The efficacy of mindfulness-based interventions in primary care: a meta-analytic review.
Open accessAbstract
PURPOSE: Positive effects have been reported after mindfulness-based interventions (MBIs) in diverse clinical and nonclinical populations. Primary care is a key health care setting for addressing common chronic conditions, and an effective MBI designed for this setting could benefit countless people worldwide. Meta-analyses of MBIs have become popular, but little is known about their efficacy in primary care. Our aim was to investigate the application and efficacy of MBIs that address primary care patients. METHODS: We performed a meta-analytic review of randomized controlled trials addressing the effect of MBIs in adult patients recruited from primary care settings. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and Cochrane guidelines were followed. Effect sizes were calculated with the Hedges g in random effects models. RESULTS: The meta-analyses were based on 6 trials having a total of 553 patients. The overall effect size of MBI compared with a control condition for improving general health was moderate (g = 0.48; P = .002), with moderate heterogeneity (I(2) = 59; P <.05). We found no indication of publication bias in the overall estimates. MBIs were efficacious for improving mental health (g = 0.56; P = .007), with a high heterogeneity (I(2) = 78; P <.01), and for improving quality of life (g = 0.29; P = .002), with a low heterogeneity (I(2) = 0; P >.05). CONCLUSIONS: Although the number of randomized controlled trials applying MBIs in primary care is still limited, our results suggest that these interventions are promising for the mental health and quality of life of primary care patients. We discuss innovative approaches for implementing MBIs, such as complex intervention and stepped care.
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For many people, mindfulness as a healthcare approach remains unfamiliar.
“for many people, mindfulness as a healthcare approach remains unfamiliar [14, 32].”
From Exploring patient experiences with a mindfulness course in a general practice setting: a qualitative study. (2025) · cites this paper as [32]
The introduction discusses growing recognition of mindfulness-based interventions among clinicians and policy makers, and Findings in Context discusses adapting them for primary care (page numbers unavailable). Neither addresses whether mindfulness as a healthcare approach is unfamiliar to many people. Searches for unfamiliarity, awareness, and patient knowledge found no supporting passage. (LLM, conf=0.72)
Experimental — accuracy not yet measuredMindfulness-based interventions have been shown to enhance quality of life in many different chronic conditions.
“Mindfulness-based interventions have been shown to enhance quality of life in many different chronic conditions (Demarzo et al., 2015; Crowe et al., 2016; Veehof et al., 2016; Haller et al., 2017) and we confirmed this with respect to MS in our study.”
From The effectiveness of a body-affective mindfulness intervention for multiple sclerosis patients with depressive symptoms: A randomized controlled clinical trial (2017) · cites this paper as Demarzo et al., 2015
Meta-analyses show moderate effects of 8-week mindfulness-based programs on anxiety, depression, and quality of life in chronic disease.
“Meta-analyses demonstrate moderate effects of 8-week MBPs on anxiety, depression, and quality of life during chronic disease.37,38”
From Mindfulness training enhances self-regulation and facilitates health behavior change for primary care patients: A randomized controlled trial (2019) · cites this paper as [38]
Evidence-based mindfulness programs have well-established benefits for a wide range of populations and outcome variables.
“The benefits of mindfulness-based programs (MBPs) for a wide range of populations and outcome variables are well supported in meta-analytic reviews (Dawson et al. 2019; Demarzo et al. 2015; Goldberg et al. 2018; Khoury et al. 2013).”
From Frequency of Self-reported Unpleasant Events and Harm in a Mindfulness-Based Program in Two General Population Samples (2021) · cites this paper as Demarzo et al. 2015
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“Many clinicians in routine care apply mindfulness exercises in individual therapy (Cigolla & Brown, 2011; Demarzo et al., 2015; Dimidjian & Segal, 2015) and already do so during their training (Ivanovic, Swift, Callahan, & Dunn, 2015; Mander et al., 2017a).”
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“Practices based on mindfulness improve the quality of sleep [55] and of life [56].”
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the collaborative group of the MINDUUDD study, de Torres, L. Á. P., Atalaya, J. C. V.-M., García‐Campayo, J., Villalobos, A. R., Magallón-Botaya, R. M., Bartolomé-Moreno, C., Moreno-Martos, H., Melús-Palazón, E., Liétor-Villajos, N., et al. (2019) · BMC Family Practice · doi:10.1186/s12875-019-0913-z · Cited by 42 · see citing works
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Citation patterns and trends of systematic reviews about mindfulness
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Religiosity and Meditation Practice: Exploring Their Explanatory Power on Psychological Adjustment
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Sakai, A., Terao, T., Kawano, N., Akase, M., Hatano, K., Shirahama, M., Hirakawa, H., Kohno, K., Inoue, A., & Ishii, N. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00538 · Cited by 22 · see citing works
Impact of a blended web-based mindfulness programme for general practitioners: a pilot study
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Yoga in major depressive disorder: molecular mechanisms and clinical utility
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Self-citationMindfulness for Health and Well Being
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Complementary medicine and the NHS: Experiences of integration with UK primary care
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Jedel, S., Beck, T. L., Swanson, G. R., Hood, M. M., Voigt, R. M., Gorenz, A., Jakate, S. M., Raeisi, S., Hobfoll, S. E., & Keshavarzian, A. (2022) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izac036 · Cited by 15 · see citing works
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Mindfulness Training for Primary Care for Portuguese-Speaking Immigrants: A Pilot Study
Trombka, M., Creedon, T., Demarzo, M., Cuoco, L. T., Smith, L., Oxnard, A., Rozembaque, A. T., Hirayama, M. S., Moreno, N. B., Comeau, A., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.664381 · Cited by 12 · see citing works
Self-citationA longitudinal, randomized and controlled study of app-delivered mindfulness in the workplace
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“Recent meta-analyses indicate that mindfulness meditation interventions may be effective for enhancing well-being [3], reducing anxiety and depression [4], and optimizing immune physiology [5] and daily functioning [6].”
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Estilo de vida saludable: un factor de protección minusvalorado frente a la depresión
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Martial arts masters identify the essential components of training
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“and the absence of mindfulness skills can be addressed through the practice of meditative exercises that promote attention to the present moment [29].”
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van Loggerenberg, F., Akena, D. H., Alinaitwe, R., Birabwa‐Oketcho, H., Méndez, C. A. C., Gómez–Restrepo, C., Kulenović, A. D., Selak, N., Kiseljaković, M., Musisi, S., et al. (2023) · BMC Family Practice · doi:10.1186/s12875-023-02197-0 · Cited by 9 · see citing works
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Self-citationMindfulness-based therapy for insomnia in Black women: a pilot randomized controlled trial
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Mindfulness Training Has Elements Common to Other Techniques
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Brief Mindfulness-Based Interventions: Teacher and Course Attendee Perspectives on Content
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Outcomes of a 6-week cognitive–behavioral and mindfulness group intervention in primary care.
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- Authors
- Demarzo, M. M. P., Montero-Marin, J., Cuijpers, P., Zabaleta-del-Olmo, E., Mahtani, K. R., Vellinga, A., Vicens, C., Lopez-del-Hoyo, Y., & Garcia-Campayo, J.
- Affiliations
- Universidade Federal de São Paulo (BR)
- Vrije Universiteit Amsterdam (NL)
- University of Oxford (GB)
- Ollscoil na Gaillimhe – University of Galway (IE)
- Red de Investigación en Actividades Preventivas y Promoción de la Salud (ES)
- Venue
- The Annals of Family Medicine
- Publisher
- Annals of Family Medicine
- Published
- 2015-11-01
- Volume
- 13
- Issue
- 6
- Pages
- 573-582
- ISSN
- 1544-1709 (ISSN-L)
- 1544-1717
- PMC
- PMC4639383
- OpenAlex
- W2192018121
- Cited by
- 152
- References
- 60
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 13 · 2023: 10 · 2022: 11 · 2021: 20 · 2020: 25 · 2019: 16 · 2018: 19 · 2017: 21 · 2016: 3 · 2015: 1
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- The Annals of Family Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (acceptedVersion, cc-by-nc-nd)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc-nd)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion)
- Docusalut (Conselleria de Salut i Consum del Govern de les Illes Balears) (submittedVersion)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- National Institute for Health and Care Research (CL-2011-13-006)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- mindfulness-based interventions, primary care, mental health, quality of life, health status, stepped care, complex interventions, chronic disease, intervention efficacy
- MeSH terms
- Adult, Aged, Chronic Disease, Female, Humans, Male, Middle Aged, Primary Health Care, Randomized Controlled Trials as Topic, Treatment Outcome, Mindfulness
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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