The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation.
Open accessAbstract
DNA-binding proteins containing the basic helix-loop-helix (bHLH) domain have been implicated in lineage determination and the regulation of specific gene expression in a number of cell types. By oligonucleotide screening of an adipocyte cDNA expression library, we have identified a novel member of the bHLH-leucine zipper transcription factor family designated ADD1. ADD1 mRNA is expressed predominantly in brown adipose tissue in vivo and is regulated during both determination and differentiation of cultured adipocyte cell lines. ADD1 can function as a sequence-specific transcriptional activator in that it stimulates expression of a chloramphenicol acetyltransferase vector containing multiple ADD1 binding sequences but is unable to activate the myosin light-chain enhancer, which contains multiple binding sites for another bHLH factor, MyoD. ADD1 can also activate transcription through a binding site present in the 5'-flanking region of the fatty acid synthetase gene which is expressed in a differentiation-dependent manner in adipose cells. These data suggest that ADD1 plays a role in the regulation of determination- and differentiation-specific gene expression in adipocytes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation
Davis, R. L., Cheng, P.-F., Lassar, A. B., & Weintraub, H. (1990) · Cell · doi:10.1016/0092-8674(90)90088-v · Cited by 765
CCAAT-Enhancer Binding Protein: A Component of a Differentiation Switch
Umek, R. M., Friedman, A. D., & McKnight, S. L. (1991) · Science · doi:10.1126/science.1987644 · Cited by 712
Cited by
Brown, M. S., & Goldstein, J. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80213-5 · Cited by 3,834
Metabolic control through the PGC-1 family of transcription coactivators
Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130
“SREBPs are key transcription factors that control the expression of many genes that regulate fatty-acid, triglyceride (Kim and Spiegelman, 1996; Shimano et al., 1996; Tontonoz et al., 1993), and cholesterol biosynthesis (Brown and Goldstein, 1997), while LXRs are important in the control of lipoprotein secretion.”
BackgroundSelf-citationThe multifaceted roles of fatty acid synthesis in cancer
Röhrig, F., & Schulze, A. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.89 · Cited by 1,651
SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology
Shimano, H., & Sato, R. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.91 · Cited by 1,174
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
Brown, M. S., & Goldstein, J. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11041 · Cited by 1,134
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., & Goldstein, J. L. (1999) · Nature · doi:10.1038/43448 · Cited by 1,038
Shimomura, I., Hammer, R. E., Richardson, J. A., Ikemoto, S., Bashmakov, Y., Goldstein, J. L., & Brown, M. S. (1998) · Genes & Development · doi:10.1101/gad.12.20.3182 · Cited by 790
Shimano, H., Horton, J. D., Shimomura, I., Hammer, R. E., Brown, M. S., & Goldstein, J. L. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119248 · Cited by 730
Mechanisms of nutritional and hormonal regulation of lipogenesis
Kersten, S. (2001) · The EMBO Reports · doi:10.1093/embo-reports/kve071 · Cited by 700
Transcriptional regulation of hepatic lipogenesis
Wang, Y., Viscarra, J., Kim, S.-J., & Sul, H. S. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4074 · Cited by 646
PPARγ, the ultimate thrifty gene
Auwerx, J. (1999) · Diabetologia · doi:10.1007/s001250051268 · Cited by 612
Shimano, H., Yahagi, N., Amemiya-Kudo, M., Hasty, A. H., Osuga, J.-I., Tamura, Y., Shionoiri, F., Iizuka, Y., Ohashi, K., Harada, K., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.50.35832 · Cited by 607
Regulation of Sterol Synthesis in Eukaryotes
Espenshade, P. J., & Hughes, A. L. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130315 · Cited by 593
Gregor, M. F., & Hotamisligil, G. S. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700007-jlr200 · Cited by 586
Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice
Horton, J. D., Bashmakov, Y., Shimomura, I., & Shimano, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.5987 · Cited by 577
The helix-loop-helix gene E2A is required for B cell formation
ZHUANG, Y. (1994) · Cell · doi:10.1016/0092-8674(94)90076-0 · Cited by 545
Osborne, T. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000017200 · Cited by 521
Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL
Brown, M. S., & Goldstein, J. L. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800054-jlr200 · Cited by 441
Rawson, R. B., Zelenski, N. G., Nijhawan, D., Ye, J., Sakai, J., Hasan, M. T., Chang, T. Y., Brown, M. S., & Goldstein, J. L. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80006-4 · Cited by 429
Shimomura, I., Shimano, H., Korn, B. S., Bashmakov, Y., & Horton, J. D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.52.35299 · Cited by 333
Sarjeant, K., & Stephens, J. M. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008417 · Cited by 328
The SREBP pathway — insights from insigs and insects
Rawson, R. B. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1174 · Cited by 323
Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver.
Sheng, Z., Otani, H., Brown, M. S., & Goldstein, J. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.4.935 · Cited by 265
Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer
Dey, P., Baddour, J., Muller, F., Wu, C. C., Wang, H., Liao, W.-T., Lan, Z., Chen, A., Gutschner, T., Kang, Y., et al. (2017) · Nature · doi:10.1038/nature21052 · Cited by 264
Seo, J. B., Moon, H. M., Kim, W. S., Lee, Y. S., Jeong, H. W., Yoo, E. J., Ham, J., Kang, H., Park, M.-G., Steffensen, K. R., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.8.3430-3444.2004 · Cited by 250
Self-citationOsborne, T. F., & Espenshade, P. J. (2009) · Genes & Development · doi:10.1101/gad.1854309 · Cited by 238
MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels
Goedeke, L., Rotllan, N., Canfrán-Duque, A., Aranda, J. F., Ramírez, C. M., Araldi, E., Lin, C.-S., Anderson, N. N., Wagschal, A., de Cabo, R., et al. (2015) · Nature Medicine · doi:10.1038/nm.3949 · Cited by 238
Jia, Y., Rothermel, B., Thornton, J., & Butow, R. A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.3.1110 · Cited by 219
Disorders in the initial steps of steroid hormone synthesis
Miller, W. L. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.03.009 · Cited by 205
PPARα is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue
Lee, Y., Yu, X., Gonzales, F., Mangelsdorf, D. J., Wang, M.-Y., Richardson, C., Witters, L. A., & Unger, R. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182420899 · Cited by 181
Blatzer, M., Barker, B. M., Willger, S. D., Beckmann, N., Blosser, S. J., Cornish, E. J., Mazurie, A., Grahl, N., Haas, H., & Cramer, R. A. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002374 · Cited by 175
Duncan, E. A., Brown, M. S., Goldstein, J. L., & Sakai, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.19.12778 · Cited by 158
Shamma, A., Takegami, Y., Miki, T., Kitajima, S., Noda, M., Obara, T., Okamoto, T., & Takahashi, C. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.03.001 · Cited by 140
Duncan, E. A., Davé, U. P., Sakai, J., Goldstein, J. L., & Brown, M. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17801 · Cited by 135
Lee, G., Kim, Y. Y., Jang, H., Han, J. S., Nahmgoong, H., Park, Y. J., Han, S. M., Cho, C., Lim, S., Noh, J.-R., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.03.010 · Cited by 111
Self-citationKotzka, J., Lehr, S., Roth, G., Avci, H., Knebel, B., & Muller-Wieland, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401198200 · Cited by 111
Athanikar, J. N., Sanchez, H. B., & Osborne, T. F. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.5193 · Cited by 88
Nakatsu, Y., Sakoda, H., Kushiyama, A., Zhang, J., Ono, H., Fujishiro, M., Kikuchi, T., Fukushima, T., Yoneda, M., Ohno, H., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.206904 · Cited by 69
Roy, D., & Tedeschi, A. (2021) · Cells · doi:10.3390/cells10051078 · Cited by 68
A-type nuclear lamins, progerias and other degenerative disorders
Smith, E. D., Kudlow, B. A., Frock, R. L., & Kennedy, B. K. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.10.006 · Cited by 47
Adiponectin and HIV-Lipodystrophy: Taking HAART
Kinlaw, W. B., & Marsh, B. (2004) · Endocrinology · doi:10.1210/en.2003-1513 · Cited by 44
Kober, D. L., Xu, S., Li, S., Bajaj, B., Liang, G., Rosenbaum, D. M., & Radhakrishnan, A. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2018578117 · Cited by 33
Metadata
- Authors
- Tontonoz, P., Kim, J. B., Graves, R. A., & Spiegelman, B. M.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1993-08
- Volume
- 13
- Issue
- 8
- Pages
- 4753-4759
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2065163855
- Cited by
- 611
- References
- 2
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
