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Cited by 1,380

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

What contributes to quality of life in patients with Parkinson's disease?

Open access
Schrag, A.·2000·Journal of Neurology, Neurosurgery & Psychiatry
DOI 10.1136/jnnp.69.3.308
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Abstract

OBJECTIVE: To identify the factors that determine quality of life (QoL) in patients with idiopathic Parkinson's disease in a population based sample. Quality of life (QoL) is increasingly recognised as a critical measure in health care as it incorporates the patients' own perspective of their health. METHODS: All patients with Parkinson's disease seen in a population based study on the prevalence of parkinsonism were asked to complete a disease-specific QoL questionnaire (PDQ-39) and the Beck depression inventory. A structured questionnaire interview and a complete neurological examination, including the Hoehn and Yahr scale, the Schwab and England disability scale, the motor part of the unified Parkinson's disease rating scale (UPDRS part III), and the mini mental state examination were performed by a neurologist on the same day. RESULTS: The response rate was 78%. The factor most closely associated with QoL was the presence of depression, but disability, as measured by the Schwab and England scale, postural instability, and cognitive impairment additionally contributed to poor QoL. Although the UPDRS part III correlated significantly with QoL scores, it did not contribute substantially to predicting their variance once depression, disability, and postural instability had been taken into account. In addition, patients with akinetic rigid Parkinson's disease had worse QoL scores than those with tremor dominant disease, mainly due to impairment of axial features. CONCLUSION: Depression, disability, postural instability, and cognitive impairment have the greatest influence on QoL in Parkinson's disease. The improvement of these features should therefore become an important target in the treatment of the disease.

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Metadata

Authors
Schrag, A.
Venue
Journal of Neurology, Neurosurgery & Psychiatry
Publisher
BMJ
Published
2000-09-01
Volume
69
Issue
3
Pages
308-312
ISSN
0022-3050 (ISSN-L)
DOI
10.1136/jnnp.69.3.308
OpenAlex
W2140374231
Cited by
1,380
References
8
FWCI
14.73
Type
journal article
Language
en
Open access
bronze

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