How accurate is pulse rate variability as an estimate of heart rate variability?
Abstract
Background The usefulness of heart rate variability (HRV) as a clinical research and diagnostic tool has been verified in numerous studies. The gold standard technique comprises analyzing time series of RR intervals from an electrocardiographic signal. However, some authors have used pulse cycle intervals instead of RR intervals, as they can be determined from a pulse wave (e.g. a photoplethysmographic) signal. This option is often called pulse rate variability (PRV), and utilizing it could expand the serviceability of pulse oximeters or simplify ambulatory monitoring of HRV.Methods We review studies investigating the accuracy of PRV as an estimate of HRV, regardless of the underlying technology (photoplethysmography, continuous blood pressure monitoring or Finapresi, impedance plethysmography).Results/conclusions Results speak in favor of sufficient accuracy when subjects are at rest, although many studies suggest that short-term variability is somewhat overestimated by PRV, which reflects coupling effects between respiration and the cardiovascular system. Physical activity and some mental stressors seem to impair the agreement of PRV and HRV, often to an inacceptable extent. Findings regarding the position of the sensor or the detection algorithm are not conclusive. Generally, quantitative conclusions are impeded by the fact that results of different studies are mostly incommensurable due to diverse experimental settings and/or methods of analysis.
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Photoplethysmography can be used during rest but not during stress.
“A comparative review of photoplethysmography against ECG stated that photoplethysmography can be used during rest but not during stress (Schafer and Vagedes, 2013).”
From Heart Rate Variability and Cardiac Vagal Tone in Psychophysiological Research – Recommendations for Experiment Planning, Data Analysis, and Data Reporting (2017) · cites this paper as Schafer and Vagedes, 2013
Pulse rate variability cannot yet be considered a surrogate of heart rate variability during exercise or stress.
“However, it cannot yet be considered to be a surrogate during exercise or stress [17], [129].”
From Wearable Photoplethysmography for Cardiovascular Monitoring (2022) · cites this paper as [17]
Reviews have concluded that pulse rate variability is a good surrogate of heart rate variability for certain applications at rest.
“Nonetheless, reviews have concluded that PRV is a good surrogate of HRV for certain applications at rest.”
From Wearable Photoplethysmography for Cardiovascular Monitoring (2022) · cites this paper as [17]
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Poincaré plot analysis for pulse interval extracted from non-contact photoplethysmography
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Laborde, S., Mosley, E., & Thayer, J. F. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00213 · Cited by 2,336 · see citing works
“A comparative review of photoplethysmography against ECG stated that photoplethysmography can be used during rest but not during stress (Schafer and Vagedes, 2013).”
BackgroundShaffer, F., McCraty, R., & Zerr, C. L. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01040 · Cited by 1,866 · see citing works
Photoplethysmography Revisited: From Contact to Noncontact, From Point to Imaging
Sun, Y., & Thakor, N. V. (2015) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2015.2476337 · Cited by 567 · see citing works
“Regardless of how successful these systems has been in acquiring physiological parameters, e.g., HR/respiration rate (RR) and HRV, a number of key questions still remain regarding IPPG systems that utilize ambient light as the illumination source, such as the practical issue of how variations in ambient light intensit…”
InfluentialWearable Sleep Technology in Clinical and Research Settings
DE ZAMBOTTI, M., CELLINI, N., GOLDSTONE, A., COLRAIN, I. M., & BAKER, F. C. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001947 · Cited by 564 · see citing works
Digital biomarkers for Alzheimer’s disease: the mobile/wearable devices opportunity
Kourtis, L. C., Regele, O. B., Wright, J. M., & Jones, G. B. (2019) · npj Digital Medicine · doi:10.1038/s41746-019-0084-2 · Cited by 476 · see citing works
Photoplethysmogram Analysis and Applications: An Integrative Review
Park, J., Seok, H. S., Kim, S.-S., & Shin, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.808451 · Cited by 450 · see citing works
“However, it was reported that PRV could be differ from HRV under dynamic conditions, such as exercise or mental stress conditions (Schäfer and Vagedes, 2013; Mejía-Mejía et al., 2020).”
BackgroundAssociation between heart rate variability and fluctuations in resting-state functional connectivity
Chang, C., Metzger, C. D., Glover, G. H., Duyn, J. H., Heinze, H., & Walter, M. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.11.038 · Cited by 353 · see citing works
A Review of Psychophysiological Measures to Assess Cognitive States in Real-World Driving
Lohani, M., Payne, B. R., & Strayer, D. L. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00057 · Cited by 347 · see citing works
“Such methodological differences between PPG and ECG can explain why PPG and ECG findings are comparable during rest, but are not comparable during stress, for example (Schäfer and Vagedes, 2013).”
Plews, D. J., Scott, B., Altini, M., Wood, M., Kilding, A. E., & Laursen, P. B. (2017) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.2016-0668 · Cited by 323 · see citing works
“When we contrast other studies that have compared HRV values measured through PPG against ECG it is currently difficult, as differences between experimental settings and/or methods of analysis are apparent.(19) Furthermore, many of these studies have been carried out using a variety of “clip-on” devices (e.”
Resultde Zambotti, M., Goldstein, C. A., Cook, J. D., Menghini, L., Altini, M., Cheng, P., & Robillard, R. (2023) · SLEEP · doi:10.1093/sleep/zsad325 · Cited by 262 · see citing works
A Critical Review of Ultra-Short-Term Heart Rate Variability Norms Research
Shaffer, F., Meehan, Z. M., & Zerr, C. L. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.594880 · Cited by 264 · see citing works
“The ECG method is more accurate than PPG during paced breathing (Jan et al., 2019) and when increased sympathetic tone results in vasoconstriction in monitored fingers (Giardino et al., 2002; Schafer and Vagedes, 2013).”
MethodWearable Photoplethysmography for Cardiovascular Monitoring
Charlton, P. H., Kyriacou, P. A., Mant, J., Marozas, V., Chowienczyk, P., & Alastruey, J. (2022) · Proceedings of the IEEE · doi:10.1109/jproc.2022.3149785 · Cited by 250 · see citing works
Can Wearable Devices Accurately Measure Heart Rate Variability? A Systematic Review
Georgiou, K., Larentzakis, A. V., Khamis, N. N., Alsuhaibani, G. I., Alaska, Y. A., & Giallafos, E. J. (2018) · Folia Medica · doi:10.2478/folmed-2018-0012 · Cited by 244 · see citing works
Physiological and Behavioral Responses Reveal 9-Month-Old Infants’ Sensitivity to Pleasant Touch
Fairhurst, M. T., Löken, L. S., & Großmann, T. (2014) · Psychological Science · doi:10.1177/0956797614527114 · Cited by 242 · see citing works
“In the absence of excessive movement, the signal from pulse oximetry is comparable to that from the ECG (Schäfer & Vagedes, 2013).”
MethodQuigley, K. S., Gianaros, P. J., Norman, G. J., Jennings, J. R., Berntson, G. G., & de Geus, E. J. C. (2024) · Psychophysiology · doi:10.1111/psyp.14604 · Cited by 253 · see citing works
Kim, K. B., & Baek, H. J. (2023) · Electronics · doi:10.3390/electronics12132923 · Cited by 238 · see citing works
“Pulse rate variability (PRV) measurement is a commonly used parameter in addition to pulse rate measurement [51,52].”
The 2023 wearable photoplethysmography roadmap
Charlton, P. H., Allen, J., Bailón, R., Baker, S., Behar, J. A., Chen, F., Clifford, G. D., Clifton, D. A., Davies, H. J., Ding, C., et al. (2023) · Physiological Measurement · doi:10.1088/1361-6579/acead2 · Cited by 210 · see citing works
Dobbs, W. C., Fedewa, M. V., MacDonald, H. V., Holmes, C. J., Cicone, Z. S., Plews, D. J., & Esco, M. R. (2019) · Sports Medicine · doi:10.1007/s40279-019-01061-5 · Cited by 194 · see citing works
Kinnunen, H., Rantanen, A., Kenttä, T., & Koskimäki, H. (2020) · Physiological Measurement · doi:10.1088/1361-6579/ab840a · Cited by 184 · see citing works
“The main challenge is sensitivity to motion, and studies have illustrated more noisy estimates of HRV with PPG than those measured with ECG, particularly in high-frequency parameters (Schäfer and Vagedes 2013).”
BackgroundDüking, P., Andreas Hotho, A., Holmberg, H., Fuss, F. K., & Sperlich, B. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00071 · Cited by 184 · see citing works
“However, it should be noted that such devices measure variations in pulse rate rather than HRV directly (Schäfer and Vagedes, 2013).”
BackgroundUBFC-Phys: A Multimodal Database For Psychophysiological Studies of Social Stress
Sabour, R. M., Benezeth, Y., Oliveira, P. D., Chappé, J., & Yang, F. (2021) · IEEE Transactions on Affective Computing · doi:10.1109/taffc.2021.3056960 · Cited by 176 · see citing works
“Several studies focused on the analogy between PRV and HRV, leading to the result that both are linked to the ANS activity, and that the same features can be extracted from the two signals [5].”
BackgroundMejía‐Mejía, E., Budidha, K., Abay, T. Y., May, J. M., & Kyriacou, P. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00779 · Cited by 172 · see citing works
“Nonetheless, although PRV has been treated as a valid surrogate of HRV, their relationship is not entirely clear, and PRV has been found to significantly differ from HRV under certain circumstances (Schäfer and Vagedes, 2013).”
BackgroundTeixeira, E., Fonseca, H., Diniz‐Sousa, F., Veras, L., Boppre, G., de Oliveira, J. J. F., Pinto, D., Alves, A. J., Barbosa, A., Mendes, R., et al. (2021) · Geriatrics · doi:10.3390/geriatrics6020038 · Cited by 172 · see citing works
“Most evidence supports PRV as a valid surrogate of HRV in healthy and younger adults at rest [67].”
BackgroundCan PPG be used for HRV analysis?
Pinheiro, N. C., Couceiro, R., Henriques, J. M. O., Muehlsteff, J., Quintal, I., Gonçalves, L. M. M., & Carvalho, P. (2016) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2016.7591347 · Cited by 163 · see citing works
“A major challenge for using PPG in HRV analysis is its sensitivity to motion artifacts [3, 5].”
BackgroundMethodInfluentialReitz, S. C., Kluetsch, R. C., Niedtfeld, I., Knorz, T., Lis, S., Paret, C., Kirsch, P., Meyer‐Lindenberg, A., Treede, R., Baumgärtner, U., et al. (2015) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.114.153379 · Cited by 160 · see citing works
Li, K., Cardoso, C., Moctezuma-Ramirez, A., Elgalad, A., & Perin, E. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20247146 · Cited by 160 · see citing works
Mejía‐Mejía, E., May, J. M., Torres, R., & Kyriacou, P. A. (2020) · Physiological Measurement · doi:10.1088/1361-6579/ab998c · Cited by 160 · see citing works
“…points (Constant et al 1999, Giardino et al 2002, Rauh et al 2003, Lu and Yang 2009, Charlot et al 2009, Khandoker et al 2011, Wong et al 2012, Schäfer and Vagedes 2013, Dehkordi et al 2013aa, Pellegrino et al 2014, Parasnis et al 2015, Chen et al 2015, Peng et al 2015, Shin 2016, Pinheiro…”
BackgroundResultInfluentialStressing the accuracy: Wrist‐worn wearable sensor validation over different conditions
Menghini, L., Gianfranchi, E., Cellini, N., Patron, E., Tagliabue, M., & Sarlo, M. (2019) · Psychophysiology · doi:10.1111/psyp.13441 · Cited by 157 · see citing works
Heart rate variability and self-control—A meta-analysis
Zahn, D., Adams, J., Krohn, J., Wenzel, M., Mann, C. G., Gomille, L. K., Jacobi-Scherbening, V., & Kubiak, T. (2015) · Biological Psychology · doi:10.1016/j.biopsycho.2015.12.007 · Cited by 155 · see citing works
Mulcahy, J. S., Larsson, D. E. O., Garfinkel, S. N., & Critchley, H. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.116072 · Cited by 152 · see citing works
Extraction of Heart Rate Variability from Smartphone Photoplethysmograms
Peng, R., Zhou, X.-L., Lin, W.-H., & Zhang, Y. (2015) · Computational and Mathematical Methods in Medicine · doi:10.1155/2015/516826 · Cited by 152 · see citing works
“Agreements were ranked as good (BAR < 10%), moderate (10% ≤ BAR < 20%), or insufficient (BAR ≥ 20%) [28].”
BackgroundHidden Signals—The History and Methods of Heart Rate Variability
Ernst, G. (2017) · Frontiers in Public Health · doi:10.3389/fpubh.2017.00265 · Cited by 156 · see citing works
“Smart-watches: a potential challenger to the implantable loop recorder? Europace (2016) 18(6):791–3.”
BackgroundMethodInfluentialQuandt, B. M., Scherer, L. J., Boesel, L. F., Wolf, M., Bona, G. L., & Rossi, R. M. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201400463 · Cited by 148 · see citing works
Evaluation of wearable consumer heart rate monitors based on photopletysmography
Parak, J., & Korhonen, I. (2014) · 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society · doi:10.1109/embc.2014.6944419 · Cited by 148 · see citing works
Mansi, S. A., Barone, G. B., Forzano, C., Pigliautile, I., Ferrara, M., Pisello, A. L., & Arnesano, M. (2021) · Measurement · doi:10.1016/j.measurement.2021.109872 · Cited by 146 · see citing works
Chow, H.-W., & Yang, C.-C. (2020) · JMIR mHealth and uHealth · doi:10.2196/14707 · Cited by 140 · see citing works
Touch increases autonomic coupling between romantic partners
Chatel-Goldman, J., Congedo, M., Jutten, C., & Schwartz, J.-L. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00095 · Cited by 135 · see citing works
“It has been demonstrated that PRV is an accurate estimator of HRV when applied to healthy subjects at rest (Schäfer and Vagedes, 2013), a requirement that is satisfied in our study.”
BackgroundMethodDirect and indirect effects of age on interoceptive accuracy and awareness across the adult lifespan
Murphy, J., Geary, H., Millgate, E., Catmur, C., & Bird, G. (2018) · Psychonomic Bulletin & Review · doi:10.3758/s13423-017-1339-z · Cited by 137 · see citing works
Photoplethysmography signal processing and synthesis
Mejía-Mejía, E., Allen, J., Budidha, K., El-Hajj, C., Kyriacou, P. A., & Charlton, P. H. (2022) · Photoplethysmography · doi:10.1016/b978-0-12-823374-0.00015-3 · Cited by 138 · see citing works
A Survey on Wearable Sensors for Mental Health Monitoring
Gomes, N., Pato, M. P. M., Lourenço, A., & Datia, N. (2023) · Sensors · doi:10.3390/s23031330 · Cited by 147 · see citing works
Wang, R., Mu, L., Bao, Y., Lin, H., Ji, T., Shi, Y., Zhu, J., & Wu, W. (2020) · Advanced Materials · doi:10.1002/adma.202002878 · Cited by 126 · see citing works
Autonomic dysfunction in acute ischemic stroke: An underexplored therapeutic area?
Raedt, S. D., Vos, A. D., & Keyser, J. D. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.12.007 · Cited by 125 · see citing works
“Alternatively, interbeat intervals (ibi) might be calculated from non-invasive blood pressure monitoring using plethysmography (eg NEXFIN HD®, WatchPAT®, POLAR®, Finometer®, CNAPTM®, Finapres®), which is called pulse rate variability [15–17].”
MethodGuo, C. C., Sturm, V. E., Zhou, J. H., Gennatas, E. D., Trujillo, A. J., Hua, A. Y., Crawford, R. K., Stables, L. A., Kramer, J. H., Rankin, K. P., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1509184113 · Cited by 125 · see citing works
“Although few studies have assessed clinical and older populations, pulse rate variability offers an accurate estimate of HRV at rest in healthy adults (73).”
BackgroundMethodGraphene coated textile based highly flexible and washable sports bra for human health monitoring
Shathi, M. A., Chen, M., Khoso, N. A., Rahman, M. T., & Bhattacharjee, B. (2020) · Materials & Design · doi:10.1016/j.matdes.2020.108792 · Cited by 126 · see citing works
A deep transfer learning approach for wearable sleep stage classification with photoplethysmography
Radha, M., Fonseca, P. M., Moreau, A., Ross, M., Cerny, A., Anderer, P., Long, X., & Aarts, R. M. (2021) · npj Digital Medicine · doi:10.1038/s41746-021-00510-8 · Cited by 122 · see citing works
“As mentioned before, these can be caused by, for example, the known discrepancy in hemodynamic or cardiovascular physiology between HRV data measured from ECG and PPG signals and for assessing autonomic responses 39,40 , and a higher sensitivity of wrist-worn PPG to motion artefacts than ECG 41 .”
BackgroundCardiovascular assessment by imaging photoplethysmography – a review
Zaunseder, S., Trumpp, A., Wedekind, D., & Malberg, H. (2018) · Biomedizinische Technik/Biomedical Engineering · doi:10.1515/bmt-2017-0119 · Cited by 121 · see citing works
Heart rate variability in bipolar disorder: A systematic review and meta-analysis
Faurholt‐Jepsen, M., Kessing, L. V., & Munkholm, K. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.007 · Cited by 120 · see citing works
Hettiarachchi, I. T., Hanoun, S., Nahavandi, D., & Nahavandi, S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217288 · Cited by 121 · see citing works
A Practical Guide to Resonance Frequency Assessment for Heart Rate Variability Biofeedback
Shaffer, F., & Meehan, Z. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.570400 · Cited by 133 · see citing works
Scardulla, F., Cosoli, G., Spinsante, S., Poli, A., Iadarola, G., Pernice, R., Busacca, A., Pasta, S., Scalise, L., & D’Acquisto, L. (2023) · Measurement · doi:10.1016/j.measurement.2023.113150 · Cited by 120 · see citing works
Estepp, J. R., Blackford, E. B., & Meier, C. M. (2014) · Conference proceedings/Conference proceedings - IEEE International Conference on Systems, Man, and Cybernetics · doi:10.1109/smc.2014.6974121 · Cited by 115 · see citing works
“The difference between the ECG/IBI- and PPG/IPI-derived cardiac cycle rates served as a best-case baseline comparison to calculating heart rate from ECG using rates based on individual cycle identification to create IXI time series, as cardiac cycle rates derived from ECG and PPG should not a priori assumed to be equa…”
BackgroundMethodUmair, M., Chalabianloo, N., Sas, C., & Ersoy, C. (2021) · IEEE Access · doi:10.1109/access.2021.3052131 · Cited by 116 · see citing works
“Investigation of photoplethysmography (PPG) accuracy as an estimate of HRV and the possibility of employing it as a surrogate of electrocardiography (ECG) have been the topics of many experimental and survey studies [19], [21], [55], [56].”
BackgroundWearable Photoplethysmography for Cardiovascular Monitoring.
Charlton, P. H., Kyriacou, P. A., Mant, J., Marozas, V., Chowienczyk, P., & Alastruey, J. (2022) · KTUePubl (Repository of Kaunas University of Technology) · doi:10.17863/cam.81148 · Cited by 113 · see citing works
A literature review of heart rate variability in depressive and bipolar disorders
Bassett, D. L. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415622689 · Cited by 110 · see citing works
“HRV is also highly sensitive to respiration, including respiratory rate, respiratory depth and respiratory sinus arrhythmia (RSA) (Heathers, 2014; Perakakis et al., 2009; Quintana and Heathers, 2014; Schafer and Vagedes, 2013; Shaffer et al., 2014).”
BackgroundAn Open Framework for Remote-PPG Methods and Their Assessment
Boccignone, G., Conte, D., Cuculo, V., D’Amelio, A., Grossi, G., & Lanzarotti, R. (2020) · IEEE Access · doi:10.1109/access.2020.3040936 · Cited by 109 · see citing works
“This fact is witnessed by a number of publications reporting universally good agreement between PRV and HRV, even if this concordance may be susceptible of many variables such as experimental conditions and postures (see [48] and the citations thereof).”
BackgroundMethodZhang, Y., Liu, B., & Zhang, Z. (2015) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2015.05.006 · Cited by 109 · see citing works
Cho, Y., Julier, S., & Bianchi‐Berthouze, N. (2018) · JMIR Mental Health · doi:10.2196/10140 · Cited by 103 · see citing works
“In the case of PPG, the term Pulse Rate Variability (PRV) or PPG HRV are often used to clarify the different type (even if related) of event measured [26,29–31] with respect to ECG.”
MethodA Review of Deep Learning-Based Contactless Heart Rate Measurement Methods
Ni, A., Azarang, A., & Kehtarnavaz, N. (2021) · Italian National Conference on Sensors · doi:10.3390/s21113719 · Cited by 84 · see citing works
“Contact ECG and PPG [19] 2012 Accuracy of pulse rate variability (PRV) as an estimate of HRV”
BackgroundMethodRemote Healthcare for Elderly People Using Wearables: A Review
Olmedo-Aguirre, J. O., Reyes-Campos, J., Alor‐Hernández, G., Machorro-Cano, I., Rodríguez-Mazahua, L., & Sánchez-Cervantes, J. L. (2022) · Biosensors · doi:10.3390/bios12020073 · Cited by 104 · see citing works
Donker, M. H., van Gog, T., & Mainhard, T. (2018) · Frontline Learning Research · doi:10.14786/flr.v6i3.372 · Cited by 105 · see citing works
“Seven electrodes were placed on the teacher’s chest to minimize the influence of movement (Porges & Byrne, 1992) and to get a more reliable estimate of heart rate than with wristbands based on pulse plethysmography (PPG; Rohrbaugh, 2016; Schäfer & Vagedes, 2013).”
MethodEvaluation of the beat-to-beat detection accuracy of PulseOn wearable optical heart rate monitor
Parák, J., Tarniceriu, A., Renevey, P., Bertschi, M., Delgado-Gonzalo, R., & Korhonen, I. (2015) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2015.7320273 · Cited by 100 · see citing works
“However, it has been suggested that pulse rate variability (PRV) from PPG is sufficiently accurate only for healthy (and mostly younger) subjects at rest, HRV estimated from PRV tends to be overestimated against ECG based values, and motion artifacts lead to inaccurate PPGbased beat detection [15].”
BackgroundSammito, S., Thielmann, B., Klußmann, A., Deußen, A., Braumann, K.-M., & Böckelmann, I. (2024) · Journal of Occupational Medicine and Toxicology · doi:10.1186/s12995-024-00414-9 · Cited by 107 · see citing works
“A systematic review [24] showed that only in young, healthy subjects under resting conditions are there acceptable correspondences between NN intervals and pulse NN intervals, but HRV parameters based on the pulse NN intervals are sometimes significantly increased (e.g. in HF).”
BackgroundYe, Y., Cheng, Y., He, W., Hou, M., & Zhang, Z. (2016) · IEEE Sensors Journal · doi:10.1109/jsen.2016.2597265 · Cited by 94 · see citing works
“Since rhythms of PPG signals correspond to heartbeats, estimated HR from PPG signals can be achieved by detecting instantaneous fundamental frequency of PPG signals [6], [7].”
MethodAn Ultra Low Power Personalizable Wrist Worn ECG Monitor Integrated With IoT Infrastructure
Beach, C., Krachunov, S., Pope, J., Fafoutis, X., Piechocki, R. J., Craddock, I., & Casson, A. J. (2018) · IEEE Access · doi:10.1109/access.2018.2864675 · Cited by 91 · see citing works
“For PPG signals, we note that variability measures are typically termed Pulse Rate Variability (PRV) [60] to account for the minor differences between HRV and PRV as the pulse transit time down the arm varies with posture and blood pressure.”
BackgroundMethodInfluentialPapini, G. B., Fonseca, P., van Gilst, M. M., Bergmans, J. W. M., Vullings, R., & Overeem, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-69935-7 · Cited by 90 · see citing works
Hohenschurz‐Schmidt, D., Calcagnini, G., Dipasquale, O., Jackson, J. B., Medina, S., O’Daly, O., O’Muircheartaigh, J., Rubio, A. D. L., Williams, S., McMahon, S. B., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00147 · Cited by 91 · see citing works
“Sufficient accuracy under stationary conditions has also been confirmed by a review on the topic (Schäfer and Vagedes, 2013).”
BackgroundMethodSarkar, P., & Etemad, A. (2021) · Proceedings of the AAAI Conference on Artificial Intelligence · doi:10.1609/aaai.v35i1.16126 · Cited by 88 · see citing works
Zhang, X., Kou, W., Chang, E., Gao, H., Fan, Y., & Xu, Y. L. (2018) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2018.10.010 · Cited by 86 · see citing works
Sensors Capabilities, Performance, and Use of Consumer Sleep Technology
de Zambotti, M., Cellini, N., Menghini, L., Sarlo, M., & Baker, F. C. (2020) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2019.11.003 · Cited by 88 · see citing works
Comparison of Polar M600 Optical Heart Rate and ECG Heart Rate during Exercise
HORTON, J. F., STERGIOU, P., FUNG, T. S., & KATZ, L. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001388 · Cited by 79 · see citing works
Михайлович, У. А. (2018) · Biomedical Physics & Engineering Express · doi:10.1088/2057-1976/aabd09 · Cited by 78 · see citing works
“…from electrocardiogram or assessed by pulse rate (number of pulse waves transmitted from heart to periphery per unit of time, usually highly correlated with heart rate (Schäfer and Vagedes 2013))which can be computed from indirect measurements such as photoplethysmogram (PPG, (Allen 2007).”
BackgroundMethodInfluentialWeiler, D. T., Villajuan, S. O., Edkins, L., Cleary, S., & Saleem, J. J. (2017) · Proceedings of the Human Factors and Ergonomics Society Annual Meeting · doi:10.1177/1541931213601804 · Cited by 87 · see citing works
“In fact, the usefulness of heart rate variability as a clinical diagnostic and research tool has previously been verified (Schafer & Vagedes, 2013).”
MethodInfluentialMayo, O., Lavidor, M., & Gordon, I. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113391 · Cited by 73 · see citing works
Shilton, A. L., Laycock, R., & Crewther, S. G. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00567 · Cited by 76 · see citing works
Ding, Z., Li, W., Wang, W., Zhao, Z., Zhu, Y., Hou, B., Zhu, L., Chen, M., & Che, L. (2024) · Advanced Science · doi:10.1002/advs.202309407 · Cited by 76 · see citing works
A scoping review of heart rate variability in sport and exercise psychology
Mosley, E., & Laborde, S. (2022) · International Review of Sport and Exercise Psychology · doi:10.1080/1750984x.2022.2092884 · Cited by 78 · see citing works
Vescio, B., Salsone, M., Gambardella, A., & Quattrone, A. (2018) · Sensors · doi:10.3390/s18030844 · Cited by 73 · see citing works
Bruehl, S. P., Olsen, R. B., Tronstad, C., Sevre, K., Burns, J. W., Schirmer, H., Nielsen, C. S., Stubhaug, A., & Rosseland, L. A. (2017) · Pain · doi:10.1097/j.pain.0000000000001070 · Cited by 73 · see citing works
“intervals reflected in both measures, R-R intervals can be estimated using pulse wave data obtained by plethysmography in the course of acquiring continuous noninvasive beat-to-beat BPs.(50) A systematic review showed that most investigations demonstrated good agreement between HRV estimates based on”
BackgroundMethodInfluentialEffects of slow breathing rate on blood pressure and heart rate variabilities
Chang, Q., Liu, R., & Shen, Z. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.08.121 · Cited by 66 · see citing works
Scardulla, F., D’Acquisto, L., Colombarini, R., Hu, S., Pasta, S., & Bellavia, D. (2020) · Sensors · doi:10.3390/s20185052 · Cited by 72 · see citing works
Valenza, G., Passamonti, L., Duggento, A., Toschi, N., & Barbieri, R. (2020) · Journal of The Royal Society Interface · doi:10.1098/rsif.2019.0878 · Cited by 72 · see citing works
Shilaih, M., Clerck, V. D., Falco, L., Kübler, F., & Leeners, B. (2017) · Scientific Reports · doi:10.1038/s41598-017-01433-9 · Cited by 69 · see citing works
Analysis of a Pulse Rate Variability Measurement Using a Smartphone Camera
Bánhalmi, A., Borbás, J., Fidrich, M., Bilicki, V., Gingl, Z., & Rudas, L. (2018) · Journal of Healthcare Engineering · doi:10.1155/2018/4038034 · Cited by 69 · see citing works
“PRV and HRV have good correlations, and it was con fi rmed by several previous publications [9 – 11].”
BackgroundResultSelf-Compassion and Psycho-Physiological Recovery From Recalled Sport Failure
Ceccarelli, L. A., Giuliano, R. J., Glazebrook, C. M., & Strachan, S. M. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01564 · Cited by 73 · see citing works
“It should also be noted that here we used photoplethysmography as a proxy for electrocardiogram activity, and although these two measures may diverge under conditions of acute stress (Schäfer and Vagedes, 2013), photoplethysmography has been demonstrated to reliably assess acute stress reactivity (Charlton et al.”
MethodAccuracy of heart rate variability estimated with reflective wrist-PPG in elderly vascular patients
Antink, C. H., Mai, Y., Peltokangas, M., Leonhardt, S. K., Oksala, N., & Vehkaoja, A. T. (2021) · Scientific Reports · doi:10.1038/s41598-021-87489-0 · Cited by 66 · see citing works
Iozzia, L., Cerina, L., & Mainardi, L. T. (2016) · Physiological Measurement · doi:10.1088/0967-3334/37/11/1934 · Cited by 66 · see citing works
“[23] on the accuracy of PRV as an estimate of HRV.”
BackgroundResultMember, I., Pernice, R., Javorka, M., Krohová, J., Czippelová, B., Turianiková, Z., Busacca, A., & Faes, L. (2019) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-019-01957-4 · Cited by 66 · see citing works
Quantitative detection of sleep apnea with wearable watch device
Hayano, J., Yamamoto, H., Nonaka, I., Komazawa, M., Itao, K., Ueda, N., 田中, 春., & Yuda, E. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237279 · Cited by 67 · see citing works
Jan, H.-Y., Chen, M.-F., Fu, T., Lin, W., Tsai, C.-L., & Lin, K. (2019) · Journal of Medical and Biological Engineering · doi:10.1007/s40846-019-00468-9 · Cited by 64 · see citing works
“We found that the PPGderived PR from either limb was an acceptable surrogate of ECG-derived HR, as reported in the literature [10, 11, 24, 33].”
BackgroundResultInfluentialReduction of Periodic Motion Artifacts in Photoplethysmography
Wijshoff, R. W. C. G. R., Mischi, M., & Aarts, R. M. (2016) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2016.2553060 · Cited by 65 · see citing works
“This may result from residual motion artifacts, or from physiological fluctuations in IBIs during walking caused by variations in pre-ejection time and pulse transit time [22].”
Shin, H. (2015) · Journal of Clinical Monitoring and Computing · doi:10.1007/s10877-015-9798-0 · Cited by 62 · see citing works
Lyu, Y., Luo, X., Zhou, J., Yu, C., Miao, C., Wang, T., Shi, Y., & Kameyama, K.-I. (2015) · CHI Conference on Human Factors in Computing Systems · doi:10.1145/2702123.2702399 · Cited by 60 · see citing works
“The ECG was measured using a SMOTE PSG device (Compumedics Ltd., Australia) at a sampling rate of 200Hz [24].”
BackgroundMethodKoenig, N., Seeck, A., Eckstein, J., Mainka, A., Huebner, T. A., Voss, A., & Weber, S. (2016) · Telemedicine Journal and e-Health · doi:10.1089/tmj.2015.0212 · Cited by 60 · see citing works
“In the studies reviewed by Scha¨fer and Vagedes, 10 correlation values of R ‡ 0.9 were achieved for all HRV parameters when comparing HRV analysis by plethysmography with ECG recordings.”
InfluentialThe accuracy of heartbeat detection using photoplethysmography technology in cardiac patients
Blok, S., Piek, M. A., Tulevski, I. I., Somsen, G. A., & Winter, M. M. (2021) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2021.06.009 · Cited by 59 · see citing works
Towards Photoplethysmography-Based Estimation of Instantaneous Heart Rate During Physical Activity
Jarchi, D., & Casson, A. J. (2017) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2017.2668763 · Cited by 58 · see citing works
“have shown that despite these minor differences PRV can be a useful measure of instantaneous heart rate [19]–[21], but it has not been possible to extract measures of instantaneous heart”
BackgroundPietilä, J., Mehrang, S., Tolonen, J., Helander, E. E., Jimison, H. B., Misha Pavel, C., & Korhonen, I. (2017) · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany · doi:10.1007/978-981-10-5122-7_37 · Cited by 59 · see citing works
Estimation of Mental Distress from Photoplethysmography
Zangróniz, R., Martínez‐Rodrigo, A., López, M. T., Pastor, J. M., & Fernández‐Caballero, A. (2018) · Applied Sciences · doi:10.3390/app8010069 · Cited by 58 · see citing works
“However, a high correlation between both metrics has been reported for subjects at rest [20].”
BackgroundTasmurzayev, N., Amangeldy, B., Imanbek, B., Baigarayeva, Z. E., Imankulov, T., Dikhanbayeva, G., Amangeldi, I., & Sharipova, S. (2025) · Italian National Conference on Sensors · doi:10.3390/s25175272 · Cited by 54 · see citing works
“…strategies address this by first applying timestamp normalization to a common reference clock, often using the ECG R-wave peaks as temporal anchors for resampling lower-frequency signals such as PPG or respiration to physiologically relevant intervals (e.g., RR-interval alignment) [41].”
Blackford, E. B., & Estepp, J. R. (2015) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.2083940 · Cited by 55 · see citing works
Weinschenk, S. W., Beise, R. D., & Lorenz, J. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-016-3401-3 · Cited by 56 · see citing works
“In accordance with other studies [for review, see (Schafer and Vagedes 2013)], HRV parameters reflecting long-term variability, such as mean-HR, SD2, and SDNN, agreed better than parameters reflecting the highly dynamic short-term changes of the heart rate (e.g., SD1, Power HF band, and RMSSD).”
BackgroundMethodResultInfluential
- Authors
- Schäfer, A., & Vagedes, J.
- Affiliations
- Academic Research in Complementary and Integrative Medicine (DE)
- University Children's Hospital Tübingen (DE)
- Corresponding author
- Vagedes, Jan
- ORCID
- Vagedes, Jan
- Venue
- International Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 166
- Issue
- 1
- Pages
- 15-29
- ISSN
- 0167-5273 (ISSN-L)
- OpenAlex
- W188715143
- Cited by
- 661
- References
- 114
- Citations by year
- 2026: 59 · 2025: 51 · 2024: 56 · 2023: 52 · 2022: 57 · 2021: 72 · 2020: 67 · 2019: 49 · 2018: 59 · 2017: 40 · 2016: 40 · 2015: 29 · 2014: 19 · 2013: 9 · 2012: 1
- FWCI
- 11.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- pulse rate variability, heart rate variability, photoplethysmography, pulse oximetry, RR interval, measurement accuracy, physical activity, psychological stress, sensor position, detection algorithm, ambulatory monitoring
- MeSH terms
- Electrocardiography, Heart Rate, Humans, Motor Activity, Pulse, Rest, Photoplethysmography
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