The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
The Human Oral Microbiome
Open accessAbstract
The human oral cavity contains a number of different habitats, including the teeth, gingival sulcus, tongue, cheeks, hard and soft palates, and tonsils, which are colonized by bacteria. The oral microbiome is comprised of over 600 prevalent taxa at the species level, with distinct subsets predominating at different habitats. The oral microbiome has been extensively characterized by cultivation and culture-independent molecular methods such as 16S rRNA cloning. Unfortunately, the vast majority of unnamed oral taxa are referenced by clone numbers or 16S rRNA GenBank accession numbers, often without taxonomic anchors. The first aim of this research was to collect 16S rRNA gene sequences into a curated phylogeny-based database, the Human Oral Microbiome Database (HOMD), and make it web accessible ( www.homd.org ). The HOMD includes 619 taxa in 13 phyla, as follows: Actinobacteria , Bacteroidetes , Chlamydiae , Chloroflexi , Euryarchaeota , Firmicutes , Fusobacteria , Proteobacteria , Spirochaetes , SR1, Synergistetes , Tenericutes , and TM7. The second aim was to analyze 36,043 16S rRNA gene clones isolated from studies of the oral microbiota to determine the relative abundance of taxa and identify novel candidate taxa. The analysis identified 1,179 taxa, of which 24% were named, 8% were cultivated but unnamed, and 68% were uncultivated phylotypes. Upon validation, 434 novel, nonsingleton taxa will be added to the HOMD. The number of taxa needed to account for 90%, 95%, or 99% of the clones examined is 259, 413, and 875, respectively. The HOMD is the first curated description of a human-associated microbiome and provides tools for use in understanding the role of the microbiome in health and disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“It is estimated that about 50% of oral bacterial species are resistant to cultivation (Dewhirst et al., 2010)”
From Microbial colonisation associated with conventional and self-ligating brackets: a systematic review (2022) · cites this paper as Dewhirst et al., 2010
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“These species are known to play roles in dental biofilm maturation and oral inflammatory conditions [35,36].”
From Severity-dependent alterations in oral microbiota and antibiotic resistance in children with dental fluorosis (2026) · cites this paper as [36]
Experimental — accuracy not yet measuredIn the citing paper
“Other core members with greater than 1% abundance across at least 80% of samples from 1 or more sites, included those from the family Pasteurellaceae, those from the genera Gemella, Veillonella, Prevotella, Fusobacterium, Porphyromonas, Neisseria, Capnocytophaga, Corynebacterium, and Actinomyces, and those from the orders Lactobacillales and Lachnospiraceae.160”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [160]
In the citing paper
“Moreover, the Human Microbiome Project found that the main genus among intraoral sites, at greater than 10% abundance and present in more than 75% of samples, was Streptococcus, specifically Streptococcus oralis, S mitis, and Streptococcus peroris.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [160]
In the citing paper
“The oral cavity houses the second largest microbiota in the human body and can include bacteria, fungi, viruses, and archaea (Dewhirst et al., 2010).”
From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as Dewhirst et al., 2010
In the citing paper
“Most of above mentioned microbiota can be found in human oral cavity (Dewhirst et al., 2010)”
From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as Dewhirst et al., 2010
In the citing paper
“Culture-independent sequencing of the bacterial 16S ribosome has suggested an estimated 50–100 billion bacteria in the mouth, comprised of nearly 700 identified bacterial species[170,171].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [171]
In the citing paper
“Up to 80% of oral bacteria are dominated by about 200 species in the Phyla Firmicutes (esp. Streptococcus, Veillonella, Granulicatella, Gemella spp.) and Proteobacteria (esp. Neisseria, Haemophilus spp.), with contributions from Bacteroidetes, Actinobacteria and Fusobacteria totaling upwards of 95% of all identified oral microbiota (Figure 2)[171–177].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [171]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
Saitou, N., & Nei, M. (1987) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040454 · Cited by 59,959
MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0
Tamura, K., Dudley, J. T., Nei, M., & Kumar, S. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msm092 · Cited by 28,734
Bergey's Manual of Systematic Bacteriology
(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-5-391_3 · Cited by 15,633
Evolution of Protein Molecules
JUKES, T. H., & CANTOR, C. R. (1969) · Mammalian Protein Metabolism · doi:10.1016/b978-1-4832-3211-9.50009-7 · Cited by 11,032
Greengenes, a Chimera-Checked 16S rRNA Gene Database and Workbench Compatible with ARB
DeSantis, T. Z., Hugenholtz, P., Larsen, N., Rojas, M., Brodie, E. L., Keller, K., Huber, T., Dalevi, D., Hu, P., & Andersen, G. L. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.03006-05 · Cited by 10,891
Bacterial biofilms: from the Natural environment to infectious diseases
Hall‐Stoodley, L., Costerton, J. W., & Stoodley, P. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro821 · Cited by 7,133
Turnbaugh, P. J., Ley, R. E., Hamady, M., Fraser-Liggett, C. M., Knight, R., & Gordon, J. I. (2007) · Nature · doi:10.1038/nature06244 · Cited by 6,091
The Ribosomal Database Project: improved alignments and new tools for rRNA analysis
Cole, J. R., Wang, Q., Cardenas, E., Fish, J., Chai, B., Farris, R. J., Kulam-Syed-Mohideen, A. S., McGarrell, D. M., Marsh, T. L., Garrity, G. M., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn879 · Cited by 4,873
(1964) · Elsevier eBooks · doi:10.1016/b978-1-4832-3210-2.50006-6 · Cited by 3,130
Defining the normal bacterial flora of the oral cavity
Aas, J. A., Paster, B. J., Stokes, L. N., Olsen, I., & Dewhirst, F. E. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.11.5721-5732.2005 · Cited by 3,092
Self-citation
Cited by
Sorted by citations
Grice, E. A., & Segre, J. A. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2537 · Cited by 3,143
Periodontitis: from microbial immune subversion to systemic inflammation
Hajishengallis, G. (2015) · Nature Reviews Immunology · doi:10.1038/nri3785 · Cited by 3,046
Evaluation of 16S rRNA gene sequencing for species and strain-level microbiome analysis
Johnson, J. S., Spakowicz, D. J., Hong, B., Petersen, L., Demkowicz, P. C., Chen, L., Leopold, S. R., Hanson, B., Agresta, H. O., Gerstein, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13036-1 · Cited by 2,457
The Oral Microbiota: Dynamic Communities and Host Interactions
Lamont, R. J., Koo, H., & Hajishengallis, G. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0089-x · Cited by 2,217
Occlusal Caries: Biological Approach for Its Diagnosis and Management
Carvalho, J. C., Dige, I., Mačhiulskienė, V., Qvist, V., Bakhshandeh, A., Parolo, C. C. F., & Maltz, M. (2016) · Caries Research · doi:10.1159/000448662 · Cited by 2,159
The oral microbiome in health and disease
Wade, W. G. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.11.006 · Cited by 1,347
Self-citationHajishengallis, G., & Lamont, R. J. (2012) · Molecular Oral Microbiology · doi:10.1111/j.2041-1014.2012.00663.x · Cited by 1,267
Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response
Hajishengallis, G. (2014) · Trends in Immunology · doi:10.1016/j.it.2013.09.001 · Cited by 1,150
The oral microbiome – an update for oral healthcare professionals
Kilian, M., Chapple, I. L. C., Hannig, M., Marsh, P. D., Meuric, V., Pedersen, A. M. L., Tonetti, M. S., Wade, W. G., & Zaura, E. (2016) · British Dental Journal · doi:10.1038/sj.bdj.2016.865 · Cited by 1,269
Self-citationAbusleme, L., Dupuy, A. K., Dutzan, N., Silva, N., Burleson, J. A., Strausbaugh, L. D., Gamonal, J. A., & Diaz, P. I. (2013) · The ISME Journal · doi:10.1038/ismej.2012.174 · Cited by 1,118
Oral microbiome: Unveiling the fundamentals
Deo, P., & Deshmukh, R. (2019) · Journal of Oral and Maxillofacial Pathology · doi:10.4103/jomfp.jomfp_304_18 · Cited by 1,121
Segata, N., Haake, S. K., Mannon, P., Lemon, K. P., Waldron, L., Gevers, D., Huttenhower, C., & Izard, J. (2012) · Genome Biology · doi:10.1186/gb-2012-13-6-r42 · Cited by 1,076
Self-citationGupta, V. K., Paul, S., & Dutta, C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01162 · Cited by 1,019
Microbes, Metabolites, and the Gut-Lung Axis
Dang, A. T., & Marsland, B. J. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0160-6 · Cited by 1,028
Griffen, A. L., Beall, C. J., Campbell, J. H., Firestone, N. D., Kumar, P., Yang, Z. K., Podar, M., & Leys, E. J. (2011) · The ISME Journal · doi:10.1038/ismej.2011.191 · Cited by 1,006
Biogeography of a human oral microbiome at the micron scale
Mark Welch, J. L., Rossetti, B. J., Rieken, C. W., Dewhirst, F. E., & Borisy, G. G. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522149113 · Cited by 968
Self-citationThe Biology of Streptococcus mutans
Lemos, J. A., Palmer, S. R., Zeng, L., Wen, Z. T., Kajfasz, J. K., Freires, I. A., Abranches, J., & Brady, L. J. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0051-2018 · Cited by 794
Abed, J., Emgård, J. E. M., Zamir, G., Faroja, M., Almogy, G., Grenov, A., Sol, A., Naor, R., Pikarsky, E., Atlan, K. A., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.07.006 · Cited by 888
The Intestinal Microbiome in Early Life: Health and Disease
Arrieta, M.-C., Stiemsma, L. T., Amenyogbe, N., Brown, E. M., & Finlay, B. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00427 · Cited by 1,024
Association between periodontal pathogens and systemic disease
Bui, F. Q., Almeida-da-Silva, C. L. C., Huynh, B. C., Trinh, A., Liu, J., Woodward, J., Asadi, H., & Ojcius, D. M. (2019) · Biomedical Journal · doi:10.1016/j.bj.2018.12.001 · Cited by 882
Fan, X., Alekseyenko, A. V., Wu, J., Peters, B. A., Jacobs, E. J., Gapstur, S. M., Purdue, M. P., Abnet, C. C., Stolzenberg-Solomon, R., Miller, G., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-312580 · Cited by 702
Oral microbiomes: more and more importance in oral cavity and whole body
Gao, L., Xu, T., Huang, G., Jiang, S., Gu, Y., & Chen, F. (2018) · Protein & Cell · doi:10.1007/s13238-018-0548-1 · Cited by 770
The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755
Biogeography of the ecosystems of the healthy human body
Zhou, Y., Gao, H., Mihindukulasuriya, K. A., Rosa, P. S. L., Wylie, K. M., Vishnivetskaya, T. A., Podar, M., Warner, B., Tarr, P. I., Nelson, D. E., et al. (2013) · Genome biology · doi:10.1186/gb-2013-14-1-r1 · Cited by 689
Genomic insights into the marine sponge microbiome
Hentschel, U., Piel, J., Degnan, S. M., & Taylor, M. W. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2839 · Cited by 659
Bacterial diversity in the oral cavity of 10 healthy individuals
Bik, E. M., Long, C. D., Armitage, G. C., Loomer, P., Emerson, J., Mongodin, E. F., Nelson, K. E., Gill, S. R., Fraser-Liggett, C. M., & Relman, D. A. (2010) · The ISME Journal · doi:10.1038/ismej.2010.30 · Cited by 651
The oral microbiome and the immunobiology of periodontal disease and caries
Costalonga, M., & Herzberg, M. C. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.08.017 · Cited by 645
Mandell, L. A., & Niederman, M. S. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1714562 · Cited by 666
Pathogens and host immunity in the ancient human oral cavity
Warinner, C., Rodrigues, J. F. M., Vyas, R., Trachsel, C., Shved, N., Grossmann, J., Radini, A., Hancock, Y., Tito, R. Y., Fiddyment, S., et al. (2014) · Nature Genetics · doi:10.1038/ng.2906 · Cited by 618
Major New Microbial Groups Expand Diversity and Alter our Understanding of the Tree of Life
Castelle, C. J., & Banfield, J. F. (2018) · Cell · doi:10.1016/j.cell.2018.02.016 · Cited by 595
Adler, C. J., Dobney, K., Weyrich, L. S., Kaidonis, J., Walker, A. W., Haak, W., Bradshaw, C. J. A., Townsend, G., Sołtysiak, A., Alt, K. W., et al. (2013) · Nature Genetics · doi:10.1038/ng.2536 · Cited by 621
Microbial Changes during Pregnancy, Birth, and Infancy
Nuriel‐Ohayon, M., Neuman, H., & Koren, O. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01031 · Cited by 647
Effects of Material Properties on Bacterial Adhesion and Biofilm Formation
Song, F., Koo, H., & Ren, D. (2015) · Journal of Dental Research · doi:10.1177/0022034515587690 · Cited by 648
Eren, A. M., Morrison, H. G., Lescault, P. J., Réveillaud, J., Vineis, J. H., & Sogin, M. L. (2014) · The ISME Journal · doi:10.1038/ismej.2014.195 · Cited by 611
Polymicrobial synergy and dysbiosis in inflammatory disease
Lamont, R. J., & Hajishengallis, G. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.11.004 · Cited by 585
Escapa, I. F., Chen, T., Huang, Y., Gajare, P., Dewhirst, F. E., & Lemon, K. P. (2018) · mSystems · doi:10.1128/msystems.00187-18 · Cited by 615
Self-citationMicrobial Ecology along the Gastrointestinal Tract
Hillman, E. T., Lu, H., Yao, T., & Nakatsu, C. H. (2017) · Microbes and Environments · doi:10.1264/jsme2.me17017 · Cited by 614
Vertical mother–neonate transfer of maternal gut bacteria via breastfeeding
Jost, T., Lacroix, C., Braegger, C., Rochat, F., & Chassard, C. (2013) · Environmental Microbiology · doi:10.1111/1462-2920.12238 · Cited by 611
Microbiota of Human Breast Tissue
Urbaniak, C., Cummins, J., Brackstone, M., Macklaim, J. M., Gloor, G. B., Baban, C. K., Scott, L., O'Hanlon, D. M., Burton, J. P., Francis, K. P., et al. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.00242-14 · Cited by 552
Cigarette smoking and the oral microbiome in a large study of American adults
Wu, J., Peters, B. A., Dominianni, C., Zhang, Y., Pei, Z., Yang, L., Ma, Y., Purdue, M. P., Jacobs, E. J., Gapstur, S. M., et al. (2016) · The ISME Journal · doi:10.1038/ismej.2016.37 · Cited by 572
He, X., McLean, J. S., Edlund, A., Yooseph, S., Hall, A. P., Liu, S.-Y., Dorrestein, P. C., Esquenazi, E., Hunter, R. C., Cheng, G., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419038112 · Cited by 525
Human oral microbiota and its modulation for oral health
Zhang, Y., Wang, X., Li, H., Ni, C., Du, Z., & Yan, F. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.01.146 · Cited by 582
Insights into the human oral microbiome
Verma, D., Garg, P. K., & Dubey, A. K. (2018) · Archives of Microbiology · doi:10.1007/s00203-018-1505-3 · Cited by 586
Oral Candidiasis: A Disease of Opportunity
Vila, T., Sultan, A. S., Montelongo-Jauregui, D., & Jabra-Rizk, M. A. (2020) · Journal of Fungi · doi:10.3390/jof6010015 · Cited by 537
The respiratory tract microbiome and lung inflammation: a two-way street.
Huffnagle, G. B., Dickson, R. P., & Lukacs, N. W. (2017) · Mucosal Immunology · doi:10.1038/mi.2016.108 · Cited by 535
The Exopolysaccharide Matrix: A Virulence Determinant of Cariogenic Biofilm
Koo, H., Falsetta, M. L., & Klein, M. I. (2013) · Journal of Dental Research · doi:10.1177/0022034513504218 · Cited by 523
Analysis of Gut Microbiota in Patients with Parkinson’s Disease
Petrov, V. A., Saltykova, I. V., Zhukova, I. A., Alifirova, V. M., Zhukova, N. G., Dorofeeva, Y. B., Tyakht, A. V., Kovarsky, B. A., Alekseev, D. G., Kostryukova, E. S., et al. (2017) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-017-3700-7 · Cited by 487
Xiao, J., Klein, M. I., Falsetta, M. L., Lu, B., Delahunty, C. M., Yates, J. R., Heydorn, A., & Koo, H. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002623 · Cited by 523
Coping with low pH: molecular strategies in neutralophilic bacteria
Lund, P. A., Tramonti, A., & Biase, D. D. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12076 · Cited by 537
The secretion, components, and properties of saliva.
Carpenter, G. (2013) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030212-182700 · Cited by 457
Current understanding of periodontal disease pathogenesis and targets for host‐modulation therapy
Hajishengallis, G., Chavakis, T., & Lambris, J. D. (2020) · Periodontology 2000 · doi:10.1111/prd.12331 · Cited by 558
Actinomyces and Related Organisms in Human Infections
Könönen, E., & Wade, W. G. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00100-14 · Cited by 517
Self-citationThe oral microbiome in health and disease and the potential impact on personalized dental medicine
Zarco, M., Vess, T., & Ginsburg, G. (2011) · Oral Diseases · doi:10.1111/j.1601-0825.2011.01851.x · Cited by 521
Chapter 12: Human Microbiome Analysis
Morgan, X. C., & Huttenhower, C. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002808 · Cited by 496
Functions of the skin microbiota in health and disease
Sanford, J. A., & Gallo, R. L. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.09.005 · Cited by 512
The Human Oral Microbiome in Health and Disease: From Sequences to Ecosystems
Willis, J. R., & Gabaldón, T. (2020) · Microorganisms · doi:10.3390/microorganisms8020308 · Cited by 495
Periodontal disease and the oral microbiota in new‐onset rheumatoid arthritis
Scher, J. U., Úbeda, C., Equinda, M. J., Khanin, R., Buischi, Y. D. P., Viale, A. J., Lipuma, L., Attur, M. G., Pillinger, M. H., Weissmann, G., et al. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34539 · Cited by 480
Regional Diversity of the Gastrointestinal Microbiome
Martinez, K., Leone, V., & Chang, E. B. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.08.011 · Cited by 488
The role of the gut microbiome in the healthy adult status
D’Argenio, V., & Salvatore, F. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.01.003 · Cited by 492
Biosynthetic capacity, metabolic variety and unusual biology in the CPR and DPANN radiations
Castelle, C. J., Brown, C. T., Anantharaman, K., Probst, A. J., Huang, R. H., & Banfield, J. F. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0076-2 · Cited by 454
DiGiulio, D. B., Romero, R. J., Kusanovic, J. P., Gómez, R., Kim, C. J., Seok, K. S., Gotsch, F., Mazaki‐Tovi, S., Vaisbuch, E., Sanders, K. M., et al. (2010) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2010.00830.x · Cited by 466
Variations in oral microbiota associated with oral cancer
Zhao, H., Chu, M., Huang, Z., Yang, X., Ran, S., Hu, B., Zhang, C., & Liang, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-11779-9 · Cited by 469
The lung microbiome in moderate and severe chronic obstructive pulmonary disease
Pragman, A. A., Kim, H. B., Reilly, C. S., Wendt, C., & Isaacson, R. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047305 · Cited by 437
Resilience of the Oral Microbiota in Health: Mechanisms That Prevent Dysbiosis
Rosier, B. T., Marsh, P. D., & Mira, A. (2018) · Journal of Dental Research · doi:10.1177/0022034517742139 · Cited by 448
The oral microbiota is modified by systemic diseases.
Graves, D. T., Corrêa, J. D., & Silva, T. A. (2019) · Journal of Dental Research · doi:10.1177/0022034518805739 · Cited by 423
Langelier, C., Kalantar, K. L., Moazed, F., Wilson, M. R., Crawford, E. D., Deiss, T., Belzer, A., Bolourchi, S., Caldera, S., Fung, M., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809700115 · Cited by 411
The inflammophilic character of the periodontitis-associated microbiota
Hajishengallis, G. (2014) · Molecular Oral Microbiology · doi:10.1111/omi.12065 · Cited by 407
Tissue-Specific Immunity at the Oral Mucosal Barrier
Moutsopoulos, N. M., & Konkel, J. E. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.08.005 · Cited by 415
Microbial signatures of health, gingivitis and periodontitis
Abusleme, L., Hoare, A., Hong, B., & Diaz, P. I. (2021) · Periodontology 2000 · doi:10.1111/prd.12362 · Cited by 400
Role of Oral Microbiome Signatures in Diagnosis and Prognosis of Oral Cancer
Chattopadhyay, I., Verma, M., & Panda, M. (2019) · Technology in Cancer Research & Treatment · doi:10.1177/1533033819867354 · Cited by 407
Michaud, D. S., Izard, J., Wilhelm-Benartzi, C. S., You, D.-H., Grote, V. A., Tjønneland, A. M., Dahm, C. C., Overvad, K., Jenab, M., Fedirko, V., et al. (2012) · Gut · doi:10.1136/gutjnl-2012-303006 · Cited by 412
Self-citationValm, A. M. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.05.016 · Cited by 450
A comprehensive repertoire of prokaryotic species identified in human beings
Hugon, P., Dufour, J.-C., Colson, P., Fournier, P., Sallah, K., & Raoult, D. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)00293-5 · Cited by 424
Periodontal Disease, Systemic Inflammation and the Risk of Cardiovascular Disease
Carrizales‐Sepúlveda, E. F., Ordaz‐Farías, A., Vera‐Pineda, R., & Flores‐Ramírez, R. (2018) · Heart Lung and Circulation · doi:10.1016/j.hlc.2018.05.102 · Cited by 401
Bacterial biogeography of the human digestive tract
Stearns, J. C., Lynch, M. D. J., Senadheera, D. B., Tenenbaum, H. C., Goldberg, M. B., Cvitkovitch, D. G., Croitoru, K., Moreno‐Hagelsieb, G., & Neufeld, J. D. (2011) · Scientific Reports · doi:10.1038/srep00170 · Cited by 411
Said, H. S., Suda, W., Nakagome, S., Chinen, H., Oshima, K., Kim, S., Kimura, R., Iraha, A., Ishida, H., Fujita, J., et al. (2013) · DNA Research · doi:10.1093/dnares/dst037 · Cited by 394
Sanz, M., Beighton, D., Curtis, M. A., Cury, J. A., Dige, I., Dommisch, H., Ellwood, R., Giacaman, R. A., Herrera, D., Herzberg, M. C., et al. (2017) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12682 · Cited by 390
Roles of Porphyromonas gingivalis and its virulence factors in periodontitis
Xu, W., Zhou, W., Wang, H., & Liang, S. (2020) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2019.12.001 · Cited by 423
Targeted isolation and cultivation of uncultivated bacteria by reverse genomics
Cross, K. L., Campbell, J. H., Balachandran, M., Campbell, A. G., Cooper, C. J., Griffen, A. L., Heaton, M., Joshi, S. S., Klingeman, D. M., Leys, E. J., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0260-6 · Cited by 380
Changes in Abundance of Oral Microbiota Associated with Oral Cancer
Schmidt, B. L., Kuczynski, J., Bhattacharya, A., Huey, B., Corby, P. M. A., Queiroz, E. L. S., Nightingale, K., Kerr, A. R., DeLacure, M. D., Veeramachaneni, R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098741 · Cited by 385
Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis
Abdulkareem, A. A., Al-Taweel, F. B. H., Al-Sharqi, A. J. B., Gul, S. S., Sha, A. M., & Chapple, I. (2023) · Journal of Oral Microbiology · doi:10.1080/20002297.2023.2197779 · Cited by 438
Thomas, S., Izard, J., Walsh, E. K., Batich, K. A., Chongsathidkiet, P., Clarke, G. A., Sela, D. A., Muller, A. J., Mullin, J. M., Albert, K., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2929 · Cited by 400
Self-citationDental biofilm infections – an update
Larsen, T. E., & Fiehn, N. (2017) · Apmis · doi:10.1111/apm.12688 · Cited by 366
Ecology of the Oral Microbiome: Beyond Bacteria
Baker, J. L., Bor, B., Agnello, M., Shi, W., & He, X. (2017) · Trends in Microbiology · doi:10.1016/j.tim.2016.12.012 · Cited by 376
The oral microbiome and human health
Yamashita, Y., & Takeshita, T. (2017) · Journal of Oral Science · doi:10.2334/josnusd.16-0856 · Cited by 305
Lessons learned and unlearned in periodontal microbiology
Teles, R. P., Teles, F., Frias‐Lopez, J., Paster, B. J., & Haffajee, A. D. (2013) · Periodontology 2000 · doi:10.1111/prd.12010 · Cited by 387
Self-citationTowards diagnostic guidelines for biofilm-associated infections
Hall‐Stoodley, L., Stoodley, P., Kathju, S., Høiby, N., Moser, C. E., Costerton, J. W., Moter, A., & Bjarnsholt, T. (2012) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2012.00968.x · Cited by 366
Term-seq reveals abundant ribo-regulation of antibiotics resistance in bacteria
Dar, D., Voichek, M., Mellin, J. R., Koutero, M., Stern‐Ginossar, N., Cossart, P., & Sorek, R. (2016) · Science · doi:10.1126/science.aad9822 · Cited by 357
Oral cavity contains distinct niches with dynamic microbial communities
Xu, X., He, J., Xue, J., Wang, Y., Li, K., Zhang, K., Guo, Q., Liu, X., Zhou, Y., Cheng, L., et al. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.12502 · Cited by 335
A practical guide to the oral microbiome and its relation to health and disease
Krishnan, K., Chen, T., & Paster, B. (2017) · Oral Diseases · doi:10.1111/odi.12509 · Cited by 347
Self-citationd’Enfert, C., Kaune, A.-K., Alaban, L. R., Chakraborty, S., Cole, N. L., Delavy, M., Kosmala, D., Marsaux, B., Fróis-Martins, R., Morelli, M., et al. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa060 · Cited by 377
Oligotyping analysis of the human oral microbiome
Eren, A. M., Borisy, G. G., Huse, S. M., & Mark Welch, J. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409644111 · Cited by 347
Valm, A. M., Welch, J. L. M., Rieken, C. W., Hasegawa, Y., Sogin, M. L., Oldenbourg, R., Dewhirst, F. E., & Borisy, G. G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101134108 · Cited by 348
Self-citationEffects of Chlorhexidine mouthwash on the oral microbiome
Bescós, R., Ashworth, A., Clarke, C., Brookes, Z. L. S., Belfield, L., Rodiles, A., Casas‐Agustench, P., Farnham, G., Liddle, L., Burleigh, M. C., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-61912-4 · Cited by 361
Pushalkar, S., Ji, X., Li, Y., Estilo, C. L., Ramanathan, Y., Singh, B., Li, X., & Saxena, D. B. (2012) · BMC Microbiology · doi:10.1186/1471-2180-12-144 · Cited by 344
Oral microbiome: a review of its impact on oral and systemic health
Rajasekaran, J. J., Krishnamurthy, H. K., Bosco, J., Jayaraman, V., Krishna, K., Wang, T., & Bei, K. (2024) · Microorganisms · doi:10.3390/microorganisms12091797 · Cited by 272
Association of Oral Microbiome With Risk for Incident Head and Neck Squamous Cell Cancer
Hayes, R. B., Ahn, J., Fan, X., Peters, B. A., Ma, Y., Yang, L., Agalliu, I., Burk, R. D., Ganly, I., Purdue, M. P., et al. (2018) · JAMA Oncology · doi:10.1001/jamaoncol.2017.4777 · Cited by 332
Surgical and nonsurgical periodontal therapy. Learned and unlearned concepts
Heitz‐Mayfield, L. J. A., & Lang, N. P. (2013) · Periodontology 2000 · doi:10.1111/prd.12008 · Cited by 336
Breaking bad: Manipulation of the host response by P orphyromonas gingivalis
Hajishengallis, G., & Lamont, R. J. (2013) · European Journal of Immunology · doi:10.1002/eji.201344202 · Cited by 355
Intestinal microbiome composition and its relation to joint pain and inflammation
Boer, C. G., Radjabzadeh, D., Medina‐Gómez, C., Garmaeva, S., Schiphof, D., Arp, P., Koet, T., Kurilshikov, A., Fu, J., Ikram, M. A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12873-4 · Cited by 349
Metadata
- Authors
- Dewhirst, F. E., Chen, T., Izard, J., Paster, B. J., Tanner, A. C. R., Yu, W.-H., Lakshmanan, A., & Wade, W. G.
- Affiliations
- Harvard University (US)
- The Forsyth Institute (US)
- King's College London (GB)
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2010-10
- Volume
- 192
- Issue
- 19
- Pages
- 5002-5017
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- PMC
- PMC2944498
- OpenAlex
- W2121748291
- Cited by
- 3,352
- References
- 75
- Citations by year
- 2026: 188 · 2025: 232 · 2024: 250 · 2023: 290 · 2022: 276 · 2021: 327 · 2020: 325 · 2019: 246 · 2018: 193 · 2017: 211 · 2016: 152 · 2015: 174 · 2014: 183 · 2013: 106 · 2012: 108
- FWCI
- 111.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Bacteriology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Lincoln (University of Nebraska) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- National Institute of Dental and Craniofacial Research (DE017106, DE-015847, U01DE016937, DE-016937, R01DE015847, R37DE016937, R21DE017106, R01DE016937)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- oral microbiota, 16S rRNA gene sequences, bacterial diversity, bacterial phylogeny, novel bacterial taxa, bacterial abundance
- MeSH terms
- Bacteria, Chlamydia, Humans, Molecular Sequence Data, Mouth, Phylogeny, RNA, Ribosomal, 16S, Spirochaetales, Proteobacteria, Actinobacteria, Chloroflexi, Bacteroidetes, Fusobacteria, Metagenome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
