escape at the T cell level. This study shows that vaccinated individuals retain T cell immunity to the SARS-CoV-2 Omicron variant, potentially balancing the lack of neutralizing antibodies in preventing or limiting severe COVID-19. Booster vaccinations are needed to further restore Omicron cross-neutralization by antibodies.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1126/sciimmunol.abo2202

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Cited by

See all 420

Metadata

Authors
GeurtsvanKessel, C. H., Geers, D., Schmitz, K. S., Mykytyn, A. Z., Lamers, M. M., Bogers, S., Scherbeijn, S., Gommers, L., Sablerolles, R. S. G., Nieuwkoop, N. N., Rijsbergen, L. C., van Dijk, L. L. A., de Wilde, J., Alblas, K., Breugem, T. I., Rijnders, B. J. A., de Jager, H., Weiskopf, D., van der Kuy, P. H. M., Sette, A., Koopmans, M. P. G., Grifoni, A., Haagmans, B. L., & de Vries, R. D.
Venue
Science Immunology
Publisher
American Association for the Advancement of Science (AAAS)
Published
2022-03-25
Volume
7
Issue
69
Pages
eabo2202-eabo2202
ISSN
2470-9468 (ISSN-L)
DOI
10.1126/sciimmunol.abo2202
OpenAlex
W4210708247
Cited by
420
References
60
FWCI
46.16
Type
journal article
Language
en
Open access
hybrid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.