Short‐term sprint interval training increases insulin sensitivity in healthy adults but does not affect the thermogenic response to β‐adrenergic stimulation

Richards, Jennifer C.; Johnson, Tyler K.; Kuzma, Jessica N.; Lonac, Mark C.; Schweder, Melani M.; Voyles, Wyatt F.; Bell, Christopher

doi:10.1113/jphysiol.2010.189886

Cited by 187Cardiovascular and exercise physiologyPhysical Activity and HealthSports Performance and Training

Short‐term sprint interval training increases insulin sensitivity in healthy adults but does not affect the thermogenic response to β‐adrenergic stimulation

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Richards, Jennifer C., Johnson, Tyler K., Kuzma, Jessica N., Lonac, Mark C., Schweder, Melani M., Voyles, Wyatt F., Bell, Christopher·2010·The Journal of Physiology

DOI 10.1113/jphysiol.2010.189886PMC PMC2956910

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Abstract

Sprint interval training (SIT) and traditional endurance training elicit similar physiological adaptations. From the perspective of metabolic function, superior glucose regulation is a common characteristic of endurance‐trained adults. Accordingly, we have investigated the hypothesis that short‐term SIT will increase insulin sensitivity in sedentary/recreationally active humans. Thirty one healthy adults were randomly assigned to one of three conditions: (1) SIT (n= 12): six sessions of repeated (4–7) 30 s bouts of very high‐intensity cycle ergometer exercise over 14 days; (2) sedentary control (n= 10); (3) single‐bout SIT (n= 9): one session of 4 × 30 s cycle ergometer sprints. Insulin sensitivity was determined (hyperinsulinaemic euglycaemic clamp) prior to and 72 h following each intervention. Compared with baseline, and sedentary and single‐bout controls, SIT increased insulin sensitivity (glucose infusion rate: 6.3 ± 0.6 vs. 8.0 ± 0.8 mg kg−1 min−1; mean ±s.e.m.; P= 0.04). In a separate study, we investigated the effect of SIT on the thermogenic response to beta‐adrenergic receptor (β‐AR) stimulation, an important determinant of energy balance. Compared with baseline, and sedentary and single‐bout control groups, SIT did not affect resting energy expenditure (EE: ventilated hood technique; 6274 ± 226 vs. 6079 ± 297 kJ day−1; P= 0.51) or the thermogenic response to isoproterenol (6, 12 and 24 ng (kg fat‐free mass)−1 min−1: %ΔEE 11 ± 2, 14 ± 3, 23 ± 2 vs. 11 ± 1, 16 ± 2, 25 ± 3; P= 0.79). Combined data from both studies revealed no effect of SIT on fasted circulating concentrations of glucose, insulin, adiponectin, pigment epithelial‐derived factor, non‐esterified fatty acids or noradrenaline (all P > 0.05). Sixteen minutes of high‐intensity exercise over 14 days augments insulin sensitivity but does not affect the thermogenic response to β‐AR stimulation.

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High-intensity interval training has beneficial effects on insulin sensitivity.
“we have recently demonstrated the beneficial effects of HIT on insulin sensitivity (Babraj et al. 2009), a finding that has since been confirmed by others (Little et al. 2011;Richards et al. 2010;Whyte et al. 2010).”
From Towards the minimal amount of exercise for improving metabolic health: beneficial effects of reduced-exertion high-intensity interval training (2012) · cites this paper as Richards et al. 2010
The magnitude of the increase in insulin sensitivity in men following REHIT is comparable to responses to 2 weeks of classic HIT in recreationally active men and women and in obese men.
“The magnitude of this change is comparable with responses to 2 weeks of classic HIT in recreationally active men and women (Babraj et al. 2009;Richards et al. 2010) and in obese men (Whyte et al. 2010).”
From Towards the minimal amount of exercise for improving metabolic health: beneficial effects of reduced-exertion high-intensity interval training (2012) · cites this paper as Richards et al. 2010
A previous study did not observe gender differences in the improvements in insulin sensitivity in 12 recreationally active subjects after 2 weeks of classic HIT.
“This is in contrast to a previous study which did not observe gender differences in the improvements in insulin sensitivity in 12 recreationally active subjects after 2 weeks of classic HIT (Richards et al. 2010).”
From Towards the minimal amount of exercise for improving metabolic health: beneficial effects of reduced-exertion high-intensity interval training (2012) · cites this paper as Richards et al. 2010
This study extends previous literature showing beneficial effects of high-intensity interval training by showing that sprint number and duration can be substantially reduced whilst still maintaining positive effects.
“This study extends the previous literature showing the beneficial effects of HIT (Burgomaster et al. 2007;Babraj et al. 2009;Richards et al. 2010;Whyte et al. 2010;Rakobowchuk et al. 2008;Trilk et al. 2010) by showing that the sprint number and duration can be substantially reduced whilst still maintaining positive effects.”
From Towards the minimal amount of exercise for improving metabolic health: beneficial effects of reduced-exertion high-intensity interval training (2012) · cites this paper as Richards et al. 2010
SIT has been shown to improve insulin sensitivity.
“SIT has been shown to improve insulin sensitivity, based on hyperinsulinemic euglycemic clamps performed on sedentary and recreationally active individuals [2] as well as oral glucose tolerance tests (OGTTs) performed on young healthy [4] and overweight/obese [13] men.”
From Three minutes of all-out intermittent exercise per week increases skeletal muscle oxidative capacity and improves cardiometabolic health (2014) · cites this paper as [2]

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Sex differences in left ventricular function and β-receptor responsiveness following prolonged strenuous exercise
Scott, J. M., Esch, B. T. A., Haykowsky, M. J., Isserow, S., Koehle, M. S., Hughes, B., Zbogar, D., Bredin, S. S. D., McKenzie, D. C., & Warburton, D. E. R. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00641.2006 · Cited by 50 · see citing works
Dose-Response Effects of Free Fatty Acids on Glucose and Lipid Metabolism during Somatostatin Blockade of Growth Hormone and Insulin in Humans
Gormsen, L. C., Jessen, N., Gjedsted, J., Gjedde, S., Nørrelund, H., Lund, S. A., Christiansen, J. S., Nielsen, S., Schmitz, O., & Møller, N. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2659 · Cited by 48 · see citing works
Role of Sympathetic Neural Activation in Age- and Habitual Exercise-Related Differences in the Thermic Effect of Food
Jones, P. P., Pelt, R. E. V., Johnson, D. G., & Seals, D. R. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0101 · Cited by 43 · see citing works
Thermic effect of food and β-adrenergic thermogenic responsiveness in habitually exercising and sedentary healthy adult humans
Stob, N. R., Bell, C., van Baak, M. A., & Seals, D. R. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01434.2006 · Cited by 42 · see citing works
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Use of Acetylene Breathing to Determine Cardiac Output in Young and Older Adults
Bell, C., Monahan, K. D., Donato, A. J., Hunt, B. E., Seals, D. R., & Beck, K. C. (2003) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200301000-00010 · Cited by 39 · see citing works
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Home-based resistance training improves arterial stiffness in healthy premenopausal women
Okamoto, T., Masuhara, M., & Ikuta, K. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1102-x · Cited by 37 · see citing works
Exercise training reduces circulating adiponectin levels in patients with chronic heart failure
Berendoncks, A. M. V., Beckers, P. J., Hoymans, V. Y., Possemiers, N. M., Wuyts, F. L., Vrints, C. J., & Conraads, V. M. (2009) · Clinical Science · doi:10.1042/cs20090213 · Cited by 31 · see citing works
Acute lowering of circulating fatty acids improves insulin secretion in a subset of type 2 diabetes subjects
Qvigstad, E., Mostad, I. L., Bjerve, K. S., & Grill, V. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00114.2002 · Cited by 31 · see citing works
Increased insulin-stimulated Akt pSer473and cytosolic SHP2 protein abundance in human skeletal muscle following acute exercise and short-term training
Wadley, G. D., Konstantopoulos, N., Macaulay, L. S., Howlett, K. F., GARNHAM, A. P., Hargreaves, M., & Cameron‐Smith, D. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00821.2006 · Cited by 28 · see citing works
Effects of Exercise Training on Circulating High Molecular Weight Adiponectin and Adiponectin Oligomer Composition: a Randomized Controlled Trial
Ando, D., Hosaka, Y., Suzuki, K., & Yamagata, Z. (2009) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.2089 · Cited by 26 · see citing works
The effect of exercise training on β-adrenergic stimulation of fat metabolism in obese men
van Aggel-Leijssen, D., Saris, W. H. M., Homan, M., & van Baak, M. A. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801470 · Cited by 25 · see citing works
Thermogenic responsiveness to β‐adrenergic stimulation is augmented in exercising versus sedentary adults: role of oxidative stress
Bell, C., Stob, N. R., & Seals, D. R. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.098756 · Cited by 25 · see citing works
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Central Obesity and Insulin Resistance in the Cardiometabolic Syndrome: Pathways to Preclinical Cardiovascular Structure and Function
Klaus, J. R., Hurwitz, B. E., Llabre, M. M., Skyler, J. S., Goldberg, R. B., Marks, J. B., Bilsker, M., & Schneiderman, N. (2009) · Journal of the CardioMetabolic Syndrome · doi:10.1111/j.1559-4572.2008.00038.x · Cited by 24 · see citing works
Effects of diabetes family history and exercise training on the expression of adiponectin and leptin and their receptors
Moran, C. N., Barwell, N. D., Malkova, D., Cleland, S., McPhee, I., Packard, C. J., Zammit, V. A., & Gill, J. M. R. (2010) · Metabolism · doi:10.1016/j.metabol.2009.12.026 · Cited by 24 · see citing works
β-adrenergic receptor regulation of pigment epithelial-derived factor expression in rat retina
Lashbrook, B. L., & Steinle, J. J. (2005) · Autonomic Neuroscience · doi:10.1016/j.autneu.2005.05.006 · Cited by 23 · see citing works
Beta-adrenergic receptor regulation of growth factor protein levels in human choroidal endothelial cells
Steinle, J. J., Cappocia, F. C., & Jiang, Y. (2008) · Growth Factors · doi:10.1080/08977190802442070 · Cited by 22 · see citing works
THE EFFECTS OF CAFFEINE ON THE KINETICS OF O2UPTAKE, CO2PRODUCTION AND EXPIRATORY VENTILATION IN HUMANS DURING THE ON-TRANSIENT OF MODERATE AND HEAVY INTENSITY EXERCISE
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Non-esterified fatty acid levels and physical inactivity: the relative importance of low habitual energy expenditure and cardio-respiratory fitness
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Influence of adiposity on tonic sympathetic support of resting metabolism in healthy adults
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Influence of Ascorbic Acid on the Thermic Effect of Feeding in Overweight and Obese Adult Humans
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Thermogenic responsiveness to nonspecific β-adrenergic stimulation is not related to genetic variation in codon 16 of the β2-adrenergic receptor
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Self-citation
Increased thermogenic responsiveness to intravenous β‐adrenergic stimulation in habitually exercising humans is not related to skeletal muscle β2‐adrenergic receptor density
Stob, N. R., Seals, D. R., Jensen, J., van Baak, M. A., Steig, A. J., Lindstrom, R. C., Bikman, B. T., & Bell, C. (2007) · Experimental Physiology · doi:10.1113/expphysiol.2007.038174 · Cited by 7 · see citing works
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Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training
Roberts, C. K., Hevener, A. L., & Barnard, R. J. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110062 · Cited by 919 · see citing works
Effects of high-intensity interval training on cardiometabolic health: a systematic review and meta-analysis of intervention studies
Batacan, R. B., Duncan, M. J., Dalbo, V. J., Tucker, P. S., & Fenning, A. S. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2015-095841 · Cited by 799 · see citing works
Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes
Little, J. P., Gillen, J. B., Percival, M. E., Safdar, A., Tarnopolsky, M. A., Punthakee, Z., Jung, M. E., & Gibala, M. J. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00921.2011 · Cited by 787 · see citing works
The effects of high-intensity interval training on glucose regulation and insulin resistance: A meta-analysis
Jelleyman, C., Yates, T., O'Donovan, G., Gray, L. J., King, J. A., Khunti, K., & Davies, M. J. (2015) · Obesity Reviews · doi:10.1111/obr.12317 · Cited by 588 · see citing works
High-intensity interval running is perceived to be more enjoyable than moderate-intensity continuous exercise: Implications for exercise adherence
Bartlett, J. D., Close, G. L., MacLaren, D. P. M., Gregson, W., Drust, B., & Morton, J. P. (2011) · Journal of Sports Sciences · doi:10.1080/02640414.2010.545427 · Cited by 593 · see citing works
Is high-intensity interval training a time-efficient exercise strategy to improve health and fitness?
Gillen, J. B., & Gibala, M. J. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0187 · Cited by 506 · see citing works
The Potential for High-Intensity Interval Training to Reduce Cardiometabolic Disease Risk
Kessler, H. S., Sisson, S. B., & Short, K. R. (2012) · Sports Medicine · doi:10.2165/11630910-000000000-00000 · Cited by 461 · see citing works
The Role of Skeletal Muscle Glycogen Breakdown for Regulation of Insulin Sensitivity by Exercise
Jensen, J., Rustad, P. I., Kolnes, A. J., & Lai, Y.-C. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00112 · Cited by 412 · see citing works
Effects of Low-Volume High-Intensity Interval Training (HIT) on Fitness in Adults: A Meta-Analysis of Controlled and Non-Controlled Trials
Weston, M., Taylor, K. L., Batterham, A. M., & Hopkins, W. G. (2014) · Sports Medicine · doi:10.1007/s40279-014-0180-z · Cited by 407 · see citing works
Low-Volume Interval Training Improves Muscle Oxidative Capacity in Sedentary Adults
HOOD, M. S., LITTLE, J. P., TARNOPOLSKY, M. A., MYSLIK, F., & GIBALA, M. J. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3182199834 · Cited by 375 · see citing works
Twelve weeks of sprint interval training improves indices of cardiometabolic health similar to traditional endurance training despite a five-fold lower exercise volume and time commitment
Gillen, J. B., Martin, B. J., MacInnis, M. J., Skelly, L. E., Tarnopolsky, M. A., & Gibala, M. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154075 · Cited by 363 · see citing works
“It has previously been shown that SIT improves indices of glycemic control, as determined by the hyperinsulinemic-euglycemic clamp method [40], continuous glucose monitoring [17] and oral glucose tolerance tests [13,41].”
Method
Effects of sprint interval training on VO 2max and aerobic exercise performance: A systematic review and meta‐analysis
Sloth, M., Sloth, D., Overgaard, K., & Dalgas, U. (2013) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12092 · Cited by 314 · see citing works
Towards the minimal amount of exercise for improving metabolic health: beneficial effects of reduced-exertion high-intensity interval training
Metcalfe, R. S., Babraj, J. A., Fawkner, S. G., & Vollaard, N. B. J. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2254-z · Cited by 294 · see citing works
The effect of low-volume high-intensity interval training on body composition and cardiorespiratory fitness: a systematic review and meta-analysis.
Sultana, R. N., Sabag, A., Keating, S. E., & Johnson, N. A. (2019) · Sports Medicine · doi:10.1007/s40279-019-01167-w · Cited by 286 · see citing works
Exercise prescription for patients with type 2 diabetes and pre-diabetes: a position statement from Exercise and Sport Science Australia
Hordern, M. D., Dunstan, D. W., Prins, J. B., Baker, M. K., Singh, M. A. F., & Coombes, J. S. (2012) · Journal of Science and Medicine in Sport · doi:10.1016/j.jsams.2011.04.005 · Cited by 273 · see citing works
Evidence-Based Effects of High-Intensity Interval Training on Exercise Capacity and Health: A Review with Historical Perspective
ATAKAN, M. M., Li, Y., Koşar, Ş. N., Turnagöl, H. H., & Yan, X. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18137201 · Cited by 291 · see citing works
Interval training in the fed or fasted state improves body composition and muscle oxidative capacity in overweight women: Interval Training Improves Body Composition
Gillen, J. B., Percival, M. E., Ludzki, A., Tarnopolsky, M. A., & Gibala, M. J. (2013) · Obesity · doi:10.1002/oby.20379 · Cited by 222 · see citing works
Physiological and Health-Related Adaptations to Low-Volume Interval Training: Influences of Nutrition and Sex
Gibala, M. J., Gillen, J. B., & Percival, M. E. (2014) · Sports Medicine · doi:10.1007/s40279-014-0259-6 · Cited by 223 · see citing works
Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5
Shepherd, S. O., Cocks, M., Tipton, K. D., Ranasinghe, A. M., Barker, T. A., Burniston, J. G., Wagenmakers, A. J. M., & Shaw, C. S. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.240952 · Cited by 207 · see citing works
Matched work high-intensity interval and continuous running induce similar increases in PGC-1α mRNA, AMPK, p38, and p53 phosphorylation in human skeletal muscle
Bartlett, J. D., Joo, C.-H., Jeong, T.-S., Louhelainen, J., Cochran, A. J. R., Gibala, M. J., Gregson, W. A., Close, G. L., Drust, B., & Morton, J. P. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01040.2011 · Cited by 200 · see citing works
Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training
Roberts, C. K., Hevener, A. L., & Barnard, R. J. (2013) · Comprehensive physiology · doi:10.1002/j.2040-4603.2013.tb00484.x · Cited by 184 · see citing works
Three minutes of all-out intermittent exercise per week increases skeletal muscle oxidative capacity and improves cardiometabolic health
Gillen, J. B., Percival, M. E., Skelly, L. E., Martin, B. J., Tan, R. B., Tarnopolsky, M. A., & Gibala, M. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111489 · Cited by 181 · see citing works
Continuous Exercise but Not High Intensity Interval Training Improves Fat Distribution in Overweight Adults
Keating, S. E., Cayanan, E. A., O'Connor, H. T., Gerofi, J. A., Sainsbury, A., Caterson, I. D., & Johnson, N. A. (2014) · Journal of Obesity · doi:10.1155/2014/834865 · Cited by 171 · see citing works
The impact of brief high-intensity exercise on blood glucose levels
Adams, P. J. (2013) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s29222 · Cited by 173 · see citing works
Greater muscle protein synthesis and mitochondrial biogenesis in males compared with females during sprint interval training
Scalzo, R. L., Peltonen, G. L., Binns, S. E., Shankaran, M., Giordano, G. R., Hartley, D. A., Klochak, A. L., Lonac, M. C., Paris, H. L. R., Szallar, S. E., et al. (2014) · The FASEB Journal · doi:10.1096/fj.13-246595 · Cited by 167 · see citing works
Self-citation
Appetite, gut hormone and energy intake responses to low volume sprint interval and traditional endurance exercise
Deighton, K., Barry, R., Connon, C. E., & Stensel, D. J. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2535-1 · Cited by 165 · see citing works
HIGH-INTENSITY CIRCUIT TRAINING USING BODY WEIGHT
Klika, B., & Jordan, C. A. (2013) · ACSMʼs Health & Fitness Journal · doi:10.1249/fit.0b013e31828cb1e8 · Cited by 152 · see citing works
More efficient, perhaps, but at what price? Pleasure and enjoyment responses to high-intensity interval exercise in low-active women with obesity
Decker, E. S., & Ekkekakis, P. (2017) · Psychology of Sport and Exercise · doi:10.1016/j.psychsport.2016.09.005 · Cited by 139 · see citing works
Exercise and nutritional interventions for improving aging muscle health
Forbes, S. C., Little, J. P., & Candow, D. G. (2012) · Endocrine · doi:10.1007/s12020-012-9676-1 · Cited by 133 · see citing works
Enhanced insulin sensitivity in successful, long-term weight loss maintainers compared with matched controls with no weight loss history
Clamp, L. D., Hume, D. J., Lambert, E. V., & Kroff, J. (2017) · Nutrition and Diabetes · doi:10.1038/nutd.2017.31 · Cited by 123 · see citing works
Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males
Leggate, M., Carter, W. G., Evans, M. J. C., Vennard, R. A., Sribala-Sundaram, S., & Nimmo, M. A. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01080.2011 · Cited by 114 · see citing works
Effect of Number of Sprints in an SIT Session on Change in V˙O2max
Vollaard, N. B. J., Metcalfe, R. S., & Williams, S. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001204 · Cited by 110 · see citing works
Effects of single bout of very high-intensity exercise on metabolic health biomarkers in overweight/obese sedentary men
Forrest, L. J., Ferguson, C., Wilson, J., Scott, R. A., & Gill, J. M. R. (2012) · Metabolism · doi:10.1016/j.metabol.2012.07.019 · Cited by 106 · see citing works
Affective Responses to Repeated Sessions of High-Intensity Interval Training
Saanijoki, T., Nummenmaa, L., Eskelinen, J., Savolainen, A., Vahlberg, T. J., Kalliokoski, K. K., & Hannukainen, J. C. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000721 · Cited by 105 · see citing works
High-intensity interval training improves insulin sensitivity in older individuals.
Søgaard, D., Lund, M. T., Scheuer, C. M., Dehlbæk, M. S., Dideriksen, S. G., Abildskov, C. V., Christensen, K. K., Dohlmann, T. L., Larsen, S., Vigelsø, A. H., et al. (2018) · Acta Physiologica · doi:10.1111/apha.13009 · Cited by 98 · see citing works
Modification of Insulin Sensitivity and Glycemic Control by Activity and Exercise
ROBERTS, C. K., LITTLE, J. P., & THYFAULT, J. P. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318295cdbb · Cited by 95 · see citing works
Creb coactivators direct anabolic responses and enhance performance of skeletal muscle
Bruno, N. E., Kelly, K. A., Hawkins, R. L., Lawani, M. B., Amelio, A. L., Nwachukwu, J. C., Nettles, K. W., & Conkright, M. D. (2014) · The EMBO Journal · doi:10.1002/embj.201386145 · Cited by 95 · see citing works
Treating NAFLD in OLETF Rats with Vigorous-Intensity Interval Exercise Training
Linden, M. A., Fletcher, J. A., Morris, E. M., Meers, G. M.-E., Laughlin, M. H., Booth, F. W., Sowers, J. R., Ibdah, J. A., Thyfault, J. P., & Rector, R. S. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000430 · Cited by 91 · see citing works
The Acute Effects of Interval- Vs Continuous-Walking Exercise on Glycemic Control in Subjects With Type 2 Diabetes: A Crossover, Controlled Study
Karstoft, K., Christensen, C. S., Pedersen, B. K., & Solomon, T. P. J. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1837 · Cited by 85 · see citing works
Running sprint interval training induces fat loss in women
Hazell, T. J., Hamilton, C. D., Olver, T. D., & Lemon, P. W. R. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0503 · Cited by 86 · see citing works
High-intensity interval training without weight loss improves exercise but not basal or insulin-induced metabolism in overweight/obese African American women
Arad, A. D., DiMenna, F. J., Thomas, N., Tamis‐Holland, J. E., Weil, R. M., Geliebter, A., & Albu, J. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00306.2015 · Cited by 82 · see citing works
High-intensity interval training: Modulating interval duration in overweight/obese men
Smith‐Ryan, A. E., Melvin, M. N., & Wingfield, H. L. (2015) · The Physician and Sportsmedicine · doi:10.1080/00913847.2015.1037231 · Cited by 80 · see citing works
Appetite, energy intake, and PYY3–36 responses to energy-matched continuous exercise and submaximal high-intensity exercise
Deighton, K., Karra, E., Batterham, R. L., & Stensel, D. J. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0484 · Cited by 81 · see citing works
High-intensity interval training in overweight and obese children and adolescents: systematic review and meta-analysis
Thivel, D., Masurier, J., Baquet, G., Timmons, B. W., Pereira, B., Berthoin, S., Duclos, M., & Aucouturier, J. (2019) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.18.08075-1 · Cited by 80 · see citing works
Sprint interval running increases insulin sensitivity in young healthy subjects.
Sandvei, M., Jeppesen, P. B., Støen, L., Litleskare, S., Johansen, E., Stensrud, T., Enoksen, E., Hautala, A., Martinmäki, K., Kinnunen, H., et al. (2012) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2012.677454 · Cited by 75 · see citing works
High-intensity interval training attenuates the exercise-induced increase in plasma IL-6 in response to acute exercise
Croft, L., Bartlett, J. D., MacLaren, D. P. M., Reilly, T. P., Evans, L., Mattey, D. L., Nixon, N. B., Drust, B., & Morton, J. P. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-117 · Cited by 71 · see citing works
Rating of perceived exertion as a tool for prescribing and self regulating interval training: a pilot study
Ciolac, E. G., Mantuani, S. D. S., Neiva, C. M., Verardi, C. E. L., Filho, D. M. P., & Pimenta, L. (2014) · Biology of Sport · doi:10.5604/20831862.1134312 · Cited by 71 · see citing works
Changes in aerobic capacity and glycaemic control in response to reduced-exertion high-intensity interval training (REHIT) are not different between sedentary men and women
Metcalfe, R. S., Tardif, N., Thompson, D., & Vollaard, N. B. J. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0253 · Cited by 68 · see citing works
Two weeks of reduced-volume sprint interval or traditional exercise training does not improve metabolic functioning in sedentary obese men
Skleryk, J. R., Karagounis, L. G., Hawley, J. A., Sharman, M. J., Laursen, P. B., & Watson, G. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12150 · Cited by 63 · see citing works
Exercise intensity regulates cytokine and klotho responses in men
Middelbeek, R. J. W., Motiani, P., Brandt, N., Nigro, P., Zheng, J., Virtanen, K. A., Kalliokoski, K. K., Hannukainen, J. C., & Goodyear, L. J. (2021) · Nutrition and Diabetes · doi:10.1038/s41387-020-00144-x · Cited by 64 · see citing works
Regulators of Human White Adipose Browning: Evidence for Sympathetic Control and Sexual Dimorphic Responses to Sprint Interval Training
Scalzo, R. L., Peltonen, G. L., Giordano, G., Binns, S. E., Klochak, A. L., Paris, H. L. R., Schweder, M. M., Szallar, S. E., Wood, L. M., Larson, D. G., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090696 · Cited by 59 · see citing works
Self-citation
Supplements and Nutritional Interventions to Augment High-Intensity Interval Training Physiological and Performance Adaptations—A Narrative Review
Forbes, S. C., Candow, D. G., Smith‐Ryan, A. E., Hirsch, K. R., Roberts, M. D., VanDusseldorp, T. A., Stratton, M. T., Kaviani, M., & Little, J. P. (2020) · Nutrients · doi:10.3390/nu12020390 · Cited by 60 · see citing works
Regulation of Muscle Pyruvate Dehydrogenase Complex in Insulin Resistance: Effects of Exercise and Dichloroacetate
Constantin‐Teodosiu, D. (2013) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2013.37.5.301 · Cited by 56 · see citing works
Just HIT it! A time-efficient exercise strategy to improve muscle insulin sensitivity
Gibala, M. J., & Little, J. P. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.196303 · Cited by 54 · see citing works
Oxygen consumption, substrate oxidation, and blood pressure following sprint interval exercise
Chan, H. H., & Burns, S. F. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0136 · Cited by 54 · see citing works
Aerobic Training Effects on Glucose Tolerance in Prediabetic and Normoglycemic Humans
Jenkins, N. T., & Hagberg, J. M. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318223b5f9 · Cited by 53 · see citing works
Sex differences in the effects of 12 weeks sprint interval training on body fat mass and the rates of fatty acid oxidation and VO<sub>2</sub>max during exercise
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Sympathetic inhibition attenuates hypoxia induced insulin resistance in healthy adult humans
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Authors: Richards, J. C., Johnson, T. K., Kuzma, J. N., Lonac, M. C., Schweder, M. M., Voyles, W. F., & Bell, C.
Affiliations: Colorado State University (US)
ORCID: Kuzma, Jessica N.
Bell, Christopher
Venue: The Journal of Physiology
Publisher: Wiley
Published: 2010-08
Volume: 588
Issue: 15
Pages: 2961-2972
ISSN: 0022-3751 (ISSN-L)
1469-7793
DOI: 10.1113/jphysiol.2010.189886
PMC: PMC2956910
OpenAlex: W1597933301
Cited by: 187
References: 89
Citations by year: 2026: 5 · 2025: 4 · 2024: 1 · 2023: 7 · 2022: 7 · 2021: 9 · 2020: 5 · 2019: 11 · 2018: 6 · 2017: 14 · 2016: 12 · 2015: 13 · 2014: 34 · 2013: 23 · 2012: 21
FWCI: 49.61
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2 d)
Locations: The Journal of Physiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Diabetes Association
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Health Sciences › Medicine › Physiology › Physical Activity and Health
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords: sprint interval training, insulin sensitivity, thermogenesis, beta-adrenergic stimulation, isoproterenol, resting energy expenditure, high-intensity exercise, glucose regulation, adiponectin, norepinephrine, energy balance, sedentary adults, single bout exercise, hyperinsulinemic-euglycemic clamp, short-term exercise
MeSH terms: Adult, Body Temperature Regulation, Dose-Response Relationship, Drug, Physical Exertion, Female, Humans, Insulin Resistance, Isoproterenol, Male, Physical Endurance, Receptors, Adrenergic, beta, Reference Values, Running, Exercise

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Short‐term sprint interval training increases insulin sensitivity in healthy adults but does not affect the thermogenic response to β‐adrenergic stimulation

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