CoChat
Sign Up
Cited by 79Cardiovascular and exercise physiologyExercise and Physiological ResponsesSirtuins and Resveratrol in Medicine

Resveratrol supplementation does not augment performance adaptations or fibre-type-specific responses to high-intensity interval training in humans

Scribbans, Trisha D., Ma, Jasmin K., Edgett, Brittany A., Vorobej, Kira A., Mitchell, Andrew S., Zelt, Jason G.E., Simpson, Craig A., Quadrilatero, Joe +1 more·2014·Applied Physiology Nutrition and Metabolism
DOI 10.1139/apnm-2014-0070
Open this paper in CoChat — free account

Abstract

The present study examined the effect of concurrent exercise training and daily resveratrol (RSV) supplementation (150 mg) on training-induced adaptations following low-dose high-intensity interval training (HIIT). Sixteen recreationally active (∼22 years, ∼51 mL·kg(-1)·min(-1)) men were randomly assigned in a double-blind fashion to either the RSV or placebo group with both groups performing 4 weeks of HIIT 3 days per week. Before and after training, participants had a resting muscle biopsy taken, completed a peak oxygen uptake test, a Wingate test, and a submaximal exercise test. A main effect of training (p < 0.05) and interaction effect (p < 0.05) on peak aerobic power was observed; post hoc pairwise comparisons revealed that a significant (p < 0.05) increase occurred in the placebo group only. Main effects of training (p < 0.05) were observed for both peak oxygen uptake (placebo - pretraining: 51.3 ± 1.8, post-training: 54.5 ± 1.5 mL·kg(-1)·min(-1), effect size (ES) = 0.93; RSV - pretraining: 49.6 ± 2.2, post-training: 52.3 ± 2.5 mL·kg(-1)·min(-1), ES = 0.50) and Wingate peak power (placebo: pretraining: 747 ± 39, post-training: 809 ± 31 W, ES = 0.84; RSV - pretraining: 679 ± 39, post-training: 691 ± 43 W, ES = 0.12). Fibre-type distribution was unchanged, while a main effect of training (p < 0.05) was observed for succinate dehydrogenase activity and glycogen content, but not α-glycerophosphate dehydrogenase activity or intramuscular lipids in type I and IIA fibres. The fold change in PGC-1α, SIRT1, and SOD2 gene expression following training was significantly (p < 0.05) lower in the RSV group than placebo. These results suggest that concurrent exercise training and RSV supplementation may alter the normal training response induced by low-volume HIIT.

Integrity signals

Registry

Crossref · 10.1139/apnm-2014-0070

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Resveratrol supplementation during exercise training in healthy individuals can result in a maladaptive response in exercise-stimulated gene expression.

    “resveratrol supplementation during exercise training in healthy individuals can result in a maladaptive response in exercise-stimulated gene expression [176].”

    From New strategies in sport nutrition to increase exercise performance (2016) · cites this paper as [176]

Cites

Flagged first, then by citations

1 of the 50 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Scribbans, T. D., Ma, J. K., Edgett, B. A., Vorobej, K. A., Mitchell, A. S., Zelt, J. G. E., Simpson, C. A., Quadrilatero, J., & Gurd, B. J.
Affiliations
  • Queen's University (CA)
  • University of Waterloo (CA)
Corresponding author
  • Scribbans, Trisha D.
  • Ma, Jasmin K.
ORCID
Venue
Applied Physiology Nutrition and Metabolism
Publisher
Canadian Science Publishing
Published
2014-11
Volume
39
Issue
11
Pages
1305-1313
ISSN
  • 1715-5312 (ISSN-L)
  • 1715-5320
DOI
10.1139/apnm-2014-0070
OpenAlex
W2112101316
Cited by
79
References
50
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 1 · 2021: 11 · 2020: 5 · 2019: 14 · 2018: 7 · 2017: 9 · 2016: 9 · 2015: 10
FWCI
20.09
Type
journal article
Language
en
Open access
closed
Licence
www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)
Locations
  • Applied Physiology, Nutrition, and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Keywords
resveratrol supplementation, high-intensity interval training, training effects, muscle fiber type distribution, peak oxygen uptake, anaerobic power, succinate dehydrogenase, glycogen content, PGC-1α, SIRT1, manganese superoxide dismutase, gene expression, low-volume training, muscle biopsy, intramuscular fat
MeSH terms
Resveratrol, Adaptation, Physiological, Biopsy, Double-Blind Method, Exercise Test, Female, Humans, Male, Oxygen, Stilbenes, Exercise, Gene Expression, Muscle, Skeletal, Muscle Fibers, Skeletal, Young Adult, Real-Time Polymerase Chain Reaction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review