The DOI matches its Crossref record; 230 of the 230 references it cites were found in a registry or an index.
Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress
Open accessAbstract
The psychology of extinction has been studied for decades. Approximately 10 years ago, however, there began a concerted effort to understand the neural circuits of extinction of fear conditioning, in both animals and humans. Progress during this period has been facilitated by a high degree of coordination between rodent and human researchers examining fear extinction. Here we review the major advances and highlight new approaches to understanding and exploiting fear extinction. Research in fear extinction could serve as a model for translational research in other areas of behavioral neuroscience.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“A closely related domain of research on conditioning and extinction in both rodents and humans also suggests that ventromedial PFC (vmPFC), an area neighboring rACC, supports extinction while cACC supports increased aversive processing (Milad and Quirk, 2012; see Figure 7).”
From Top-Down Dysregulation—From ADHD to Emotional Instability (2016) · cites this paper as Milad and Quirk, 2012
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“The vmPFC is proposed to be the homologue for the IL in rodents [87] and serves to inhibit threat responses produced by the amygdala.”
From Prefrontal cortex, amygdala, and threat processing: implications for PTSD (2022) · cites this paper as [87]
The cited source says what the claim attributes to it.
In the citing paper
“The vmPFC is thought to modulate amygdala processing of conditioned fear by suppressing fear responses through a set of amygdala neurons in the intercalated region between the basolateral and central amygdala nucleus (Milad and Quirk, 2012).”
From Top-Down Dysregulation—From ADHD to Emotional Instability (2016) · cites this paper as Milad and Quirk, 2012
In the citing paper
“The vmPFC is activated during retrieval of extinction learning and down-regulates the amygdala”
From Childhood adversity and neural development: Deprivation and threat as distinct dimensions of early experience (2014) · cites this paper as Milad and Quirk, 2012
In the citing paper
“Therefore, in PTSD, there is both hyperactivation of the fear expression and hypoactivation of the extinction memory networks [59, 60].”
From Sleep and REM sleep disturbance in the pathophysiology of PTSD: the role of extinction memory (2015) · cites this paper as [59]
In the citing paper
“However, rather than erasing the CS-US association, extinction represents formation of a new memory, an “extinction memory,” signifying “CS-no US,” that competitively inhibits the memory of the CS-US contingency and expression of its associated CR when the CS is again encountered [51–59].”
From Sleep and REM sleep disturbance in the pathophysiology of PTSD: the role of extinction memory (2015) · cites this paper as [59]
In the citing paper
“A deficit in the ability to encode, consolidate, or retrieve extinction memory is believed to play a role in the development and perpetuation of such disorders [6, 59, 61, 87].”
From Sleep and REM sleep disturbance in the pathophysiology of PTSD: the role of extinction memory (2015) · cites this paper as [59]
In the citing paper
“Neuroimaging research using de novo fear-conditioning and extinction paradigms has revealed areas in the brain associated with experiencing conditioned fear (a “fear expression network”) in the amygdala and dorsal anterior cingulate cortex (dACC) and other areas associated with memory for the extinction (inhibition) of this fear (an “extinction memory network”) that includes the hippocampus and”
From Sleep and REM sleep disturbance in the pathophysiology of PTSD: the role of extinction memory (2015) · cites this paper as [59]
In the citing paper
“Brain circuitry at the core of threat discrimination learning includes areas within the amygdala and medial prefrontal cortex (mPFC)1.”
From Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood (2019) · cites this paper as [1]
In the citing paper
“During threat extinction training, the CS is presented without the aversive outcome, which results in reduced amygdala responses to the CS over time3, with the mPFC playing a critical role1,4,5.”
From Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood (2019) · cites this paper as [1]
In the citing paper
“During threat extinction training, the CS is presented without the aversive outcome, which results in reduced amygdala responses to the CS over time3, with the mPFC playing a critical role1,4,5.”
From Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood (2019) · cites this paper as [1]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., Sanislow, C., & Wang, P. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091379 · Cited by 7,067
Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135058100 · Cited by 6,358
Psychophysiological and Modulatory Interactions in Neuroimaging
Friston, K. J., Buechel, C., Fink, G. R., Morris, J., Rolls, E., & Dolan, R. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0291 · Cited by 3,097
Emotional processing in anterior cingulate and medial prefrontal cortex
Etkin, A., Egner, T., & Kalisch, R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.004 · Cited by 3,059 · cited 1×
“Numerous reviews on molecular mechanisms of extinction, clinical relevance, and inhibition circuitry within the amygdala have recently appeared (Pape & Paré 2010, Herry et al 2010, Sotres-Bayon & Quirk 2010, Myers et al 2011, Etkin et al 2011).”
BackgroundTrauma and Posttraumatic Stress Disorder in the Community: The 1996 Detroit Area Survey of Trauma
Breslau, N., Kessler, R. C., Chilcoat, H. D., Schultz, L. R., Davis, G. C., & Andreski, P. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.7.626 · Cited by 2,407
Whalen, P. J., Rauch, S. L., Etcoff, N. L., McInerney, S. C., Lee, M. B., & Jenike, M. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00411.1998 · Cited by 2,205
Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network
Greicius, M. D., Supekar, K., Menon, V., & Dougherty, R. F. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn059 · Cited by 2,175
Integrative activity of the brain
Konorski, J. (1967) · University of Chicago Press eBooks · Cited by 2,043
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980
Cited by
Sorted by citations
Items 501–600 of 1,002
Cerebellar modulation of memory encoding in the periaqueductal grey and fear behaviour
Lawrenson, C. L., Paci, E., Pickford, J., Drake, R. A., Lumb, B. M., & Apps, R. (2022) · eLife · doi:10.7554/elife.76278 · Cited by 37
Social modulation in extinction of aversive memories
Nowak, A., Werka, T., & Knapska, E. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.031 · Cited by 37
Age and adolescent social stress effects on fear extinction in female rats
McCormick, C. M., Mongillo, D. L., & Simone, J. J. (2013) · Stress · doi:10.3109/10253890.2013.840283 · Cited by 36
Smith, R. S., Fass, H. G., & Lane, R. D. (2014) · Consciousness and Cognition · doi:10.1016/j.concog.2014.08.002 · Cited by 38
Over-generalization in youth with anxiety disorders
El-Bar, N., Laufer, O., Yoran‐Hegesh, R., & Paz, R. (2016) · Social Neuroscience · doi:10.1080/17470919.2016.1167123 · Cited by 42
Fear Expression Suppresses Medial Prefrontal Cortical Firing in Rats
Giustino, T. F., Fitzgerald, P. J., & Maren, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165256 · Cited by 41
Intolerance of uncertainty predicts increased striatal volume.
Kim, M. J., Shin, J., Taylor, J. M., Mattek, A. M., Chavez, S., & Whalen, P. J. (2017) · Emotion · doi:10.1037/emo0000331 · Cited by 36
Feng, P., Becker, B., Feng, T., & Zheng, Y. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.01.057 · Cited by 35
Huggins, A. A., Baird, C. L., Briggs, M., Laskowitz, S., Haswell, C. C., Fouda, S., Haswell, C., Sun, D., Salminen, L. E., Jahanshad, N., et al. (2023) · Molecular Psychiatry · doi:10.1016/j.biopsych.2023.02.123 · Cited by 39
Memory Trace for Fear Extinction: Fragile yet Reinforceable
Liu, Y., Ye, S., Li, X.-N., & Li, W. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01129-3 · Cited by 35
Involvement of CRFR 1 in the Basolateral Amygdala in the Immediate Fear Extinction Deficit
Hollis, F., Sevelinges, Y., Grosse, J., Zanoletti, O., & Sandi, C. (2016) · eNeuro · doi:10.1523/eneuro.0084-16.2016 · Cited by 35
Yin, S., Liu, Y., Petro, N. M., Keil, A., & Ding, M. (2018) · eNeuro · doi:10.1523/eneuro.0445-17.2018 · Cited by 41
Stegmann, Y., Reicherts, P., Andreatta, M., Pauli, P., & Wieser, M. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-45239-3 · Cited by 36
A prefrontal-bed nucleus of the stria terminalis circuit limits fear to uncertain threat
Glover, L. R., McFadden, K. M., Bjorni, M., Smith, S. R., Rovero, N. G., Oreizi-Esfahani, S., Yoshida, T., Postle, A. F., Nonaka, M., Halladay, L. R., et al. (2020) · eLife · doi:10.7554/elife.60812 · Cited by 35
Harsh Parenting and Child Brain Morphology: A Population-Based Study
Hidalgo, A. P. C., Thijssen, S., Delaney, S., Vernooij, M. W., Jansen, P. W., Bakermans‐Kranenburg, M. J., van IJzendoorn, M. H., White, T. J. H., & Tiemeier, H. W. (2021) · Child Maltreatment · doi:10.1177/1077559520986856 · Cited by 35
Cannabinoids: Revealing their complexity and role in central networks of fear and anxiety
Murkar, A., Koninck, J. D., & Merali, Z. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.002 · Cited by 35
Purinergic P2X7 Receptor-mediated inflammation precedes PTSD-related Behaviors in Rats
Torres-Rodríguez, O. I., Rivera-Escobales, Y., Castillo-Ocampo, Y., Velázquez, B., Colón, M., & Porter, J. T. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.02.015 · Cited by 34
The emotion paradox in the aging body and brain
Mather, M. (2024) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.15138 · Cited by 38
Legrand, M., Troubat, R., Brizard, B., Guisquet, A. L., Belzung, C., & El‐Hage, W. (2018) · Brain stimulation · doi:10.1016/j.brs.2018.09.003 · Cited by 36
Panitz, C., Keil, A., & Mueller, E. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-52315-1 · Cited by 34
The effects of age and trait anxiety on avoidance learning and its generalization
Klein, Z., Shner, G., Ginat‐Frolich, R., Vervliet, B., & Shechner, T. (2020) · Behaviour Research and Therapy · doi:10.1016/j.brat.2020.103611 · Cited by 34
Ip, K. I., Sisk, L. M., Horien, C. L., Conley, M. I., Rapuano, K. M., Rosenberg, M. D., Greene, A. S., Scheinost, D., Constable, R. T., Casey, B., et al. (2022) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01826 · Cited by 40
Easy to remember, difficult to forget: The development of fear regulation
Johnson, D. C., & Casey, B. J. (2014) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2014.07.006 · Cited by 37
Sharko, A. C., Fadel, J. R., Kaigler, K. F., & Wilson, M. A. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.10.008 · Cited by 38
Shi, Y., Fan, B., Li, X., Wen, J.-L., & Zhao, H. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00116 · Cited by 34
Socioeconomic disadvantage, brain morphometry, and attentional bias to threat in middle childhood
Dufford, A. J., Bianco, H., & Kim, P. (2018) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-018-00670-3 · Cited by 35
Piantadosi, P. T., Yeates, D. C. M., & Floresco, S. (2020) · Learning & Memory · doi:10.1101/lm.051912.120 · Cited by 35
Morriss, J., Wake, S., Lindner, M., McSorley, E., & Dodd, H. (2020) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2020.04.012 · Cited by 33
Stress, microRNAs, and stress-related psychiatric disorders: an overview
Musazzi, L., Mingardi, J., Ieraci, A., Barbon, A., & Popoli, M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02139-3 · Cited by 35
Modulating fear extinction memory by manipulating SK potassium channels in the infralimbic cortex
Criado‐Marrero, M., Santini, E., & Porter, J. T. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00096 · Cited by 34
One-year-old fear memories rapidly activate human fusiform gyrus
Mueller, E. M., & Pizzagalli, D. A. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv122 · Cited by 33
Fear Erasure Facilitated by Immature Inhibitory Neuron Transplantation
Yang, W., Liu, T., Cao, J.-W., Chen, X.-F., Liu, X., Wang, M., Su, X., Zhang, S., Qiu, B., Hu, W., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.11.018 · Cited by 33
The effect of ketamine on the consolidation and extinction of contextual fear memory
Clifton, N. E., Thomas, K. L., & Hall, J. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881117748903 · Cited by 33
Sun, W., Li, J., Cui, S., Luo, L., Huang, P., Tang, C., & An, L. (2019) · eNeuro · doi:10.1523/eneuro.0165-19.2019 · Cited by 33
Bukalo, O., Nonaka, M., Weinholtz, C. A., Mendez, A., Taylor, W. W., & Holmes, A. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112913 · Cited by 37
Wake, S. J., Morriss, J., Johnstone, T., van Reekum, C. M., & Dodd, H. F. (2021) · Behaviour Research and Therapy · doi:10.1016/j.brat.2021.103818 · Cited by 33
IGF-1 facilitates extinction of conditioned fear
Noriega‐Prieto, J. A., Maglio, L. E., Maroto, I. B., Martín-Cortecero, J., Muñoz‐Callejas, A., Callejo-Móstoles, M., & de Sevilla, D. F. (2021) · eLife · doi:10.7554/elife.67267 · Cited by 33
Klingelhöfer-Jens, M., Ehlers, M. R., Kuhn, M., Keyaniyan, V., & Lonsdorf, T. B. (2022) · eLife · doi:10.7554/elife.78717 · Cited by 33
Increased Prefrontal Cortex Neurogranin Enhances Plasticity and Extinction Learning
Zhong, L., Brown, J. C., Kramer, A. A., Kaleka, K. S., Petersen, A., Krueger, J. N., Florence, M. A., Muelbl, M. J., Battle, M., Murphy, G. G., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0274-15.2015 · Cited by 34
Winkelmann, T., Grimm, O., Pohlack, S. T., Nees, F., Cacciaglia, R., Dinu-Biringer, R., Steiger, F., Wicking, M., Ruttorf, M., Schad, L. R., et al. (2016) · Brain Structure and Function · doi:10.1007/s00429-015-1013-z · Cited by 33
Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood
Morriss, J., Christakou, A., & van Reekum, C. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-44150-1 · Cited by 32
Deep Brain Stimulation for Treatment-Refractory Mood and Obsessive-Compulsive Disorders
Widge, A. S., & Dougherty, D. D. (2015) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-015-0049-y · Cited by 32
Extinction resistant changes in the human auditory association cortex following threat learning
Apergis-Schoute, A. M., Schiller, D., LeDoux, J. E., & Phelps, E. A. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.01.016 · Cited by 32
Converging Prefronto-Insula-Amygdala Pathways in Negative Emotion Regulation in Marmoset Monkeys
Shiba, Y., Oikonomidis, L., Sawiak, S. J., Fryer, T. D., Hong, Y. T., Cockcroft, G. J., Santangelo, A. M., & Roberts, A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.016 · Cited by 32
Mapping stress networks using functional magnetic resonance imaging in awake animals
Dopfel, D., & Zhang, N. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.06.002 · Cited by 34
Morriss, J., Chapman, C., Tomlinson, S., & van Reekum, C. M. (2018) · Biological Psychology · doi:10.1016/j.biopsycho.2018.08.017 · Cited by 32
Inconsistent analytic strategies reduce robustness in fear extinction via skin conductance response
Ney, L. J., Laing, P. A. F., Steward, T., Zuj, D. V., Dymond, S., & Felmingham, K. L. (2020) · Psychophysiology · doi:10.1111/psyp.13650 · Cited by 32
Ibrahim, K., Kalvin, C. B., Li, F., He, G. S., Pelphrey, K. A., McCarthy, G., & Sukhodolsky, D. G. (2020) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2020.100884 · Cited by 33
Oxytocin and Fear Memory Extinction: Possible Implications for the Therapy of Fear Disorders?
Baldi, E., Costa, A., Rani, B., Passani, M. B., Blandina, P., Romano, A., & Provensi, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810000 · Cited by 35
Controlled cortical impact before or after fear conditioning does not affect fear extinction in mice
Sierra‐Mercado, D., McAllister, L. M., Lee, C. C. H., Milad, M. R., Eskandar, E. N., & Whalen, M. J. (2015) · Brain Research · doi:10.1016/j.brainres.2015.02.031 · Cited by 35
Self-citationWendt, J., Hamm, A. O., Pané‐Farré, C. A., Thayer, J. F., Gerlach, A. L., Gloster, A. T., Lang�, T., Helbig‐Lang, S., Pauli, P., Fydrich, T., et al. (2018) · Psychotherapy and Psychosomatics · doi:10.1159/000487599 · Cited by 32
Dębiec, J., Díaz-Mataix, L., Bush, D. E. A., Doyère, V., & LeDoux, J. E. (2013) · Learning & Memory · doi:10.1101/lm.031609.113 · Cited by 35
The role of mediodorsal thalamic nucleus in fear extinction
Lee, S., & Shin, H. (2016) · Journal of Analytical Science & Technology · doi:10.1186/s40543-016-0093-6 · Cited by 32
Altered neural connectivity in adult female rats exposed to early life social stress
Nephew, B. C., Huang, W., Poirier, G. L., Payne, L., & King, J. A. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.08.051 · Cited by 31
Konova, A. B., Parvaz, M. A., Bernstein, V., Zilverstand, A., Moeller, S. J., Delgado, M. R., Alia‐Klein, N., & Goldstein, R. Z. (2017) · Addiction Biology · doi:10.1111/adb.12545 · Cited by 34
Tackling fear: Beyond associative memory activation as the only determinant of fear responding
Boddez, Y., Moors, A., Mertens, G., & Houwer, J. D. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.009 · Cited by 32
Ney, L. J., Vicario, C. M., Nitsche, M. A., & Felmingham, K. L. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107356 · Cited by 33
Seo, J., Oliver, K. I., Daffre, C., Moore, K. N., Gazecki, S., Lasko, N. B., Milad, M. R., & Pace-Schott, E. F. (2021) · SLEEP · doi:10.1093/sleep/zsab261 · Cited by 31
Self-citationHur, J., Kuhn, M., Grogans, S. E., Anderson, A. S., Islam, S., Kim, H. C., Tillman, R. M., Fox, A. S., Smith, J. F., DeYoung, K. A., et al. (2022) · Psychological Science · doi:10.1177/09567976211056635 · Cited by 32
Sensitive periods in fear learning and memory
King, E. C., Pattwell, S. S., Glatt, C. E., & Lee, F. S. (2013) · Stress · doi:10.3109/10253890.2013.796355 · Cited by 33
Greenwald, J. D., & Shafritz, K. M. (2018) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2018.00018 · Cited by 35
Jenness, J. L., Miller, A. B., Rosen, M. L., & McLaughlin, K. A. (2018) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-018-0464-0 · Cited by 31
Schwarzmeier, H., Kleint, N. I., Wïttchen, H., Ströhle, A., Hamm, A. O., & Lueken, U. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.11.1108 · Cited by 31
Learning-induced intrinsic and synaptic plasticity in the rodent medial prefrontal cortex
Porter, J. T., & Sepulveda-Orengo, M. T. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.107117 · Cited by 30
Merz, E. C., Myers, B., Hansen, M., Simon, K. R., Strack, J., & Noble, K. G. (2023) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2023.10.004 · Cited by 34
Lengersdorf, D., Stüttgen, M. C., Uengoer, M., & Güntürkün, O. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.02.025 · Cited by 34
Clarifying the neural substrates of threat and safety reversal learning in humans
Savage, H. S., Davey, C. G., Fullana, M. A., & Harrison, B. J. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.116427 · Cited by 31
A cognitively demanding working-memory intervention enhances extinction
de Voogd, L. D., & Phelps, E. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-63811-0 · Cited by 30
Szeska, C., Richter, J., Wendt, J., Weymar, M., & Hamm, A. O. (2021) · Psychophysiology · doi:10.1111/psyp.13812 · Cited by 32
Translation of animal endocannabinoid models of PTSD mechanisms to humans: Where to next?
Ney, L. J., Crombie, K. M., Mayo, L. M., Felmingham, K. L., Bowser, T. A., & Matthews, A. J. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.11.040 · Cited by 30
FAAH polymorphism (rs324420) modulates extinction recall in healthy humans: an fMRI study
Spohrs, J., Martin, U., Grön, G., Plener, P. L., & Abler, B. (2021) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01367-4 · Cited by 32
Ney, L. J., Schenker, M. T., & Lipp, O. V. (2022) · Behaviour Research and Therapy · doi:10.1016/j.brat.2022.104081 · Cited by 33
Half a Century of Research on Posttraumatic Stress Disorder: A Scientometric Analysis
Sabé, M., Chen, C., El‐Hage, W., Leroy, A., Vaïva, G., Monari, S., Prémand, N., Bartolomei, J., Caiolo, S., Maercker, A. R. A., et al. (2023) · Current Neuropharmacology · doi:10.2174/1570159x22666230927143106 · Cited by 31
NPY Y2 receptors in the central amygdala reduce cued but not contextual fear
Verma, D., Wood, J. C., Lach, G., Mietzsch, M., Weger, S., Heilbronn, R., Herzog, H., Bonaventure, P., Sperk, G., & Tasan, R. O. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.08.038 · Cited by 35
Gonçalves, R., Rodrigues, H., Novaes, F. C., Árbol, J. R., Volchan, E., Coutinho, E. S. F., Figueira, I. L. D. V., & Ventura, P. R. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.09.058 · Cited by 30
Kim, M. J., Brown, A. C., Mattek, A. M., Chavez, S., Taylor, J. M., Palmer, A. L., Wu, Y., & Whalen, P. J. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2016.00093 · Cited by 30
A Neural Model of Empathic States in Attachment-Based Psychotherapy
Cittern, D., & Edalat, A. (2017) · Computational Psychiatry · doi:10.1162/cpsy_a_00006 · Cited by 30
Strekalova, T. V., Markova, N., Shevtsova, E. F., Zubareva, O. E., Bakhmet, А. А., Steinbusch, H. W. M., Бачурин, С. О., & Lesch, K. (2016) · Neural Plasticity · doi:10.1155/2016/5098591 · Cited by 29
Neurobiological correlates of EMDR therapy effect in PTSD
Rousseau, P., Khoury-Malhame, M. E., Reynaud, E., Zendjidjian, X. Y., Samuelian, J., & Khalfa, S. (2018) · European Journal of Trauma & Dissociation · doi:10.1016/j.ejtd.2018.07.001 · Cited by 30
La Buissonniere-Ariza, V., Fitzgerald, K., Meoded, A., Williams, L. L., Liu, G., Goodman, W. K., & Storch, E. A. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.12.182 · Cited by 29
Nawreen, N., Baccei, M. L., & Herman, J. P. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.705660 · Cited by 29
Modeling hormonal contraception in female rats: A framework for studies in behavioral neurobiology
Lacasse, J. M., Gomez‐Perales, E. L., & Brake, W. G. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.101020 · Cited by 29
Inhibitory circuits in fear memory and fear-related disorders
Singh, S. P., & Topolnik, L. (2023) · Frontiers in Neural Circuits · doi:10.3389/fncir.2023.1122314 · Cited by 29
The cerebellum and fear extinction: evidence from rodent and human studies
Doubliez, A., Nio, E., Senovilla-Sanz, F., Spatharioti, V., Apps, R., Timmann, D., & Lawrenson, C. L. (2023) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2023.1166166 · Cited by 29
Widge, A. S., & Moritz, C. T. (2014) · Journal of Neural Engineering · doi:10.1088/1741-2560/11/2/024001 · Cited by 29
Emotional trait and memory associates of sleep timing and quality
Pace-Schott, E. F., Rubin, Z. S., Tracy, L. E., Spencer, R. M. C., Orr, S. P., & Verga, P. W. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.05.069 · Cited by 29
Functional neuroimaging of associative learning and generalization in specific phobia
Lange, I., Goossens, L., Bakker, J. M., Michielse, S., Marcelis, M. C., Wichers, M., van Os, J., van Amelsvoort, T., & Schruers, K. R. J. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.09.008 · Cited by 29
Control of fear extinction by hypothalamic melanin-concentrating hormone–expressing neurons
Concetti, C., Bracey, E. F., Peleg‐Raibstein, D., & Burdakov, D. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2007993117 · Cited by 30
Dynamic expression of FKBP5 in the medial prefrontal cortex regulates resiliency to conditioned fearPreprint
Criado‐Marrero, M., Silva, R. J. M., Velázquez, B., Hernández, A., Colon, M., Cruz, E., Soler‐Cedeño, O., & Porter, J. T. (2017) · Learning & Memory · doi:10.1101/lm.043000.116 · Cited by 32
Measuring human trace fear conditioning
Wehrli, J. M., Xia, Y., Gerster, S., & Bach, D. R. (2022) · Psychophysiology · doi:10.1111/psyp.14119 · Cited by 29
Risbrough, V. B., Glenn, D. E., & Baker, D. G. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_5010 · Cited by 28
Ebrahimi, C., Gechter, J., Lueken, U., Schlagenhauf, F., Wïttchen, H., Hamm, A. O., & Ströhle, A. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0552-z · Cited by 32
Prior fear conditioning and reward learning interact in fear and reward networks
Bulganin, L., Bach, D. R., & Wittmann, B. C. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00067 · Cited by 30
Zhang, Z., Mendelsohn, A., Manson, K. F., Schiller, D., & Levy, I. (2015) · eNeuro · doi:10.1523/eneuro.0072-15.2015 · Cited by 29
Contextual fear conditioning depresses infralimbic excitability
Soler‐Cedeño, O., Cruz, E., Criado‐Marrero, M., & Porter, J. T. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.01.015 · Cited by 29
Furini, C. R. G., Behling, J. A. K., Zinn, C. G., Zanini, M. L., Brasil, E. S. D. A., Pereira, L. D., Izquierdo, I., & Myskiw, J. D. C. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.03.027 · Cited by 28
Cholinergic neurotransmission in the basolateral amygdala during cued fear extinction
Kellis, D. M., Kaigler, K. F., Witherspoon, E., Fadel, J. R., & Wilson, M. A. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100279 · Cited by 29
Insana, S. P., Banihashemi, L., Herringa, R. J., Kolko, D. J., & Germain, A. (2016) · Development and Psychopathology · doi:10.1017/s0954579415000589 · Cited by 27
Imaging of Posttraumatic Stress Disorder
Kamiya, K., & Abe, O. (2019) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2019.09.010 · Cited by 29
Metadata
- Authors
- Milad, M. R., & Quirk, G. J.
- Affiliations
- Harvard University (US)
- University of Puerto Rico, Medical Sciences Campus (PR)
- Venue
- Annual Review of Psychology
- Publisher
- Annual Reviews
- Published
- 2012-01-10
- Volume
- 63
- Issue
- 1
- Pages
- 129-151
- ISSN
- 0066-4308 (ISSN-L)
- 1545-2085
- PMC
- PMC4942586
- OpenAlex
- W2160253364
- Semantic Scholar
- 3e1b47b5a0d8ab9823c918aa6f6ce64eb2eba033
- Cited by
- 1,466
- References
- 228
- Citations by year
- 2026: 105 · 2025: 96 · 2024: 80 · 2023: 96 · 2022: 110 · 2021: 114 · 2020: 131 · 2019: 120 · 2018: 109 · 2017: 102 · 2016: 100 · 2015: 105 · 2014: 88 · 2013: 73 · 2012: 36
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5p50mh086400-05, 5r01mh081975-05)
- National Institute of Mental Health (P-50-MH-086400, K01-MH08036, R01-MH081975, R01MH058883, K01MH080346)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- fear extinction, fear conditioning, neural circuits, translational neuroscience, psychobiology, anxiety disorders
- MeSH terms
- Brain, Conditioning, Psychological, Extinction, Psychological, Fear, Humans, Magnetic Resonance Imaging, Neurosciences
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
