Presleep protein ingestion does not compromise the muscle protein synthetic response to protein ingested the following morning

Wall, Benjamin T.; Burd, Nicholas A.; Franssen, Rinske; Gorissen, Stefan H. M.; Snijders, Tim; Senden, Joan M.; Gijsen, Annemie P.; van Loon, Luc J. C.

doi:10.1152/ajpendo.00325.2016

Cited by 34Muscle metabolism and nutritionMuscle Physiology and DisordersSports Performance and Training

Presleep protein ingestion does not compromise the muscle protein synthetic response to protein ingested the following morning

Wall, Benjamin T., Burd, Nicholas A., Franssen, Rinske, Gorissen, Stefan H. M., Snijders, Tim, Senden, Joan M., Gijsen, Annemie P., van Loon, Luc J. C.·2016·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00325.2016

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Abstract

Protein ingestion before sleep augments postexercise muscle protein synthesis during overnight recovery. It is unknown whether postexercise and presleep protein consumption modulates postprandial protein handling and myofibrillar protein synthetic responses the following morning. Sixteen healthy young (24 ± 1 yr) men performed unilateral resistance-type exercise (contralateral leg acting as a resting control) at 2000. Participants ingested 20 g of protein immediately after exercise plus 60 g of protein presleep (PRO group; n = 8) or equivalent boluses of carbohydrate (CON; n = 8). The subsequent morning participants received primed, continuous infusions of l-[ ring-2H5]phenylalanine and l-[1-13C]leucine combined with ingestion of 20 g intrinsically l-[1-13C]phenylalanine- and l-[1-13C]leucine-labeled protein to assess postprandial protein handling and myofibrillar protein synthesis in the rested and exercised leg in CON and PRO. Exercise increased postabsorptive myofibrillar protein synthesis rates the subsequent day ( P < 0.001), with no differences between CON and PRO. Protein ingested in the morning increased myofibrillar protein synthesis in both the exercised and rested leg ( P < 0.01), with no differences between treatments. Myofibrillar protein bound l-[1-13C]phenylalanine enrichments were greater in the exercised (0.016 ± 0.002 and 0.015 ± 0.002 MPE in CON and PRO, respectively) vs. rested (0.010 ± 0.002 and 0.009 ± 0.002 MPE in CON and PRO, respectively) leg ( P < 0.05), with no differences between treatments ( P > 0.05). The additive effects of resistance-type exercise and protein ingestion on myofibrillar protein synthesis persist for more than 12 h after exercise and are not modulated by protein consumption during acute postexercise recovery. This work provides evidence of an extended window of opportunity where presleep protein supplementation can be an effective nutrient timing strategy to optimize skeletal muscle reconditioning.

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“For example, brown rice (eg, a grain) is low in lysine but high in methionine, whereas pea (eg, a pulse) is low in methionine and high in lysine [7,77].”
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“Therefore, the extended window of opportunity as a result of the additive effects of resistance exercise training and protein ingestion on MPS makes the pre-sleep casein protein supplementation an effective nutrient timing strategy to optimize muscle conditioning and recovery [151] with no need to add extra leucine [152].”
From The 4R’s Framework of Nutritional Strategies for Post-Exercise Recovery: A Review with Emphasis on New Generation of Carbohydrates (2020) · cites this paper as [151]

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Authors: Wall, B. T., Burd, N. A., Franssen, R., Gorissen, S. H. M., Snijders, T., Senden, J. M., Gijsen, A. P., & van Loon, L. J. C.
Affiliations: Maastricht University Medical Centre (NL)
Department of Human Biology and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
ORCID: Wall, Benjamin T.
Burd, Nicholas A.
Gorissen, Stefan H. M.
Snijders, Tim
Senden, Joan M.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2016-12-01
Volume: 311
Issue: 6
Pages: E964-E973
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00325.2016
OpenAlex: W2535245181
Cited by: 34
References: 42
Citations by year: 2025: 2 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 11 · 2018: 3 · 2016: 1
FWCI: 3.43
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion)
Open Research Exeter (University of Exeter) (acceptedVersion)
Research Bank (Australian Catholic University) (submittedVersion)
Figshare (submittedVersion)
VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Research Publications (Maastricht University) (submittedVersion)
Funders: N/A
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords: protein synthesis, myofibrillar protein synthesis, resistance training, nutrient timing, phenylalanine, leucine
MeSH terms: Adult, Carbon Isotopes, Deuterium, Dietary Carbohydrates, Dietary Proteins, Humans, Leucine, Male, Muscle Proteins, Phenylalanine, Sleep, Protein Biosynthesis, Exercise, Muscle, Skeletal, Resistance Training, Young Adult, Healthy Volunteers

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Presleep protein ingestion does not compromise the muscle protein synthetic response to protein ingested the following morning

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