The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Transfer function analysis of the circulation: unique insights into cardiovascular regulation
Abstract
We have demonstrated previously that transfer function analysis can be used to precisely characterize the respiratory sinus arrhythmia (RSA) in normal humans. To further investigate the role of the autonomic nervous system in RSA and to understand the complex links between respiratory activity and arterial pressure, we determined the transfer functions between respiration, heart rate (HR), and phasic, systolic, diastolic, and pulse arterial pressures in 14 healthy subjects during 6-min periods in which the respiratory rate was controlled in a predetermined but erratic fashion. Pharmacological autonomic blockade with atropine, propranolol, and both, in combination with changes in posture, was used to characterize the sympathetic and vagal contributions to these relationships, as well as to dissect the direct mechanical links between respiration and arterial pressure from the effects of the RSA on arterial pressure. We found that 1) the pure sympathetic (standing + atropine) HR response is characterized by markedly reduced magnitude at frequencies greater than 0.1 Hz and a phase delay, whereas pure vagal (supine + propranolol) modulation of HR is characterized by higher magnitude at all frequencies and no phase delay; 2) both the mechanical links between respiration and arterial pressure and the RSA contribute significantly to the effects of respiration on arterial pressure; 3) the RSA contribution to arterial pressure fluctuations is significant for vagal but not for sympathetic modulation of HR; 4) the mechanical effects of respiration on arterial pressure are related to the negative rate of change of instantaneous lung volume; 5) the mechanical effects have a higher magnitude during systole than during diastole; and 6) the mechanical effects are larger in teh standing than the supine position. Most of these findings can be explained by a simple model of circulatory control based on previously published experimental transfer functions from our laboratory.
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Cites
Respiratory sinus arrhythmia in humans: how breathing pattern modulates heart rate
Hirsch, J. A., & Bishop, B. (1981) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1981.241.4.h620 · Cited by 1,105
Respiratory sinus arrhythmia: noninvasive measure of parasympathetic cardiac control
Katona, P. G., & Jih, F. (1975) · Journal of Applied Physiology · doi:10.1152/jappl.1975.39.5.801 · Cited by 792
Respiratory sinus arrhythmia: a frequency dependent phenomenon
Angelone, A., & Coulter, N. A. (1964) · Journal of Applied Physiology · doi:10.1152/jappl.1964.19.3.479 · Cited by 441
Respiratory sinus arrhythmia in the denervated human heart
Bernardi, L., Keller, F., Sanders, M., Reddy, P. S., Griffith, B., Meno, F., & Pinsky, M. R. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.67.4.1447 · Cited by 272
Phase relationship between normal human respiration and baroreflex responsiveness.
Eckberg, D. L., Kifle, Y. T., & Roberts, V. L. (1980) · The Journal of Physiology · doi:10.1113/jphysiol.1980.sp013338 · Cited by 233
Cited by
Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
Malik, M., Bigger, J. T., Camm, A. J., Kleiger, R. E., Malliani, A., Moss, A. J., & Schwartz, P. J. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014868 · Cited by 15,289
Heart rate variability: origins, methods, and interpretive caveats
BERNTSON, G. G., THOMAS BIGGER, J., ECKBERG, D. L., GROSSMAN, P., KAUFMANN, P. G., MALIK, M., NAGARAJA, H. N., PORGES, S. W., SAUL, J. P., STONE, P. H., et al. (1997) · Psychophysiology · doi:10.1111/j.1469-8986.1997.tb02140.x · Cited by 3,962
Self-citationSympathovagal Balance: A Critical Appraisal
Eckberg, D. L. (1997) · Circulation · doi:10.1161/01.cir.96.9.3224 · Cited by 1,087
Reyes del Paso, G. A., Langewitz, W., Mulder, L. J. M., van Roon, A., & Duschek, S. (2013) · Psychophysiology · doi:10.1111/psyp.12027 · Cited by 954
Parati, G., Saul, J. P., Di Rienzo, M., & Mancia, G. (1995) · Hypertension · doi:10.1161/01.hyp.25.6.1276 · Cited by 849
Self-citationHow accurate is pulse rate variability as an estimate of heart rate variability?
Schäfer, A., & Vagedes, J. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.03.119 · Cited by 661
The human sympathetic nervous system: its relevance in hypertension and heart failure
Parati, G., & Esler, M. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs041 · Cited by 538
Zhong, X., Hilton, H. J., Gates, G. J., Jelic, S., Stern, Y., Bartels, M. N., DeMeersman, R. E., & Basner, R. C. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00620.2004 · Cited by 468
Heart Rate Turbulence: Standards of Measurement, Physiological Interpretation, and Clinical Use
Bauer, A., Malik, M., Schmidt, G., Barthel, P., Bonnemeier, H., Cygankiewicz, I., Guzik, P., Lombardi, F., Müller, A., Oto, A., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.07.041 · Cited by 462
Quintana, D. S., Alvares, G. A., & Heathers, J. A. J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.73 · Cited by 420
Neural influences on cardiovascular variability: possibilities and pitfalls.
Malpas, S. C. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2002.282.1.h6 · Cited by 408
Eckberg, D. L. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.037192 · Cited by 431
Hayano, J., Yasuma, F., Okada, A., Mukai, S., & Fujinami, T. (1996) · Circulation · doi:10.1161/01.cir.94.4.842 · Cited by 332
Parati, G., Mancia, G., Rienzo, M. D., & Castiglioni, P. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00446.2006 · Cited by 325
Beauchaine, T. P., Katkin, E. S., Strassberg, Z., & Snarr, J. (2001) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.110.4.610 · Cited by 288
Taylor, J. A., Myers, C. W., Halliwill, J. R., Seidel, H., & Eckberg, D. L. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.6.h2804 · Cited by 249
Anxiety, antisocial behavior, and heart rate regulation in adolescent males
Mezzacappa, E., Tremblay, R. E., Kindlon, D., Saul, J. P., Arseneault, L., Seguin, J., Pihl, R. O., & Earls, F. (1997) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1997.tb01531.x · Cited by 223
Self-citationStewart, J. M. (2000) · Pediatric Research · doi:10.1203/00006450-200008000-00016 · Cited by 198
Respiratory sinus arrhythmia, cardiac vagal control, and daily activity.
Grossman, P., Wilhelm, F. H., & Spoerle, M. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00825.2003 · Cited by 197
Relative Timing Of Inspiration And Expiration Affects Respiratory Sinus Arrhythmia
Strauss‐Blasche, G., Moser, M., Voica, M., McLeod, D., Klammer, N., & Marktl, W. (2000) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2000.03306.x · Cited by 149
Respiratory sinus arrhythmia as a predictor of outcome in major depressive disorder
Rottenberg, J., Wilhelm, F. H., Gross, J. J., & Gotlib, I. H. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00406-2 · Cited by 118
Hostility, gender, and cardiac autonomic control
Sloan, R. P., Bagiella, E., Shapiro, P. A., Kuhl, J. P., Chernikhova, D., Berg, J., & Myers, M. M. (2001) · Psychosomatic Medicine · doi:10.1097/00006842-200105000-00012 · Cited by 107
Bruchfeld, A., Goldstein, R. S., Chavan, S., Patel, N. B., Rosas‐Ballina, M., Kohn, N., Qureshi, A. R., & Tracey, K. J. (2010) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02226.x · Cited by 99
Sympathetic control of short-term heart rate variability and its pharmacological modulation.
Elghozi, J., & Julien, C. (2007) · Fundamental & Clinical Pharmacology · doi:10.1111/j.1472-8206.2007.00502.x · Cited by 97
Psychophysiological Effects of Breathing Instructions for Stress Management
Conrad, A., Müller, A., Doberenz, S., Kim, S., Meuret, A. E., Wollburg, E., & Roth, W. T. (2007) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-007-9034-x · Cited by 94
Bertram, D., Barrès, C., Cuisinaud, G., & Julien, C. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.251by.x · Cited by 90
Sin, P. Y. W., Galletly, D. C., & Tzeng, Y. C. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00036.2010 · Cited by 81
Stewart, J. M., Munoz, J., & Weldon, A. (2002) · Circulation · doi:10.1161/01.cir.0000040999.00692.f3 · Cited by 71
Cardiac autonomic control and the effects of age, race, and sex: The CARDIA study
Sloan, R. P., Huang, M.-H., McCreath, H., Sidney, S., Liu, K., Dale Williams, O., & Seeman, T. (2008) · Autonomic Neuroscience · doi:10.1016/j.autneu.2008.01.006 · Cited by 65
Wilhelm, F. H., Grossman, P., & Coyle, M. A. (2004) · Instrument Society of America · doi:10.5451/unibas-ep9419 · Cited by 62
Complex demodulation of cardiorespiratory dynamics preceding vasovagal syncope
Lipsitz, L. A., Hayano, J., Sakata, S., Okada, A., & Morin, R. J. (1998) · Circulation · doi:10.1161/01.cir.98.10.977 · Cited by 61
Effects of exercise training on arterial-cardiac baroreflex function in POTS
Galbreath, M. M., Shibata, S., VanGundy, T. B., Okazaki, K., Fu, Q., & Levine, B. D. (2011) · Clinical Autonomic Research · doi:10.1007/s10286-010-0091-5 · Cited by 54
Gerlach, A. L., Spellmeyer, G., Vögele, C., Huster, R., Stevens, S., Hetzel, G., & Deckert, J. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000203284.53066.4b · Cited by 53
Bosch, N. M., Riese, H., Ormel, J., Verhulst, F., & Oldehinkel, A. J. (2009) · Biological Psychology · doi:10.1016/j.biopsycho.2009.01.005 · Cited by 44
Conrad, A., Wilhelm, F. H., Roth, W. T., Spiegel, D., & Taylor, C. B. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2007.08.003 · Cited by 41
Gentili, C., Valenza, G., Nardelli, M., Lanatà, A., Bertschy, G., Weiner, L., Mauri, M., Scilingo, E. P., & Pietrini, P. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.11.008 · Cited by 32
Lopes, T. C., Beda, A., Granja-Filho, P. C. N., Jandre, F. C., & Giannella-Neto, A. (2011) · Physiological Measurement · doi:10.1088/0967-3334/32/9/003 · Cited by 14
Metadata
- Authors
- Saul, J. P., Berger, R. D., Albrecht, P., Stein, S. P., Chen, M. H., & Cohen, R. J.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 1991-10-01
- Volume
- 261
- Issue
- 4
- Pages
- H1231-H1245
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2125634053
- Cited by
- 729
- References
- 5
- FWCI
- 7.82
- Type
- journal article
- Language
- en
- Open access
- closed
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