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Cited by 83Neural dynamics and brain functionFunctional Brain Connectivity StudiesMemory and Neural Mechanisms

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Theory of the Multiregional Neocortex: Large-Scale Neural Dynamics and Distributed Cognition

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Wang, Xiao-Jing·2022·Annual Review of Neuroscience
DOI 10.1146/annurev-neuro-110920-035434PMC PMC11583996
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Abstract

The neocortex is a complex neurobiological system with many interacting regions. How these regions work together to subserve flexible behavior and cognition has become increasingly amenable to rigorous research. Here, I review recent experimental and theoretical work on the modus operandi of a multiregional cortex. These studies revealed several general principles for the neocortical interareal connectivity, low-dimensional macroscopic gradients of biological properties across cortical areas, and a hierarchy of timescales for information processing. Theoretical work suggests testable predictions regarding differential excitation and inhibition along feedforward and feedback pathways in the cortical hierarchy. Furthermore, modeling of distributed working memory and simple decision-making has given rise to a novel mathematical concept, dubbed bifurcation in space, that potentially explains how different cortical areas, with a canonical circuit organization but gradients of biological heterogeneities, are able to subserve their respective (e.g., sensory coding versus executive control) functions in a modularly organized brain.

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Metadata

Authors
Wang, X.-J.
Affiliations
New York University (US)
Corresponding author
Wang, Xiao-Jing
ORCID
Wang, Xiao-Jing
Venue
Annual Review of Neuroscience
Publisher
Annual Reviews
Published
2022-07-08
Volume
45
Issue
1
Pages
533-560
ISSN
  • 0147-006X (ISSN-L)
  • 1545-4126
DOI
10.1146/annurev-neuro-110920-035434
PMC
PMC11583996
OpenAlex
W4284974723
Cited by
83
References
58
Citations by year
2026: 18 · 2025: 24 · 2024: 23 · 2023: 14 · 2022: 3
FWCI
2.23
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Annual Review of Neuroscience (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Science Foundation (2015276)
  • National Institutes of Health (5r01mh122024-03)
  • Office of Naval Research (N00014)
  • National Institute of Mental Health (R01MH062349, R01 MH122024)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
cortical hierarchy, excitation and inhibition, decision-making, cortical heterogeneity, sensory coding, executive function, distributed cognition
MeSH terms
Cognition, Memory, Short-Term, Nerve Net, Neocortex, Executive Function

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