Alter spontaneous activity in amygdala and vmPFC during fear consolidation following 24 h sleep deprivation
Abstract
Sleep deprivation (SD) has been associated with cognitive and emotional disruptions, however its impact on the acquisition of fear and subsequent fear memory consolidation remain unknown. To address this question, we measured human brain activity before and after fear acquisition under conditions of 24 h sleep deprivation versus normal sleep using resting-state functional magnetic resonance imaging (rs-fMRI). Additionally, we explored whether the fear acquisition-induced change of brain activity during the fear memory consolidation window can be predicted by subjective fear ratings and autonomic fear response, assessed by skin conductance responses (SCR) during acquisition. Behaviorally, the SD group demonstrated increased subjective and autonomic fear responses compared to controls at the stage of fear acquisition. During the stage of fear consolidation, the SD group displayed decreased ventromedial prefrontal cortex (vmPFC) activity and concomitantly increased amygdala activity. Moreover, in the SD group fear acquisition-induced brain activity changes in amygdala were positively correlated with both, subjective and autonomic fear indices during acquisition, whereas in controls changes vmPFC activity were positively correlated with fear indices during acquisition. Together, the present findings suggested that SD may weaken the top-down ability of the vmPFC to regulate amygdala activity during fear memory consolidation. Moreover, subjective and objective fear at fear acquisition stage can predict the change of brain activity in amygdala in fear memory consolidation following SD.
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Sleep deprivation is associated with lower vmPFC-amygdala functional connectivity.
“Prior research links vmPFC-amygdala functional connectivity with sleep, suggesting that sleep deprivation (a common condition reported by students during the college years) is associated with lower vmPFC-amygdala functional connectivity [24, 105].”
From Predicting Brain Functional Connectivity Using Mobile Sensing (2020) · cites this paper as [24]
Previous studies find that sleep deprivation is related to weaker vmPFC-amygdala RSFC.
“In terms of sleep, previous studies [24, 105] find that sleep deprivation is related to weaker vmPFC-amygdala RSFC.”
From Predicting Brain Functional Connectivity Using Mobile Sensing (2020) · cites this paper as [24]
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A Review of the Relationship Between Emotional Learning and Memory, Sleep, and PTSD
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Neural mechanisms and architecture of sleep
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- Authors
- Feng, P., Becker, B., Feng, T., & Zheng, Y.
- Affiliations
- Southwest University (CN)
- University of Electronic Science and Technology of China (CN)
- Corresponding author
- Feng, Pan
- Feng, Tingyong
- Zheng, Yong
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 172
- Pages
- 461-469
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2790520964
- Semantic Scholar
- ffb4128ca7fc4c9a9db6cc25c63f4be578833f9f
- Cited by
- 35
- References
- 95
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 3 · 2020: 2 · 2019: 6
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chongqing Postdoctoral Science Foundation (Xm2017161)
- China Postdoctoral Science Foundation (2017M612880)
- National Natural Science Foundation of China (31571128)
- Fundamental Research Funds for the Central Universities (SWU1509392, SWU1709376)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- sleep deprivation, fear memory consolidation, fear acquisition, amygdala, ventromedial prefrontal cortex, resting-state brain activity, skin conductance response, emotional memory
- MeSH terms
- Memory Consolidation, Adult, Amygdala, Brain Mapping, Fear, Female, Humans, Magnetic Resonance Imaging, Male, Sleep Deprivation, Prefrontal Cortex, Young Adult
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