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Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress
Open accessAbstract
The psychology of extinction has been studied for decades. Approximately 10 years ago, however, there began a concerted effort to understand the neural circuits of extinction of fear conditioning, in both animals and humans. Progress during this period has been facilitated by a high degree of coordination between rodent and human researchers examining fear extinction. Here we review the major advances and highlight new approaches to understanding and exploiting fear extinction. Research in fear extinction could serve as a model for translational research in other areas of behavioral neuroscience.
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“A closely related domain of research on conditioning and extinction in both rodents and humans also suggests that ventromedial PFC (vmPFC), an area neighboring rACC, supports extinction while cACC supports increased aversive processing (Milad and Quirk, 2012; see Figure 7).”
From Top-Down Dysregulation—From ADHD to Emotional Instability (2016) · cites this paper as Milad and Quirk, 2012
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In the citing paper
“The vmPFC is proposed to be the homologue for the IL in rodents [87] and serves to inhibit threat responses produced by the amygdala.”
From Prefrontal cortex, amygdala, and threat processing: implications for PTSD (2022) · cites this paper as [87]
The cited source says what the claim attributes to it.
In the citing paper
“The vmPFC is thought to modulate amygdala processing of conditioned fear by suppressing fear responses through a set of amygdala neurons in the intercalated region between the basolateral and central amygdala nucleus (Milad and Quirk, 2012).”
From Top-Down Dysregulation—From ADHD to Emotional Instability (2016) · cites this paper as Milad and Quirk, 2012
In the citing paper
“The vmPFC is activated during retrieval of extinction learning and down-regulates the amygdala”
From Childhood adversity and neural development: Deprivation and threat as distinct dimensions of early experience (2014) · cites this paper as Milad and Quirk, 2012
In the citing paper
“Therefore, in PTSD, there is both hyperactivation of the fear expression and hypoactivation of the extinction memory networks [59, 60].”
From Sleep and REM sleep disturbance in the pathophysiology of PTSD: the role of extinction memory (2015) · cites this paper as [59]
In the citing paper
“However, rather than erasing the CS-US association, extinction represents formation of a new memory, an “extinction memory,” signifying “CS-no US,” that competitively inhibits the memory of the CS-US contingency and expression of its associated CR when the CS is again encountered [51–59].”
From Sleep and REM sleep disturbance in the pathophysiology of PTSD: the role of extinction memory (2015) · cites this paper as [59]
In the citing paper
“A deficit in the ability to encode, consolidate, or retrieve extinction memory is believed to play a role in the development and perpetuation of such disorders [6, 59, 61, 87].”
From Sleep and REM sleep disturbance in the pathophysiology of PTSD: the role of extinction memory (2015) · cites this paper as [59]
In the citing paper
“Neuroimaging research using de novo fear-conditioning and extinction paradigms has revealed areas in the brain associated with experiencing conditioned fear (a “fear expression network”) in the amygdala and dorsal anterior cingulate cortex (dACC) and other areas associated with memory for the extinction (inhibition) of this fear (an “extinction memory network”) that includes the hippocampus and”
From Sleep and REM sleep disturbance in the pathophysiology of PTSD: the role of extinction memory (2015) · cites this paper as [59]
In the citing paper
“Brain circuitry at the core of threat discrimination learning includes areas within the amygdala and medial prefrontal cortex (mPFC)1.”
From Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood (2019) · cites this paper as [1]
In the citing paper
“During threat extinction training, the CS is presented without the aversive outcome, which results in reduced amygdala responses to the CS over time3, with the mPFC playing a critical role1,4,5.”
From Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood (2019) · cites this paper as [1]
In the citing paper
“During threat extinction training, the CS is presented without the aversive outcome, which results in reduced amygdala responses to the CS over time3, with the mPFC playing a critical role1,4,5.”
From Multimodal evidence for delayed threat extinction learning in adolescence and young adulthood (2019) · cites this paper as [1]
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Citations
Cites
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., Sanislow, C., & Wang, P. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091379 · Cited by 7,067
Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135058100 · Cited by 6,358
Psychophysiological and Modulatory Interactions in Neuroimaging
Friston, K. J., Buechel, C., Fink, G. R., Morris, J., Rolls, E., & Dolan, R. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0291 · Cited by 3,097
Emotional processing in anterior cingulate and medial prefrontal cortex
Etkin, A., Egner, T., & Kalisch, R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.004 · Cited by 3,059 · cited 1×
“Numerous reviews on molecular mechanisms of extinction, clinical relevance, and inhibition circuitry within the amygdala have recently appeared (Pape & Paré 2010, Herry et al 2010, Sotres-Bayon & Quirk 2010, Myers et al 2011, Etkin et al 2011).”
BackgroundTrauma and Posttraumatic Stress Disorder in the Community: The 1996 Detroit Area Survey of Trauma
Breslau, N., Kessler, R. C., Chilcoat, H. D., Schultz, L. R., Davis, G. C., & Andreski, P. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.7.626 · Cited by 2,407
Whalen, P. J., Rauch, S. L., Etcoff, N. L., McInerney, S. C., Lee, M. B., & Jenike, M. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00411.1998 · Cited by 2,205
Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network
Greicius, M. D., Supekar, K., Menon, V., & Dougherty, R. F. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn059 · Cited by 2,175
Integrative activity of the brain
Konorski, J. (1967) · University of Chicago Press eBooks · Cited by 2,043
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980
Cited by
Sorted by citations
Items 201–300 of 1,002
Morena, M., Berardi, A., Colucci, P., Palmery, M., Trezza, V., Hill, M. N., & Campolongo, P. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.305 · Cited by 96
Extinction in multiple virtual reality contexts diminishes fear reinstatement in humans
Dunsmoor, J. E., Ahs, F., Zielinski, D. J., & LaBar, K. S. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.02.010 · Cited by 93
Laboratory models of post-traumatic stress disorder: The elusive bridge to translation
Dunsmoor, J. E., Cisler, J. M., Fonzo, G. A., Creech, S. K., & Nemeroff, C. B. (2022) · Neuron · doi:10.1016/j.neuron.2022.03.001 · Cited by 101
Post-Traumatic Stress Disorder: The Relationship Between the Fear Response and Chronic Stress
Maeng, L. Y., & Milad, M. R. (2017) · Chronic Stress · doi:10.1177/2470547017713297 · Cited by 92
Self-citationKattoor, J., Gizewski, E. R., Kotsis, V., Benson, S., Gramsch, C., Theysohn, N., Maderwald, S., Forsting, M., Schedlowski, M., & Elsenbruch, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0051149 · Cited by 97
Theta oscillations synchronize human medial prefrontal cortex and amygdala during fear learning
Chen, S., Tan, Z., Xia, W., Gomes, C. A., Zhang, X., Zhou, W., Liang, S., Axmacher, N., & Wang, L. (2021) · Science Advances · doi:10.1126/sciadv.abf4198 · Cited by 95
Human ventromedial prefrontal cortex and the positive affective processing of safety signals
Harrison, B. J., Fullana, M. A., Via, E., Soriano‐Mas, C., Vervliet, B., Martínez‐Zalacaín, I., Pujol, J., Davey, C. G., Kircher, T. T. J., Straube, B., et al. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.02.080 · Cited by 91
Acute stress impairs the retrieval of extinction memory in humans
Raio, C. M., Brignoni-Perez, E., Goldman, R., & Phelps, E. A. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.01.015 · Cited by 90
Borgomaneri, S., Battaglia, S., Sciamanna, G., Tortora, F., & Laricchiuta, D. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.04.036 · Cited by 90
Labus, J. S., Hubbard, C. S., Bueller, J. A., Ebrat, B., Tillisch, K., Chen, M., Stains, J., Dukes, G. E., Kelleher, D. L., Naliboff, B. D., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.016 · Cited by 90
Lonsdorf, T. B., Haaker, J., & Kalisch, R. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu018 · Cited by 89
Amygdala subnuclei resting-state functional connectivity sex and estrogen differences
Engman, J., Linnman, C., Van Dijk, K. R. A., & Milad, M. R. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.09.012 · Cited by 89
Self-citationPrefrontal oscillations during recall of conditioned and extinguished fear in humans
Mueller, E. M., Panitz, C., Hermann, C., & Pizzagalli, D. A. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3427-13.2014 · Cited by 89
Haaker, J., Maren, S., Andreatta, M., Merz, C. J., Richter, J., Richter, S. H., Drexler, S. M., Lange, M. D., Jüngling, K., Nees, F., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.020 · Cited by 92
Neural Mechanisms and Psychology of Psychedelic Ego Dissolution
Stoliker, D., Egan, G. F., Friston, K. J., & Razi, A. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000508 · Cited by 96
An integrative review of attention biases and their contribution to treatment for anxiety disorders
Barry, T. J., Vervliet, B., & Hermans, D. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00968 · Cited by 88
Amygdala-Prefrontal Synchronization Underlies Resistance to Extinction of Aversive Memories
Livneh, U., & Paz, R. (2012) · Neuron · doi:10.1016/j.neuron.2012.05.016 · Cited by 87
Neuromodulatory treatments for post-traumatic stress disorder (PTSD)
Koek, R. J., Roach, J., Athanasiou, N., Wout‐Frank, M. V. ‘., & Philip, N. S. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.01.004 · Cited by 89
Extinction of conditioned fear is better learned and recalled in the morning than in the evening
Pace-Schott, E. F., Spencer, R. M. C., Vijayakumar, S., Ahmed, N. A. K., Verga, P. W., Orr, S. P., Pitman, R. K., & Milad, M. R. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.07.027 · Cited by 87
Self-citationGoode, T. D., & Maren, S. (2014) · ILAR Journal · doi:10.1093/ilar/ilu008 · Cited by 93
Garcia, N. M., Walker, R. S. W., & Zoellner, L. A. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2018.06.005 · Cited by 92
Feldman, R., Vengrober, A., & Ebstein, R. P. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.6 · Cited by 87
Baker, K., Loughman, A., Spencer, S. J., & Reichelt, A. C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.10.014 · Cited by 92
Shvil, E., Rusch, H. L., Sullivan, G. M., & Neria, Y. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0358-3 · Cited by 86
Waters, A. M., & Craske, M. G. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.09.008 · Cited by 92
Human fear conditioning: From neuroscience to the clinic
Fullana, M. A., Dunsmoor, J. E., Schruers, K. R. J., Savage, H. S., Bach, D. R., & Harrison, B. J. (2019) · Behaviour Research and Therapy · doi:10.1016/j.brat.2019.103528 · Cited by 96
The Psychedelic Future of Post-Traumatic Stress Disorder Treatment
Zaretsky, T. G., Jagodnik, K. M., Barsic, R., Antonio, J. H., Bonanno, P. A., MacLeod, C., Pierce, C., Carney, H., Morrison, M. T., Saylor, C. F., et al. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22666231027111147 · Cited by 92
The role of progesterone in memory: An overview of three decades
Barros, L. A., Tufik, S. B., & Andersen, M. L. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.015 · Cited by 91
Wout‐Frank, M. V. ‘., Longo, S. M., Reddy, M. K., Philip, N. S., Bowker, M., & Greenberg, B. D. (2017) · Brain and Behavior · doi:10.1002/brb3.681 · Cited by 91
Neural Underpinnings of Cortisol Effects on Fear Extinction
Merz, C. J., Hamacher‐Dang, T. C., Stark, R. M., Wolf, O. T., & Hermann, A. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.227 · Cited by 87
Marin, M., Hammoud, M. Z., Klumpp, H., Simon, N. M., & Milad, M. R. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.4833 · Cited by 88
Self-citationSex differences in fear responses: Neural circuits
Bauer, E. P. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109298 · Cited by 92
Increased Prepulse Inhibition and Sensitization of the Startle Reflex in Autistic Children
Madsen, G. F., Bilenberg, N., Cantio, C., & Oranje, B. (2013) · Autism Research · doi:10.1002/aur.1337 · Cited by 83
Liang, Z., Watson, G. D. R., Alloway, K. D., Lee, G., Neuberger, T., & Zhang, N. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.05.036 · Cited by 87
Fear Extinction Retention: Is It What We Think It Is?
Lonsdorf, T. B., Merz, C. J., & Fullana, M. A. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.02.011 · Cited by 83
Gold, A. L., Shechner, T., Farber, M. J., Spiro, C. N., Leibenluft, E., Pine, D. S., & Britton, J. C. (2016) · Depression and Anxiety · doi:10.1002/da.22470 · Cited by 82
Consolidative mechanisms of emotional processing in REM sleep and PTSD
Murkar, A., & Koninck, J. D. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.03.001 · Cited by 87
Caballero, A. C., Thomases, D. R., Flores-Barrera, E., Cass, D. K., & Tseng, K. Y. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3216-4 · Cited by 86
Anticipatory Threat Responding: Associations With Anxiety, Development, and Brain Structure
Abend, R., Gold, A. L., Britton, J. C., Michalska, K. J., Shechner, T., Sachs, J. F., Winkler, A. M., Leibenluft, E., Averbeck, B. B., & Pine, D. S. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.11.006 · Cited by 83
Gass, J. T., Trantham‐Davidson, H., Kassab, A. S., Glen, W. B., Olive, M. F., & Chandler, L. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5616-12.2014 · Cited by 83
Hwang, S., Nolan, Z. T., White, S. F., Williams, W. C., Sinclair, S., & Blair, J. (2016) · Psychological Medicine · doi:10.1017/s0033291716000118 · Cited by 86
Neurocognitive Development of Motivated Behavior: Dynamic Changes across Childhood and Adolescence
Gee, D. G., Bath, K. G., Johnson, C. M., Meyer, H. C., Murty, V. P., van den Bos, W., & Hartley, C. A. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1674-18.2018 · Cited by 86
Inhibition of estradiol synthesis impairs fear extinction in male ratsPreprint
Graham, B. M., & Milad, M. R. (2014) · Learning & Memory · doi:10.1101/lm.034926.114 · Cited by 81
Self-citationSensitive periods in affective development: nonlinear maturation of fear learning
Hartley, C. A., & Lee, F. S. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.179 · Cited by 80
Extinction during memory reconsolidation blocks recovery of fear in adolescents
Johnson, D. C., & Casey, B. J. (2015) · Scientific Reports · doi:10.1038/srep08863 · Cited by 80
Annual Research Review: Developmental pathways linking early behavioral inhibition to later anxiety
Fox, N. A., Zeytinoglu, S., Valadez, E. A., Buzzell, G. A., Morales, S., & Henderson, H. A. (2022) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13702 · Cited by 87
Understanding anxiety symptoms as aberrant defensive responding along the threat imminence continuum
Abend, R. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105305 · Cited by 82
Myskiw, J. D. C., Furini, C. R. G., Benetti, F., & Izquierdo, I. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400423111 · Cited by 81
Sleep Deprivation Disrupts Recall of Conditioned Fear Extinction
Straus, L. D., Acheson, D. T., Risbrough, V. B., & Drummond, S. P. A. (2016) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.05.004 · Cited by 80
Roberts, A. C., & Clarke, H. F. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902288116 · Cited by 79
Stress attenuates the flexible updating of aversive value
Raio, C. M., Hartley, C. A., Orederu, T. A., Li, J., & Phelps, E. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1702565114 · Cited by 84
Glucocorticoid-induced enhancement of extinction—from animal models to clinical trials
de Quervain, D. J. ‐., Wolf, O. T., & Roozendaal, B. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5116-0 · Cited by 82
Self-monitoring of social facial expressions in the primate amygdala and cingulate cortex
Livneh, U., Resnik, J., Shohat, Y., & Paz, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207662109 · Cited by 80
Neural correlates of pupil dilation during human fear learning
Leuchs, L., Schneider, M., Czisch, M., & Spoormaker, V. I. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.11.072 · Cited by 78
Forcadell, E., Torrents‐Rodas, D., Vervliet, B., Leiva, D., Tortella‐Feliu, M., & Fullana, M. A. (2017) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2017.09.001 · Cited by 88
Extinction of Conditioned Fear in Adolescents and Adults: A Human fMRI Study
Ganella, D. E., Drummond, K. D., Ganella, E. P., Whittle, S., & Kim, J. H. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00647 · Cited by 82
Context-dependent extinction of threat memories: influences of healthy aging
Battaglia, S., Garofalo, S., & di Pellegrino, G. (2018) · Scientific Reports · doi:10.1038/s41598-018-31000-9 · Cited by 77
Newborn amygdala connectivity and early emerging fear
Thomas, E., Buß, C., Rasmussen, J. M., Entringer, S., Ramirez, J. S. B., Marr, M. C., Rudolph, M. D., Gilmore, J. H., Styner, M. A., Wadhwa, P. D., et al. (2018) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2018.12.002 · Cited by 77
Fear conditioning and extinction in obsessive-compulsive disorder: A systematic review
Cooper, S. E., & Dunsmoor, J. E. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.07.026 · Cited by 83
Finding translation in stress research
Hariri, A. R., & Holmes, A. (2015) · Nature Neuroscience · doi:10.1038/nn.4111 · Cited by 83
Park, J., Wood, J. T., Bondi, C. O., Arco, A. D., & Moghaddam, B. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4250-15.2016 · Cited by 78
Messina, I., Sambin, M., Beschoner, P., & Viviani, R. (2016) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-016-0440-5 · Cited by 83
Cannabinoid interventions for PTSD: Where to next?
Ney, L. J., Matthews, A. J., Bruno, R., & Felmingham, K. L. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.03.017 · Cited by 77
Fear as a translational mechanism in the psychopathology of anorexia nervosa
Murray, S. B., Strober, M., Craske, M. G., Griffiths, S., Levinson, C. A., & Strigo, I. A. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.10.013 · Cited by 75
Medial prefrontal pathways for the contextual regulation of extinguished fear in humans
Åhs, F., Kragel, P. A., Zielinski, D. J., Brady, R., & LaBar, K. S. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.07.051 · Cited by 75
Galatzer-Levy, I. R., Bonanno, G. A., Bush, D. E. A., & LeDoux, J. E. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00055 · Cited by 75
De Bellis, M. D., Hooper, S. R., Chen, S. D., Provenzale, J. M., Boyd, B. D., Glessner, C. E., MacFall, J. R., Payne, M. E., Rybczynski, R., & Woolley, D. P. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000942 · Cited by 75
Blandina, P., Provensi, G., Passani, M. B., Capasso, C., & Supuran, C. T. (2020) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2020.1766455 · Cited by 76
Dopamine: from prediction error to psychotherapy
Papalini, S., Beckers, T., & Vervliet, B. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0814-x · Cited by 75
Beyond the Medial Regions of Prefrontal Cortex in the Regulation of Fear and Anxiety
Shiba, Y., Santangelo, A., & Roberts, A. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2016.00012 · Cited by 76
Modulation of fear extinction processes using transcranial electrical stimulation
Abend, R., Jalon, I., Gurevitch, G., Sar-El, R., Shechner, T., Pine, D. S., Hendler, T., & Bar‐Haim, Y. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.197 · Cited by 80
Marin, M.-F., Song, H., VanElzakker, M. B., Staples-Bradley, L. K., Linnman, C., Pace-Schott, E. F., Lasko, N. B., Shin, L. M., & Milad, M. R. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14111460 · Cited by 74
Self-citationLange, I., Goossens, L., Michielse, S., Bakker, J. M., Vervliet, B., Marcelis, M. C., Wichers, M., van Os, J., van Amelsvoort, T., & Schruers, K. R. J. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0467-8 · Cited by 74
Kim, H.-S., Cho, H.-Y., Augustine, G. J., & Han, J. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.276 · Cited by 83
Göttlich, M., Krämer, U. M., Kordon, A., Hohagen, F., & Zurowski, B. (2015) · Biological Psychology · doi:10.1016/j.biopsycho.2015.09.004 · Cited by 73
Initial and sustained brain responses to contextual conditioned anxiety in humans
Andreatta, M., Glotzbach-Schoon, E., Mühlberger, A., Schulz, S. M., Wiemer, J., & Pauli, P. (2015) · Cortex · doi:10.1016/j.cortex.2014.09.014 · Cited by 73
Appetitive vs. Aversive conditioning in humans
Andreatta, M., & Pauli, P. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00128 · Cited by 73
Menezes, J., Alves, N., Borges, S., Roehrs, R., Myskiw, J. D. C., Furini, C. R. G., Izquierdo, I., & Mello‐Carpes, P. B. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1502295112 · Cited by 76
Telch, M. J., Bruchey, A. K., Rosenfield, D., Cobb, A. R., Smits, J. A. J., Pahl, S. A., & Gonzalez-Lima, F. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.13101407 · Cited by 77
Hermann, A., Stark, R. M., Milad, M. R., & Merz, C. J. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw047 · Cited by 81
Self-citationSocioeconomic influences on brain function: implications for health
Muscatell, K. A. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13862 · Cited by 77
Cohodes, E. M., Kribakaran, S., Odriozola, P., Bakirci, S., McCauley, S., Hodges, H. R., Sisk, L. M., Zacharek, S. J., & Gee, D. G. (2021) · Developmental Psychobiology · doi:10.1002/dev.22158 · Cited by 85
Medial prefrontal cortex stimulation modulates the processing of conditioned fear
Guhn, A., Dresler, T., Andreatta, M., Müller, L. D., Hahn, T., Tupak, S. V., Polak, T. T., Deckert, J., & Herrmann, M. J. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00044 · Cited by 76
Common neurocircuitry mediating drug and fear relapse in preclinical models
Goode, T. D., & Maren, S. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5024-3 · Cited by 77
A Tradeoff in the Neural Code across Regions and Species
Pryluk, R., Kfir, Y., Gelbard-Sagiv, H., Fried, I., & Paz, R. (2019) · Cell · doi:10.1016/j.cell.2018.12.032 · Cited by 74
Prefrontal single-unit firing associated with deficient extinction in mice
Fitzgerald, P. J., Whittle, N., Flynn, S., Graybeal, C., Pinard, C. R., Gunduz‐Cinar, O., Kravitz, A. V., Singewald, N., & Holmes, A. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.11.002 · Cited by 76
Flexibility in the face of fear: hippocampal–prefrontal regulation of fear and avoidance
Moscarello, J. M., & Maren, S. (2017) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2017.09.010 · Cited by 77
Peverill, M., Sheridan, M. A., Busso, D. S., & McLaughlin, K. A. (2019) · Child Maltreatment · doi:10.1177/1077559519852676 · Cited by 70
Fear learning and memory across adolescent development
Pattwell, S. S., Lee, F. S., & Casey, B. J. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.01.016 · Cited by 74
From Extinction Learning to Anxiety Treatment: Mind the Gap
Carpenter, J. K., Pinaire, M., & Hofmann, S. G. (2019) · Brain Sciences · doi:10.3390/brainsci9070164 · Cited by 77
Zhou, F., Geng, Y., Xin, F., Li, J., Feng, P., Liu, C., Zhao, W., Feng, T., Guastella, A. J., Ebstein, R. P., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.07.007 · Cited by 70
Wen, Z., Raio, C. M., Pace-Schott, E. F., Lazar, S. W., LeDoux, J. E., Phelps, E. A., & Milad, M. R. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204066119 · Cited by 69
Self-citationWang, Q., Jin, J., & Maren, S. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.04.002 · Cited by 75
Abdallah, C. G., Wrocklage, K. M., Averill, C. L., Akiki, T. J., Schweinsburg, B. C., Roy, A. M., Martini, B. A., Southwick, S. M., Krystal, J. H., & Scott, J. C. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.12 · Cited by 69
A window of vulnerability: Impaired fear extinction in adolescence
Baker, K., Den, M. L., Graham, B. M., & Richardson, R. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.10.009 · Cited by 73
Cowan, C. S. M., Stylianakis, A. A., & Richardson, R. (2019) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2019.100627 · Cited by 71
McGuire, J. F., Orr, S. P., Essoe, J. K.-Y., McCracken, J. T., Storch, E. A., & Piacentini, J. (2016) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2016.1199276 · Cited by 67
“Although there has been considerable research on threat conditioning and extinction in adults [28,32], there has been a relatively small, but increasing, amount of research in youth.”
Gramsch, C., Kattoor, J., Icenhour, A., Forsting, M., Schedlowski, M., Gizewski, E. R., & Elsenbruch, S. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.08.003 · Cited by 75
Cortisol modifies extinction learning of recently acquired fear in men
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Improving mental health by training the suppression of unwanted thoughts
Mamat, Z., & Anderson, M. C. (2023) · Science Advances · doi:10.1126/sciadv.adh5292 · Cited by 75
Metadata
- Authors
- Milad, M. R., & Quirk, G. J.
- Affiliations
- Harvard University (US)
- University of Puerto Rico, Medical Sciences Campus (PR)
- Venue
- Annual Review of Psychology
- Publisher
- Annual Reviews
- Published
- 2012-01-10
- Volume
- 63
- Issue
- 1
- Pages
- 129-151
- ISSN
- 0066-4308 (ISSN-L)
- 1545-2085
- PMC
- PMC4942586
- OpenAlex
- W2160253364
- Semantic Scholar
- 3e1b47b5a0d8ab9823c918aa6f6ce64eb2eba033
- Cited by
- 1,466
- References
- 228
- Citations by year
- 2026: 105 · 2025: 96 · 2024: 80 · 2023: 96 · 2022: 110 · 2021: 114 · 2020: 131 · 2019: 120 · 2018: 109 · 2017: 102 · 2016: 100 · 2015: 105 · 2014: 88 · 2013: 73 · 2012: 36
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5p50mh086400-05, 5r01mh081975-05)
- National Institute of Mental Health (P-50-MH-086400, K01-MH08036, R01-MH081975, R01MH058883, K01MH080346)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- fear extinction, fear conditioning, neural circuits, translational neuroscience, psychobiology, anxiety disorders
- MeSH terms
- Brain, Conditioning, Psychological, Extinction, Psychological, Fear, Humans, Magnetic Resonance Imaging, Neurosciences
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