Developing and evaluating complex interventions: the new Medical Research Council guidance

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1. Implementation of pregnancy weight management and obesity guidelines: a meta‐synthesis of healthcare professionals' barriers and facilitators using the <scp>T</scp> heoretical <scp>D</scp> omains <scp>F</scp> ramework
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2. Identifying change processes in group-based health behaviour-change interventions: Development of the mechanisms of action in group-based interventions (MAGI) framework
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3. Maximising the value of combining qualitative research and randomised controlled trials in health research: the QUAlitative Research in Trials (QUART) study – a mixed methods study
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4. Early Intervention to Reduce the Global Health and Economic Burden of Major Depression in Older Adults
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5. The use of Qualitative Comparative Analysis (QCA) to address causality in complex systems: a systematic review of research on public health interventions
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6. What interventions are used to improve exercise adherence in older people and what behavioural techniques are they based on? A systematic review
   Room, Jonathan, Hannink, Erin, Dawes, Helen, Barker, Karen · 2017 · BMJ Open
7. Sarcopenic obesity and complex interventions with nutrition and exercise in community-dwelling older persons &amp;ndash; a narrative review
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8. Football Fans in Training: the development and optimization of an intervention delivered through professional sports clubs to help men lose weight, become more active and adopt healthier eating habits
   Gray, Cindy M, Hunt, Kate, Mutrie, Nanette, Anderson, Annie S, Leishman, Jim, Dalgarno, Lindsay, Wyke, Sally · 2013 · BMC Public Health
9. The effect of complex interventions on depression and anxiety in chronic obstructive pulmonary disease: systematic review and meta-analysis
   Coventry, Peter A., Bower, Peter, Keyworth, Christopher, Kenning, Cassandra, Knopp, Jasmin, Garrett, Charlotte, Hind, Daniel, Malpass, Alice, Dickens, Chris · 2013 · PLoS ONE
10. EQUIP Healthcare: An overview of a multi-component intervention to enhance equity-oriented care in primary health care settings
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11. Mobile technologies to support healthcare provider to healthcare provider communication and management of care
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12. The efficacy of mindfulness-based interventions in primary care: a meta-analytic review.
    Demarzo, M. M. P., Montero-Marin, J., Cuijpers, P., Zabaleta-del-Olmo, E., Mahtani, K. R., Vellinga, A., Vicens, C., Lopez-del-Hoyo, Y., Garcia-Campayo, J. · 2015 · The Annals of Family Medicine
13. Behaviour change techniques associated with adherence to prescribed exercise in patients with persistent musculoskeletal pain: Systematic review
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14. Relationship between Green and Blue Spaces with Mental and Physical Health: A Systematic Review of Longitudinal Observational Studies
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15. Combinations of techniques that effectively change health behavior: evidence from Meta-CART analysis
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16. Evaluating policy and service interventions: framework to guide selection and interpretation of study end points
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17. The R2C2 Model in Residency Education: How Does It Foster Coaching and Promote Feedback Use?
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18. The role of theory in research to develop and evaluate the implementation of patient safety practices: Figure 1
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19. Art therapy for people with dementia
    Deshmukh, Sunita R, Holmes, John, Cardno, Alastair · 2018 · Cochrane Database of Systematic Reviews
20. Implementation science and stigma reduction interventions in low- and middle-income countries: a systematic review
    Kemp, Christopher G., Jarrett, Brooke A., Kwon, Churl-Su, Song, Lanxin, Jetté, Nathalie, Sapag, Jaime C., Bass, Judith, Murray, Laura, Rao, Deepa, Baral, Stefan · 2019 · BMC Medicine
21. Efficacy of behavioural interventions for transport behaviour change: Systematic review, meta-analysis and intervention coding
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22. Developing a complex intervention for diet and activity behaviour change in obese pregnant women (the UPBEAT trial); assessment of behavioural change and process evaluation in a pilot randomised controlled trial
    Poston, Lucilla, Briley, Annette L, Barr, Suzanne, Bell, Ruth, Croker, Helen, Coxon, Kirstie, Essex, Holly N, Hunt, Claire, Hayes, Louise, Howard, Louise M et al. · 2013 · BMC Pregnancy and Childbirth
23. Implementing supported self-management for asthma: a systematic review and suggested hierarchy of evidence of implementation studies
    Pinnock, Hilary, Epiphaniou, Eleni, Pearce, Gemma, Parke, Hannah, Greenhalgh, Trish, Sheikh, Aziz, Griffiths, Chris J., Taylor, Stephanie J. C. · 2015 · BMC Medicine
24. Developing standards for reporting implementation studies of complex interventions (StaRI): a systematic review and e-Delphi
    Pinnock, Hilary, Epiphaniou, Eleni, Sheikh, Aziz, Griffiths, Chris, Eldridge, Sandra, Craig, Peter, Taylor, Stephanie JC · 2015 · Implementation Science
25. Role of feasibility and pilot studies in randomised controlled trials: a cross-sectional study
    Blatch-Jones, Amanda Jane, Pek, Wei, Kirkpatrick, Emma, Ashton-Key, Martin · 2018 · BMJ Open
26. Effect of a Postdischarge Virtual Ward on Readmission or Death for High-Risk Patients: A Randomized Clinical Trial
    Dhalla, Irfan A., O’Brien, Tara, Morra, Dante, Thorpe, Kevin E., Wong, Brian M., Mehta, Rajin, Frost, David W., Abrams, Howard, Ko, Françoise, Van Rooyen, Patrick et al. · 2014 · JAMA
27. Smartphones in the secondary prevention of cardiovascular disease: a systematic review.
    Hamilton, Sandra J., Mills, Belynda, Birch, Eleanor M., Thompson, Sandra C. · 2018 · BMC Cardiovascular Disorders
28. A PILOT RANDOMIZED CONTROLLED TRIAL OF COGNITIVE BEHAVIORAL THERAPY FOR PERINATAL DEPRESSION ADAPTED FOR WOMEN WITH LOW INCOMES: Research Article: CBT for Perinatal Depression
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29. Using mixed methods to develop and evaluate complex interventions in palliative care research
    Farquhar, Morag C, Ewing, Gail, Booth, Sara · 2011 · Palliative Medicine
30. Integrating Evidence From Systematic Reviews, Qualitative Research, and Expert Knowledge Using Co-Design Techniques to Develop a Web-Based Intervention for People in the Retirement Transition
    O'Brien, Nicola, Heaven, Ben, Teal, Gemma, Evans, Elizabeth H, Cleland, Claire, Moffatt, Suzanne, Sniehotta, Falko F, White, Martin, Mathers, John C, Moynihan, Paula · 2016 · Journal of Medical Internet Research
31. Self‐management interventions for cancer survivors: A systematic review and evaluation of intervention content and theories
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32. A systematic review of recommended modifications of CBT for people with cognitive impairments following brain injury
    Gallagher, Melanie, McLeod, Hamish J., McMillan, Thomas M. · 2019 · Neuropsychological Rehabilitation
33. ‘It’s a can of worms’: understanding primary care practitioners’ behaviours in relation to HPV using the theoretical domains framework
    McSherry, Lisa A, Dombrowski, Stephan U, Francis, Jill J, Murphy, Judith, Martin, Cara M, O’Leary, John J, Sharp, Linda, ATHENS Group · 2012 · Implementation Science
34. Factors affecting recruitment into depression trials: Systematic review, meta-synthesis and conceptual framework
    Hughes-Morley, Adwoa, Young, Bridget, Waheed, Waquas, Small, Nicola, Bower, Peter · 2015 · Journal of Affective Disorders
35. Effectiveness of guideline dissemination and implementation strategies on health care professionals’ behaviour and patient outcomes in the cancer care context: a systematic review
    Tomasone, Jennifer R., Kauffeldt, Kaitlyn D., Chaudhary, Rushil, Brouwers, Melissa C. · 2020 · Implementation Science
36. Do health improvement programmes fit with MRC guidance on evaluating complex interventions?
    Mackenzie, M., O'Donnell, C., Halliday, E., Sridharan, S., Platt, S. · 2010 · BMJ
37. A Low-Intensity Mobile Health Intervention With and Without Health Counseling for Persons With Type 2 Diabetes, Part 1: Baseline and Short-Term Results From a Randomized Controlled Trial in the Norwegian Part of RENEWING HEALTH
    Torbjørnsen, Astrid, Jenum, Anne Karen, Småstuen, Milada Cvancarova, Årsand, Eirik, Holmen, Heidi, Wahl, Astrid Klopstad, Ribu, Lis · 2014 · JMIR mHealth and uHealth
38. Intention‐to‐treat in randomized controlled trials: Recommendations for a total trial strategy
    Polit, Denise F., Gillespie, Brigid M. · 2010 · Research in Nursing &amp; Health
39. Evaluating the Impact of Physical Activity Apps and Wearables: Interdisciplinary Review
    McCallum, Claire, Rooksby, John, Gray, Cindy M · 2018 · JMIR mhealth and uhealth
40. Behavioral Sleep Interventions in the First Six Months of Life Do not Improve Outcomes for Mothers or Infants: A Systematic Review
    Douglas, Pamela S., Hill, Peter S. · 2013 · Journal of Developmental &amp; Behavioral Pediatrics
41. Telehealthcare for asthma: a Cochrane review
    McLean, S., Chandler, D., Nurmatov, U., Liu, J., Pagliari, C., Car, J., Sheikh, A. · 2011 · Canadian Medical Association Journal
42. Series: clinical epidemiology in South Africa. paper 3: logic models help make sense of complexity in systematic reviews and health technology assessments
    Rohwer, Anke, Pfadenhauer, Lisa, Burns, Jacob, Brereton, Louise, Gerhardus, Ansgar, Booth, Andrew, Oortwijn, Wija, Rehfuess, Eva · 2017 · Journal of Clinical Epidemiology
43. Group interventions to improve health outcomes: a framework for their design and delivery
    Hoddinott, Pat, Allan, Karen, Avenell, Alison, Britten, Jane · 2010 · BMC Public Health
44. Effects of a physical education intervention on cognitive function in young children: randomized controlled pilot study
    Fisher, Abigail, Boyle, James ME, Paton, James Y, Tomporowski, Phillip, Watson, Christine, McColl, John H, Reilly, John J · 2011 · BMC Pediatrics
45. Breaking barriers: using the behavior change wheel to develop a tailored intervention to overcome workplace inhibitors to breaking up sitting time
    Ojo, Samson O., Bailey, Daniel P., Brierley, Marsha L., Hewson, David J., Chater, Angel M. · 2019 · BMC Public Health
46. Characterising an implementation intervention in terms of behaviour change techniques and theory: the ‘Sepsis Six’ clinical care bundle
    Steinmo, Siri, Fuller, Christopher, Stone, Sheldon P., Michie, Susan · 2015 · Implementation Science
47. The potential of technology-based psychological interventions for anorexia and bulimia nervosa: a systematic review and recommendations for future research
    Schlegl, Sandra, Bürger, Carolina, Schmidt, Luise, Herbst, Nirmal, Voderholzer, Ulrich · 2015 · Journal of Medical Internet Research
48. Optimisation of complex health interventions prior to a randomised controlled trial: a scoping review of strategies used
    Levati, Sara, Campbell, Pauline, Frost, Rachael, Dougall, Nadine, Wells, Mary, Donaldson, Cam, Hagen, Suzanne · 2016 · Pilot and Feasibility Studies
49. Effects of interventions promoting monitoring of medication use and brief messaging on medication adherence for people with Type 2 diabetes: a systematic review of randomized trials
    Farmer, A. J., McSharry, J., Rowbotham, S., McGowan, L., Ricci‐Cabello, I., French, D. P. · 2016 · Diabetic Medicine
50. Defining the active ingredients of interactive computer play interventions for children with neuromotor impairments: a scoping review
    Levac, Danielle, Rivard, Lisa, Missiuna, Cheryl · 2012 · Research in Developmental Disabilities
51. The Implementation of Mindfulness-Based Cognitive Therapy: Learning From the UK Health Service Experience
    Crane, Rebecca S., Kuyken, Willem · 2013 · Mindfulness
52. Community-, facility-, and individual-level outcomes of a district mental healthcare plan in a low-resource setting in Nepal: A population-based evaluation
    Jordans, Mark J. D., Luitel, Nagendra P., Kohrt, Brandon A., Rathod, Sujit D., Garman, Emily C., De Silva, Mary, Komproe, Ivan H., Patel, Vikram, Lund, Crick · 2019 · PLOS Medicine
53. Effect of a Nurse-Led Preventive Psychological Intervention on Symptoms of Posttraumatic Stress Disorder Among Critically Ill Patients: A Randomized Clinical Trial
    Wade, Dorothy M., Mouncey, Paul R., Richards-Belle, Alvin, Wulff, Jerome, Harrison, David A., Sadique, M. Zia, Grieve, Richard D., Emerson, Lydia M., Mason, Alexina J., Aaronovitch, David et al. · 2019 · JAMA
54. Information provision for people with multiple sclerosis
    Köpke, Sascha, Solari, Alessandra, Khan, Fary, Heesen, Christoph, Giordano, Andrea · 2014 · Cochrane Database of Systematic Reviews
55. A Randomized Controlled Trial of a Mobile Health Intervention to Promote Self‐Management After Lung Transplantation
    DeVito Dabbs, A., Song, M.K., Myers, B.A., Li, R., Hawkins, R.P., Pilewski, J.M., Bermudez, C.A., Aubrecht, J., Begey, A., Connolly, M. et al. · 2016 · American Journal of Transplantation
56. Methods used to address fidelity of receipt in health intervention research: a citation analysis and systematic review
    Rixon, Lorna, Baron, Justine, McGale, Nadine, Lorencatto, Fabiana, Francis, Jill, Davies, Anna · 2016 · BMC Health Services Research
57. Telehealthcare for asthma
    McLean, Susannah, Chandler, David, Nurmatov, Ulugbek, Liu, Joseph LY, Pagliari, Claudia, Car, Josip, Sheikh, Aziz · 2010 · Cochrane Database of Systematic Reviews
58. Aphasia Recovery: When, How and Who to Treat?
    Doogan, Catherine, Dignam, Jade, Copland, David, Leff, Alex · 2018 · Current Neurology and Neuroscience Reports
59. Assessing User Engagement of an mHealth Intervention: Development and Implementation of the Growing Healthy App Engagement Index
    Taki, Sarah, Lymer, Sharyn, Russell, Catherine Georgina, Campbell, Karen, Laws, Rachel, Ong, Kok-Leong, Elliott, Rosalind, Denney-Wilson, Elizabeth · 2017 · JMIR mHealth and uHealth
60. Step-by-Step: a new WHO digital mental health intervention for depression
    Carswell, Kenneth, Harper-Shehadeh, Melissa, Watts, Sarah, van’t Hof, Edith, Abi Ramia, Jinane, Heim, Eva, Wenger, Andreas, van Ommeren, Mark · 2018 · mHealth
61. Assessing the psychosocial factors associated with adherence to exercise referral schemes: A systematic review
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62. Participatory Methods to Engage Health Service Users in the Development of Electronic Health Resources: Systematic Review
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63. Using intervention mapping to develop a theory-driven, group-based complex intervention to support self-management of osteoarthritis and low back pain (SOLAS).
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64. Getting added value from using qualitative research with randomized controlled trials: a qualitative interview study
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65. Management of tinnitus in English NHS audiology departments: An evaluation of current practice.
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66. Evaluation of district mental healthcare plans: The PRIME consortium methodology
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67. Understanding reactions to an internet-delivered health-care intervention: accommodating user preferences for information provision
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68. Implementation and effectiveness of adolescent life skills programs in low- and middle-income countries: A critical review and meta-analysis
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69. Piloting tele-monitoring in COPD: a mixed methods exploration of issues in design and implementation
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70. Pathways to a healthy net-zero future: report of the Lancet Pathfinder Commission
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71. Increasing the frequency of physical activity very brief advice for cancer patients. Development of an intervention using the behaviour change wheel
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72. Climate change and disorders of the nervous system
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73. The Contradictions of Telehealth User Experience in Chronic Obstructive Pulmonary Disease (COPD): A Qualitative Meta-Synthesis.
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74. Strategies for overcoming therapeutic inertia in type 2 diabetes: A systematic review and meta-analysis
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75. Investigating complexity in systematic reviews of interventions by using a spectrum of methods
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76. Health Behavior Change for Obesity Management
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77. Mindfulness for the Self-Management of Fatigue, Anxiety, and Depression in Women With Metastatic Breast Cancer: A Mixed Methods Feasibility Study
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78. Aerobic and strength training exercise programme for cognitive impairment in people with mild to moderate dementia: the DAPA RCT
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79. Pharmacist-led management of chronic pain in primary care: results from a randomised controlled exploratory trial
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80. Applying the behaviour change technique (BCT) taxonomy v1: A study of coder training
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81. Conceptualising nurse-patient therapeutic engagement on acute mental health wards: An integrative review
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82. Educational outreach with an integrated clinical tool for nurse-led non-communicable chronic disease management in primary care in South Africa: a pragmatic cluster randomised controlled trial
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83. Using workshops to develop theories of change in five low and middle income countries: lessons from the programme for improving mental health care (PRIME)
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84. Results of a feasibility cluster randomised controlled trial of a peer-led school-based intervention to increase the physical activity of adolescent girls (PLAN-A)
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85. Young people’s conceptualizations of the nature of cyberbullying: A systematic review and synthesis of qualitative research
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86. The feasibility and acceptability of a brief Acceptance and Commitment Therapy (ACT) group intervention for people with psychosis: The ‘ACT for Life’ study
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87. Extreme weather-driven disasters and children's health
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88. A 10‐session cognitive‐behavioral therapy (CBT‐T) for eating disorders: Outcomes from a case series of nonunderweight adult patients
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89. A Randomized Feasibility Study of a 12-Week Community-Based Exercise Program for People With Huntington's Disease
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90. Development and formative evaluation of the e-Health Implementation Toolkit (e-HIT)
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91. A realist review of mobile phone-based health interventions for non-communicable disease management in sub-Saharan Africa
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92. Understanding the management of early-stage chronic kidney disease in primary care: a qualitative study
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93. The Social Determinants of Health: Time to Re-Think?
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94. Pilot evaluation of the Sleep Ninja: A smartphone application for adolescent insomnia symptoms
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95. A User-Centered Approach to an Evidence-Based Electronic Health Pain Management Intervention for People With Chronic Pain: Design and Development of EPIO
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96. Effect and cost of an after-school dance programme on the physical activity of 11–12 year old girls: The Bristol Girls Dance Project, a school-based cluster randomised controlled trial
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97. Appropriate controls for digital therapeutic clinical trials: A narrative review of control conditions in clinical trials of digital therapeutics (DTx) deploying psychosocial, cognitive, or behavioral content
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98. Development of a behaviour change intervention to increase upper limb exercise in stroke rehabilitation
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99. Development and implementation of an integrated chronic disease model in South Africa: lessons in the management of change through improving the quality of clinical practice
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100. Development and feasibility of Inlife: a pilot study of an online social support intervention for informal caregivers of people with dementia
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