Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy

Cites (808)

Items 201–400 of 808

1. Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
   Lutsiak, M. E. Christine, Semnani, Roshanak T., De Pascalis, Roberto, Kashmiri, Syed V. S., Schlom, Jeffrey, Sabzevari, Helen · 2005 · Blood
2. The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis
   Cardone, Rosa A., Casavola, Valeria, Reshkin, Stephan J. · 2005 · Nature Reviews Cancer
3. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1
   Dong‐Ming Kuang, Qiyi Zhao, Chen Peng, Jing Xu, Jing‐Ping Zhang, Chang You Wu, Limin Zheng · 2009 · The Journal of Experimental Medicine
4. Adenosine receptors as drug targets — what are the challenges?
   Jiang‐Fan Chen, Holger K. Eltzschig, Bertil B. Fredholm · 2013 · Nature Reviews Drug Discovery
5. Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity
   Walmsley, Sarah R., Print, Cristin, Farahi, Neda, Peyssonnaux, Carole, Johnson, Randall S., Cramer, Thorsten, Sobolewski, Anastasia, Condliffe, Alison M., Cowburn, Andrew S., Johnson, Nicola et al. · 2005 · The Journal of Experimental Medicine
6. Innate lymphoid cells: A new paradigm in immunology
   Eberl, Gérard, Colonna, Marco, Di Santo, James P., McKenzie, Andrew N. J. · 2015 · Science
7. Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL
   Staller, Peter, Sulitkova, Jitka, Lisztwan, Joanna, Moch, Holger, Oakeley, Edward J., Krek, Wilhelm · 2003 · Nature
8. Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation
   Mako Nakaya, Yichuan Xiao, Xiaofei Zhou, Jae‐Hoon Chang, Mikyoung Chang, Xuhong Cheng, Marzenna Blonska, Xin Lin, Shao‐Cong Sun · 2014 · Immunity
9. The Continuum of Cancer Immunosurveillance: Prognostic, Predictive, and Mechanistic Signatures
   Jérôme Galon, Helen K. Angell, Davide Bedognetti, Francesco Maria Marincola · 2013 · Immunity
10. ATP Release Guides Neutrophil Chemotaxis via P2Y2 and A3 Receptors
    Yu Chen, Ross Corriden, Yoshiaki Inoue, Linda Yip, Naoyuki Hashiguchi, Annelies Sophie Zinkernagel, Victor Nizet, Paul A. Insel, Wolfgang Georg JUNGER · 2006 · Science
11. Cutting Edge: Cross-Talk Between Cells of the Innate Immune System: NKT Cells Rapidly Activate NK Cells
    Claude Carnaud, Daniel C. Lee, Olivier Donnars, Se‐Ho Park, Andrew J. Beavis, Yasuhiko Koezuka, Albert S Bendelac · 1999 · The Journal of Immunology
12. NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy
    Guerra, Nadia, Tan, Ying Xim, Joncker, Nathalie T., Choy, Augustine, Gallardo, Fermin, Xiong, Na, Knoblaugh, Susan, Cado, Dragana, Greenberg, Norman R., Raulet, David H. · 2008 · Immunity
13. Regulation of Ligands for the NKG2D Activating Receptor
    David H. Raulet, Stephan Gasser, Benjamin G. Gowen, Weiwen Deng, Heiyoun Jung · 2013 · Annual Review of Immunology
14. Regulation of the Chemokine Receptor CXCR4 by Hypoxia
    Tiziana Schioppa, Badarch Uranchimeg, Alessandra Saccani, Subhra Kumar Biswas, Andrea Doni, Annamaria Rapisarda, Sergio Bernasconi, Simona Saccani, Manuela Nebuloni, Luca Vago et al. · 2003 · The Journal of Experimental Medicine
15. Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming
    Tian, Lin, Goldstein, Amit, Wang, Hai, Ching Lo, Hin, Sun Kim, Ik, Welte, Thomas, Sheng, Kuanwei, Dobrolecki, Lacey E., Zhang, Xiaomei, Putluri, Nagireddy et al. · 2017 · Nature
16. Regulation of innate immune cell function by mTOR
    Thomas Weichhart, Markus Hengstschläger, Monika Linke · 2015 · Nature reviews. Immunology
17. Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1
    Long Gu, Susan Tseng, Renée M. Horner, Carmen Tam‐Amersdorfer, Massimo F. Loda, Barrett J. Rollins · 2000 · Nature
18. Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation
    Carr, Erikka L, Kelman, Alina, Wu, Glendon S, Gopaul, Ravindra, Senkevitch, Emilee, Aghvanyan, Anahit, Turay, Achmed M, Frauwirth, Kenneth A · 2010 · The Journal of Immunology
19. Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells
    Zaheed Husain, Yannu Huang, Pankaj Seth, Vikas P. Sukhatme · 2013 · The Journal of Immunology
20. Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer
    Jitka Yehudith Sagiv, Janna Michaeli, Simaan Assi, Inbal Mishalian, Hen Kisos, Liran Levy, Pazzit Damti, Delphine Lumbroso, Lola Polyansky, Ronit Vogt Sionov et al. · 2015 · Cell Reports
21. Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF-κB/IL-8 Pathway that Drives Tumor Angiogenesis
    Végran, Frédérique, Boidot, Romain, Michiels, Carine, Sonveaux, Pierre, Feron, Olivier · 2011 · Cancer Research
22. Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments
    Ilona Kryczek, Mousumi Banerjee, Pui Joan Cheng, Linhua Vatan, Wojciech Szeliga, Shuang Wei, Emina H. Huang, Emily V. A. Finlayson, Diane M. Simeone, Theodore Hobart Welling et al. · 2009 · Blood
23. Cancer--A Biological Approach: I. The Processes Of Control. II. The Significance of Somatic Mutation
    M. Burnet · 1957 · BMJ
24. The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti–PD-1 antibody
    Benson, Don M., Bakan, Courtney E., Mishra, Anjali, Hofmeister, Craig C., Efebera, Yvonne, Becknell, Brian, Baiocchi, Robert A., Zhang, Jianying, Yu, Jianhua, Smith, Megan K. et al. · 2010 · Blood
25. CTLA-4 ligation blocks CD28-dependent T cell activation.
    Theresa L. Walunas, Christina Y. Bakker, Jeffrey A. Bluestone · 1996 · The Journal of Experimental Medicine
26. Adenosine 5′-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype
    Duygu Sağ, David Carling, Robert D. Stout, Jill Suttles · 2008 · The Journal of Immunology
27. HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation
    Yu, Fang, White, Sarah B., Zhao, Quan, Lee, Frank S. · 2001 · Proceedings of the National Academy of Sciences
28. Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase
    Madhav D. Sharma, Babak Baban, Phillip Chandler, De‐Yan Hou, Nagendra Singh, Hideo Yagita∥, Miyuki Azuma, Bruce R. Blazar, Andrew L. Mellor, David H. Munn · 2007 · Journal of Clinical Investigation
29. Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development
    O’Sullivan, David, van der Windt, Gerritje J.W., Huang, Stanley Ching-Cheng, Curtis, Jonathan D., Chang, Chih-Hao, Buck, Michael D., Qiu, Jing, Smith, Amber M., Lam, Wing Y., DiPlato, Lisa M. et al. · 2014 · Immunity
30. Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival
    Steffen Walter, Toni Weinschenk, Arnulf Stenzl, Romuald Zdrojowy, Anna Pluzanska, Cezary A. Szczylik, Michael D. Staehler, Wolfram Brugger, Pierre-Yves Dietrich, Regina Mendrzyk et al. · 2012 · Nature Medicine
31. Purinergic regulation of the immune system
    Cekic, Caglar, Linden, Joel · 2016 · Nature Reviews Immunology
32. Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism
    Peng, Min, Yin, Na, Chhangawala, Sagar, Xu, Ke, Leslie, Christina S., Li, Ming O. · 2016 · Science
33. Pharmacology of Adenosine Receptors: The State of the Art
    Borea, Pier Andrea, Gessi, Stefania, Merighi, Stefania, Vincenzi, Fabrizio, Varani, Katia · 2018 · Physiological Reviews
34. Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions
    Robert Haas, Joanne Smith, Vidalba Rocher-Ros, Suchita Nadkarni, Trinidad Montero‐Melendez, Fulvio D’Acquisto, Elliot J. Bland, Michele Bombardieri, Costantino Pitzalis, Mauro Perretti et al. · 2015 · PLoS Biology
35. Tumor entrained neutrophils inhibit seeding in the premetastatic lung
    Granot, Zvi, Henke, Erik, Comen, Elizabeth A., King, Tari A., Norton, Larry, Benezra, Robert · 2011 · Cancer Cell
36. Anti-PlGF Inhibits Growth of VEGF(R)-Inhibitor-Resistant Tumors without Affecting Healthy Vessels
    Christian Fischer, Bart Jonckx, Massimiliano Mazzone, Serena Zacchigna, Sonja Loges, Lucia Pattarini, Emmanuel Chorianopoulos, Laurens Liesenborghs, Marta Koch, Maria De Mol et al. · 2007 · Cell
37. PD-1 signaling in primary T cells
    Riley, James L. · 2009 · Immunological Reviews
38. Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF-β1
    Hequan Li, Yanmei Han, Qiuli Guo, Minggang Zhang, Xuetao Cao · 2009 · The Journal of Immunology
39. CD47 blockade triggers T cell–mediated destruction of immunogenic tumors
    Xiaojuan Liu, Yang Pu, Kyle R. Cron, Liufu Deng, Justin Paul Kline, William A. Frazier, Hairong Xu, Hua Peng, Yang‐Xin Fu, Meng Michelle Xu · 2015 · Nature Medicine
40. A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells
    Barsoum, Ivraym B., Smallwood, Chelsea A., Siemens, D. Robert, Graham, Charles H. · 2014 · Cancer Research
41. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal
    Brian T. Fife, Kristen E. Pauken, Todd N. Eagar, Takashi O. Kangas, Jenny Qun Wu, Qizhi Tang, Miyuki Azuma, Matthew F. Krummel, Jeffrey A. Bluestone · 2009 · Nature Immunology
42. Fatty acid transport protein 2 reprograms neutrophils in cancer
    Filippo Veglia, Vladimir A. Tyurin, Maria Blasi, Alessandra De Leo, Andrew V. Kossenkov, Laxminarasimha Donthireddy, Tsun Ki Jerrick To, Zachary T. Schug, Subhasree Basu, Fang Wang et al. · 2019 · Nature
43. T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
    Crespo, Joel, Sun, Haoyu, Welling, Theodore H, Tian, Zhigang, Zou, Weiping · 2013 · Current Opinion in Immunology
44. B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
    Kryczek, Ilona, Zou, Linhua, Rodriguez, Paulo, Zhu, Gefeng, Wei, Shuang, Mottram, Peter, Brumlik, Michael, Cheng, Pui, Curiel, Tyler, Myers, Leann et al. · 2006 · The Journal of Experimental Medicine
45. Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth
    A. McGarry Houghton, Danuta M. Rzymkiewicz, Hongbin Ji, Alyssa D. Gregory, Eduardo Egea, Heather E. Metz, Donna Beer Stolz, Stephanie R. Land, Luiz Antonio Liarte Marconcini, Corrine R. Kliment et al. · 2010 · Nature Medicine
46. Lipid accumulation and dendritic cell dysfunction in cancer
    Donna L. Herber, Wei Cao, Yulia Nefedova, Sergey V. Novitskiy, Srinivas Nagaraj, Vladimir A. Tyurin, Alex Corzo, Hyun-Il Cho, Esteban Celis, Brianna C. Lenox et al. · 2010 · Nature Medicine
47. IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion
    Vasilena Gocheva, Hao‐Wei Wang, Bedrick B. Gadea, Tanaya Shree, Karen E. Hunter, Alfred L. Garfall, Tara A. Berman, Johanna A. Joyce · 2010 · Genes & Development
48. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation
    Valerie A. Gerriets, Rigel J. Kishton, Amanda Nichols, Andrew N. Macintyre, Makoto Inoue, Olga Ilkayeva, Peter S. Winter, Xiaojing Liu, Bhavana Priyadharshini, Marta E. Slawinska et al. · 2014 · Journal of Clinical Investigation
49. Tumor-derived lactic acid modulates dendritic cell activation and antigen expression
    Gottfried, Eva, Kunz-Schughart, Leoni A., Ebner, Stephanie, Mueller-Klieser, Wolfgang, Hoves, Sabine, Andreesen, Reinhard, Mackensen, Andreas, Kreutz, Marina · 2006 · Blood
50. Prognostic Role of Platelet to Lymphocyte Ratio in Solid Tumors: A Systematic Review and Meta-Analysis
    Arnoud J. Templeton, Olga Ace, Mairead Geraldine McNamara, Mustafa Al-Mubarak, Francisco Vera-Badillo, Thomas Hermanns, Boštjan Šeruga, Alberto Ocaña, Ian F. Tannock, Eitan Amir · 2014 · Cancer Epidemiology Biomarkers & Prevention
51. STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade
    Fu, Juan, Kanne, David B., Leong, Meredith, Glickman, Laura Hix, McWhirter, Sarah M., Lemmens, Edward, Mechette, Ken, Leong, Justin J., Lauer, Peter, Liu, Weiqun et al. · 2015 · Science Translational Medicine
52. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism
    Youdong Pan, Tian Tian, Chang Ook Park, Serena Y. Lofftus, Shenglin Mei, Xing Liu, Chi Luo, John T. O’Malley, Ahmed E. Gehad, Jessica E. Teague et al. · 2017 · Nature
53. Activation of NK cell cytotoxicity
    Mark John Smyth, Erika Cretney, Janice M. Kelly, Jennifer A. Westwood, Shayna E.A. Street, Hideo Yagita∥, Kazuyoshi Takeda, Serani L.H. van Dommelen, Mariapia A. Degli‐Esposti, Yoshihiro Hayakawa · 2004 · Molecular Immunology
54. Metabolic Reprogramming of Immune Cells in Cancer Progression
    Subhra Kumar Biswas · 2015 · Immunity
55. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
    Samuel Huber, Nicola Gagliani, Lauren A. Zenewicz, Francis J. Huber, Lidia Bosurgi, Bo Hu, Matija Hedl, Wei Kevin Zhang, William O’Connor, Andrew J. Murphy et al. · 2012 · Nature
56. Radiation-Induced CXCL16 Release by Breast Cancer Cells Attracts Effector T Cells
    Satoko Matsumura, Baomei Wang, Noriko Kawashima, Steve E. Braunstein, Michelle L. Badura, Thomas O. Cameron, James S. Babb, Robert J. Schneider, Silvia Chiara Formenti, Michael Loran Dustin et al. · 2008 · The Journal of Immunology
57. Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion
    Michael Platten, Wolfgang Wick, Benoit J. Van den Eynde · 2012 · Cancer Research
58. Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death
    Dipanjan Chowdhury, Judy Lieberman · 2008 · Annual Review of Immunology
59. The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction
    Nicole E. Scharping, Ashley V. Menk, Rebecca S. Moreci, Ryan D. Whetstone, Rebekah Dadey, Simon C. Watkins, Robert Louis Ferris, Greg M. Delgoffe · 2016 · Immunity
60. Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism
    Marc O. Johnson, Melissa M. Wolf, Matthew Z. Madden, Gabriela Andrejeva, Ayaka Sugiura, Diana C. Contreras, Damián Maseda, Maria V. Liberti, Katelyn G. Paz, Rigel J. Kishton et al. · 2018 · Cell
61. Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer
    Lucia B. De Monte, Michele Reni, Elena Tassi, Daniela Clavenna, Ilenia Papa, Helios R. Recalde, Marco Braga, Valerio Di Carlo, Claudio Doglioni, Maria Pia Protti · 2011 · The Journal of Experimental Medicine
62. Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism
    Nam Trung Nguyen, Akihiro Kimura, Taisuke Nakahama, Ichino Chinen, Kazuya Masuda, Keiko Nohara, Yoshiaki Fujii‐Kuriyama, Tadamitsu Kishimoto · 2010 · Proceedings of the National Academy of Sciences
63. Molecular Basis of T Cell Inactivation by CTLA-4
    Lee, Kyung-Mi, Chuang, Ellen, Griffin, Matthew, Khattri, Roli, Hong, David K., Zhang, Weiguo, Straus, David, Samelson, Lawrence E., Thompson, Craig B., Bluestone, Jeffrey A. · 1998 · Science
64. Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis
    Laura Bonapace, Marie‐May Coissieux, Jeffrey B. Wyckoff, Kirsten D. Mertz, Zsuzsanna Varga, Tobias Junt, Mohamed Bentires‐Alj · 2014 · Nature
65. Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport
    Yang, Chendong, Ko, Bookyung, Hensley, Christopher T., Jiang, Lei, Wasti, Ajla T., Kim, Jiyeon, Sudderth, Jessica, Calvaruso, Maria Antonietta, Lumata, Lloyd, Mitsche, Matthew et al. · 2014 · Molecular Cell
66. Tolerance and exhaustion: defining mechanisms of T cell dysfunction
    Andrea Schietinger, Philip D. Greenberg · 2013 · Trends in Immunology
67. The Interaction Properties of Costimulatory Molecules Revisited
    Alison V. Collins, Douglas W. Brodie, Robert J.C. Gilbert, Andrea Iaboni, Raquel Manso-Sancho, Björn Walse, David Ian Stuart, P. Anton van der Merwe, Simon J. Davis · 2002 · Immunity
68. TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway
    Sébastien Viel, Antoine Marçais, Fernando Souza-Fonseca-Guimarães, Róisín M. Loftus, Jessica Rabilloud, Morgan Grau, Sophie Degouve, Sophia Djebali, Amélien Sanlaville, Emily Charrier et al. · 2016 · Science Signaling
69. Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFNγ receptors
    Dighe, Anand S., Richards, Elizabeth, Old, Lloyd J., Schreiber, Robert D. · 1994 · Immunity
70. Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen
    Doedens, Andrew L, Phan, Anthony T, Stradner, Martin H, Fujimoto, Jessica K, Nguyen, Jessica V, Yang, Edward, Johnson, Randall S, Goldrath, Ananda W · 2013 · Nature Immunology
71. Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy
    Cantelmo, Anna Rita, Conradi, Lena-Christin, Brajic, Aleksandra, Goveia, Jermaine, Kalucka, Joanna, Pircher, Andreas, Chaturvedi, Pallavi, Hol, Johanna, Thienpont, Bernard, Teuwen, Laure-Anne et al. · 2016 · Cancer Cell
72. Serine is an essential metabolite for effector T cell expansion
    Ma, Eric H., Bantug, Glenn, Griss, Takla, Condotta, Stephanie, Johnson, Radia M., Samborska, Bozena, Mainolfi, Nello, Suri, Vipin, Guak, Hannah, Balmer, Maria L. et al. · 2017 · Cell Metabolism
73. Anti-CD47 antibody–mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response
    Diane Tseng, Jens-Peter Volkmer, Stephen B. Willingham, Humberto Contreras-Trujillo, John W. Fathman, Nathaniel B. Fernhoff, Jun Seita, Matthew A. Inlay, Kipp Weiskopf, Masanori Miyanishi et al. · 2013 · Proceedings of the National Academy of Sciences
74. Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells
    Barbara Molon, Stefano Ugel, Federica Del Pozzo, Cristiana Soldani, Serena Zilio, Debora Avella, Antonella De Palma, Pierluigi Mauri, Ana Monegal, María Rescigno et al. · 2011 · The Journal of Experimental Medicine
75. Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells
    Yulong Gao, Fernando Souza-Fonseca-Guimarães, Tobias Bald, Susanna S. Ng, Arabella Young, Shin Foong Ngiow, Jai Rautela, Jasmin Straube, Nicola Waddell, Stephen J. Blake et al. · 2017 · Nature Immunology
76. Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression
    Doedens, Andrew L., Stockmann, Christian, Rubinstein, Mark P., Liao, Debbie, Zhang, Na, DeNardo, David G., Coussens, Lisa M., Karin, Michael, Goldrath, Ananda W., Johnson, Randall S. · 2010 · Cancer Research
77. Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis
    Johanna A. Joyce, Amos Baruch, Kareem A. H. Chehade, Nicole Meyer-Morse, Enrico Giraudo, Fong‐Ying Tsai, Doron C. Greenbaum, Jeffrey H. Hager, Matthew S. Bogyo, Douglas Hanahan · 2004 · Cancer Cell
78. Bv8 regulates myeloid-cell-dependent tumour angiogenesis
    Farbod Shojaei, Xiumin Wu, Cuiling Zhong, Lanlan Yu, Xiao‐Huan Liang, Jenny J. Yao, Dominique Blanchard, Carlos Bais, Franklin V. Peale Jr., Nicholas van Bruggen et al. · 2007 · Nature
79. Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes
    Calcinotto, Arianna, Filipazzi, Paola, Grioni, Matteo, Iero, Manuela, De Milito, Angelo, Ricupito, Alessia, Cova, Agata, Canese, Rossella, Jachetti, Elena, Rossetti, Monica et al. · 2012 · Cancer Research
80. CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells
    Chang, Alan L., Miska, Jason, Wainwright, Derek A., Dey, Mahua, Rivetta, Claudia V., Yu, Dou, Kanojia, Deepak, Pituch, Katarzyna C., Qiao, Jian, Pytel, Peter et al. · 2016 · Cancer Research
81. Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells
    Mazzieri, Roberta, Pucci, Ferdinando, Moi, Davide, Zonari, Erika, Ranghetti, Anna, Berti, Alvise, Politi, Letterio S., Gentner, Bernhard, Brown, Jeffrey L., Naldini, Luigi et al. · 2011 · Cancer Cell
82. Proliferative activity of intratumoral CD8(+) T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity.
    Osamu Nakano, Makoto Sato, Yoshitaka Naito, Kenichi Suzuki, Seiichi Orikasa, Masataka Aizawa, Yasuyoshi Suzuki, Ichirou Shintaku, Hiroshi Nagura, Haruo Ohtani · 2001 · PubMed
83. The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism
    Haschemi, Arvand, Kosma, Paul, Gille, Lars, Evans, Charles R., Burant, Charles F., Starkl, Philipp, Knapp, Bernhard, Haas, Robert, Schmid, Johannes A., Jandl, Christoph et al. · 2012 · Cell Metabolism
84. B cell regulation in cancer and anti-tumor immunity
    Anushruti Sarvaria, J. Alejandro Madrigal, Aurore Saudemont · 2017 · Cellular and Molecular Immunology
85. Anti-CCR4 mAb selectively depletes effector-type FoxP3 + CD4 + regulatory T cells, evoking antitumor immune responses in humans
    Daisuke Sugiyama, Hiroyoshi Nishikawa, Yuka Maeda, Megumi Nishioka, Atsushi Tanemura, Ichiro Katayama, Sachiko Ezoe, Yuzuru Kanakura, Eiichi Sato, Yasuo Fukumori et al. · 2013 · Proceedings of the National Academy of Sciences
86. Dynamic T cell migration program provides resident memory within intestinal epithelium
    Masopust, David, Choo, Daniel, Vezys, Vaiva, Wherry, E. John, Duraiswamy, Jaikumar, Akondy, Rama, Wang, Jun, Casey, Kerry A., Barber, Daniel L., Kawamura, Kim S. et al. · 2010 · Journal of Experimental Medicine
87. Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity
    Andrea Casazza, Damya Laoui, Mathias Wenes, Sabrina Rizzolio, Nicklas Bassani, Marco Mambretti, Sofie Deschoemaeker, Jo A. Van Ginderachter, Luca Tamagnone, Massimiliano Mazzone · 2013 · Cancer Cell
88. Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity
    Overacre-Delgoffe, Abigail E., Chikina, Maria, Dadey, Rebekah E., Yano, Hiroshi, Brunazzi, Erin A., Shayan, Gulidanna, Horne, William, Moskovitz, Jessica M., Kolls, Jay K., Sander, Cindy et al. · 2017 · Cell
89. Metabolic reprogramming of natural killer cells in obesity limits antitumor responses
    Xavier Michelet, Lydia Dyck, Andrew E. Hogan, Róisín M. Loftus, Danielle Duquette, Kevin Wei, Semir Beyaz, Ali Tavakkoli, Cathriona Foley, Raymond Donnelly et al. · 2018 · Nature Immunology
90. Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis
    Norihiko Takeda, Ellen L O'Dea, Andrew L. Doedens, Jung‐whan Kim, Alexander Weidemann, Christian Stockmann, Masataka Asagiri, Marie Celeste Simon, Alexander Hoffmann, Randall S. Johnson · 2010 · Genes & Development
91. Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome
    Bauernfeind, Franz, Bartok, Eva, Rieger, Anna, Franchi, Luigi, Núñez, Gabriel, Hornung, Veit · 2011 · The Journal of Immunology
92. Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy
    Tina Cascone, Jodi A. McKenzie, Rina M. Mbofung, Simone Punt, Zhe Wang, Chunyu Xu, Leila J. Williams, Zhiqiang Wang, Christopher Aaron Bristow, Alessandro Carugo et al. · 2018 · Cell Metabolism
93. Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy
    Ying Zhang, Raj K. Kurupati, Ling Liu, Xiang Zhou, Gao Zhang, Abeer Hudaihed, Flavia Filisio, Wynetta Giles‐Davis, Xiaowei Xu, Giorgos Constantine Karakousis et al. · 2017 · Cancer Cell
94. The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells
    Antoine Marçais, Julien Cherfils‐Vicini, Charlotte Viant, Sophie Degouve, Sébastien Viel, Aurore Fenis, Jessica Rabilloud, Katia Mayol, Armelle Tavares, Jacques Bienvenu et al. · 2014 · Nature Immunology
95. Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase
    Jason R. Cantor, Monther Abu-Remaileh, Naama Kanarek, Elizaveta Freinkman, Xin Gao, Abner Louissaint, Caroline A. Lewis, David M. Sabatini · 2017 · Cell
96. Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma
    Paulo C. Rodrı́guez, Claudia P. Hernandez, David G. Quiceno, Steven M. Dubinett, Jovanny Zabaleta, Juan B. Ochoa, Jill Gilbert, Augusto C. Ochoa · 2005 · The Journal of Experimental Medicine
97. Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor <i>in vivo</i>
    Cerwenka, Adelheid, Baron, Jody L., Lanier, Lewis L. · 2001 · Proceedings of the National Academy of Sciences
98. Immunological mechanisms of the antitumor effects of supplemental oxygenation
    Hatfield, Stephen M., Kjaergaard, Jorgen, Lukashev, Dmitriy, Schreiber, Taylor H., Belikoff, Bryan, Abbott, Robert, Sethumadhavan, Shalini, Philbrook, Phaethon, Ko, Kami, Cannici, Ryan et al. · 2015 · Science Translational Medicine
99. PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells
    Finlay, David K., Rosenzweig, Ella, Sinclair, Linda V., Feijoo-Carnero, Carmen, Hukelmann, Jens L., Rolf, Julia, Panteleyev, Andrey A., Okkenhaug, Klaus, Cantrell, Doreen A. · 2012 · Journal of Experimental Medicine
100. Prognostic Value of Tumor-Infiltrating CD4+ T-Cell Subpopulations in Head and Neck Cancers
     Cécile Badoual, Stéphane Hans, José Rodriguez, Séverine Peyrard, Christophe Klein, Nour El Houda Agueznay, Véronique Mosseri, O. Laccourreye, Patrick Bruneval, Wolf H. Fridman et al. · 2006 · Clinical Cancer Research
101. Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulation
     Huber, Veronica, Camisaschi, Chiara, Berzi, Angela, Ferro, Simona, Lugini, Luana, Triulzi, Tiziana, Tuccitto, Alessandra, Tagliabue, Elda, Castelli, Chiara, Rivoltini, Licia · 2017 · Seminars in Cancer Biology
102. Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies
     Fokhrul M. Hossain, Amir A. Al-Khami, Dorota Danuta Wyczechowska, Claudia Hernandez, Liqin Zheng, Krzystoff Reiss, Luis Del Valle, Jimena Trillo-Tinoco, Tomasz Maj, Weiping Zou et al. · 2015 · Cancer Immunology Research
103. The Two Faces of Interferon-γ in Cancer
     M. Raza Zaidi, Glenn T Merlino · 2011 · Clinical Cancer Research
104. Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy
     Pilon-Thomas, Shari, Kodumudi, Krithika N., El-Kenawi, Asmaa E., Russell, Shonagh, Weber, Amy M., Luddy, Kimberly, Damaghi, Mehdi, Wojtkowiak, Jonathan W., Mulé, James J., Ibrahim-Hashim, Arig et al. · 2016 · Cancer Research
105. Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis
     Delgoffe, Greg M., Woo, Seng-Ryong, Turnis, Meghan E., Gravano, David M., Guy, Cliff, Overacre, Abigail E., Bettini, Matthew L., Vogel, Peter, Finkelstein, David, Bonnevier, Jody et al. · 2013 · Nature
106. JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance
     Tianyi Wang, J. Fahrmann, Heehyoung Lee, Yi-Jia Li, Satyendra C Tripathi, Chanyu Yue, Chun-Yan Zhang, Veronica Lifshitz, Jieun Song, Yuan Yuan et al. · 2017 · Cell Metabolism
107. mTORC2-IRF4 mediated metabolic reprograming is essential for macrophage alternative activation
     S. Huang, A. Smith, B. Everts, M. Colonna, Erika L. Pearce, J. Schilling, Edward J. Pearce · 2016 · Immunity
108. The hallmarks of successful anticancer immunotherapy
     Galluzzi, Lorenzo, Chan, Timothy A., Kroemer, Guido, Wolchok, Jedd D., López-Soto, Alejandro · 2018 · Science Translational Medicine
109. A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation
     Niamh C. Williams, Luke A.J. O'Neill · 2018 · Frontiers in Immunology
110. The impact of hypoxia on tumor-associated macrophages
     Anne-Theres Henze, Massimiliano Mazzone · 2016 · Journal of Clinical Investigation
111. Metabolic switching and fuel choice during T‐cell differentiation and memory development
     van der Windt, Gerritje J. W., Pearce, Erika L. · 2012 · Immunological Reviews
112. Neutrophils responsive to endogenous IFN-β regulate tumor angiogenesis and growth in a mouse tumor model
     Jadwiga Jabłońska, Sara Leschner, Kathrin Westphal, Stefan Lienenklaus, Siegfried Weiß · 2010 · Journal of Clinical Investigation
113. New insights into IL-12-mediated tumor suppression
     Sònia Tugues, Sara Burkhard, Isabel Ohs, Melissa Vrohlings, Kathrin Nussbaum, Johannes vom Berg, Paulina Kulig, Burkhard Becher · 2014 · Cell Death and Differentiation
114. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
     Clambey, Eric T., McNamee, Eóin N., Westrich, Joseph A., Glover, Louise E., Campbell, Eric L., Jedlicka, Paul, de Zoeten, Edwin F., Cambier, John C., Stenmark, Kurt R., Colgan, Sean P. et al. · 2012 · Proceedings of the National Academy of Sciences
115. Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression
     Guocan Wang, Xin Lü, Prasenjit Dey, Pingna Deng, Chia-Chin Wu, Shan Jiang, Zhuangna Fang, Kun Zhao, Ramakrishna Konaparthi, Sujun Hua et al. · 2015 · Cancer Discovery
116. Extracellular purines, purinergic receptors and tumor growth
     Francesco Di Virgilio, Elena Adinolfi · 2016 · Oncogene
117. Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
     Kidani, Yoko, Elsaesser, Heidi, Hock, M Benjamin, Vergnes, Laurent, Williams, Kevin J, Argus, Joseph P, Marbois, Beth N, Komisopoulou, Evangelia, Wilson, Elizabeth B, Osborne, Timothy F et al. · 2013 · Nature Immunology
118. Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4
     Marengère, Luc E. M., Waterhouse, Paul, Duncan, Gordon S., Mittrücker, Hans-Willi, Feng, Gen-Sheng, Mak, Tak W. · 1996 · Science
119. Targeting adenosine for cancer immunotherapy
     Robert D. Leone, Leisha A. Emens · 2018 · Journal for ImmunoTherapy of Cancer
120. Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma.
     Jacqueline Bromberg, Curt M. Horvath, Zilong Wen, Robert D. Schreiber, James E. Darnell Jr. · 1996 · Proceedings of the National Academy of Sciences
121. Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis
     Sonveaux, Pierre, Copetti, Tamara, De Saedeleer, Christophe J., Végran, Frédérique, Verrax, Julien, Kennedy, Kelly M., Moon, Eui Jung, Dhup, Suveera, Danhier, Pierre, Frérart, Françoise et al. · 2012 · PLoS ONE
122. Tumor-repopulating cells induce PD-1 expression in CD8(+) T cells by transferring kynurenine and AhR activation
     Liu, Yuying, Liang, Xiaoyu, Dong, Wenqian, Fang, Yi, Lv, Jiadi, Zhang, Tianzhen, Fiskesund, Roland, Xie, Jing, Liu, Jinyan, Yin, Xiaonan et al. · 2018 · Cancer Cell
123. Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells
     Everts, Bart, Amiel, Eyal, van der Windt, Gerritje J. W., Freitas, Tori C., Chott, Robert, Yarasheski, Kevin E., Pearce, Erika L., Pearce, Edward J. · 2012 · Blood
124. CD8+ Tumor-Infiltrating Lymphocytes Together with CD4+ Tumor-Infiltrating Lymphocytes and Dendritic Cells Improve the Prognosis of Patients with Pancreatic Adenocarcinoma
     Akira Fukunaga, Masaki Miyamoto, Yasushi Cho, Soichi Murakami, You Kawarada, Taro Oshikiri, Kentaro Kato, Takanori Kurokawa, Masato Suzuoki, Yoshihiro Nakakubo et al. · 2003 · Pancreas
125. The dual role of iNOS in cancer
     Federica Vannini, Khosrow Kashfi, Niharika Nath · 2015 · Redox Biology
126. Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model
     Kirchberger, Stefanie, Royston, Daniel J., Boulard, Olivier, Thornton, Emily, Franchini, Fanny, Szabady, Rose L., Harrison, Oliver, Powrie, Fiona · 2013 · Journal of Experimental Medicine
127. Fluorine-18 deoxyglucose and false-positive results: a major problem in the diagnostics of oncological patients
     Ludwig G. Strauss · 1996 · European Journal of Nuclear Medicine and Molecular Imaging
128. Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels
     Cordes, Thekla, Wallace, Martina, Michelucci, Alessandro, Divakaruni, Ajit S., Sapcariu, Sean C., Sousa, Carole, Koseki, Haruhiko, Cabrales, Pedro, Murphy, Anne N., Hiller, Karsten et al. · 2016 · Journal of Biological Chemistry
129. Triggering the succinate receptor GPR91 on dendritic cells enhances immunity
     Rubic, Tina, Lametschwandtner, Günther, Jost, Sandra, Hinteregger, Sonja, Kund, Julia, Carballido-Perrig, Nicole, Schwärzler, Christoph, Junt, Tobias, Voshol, Hans, Meingassner, Josef G et al. · 2008 · Nature Immunology
130. A Lactate-Induced Response to Hypoxia
     Dong Chul Lee, Hyun Ahm Sohn, Zee‐Yong Park, Sang Ho Oh, Yun Kyung Kang, Kyoung-min Lee, Minho Kang, Ye Jin Jang, Sukjin Yang, Young Ki Hong et al. · 2015 · Cell
131. Understanding subset diversity in T cell memory
     Jameson, Stephen C., Masopust, David · 2018 · Immunity
132. Tumor-infiltrating B cells: their role and application in anti-tumor immunity in lung cancer
     Sisi Wang, Wei Liu, Dalam Ly, Hao Ying Xu, Limei Qu, Li Zhang · 2018 · Cellular and Molecular Immunology
133. Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
     Klysz, Dorota, Tai, Xuguang, Robert, Philippe A., Craveiro, Marco, Cretenet, Gaspard, Oburoglu, Leal, Mongellaz, Cédric, Floess, Stefan, Fritz, Vanessa, Matias, Maria I. et al. · 2015 · Science Signaling
134. An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression
     Palazon, Asis, Tyrakis, Petros A., Macias, David, Veliça, Pedro, Rundqvist, Helene, Fitzpatrick, Susan, Vojnovic, Nikola, Phan, Anthony T., Loman, Niklas, Hedenfalk, Ingrid et al. · 2017 · Cancer Cell
135. Tumor necrosis factor or tumor promoting factor?
     Balkwill, Fran · 2002 · Cytokine &amp; Growth Factor Reviews
136. Immune suppressive mechanisms in the tumor microenvironment
     David H. Munn, Vincenzo Bronte · 2015 · Current Opinion in Immunology
137. Regulation of T Cell Receptor CD3ζ Chain Expression byl-Arginine
     Paulo C. Rodrı́guez, Arnold H. Zea, Kirk Salvatore Culotta, Jovanny Zabaleta, Juan B. Ochoa, Augusto C. Ochoa · 2002 · Journal of Biological Chemistry
138. CD4 + T Cell–Mediated Tumor Rejection Involves Inhibition of Angiogenesis that Is Dependent on IFNγ Receptor Expression by Nonhematopoietic Cells
     Zhihai Qin, Thomas J. F. Blankenstein · 2000 · Immunity
139. Glutathione primes t cell metabolism for inflammation
     Mak, Tak W., Grusdat, Melanie, Duncan, Gordon S., Dostert, Catherine, Nonnenmacher, Yannic, Cox, Maureen, Binsfeld, Carole, Hao, Zhenyue, Brüstle, Anne, Itsumi, Momoe et al. · 2017 · Immunity
140. Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance
     Susana Romero‐Garcia, María Maximina Bertha Moreno‐Altamirano, Heriberto Prado-Garcı́a, Francisco Javier Sánchez‐García · 2016 · Frontiers in Immunology
141. Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice
     Clare L. Abram, Gray Roberge, Yongmei Hu, Clifford A. Lowell · 2014 · Journal of Immunological Methods
142. Innate lymphoid cells in the initiation, regulation and resolution of inflammation
     Gregory F. Sonnenberg, David Artis · 2015 · Nature Medicine
143. Interleukin-33-Dependent Innate Lymphoid Cells Mediate Hepatic Fibrosis
     Mchedlidze, Tamar, Waldner, Maximilian, Zopf, Steffen, Walker, Jennifer, Rankin, Andrew L., Schuchmann, Marcus, Voehringer, David, McKenzie, Andrew N.J., Neurath, Markus F., Pflanz, Stefan et al. · 2013 · Immunity
144. A history of exploring cancer in context
     Maman, Shelly, Witz, Isaac P. · 2018 · Nature Reviews Cancer
145. Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis
     Wenes, Mathias, Shang, Min, Di Matteo, Mario, Goveia, Jermaine, Martín-Pérez, Rosa, Serneels, Jens, Prenen, Hans, Ghesquière, Bart, Carmeliet, Peter, Mazzone, Massimiliano · 2016 · Cell Metabolism
146. MET is required for the recruitment of anti-tumoural neutrophils
     Veronica Finisguerra, Giusy Di Conza, Mario Di Matteo, Jens Serneels, Sandra Costa, Alfred A Roger Thompson, Els Wauters, Sarah R. Walmsley, Hans Prenen, Zvi Granot et al. · 2015 · Nature
147. Differential Production of IL-12, IFN-α, and IFN-γ by Mouse Dendritic Cell Subsets
     Hubertus Hochrein, Ken Shortman, David Vremec, Bernadette Scott, Paul J. Hertzog, Meredith A O’Keeffe · 2001 · The Journal of Immunology
148. Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti–PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells
     Alfonso R. Sánchez-Paulete, Francisco J. Cueto, María Martínez‐López, Sara Labiano, Aizea Morales‐Kastresana, Maria Esperanza Rodriguez-Ruiz, Maria Jure‐Kunkel, Arantza Azpilikueta, Maria Angela Aznar, Jose Ignacio Quetglas et al. · 2015 · Cancer Discovery
149. Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch
     Patrick M. Gubser, Glenn R. Bantug, Leyla Razik, Marco Fischer, Sarah Dimeloe, Gideon Höenger, Bojana Müller-Durovic, Annaïse Jauch, Christoph Hess · 2013 · Nature Immunology
150. The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism
     Jonathan D. Powell, Greg M. Delgoffe · 2010 · Immunity
151. Transcriptional Control of Dendritic Cell Development
     Theresa L. Murphy, Gary E. Grajales‐Reyes, Xiaodi Wu, Roxane Tussiwand, Carlos G. Briseño, Arifumi Iwata, Nicole M. Kretzer, Vivek Durai, KENNETH M. M. MURPHY · 2016 · Annual Review of Immunology
152. Dendritic cell metabolism
     Edward J. Pearce, Bart Everts · 2014 · Nature reviews. Immunology
153. mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function
     Raymond P Donnelly, Róisín M. Loftus, Sinéad E. Keating, Kevin T. Liou, Christine A. Biron, Clair M. Gardiner, David K. Finlay · 2014 · The Journal of Immunology
154. Primary Antitumor Immune Response Mediated by CD4+ T Cells
     Corthay, Alexandre, Skovseth, Dag K., Lundin, Katrin U., Røsjø, Egil, Omholt, Hilde, Hofgaard, Peter O., Haraldsen, Guttorm, Bogen, Bjarne · 2005 · Immunity
155. Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions
     Ashley V. Menk, Nicole E. Scharping, Rebecca S. Moreci, Xue Zeng, Cliff S. Guy, Sonia R. Salvatore, Heekyong R. Bae, Jianxin Xie, Howard A. Young, Stacy Gelhaus Wendell et al. · 2018 · Cell Reports
156. Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils
     Amy-Jo Casbon, Damien Reynaud, Chanhyuk Park, Emily Khuc, Dennis D. Gan, Koen Schepers, Emmanuelle A. Passegue, Zena Werb · 2015 · Proceedings of the National Academy of Sciences
157. Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis
     Christian Stockmann, Andrew L. Doedens, Alexander Weidemann, Na Zhang, Norihiko Takeda, Joshua I. Greenberg, David A. Cheresh, Randall S. Johnson · 2008 · Nature
158. Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation
     Eric L. Campbell, Walter J. Bruyninckx, Caleb James Kelly, Louise Elaine Glover, Eóin N. McNamee, Brittelle Bowers, Amanda J. Bayless, Melanie M. Scully, Bejan Jon Saeedi, Lucy Golden‐Mason et al. · 2014 · Immunity
159. Tumor infiltrating Foxp3+ regulatory T‐cells are associated with recurrence in pathologic stage I NSCLC patients
     R. Petersen, Michael J. Campa, J. Sperlazza, Debbi H. Conlon, M. Joshi, D. Harpole, E. Patz · 2006 · Cancer
160. Ablative Tumor Radiation Can Change the Tumor Immune Cell Microenvironment to Induce Durable Complete Remissions
     Alexander Filatenkov, Jeanette B Baker, Antonia M. S. Müller, Justin A. Kenkel, G‐One Ahn, Suparna Dutt, Nigel Zhang, Holbrook E K Kohrt, Kent P. Jensen, Sussan Dejbakhsh‐Jones et al. · 2015 · Clinical Cancer Research
161. Regulation of Hypoxia-Inducible Factor-1a by Reactive Oxygen Species : New Developments in an Old Debate
     Movafagh, Shahrzad, Crook, Sean, Vo, Kim · 2015 · Journal of Cellular Biochemistry
162. Prognostic significance of tumor infiltrating natural killer cells subset CD57 in patients with squamous cell lung cancer
     Francisco R. Villegas, Santiago Coca, Vicente G. Villarrubia, R Torres Jiménez, M.J. Chillon, Javier Jareño, Marcos Zuil, L. Callol · 2002 · Lung Cancer
163. Immune Stimulatory Receptor CD40 Is Required for T-Cell Suppression and T Regulatory Cell Activation Mediated by Myeloid-Derived Suppressor Cells in Cancer
     Ping‐Ying Pan, Ge Ma, Kaare J. Weber, Junko J. Ozao‐Choy, George Wang, Bingjiao Yin, Celia Maria Divino, Shu‐Hsia Chen · 2009 · Cancer Research
164. High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3
     Dominic De Nardo, Larisa I. Labzin, Hajime Kono, Reiko Seki, Susanne V. Schmidt, Marc Beyer, Dakang Xu, Sebastian Zimmer, Catharina Lahrmann, Frank Alexander Schildberg et al. · 2013 · Nature Immunology
165. Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation
     Imtiyaz, Hongxia Z., Williams, Emily P., Hickey, Michele M., Patel, Shetal A., Durham, Amy C., Yuan, Li-Jun, Hammond, Rachel, Gimotty, Phyllis A., Keith, Brian, Simon, M. Celeste · 2010 · Journal of Clinical Investigation
166. T cell responses: naïve to memory and everything in between
     Pennock, Nathan D., White, Jason T., Cross, Eric W., Cheney, Elizabeth E., Tamburini, Beth A., Kedl, Ross M. · 2013 · Advances in Physiology Education
167. Evolution of Metastases in Space and Time under Immune Selection
     Mihaela Angelova, Bernhard Mlecnik, Angela Vasaturo, Gabriela Bindea, Tessa Fredriksen, Lucie Lafontaine, Bénédicte Buttard, Erwan Morgand, Daniela Bruni, Anne Jouret‐Mourin et al. · 2018 · Cell
168. Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation
     Anthony J. Covarrubias, Halil‐Ibrahim Aksoylar, Jiujiu Yu, Nathaniel W. Snyder, Andrew J Worth, Shankar S Iyer, Jiawei Wang, Issam Ben‐Sahra, Vanessa Byles, Tiffany Polynne-Stapornkul et al. · 2016 · eLife
169. Metabolism of stromal and immune cells in health and disease
     Bart Ghesquière, Brian W. Wong, Anna Kuchnio, Peter Carmeliet · 2014 · Nature
170. The Prognostic Value of FoxP3+ Tumor-Infiltrating Lymphocytes in Cancer: A Critical Review of the Literature
     R. deLeeuw, S. Kost, J. Kakal, B. Nelson · 2012 · Clinical Cancer Research
171. Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages
     Toszka Bohn, Steffen Rapp, Natascha Luther, Matthias Klein, Till-Julius Brühl, Nobuhiko Kojima, Pamela Aranda Lopez, Jennifer Hahlbrock, Sabine Muth, Shogo Endo et al. · 2018 · Nature Immunology
172. Tumor-Infiltrating Monocytic Myeloid-Derived Suppressor Cells Mediate CCR5-Dependent Recruitment of Regulatory T Cells Favoring Tumor Growth
     Eva Schlecker, Ana Stojanovic, Christian Eisen, Christian Quack, Christine Susanne Falk, Viktor Umansky, Adelheid Cerwenka · 2012 · The Journal of Immunology
173. Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth
     Lifeng Yang, Abhinav Achreja, Tsz-Lun Yeung, Lingegowda Selanere Mangala, Dahai Jiang, Cecil Han, Joelle Baddour, Juan C. Marini, Joseph Ni, Ryuichi Nakahara et al. · 2016 · Cell Metabolism
174. JunB Deficiency Leads to a Myeloproliferative Disorder Arising from Hematopoietic Stem Cells
     Emmanuelle A. Passegue, Erwin Friedrich Wagner, Irving L. Weissman · 2004 · Cell
175. Type I IFN s induce anti‐tumor polarization of tumor associated neutrophils in mice and human
     Lisa Andzinski, Nadine Kasnitz, Stephanie Stahnke, Ching‐Fang Wu, Marcus Gereke, Maren von Köckritz‐Blickwede, Bastian Schilling, Sven Brandau, Siegfried Weiß, Jadwiga Jabłońska · 2015 · International Journal of Cancer
176. S-2-hydroxyglutarate regulates CD8(+) T-lymphocyte fate
     Tyrakis, Petros A., Palazon, Asis, Macias, David, Lee, Kian. L., Phan, Anthony. T., Veliça, Pedro, You, Jia, Chia, Grace S., Sim, Jingwei, Doedens, Andrew et al. · 2016 · Nature
177. γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer
     Bruno Silva‐Santos, Sofia Mensurado, Seth B. Coffelt · 2019 · Nature reviews. Cancer
178. HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
     Zhang, Huimin, Lu, Haiquan, Xiang, Lisha, Bullen, John W., Zhang, Chuanzhao, Samanta, Debangshu, Gilkes, Daniele M., He, Jianjun, Semenza, Gregg L. · 2015 · Proceedings of the National Academy of Sciences
179. Differential Effects of Physiologically Relevant Hypoxic Conditions on T Lymphocyte Development and Effector Functions
     Caldwell, Charles C, Kojima, Hidefumi, Lukashev, Dmitriy, Armstrong, John, Farber, Mark, Apasov, Sergey G, Sitkovsky, Michail V · 2001 · The Journal of Immunology
180. Fatty acid metabolism in the regulation of T cell function
     Matthias Lochner, Luciana Berod, Tim D. Sparwasser · 2015 · Trends in Immunology
181. Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors
     Frederick Arce Vargas, Andrew J.S. Furness, Isabelle Solomon, Kroopa Joshi, Leila Mekkaoui, Marta H. Lesko, Enrique Miranda, Rony Dahan, Andrew Georgiou, Anna Śledzińska et al. · 2017 · Immunity
182. Hypoxia and Hypoxia-Inducible Factor-1α Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function
     Jantsch, Jonathan, Chakravortty, Dipshikha, Turza, Nadine, Prechtel, Alexander T, Buchholz, Björn, Gerlach, Roman G, Volke, Melanie, Gläsner, Joachim, Warnecke, Christina, Wiesener, Michael S et al. · 2008 · The Journal of Immunology
183. Novel Foxo1-dependent transcriptional programs control Treg cell function
     Weiming Ouyang, Will Liao, Chong T. Luo, Na Yin, Morgan Huse, Myoungjoo V. Kim, Min Peng, Pamela Chan, Qian Ma, Yifan Mo et al. · 2012 · Nature
184. Macrophage Responses to Hypoxia
     Lewis, Claire, Murdoch, Craig · 2005 · The American Journal of Pathology
185. Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
     Kenji Chamoto, Partha Sarathi Chowdhury, Alok Kumar, Kazuhiro Sonomura, Fumihiko Matsuda, Sidonia Fagarasan, Tasuku Honjo · 2017 · Proceedings of the National Academy of Sciences
186. Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels
     Ursula Schenk, Astrid Maria Westendorf, Enrico Radaelli, Anna Casati, Micol Ferro, Marta Fumagalli, Claudia Verderio, Jan Buer, Eugenio Scanziani, Fabio Grassi · 2008 · Science Signaling
187. Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population
     Damya Laoui, Eva Van Overmeire, Giusy Di Conza, Chiara Aldeni, Jiri Keirsse, Yannick Morias, Kiavash Movahedi, Isabelle Houbracken, Elio Schouppe, Yvon Elkrim et al. · 2013 · Cancer Research
188. Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis
     Erika Mariana Palmieri, Alessio Menga, Rosa Martín‐Pérez, Annamaria Quinto, Carla Riera‐Domingo, Giacoma De Tullio, Douglas Craig Hooper, Wouter H. Lamers, Bart Ghesquière, Daniel W. McVicar et al. · 2017 · Cell Reports
189. Preclinical characterization of 1-7F9, a novel human anti–KIR receptor therapeutic antibody that augments natural killer–mediated killing of tumor cells
     François Romagné, Pascale André, Pieter Spee, Stefan Zahn, Nicolas Anfossi, Laurent Gauthier, Marusca Capanni, Loredana Ruggeri, Don M. Benson, Bradley Wayne Blaser et al. · 2009 · Blood
190. Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes
     Madhav D. Sharma, De‐Yan Hou, Yanjun Liu, Pandelakis A. Koni, Richard A. Metz, Phillip Chandler, Andrew L. Mellor, Yukai He, David H. Munn · 2009 · Blood
191. Induction of interleukin-8 preserves the angiogenic response in HIF-1α–deficient colon cancer cells
     Yusuke Mizukami, Won–Seok Jo, Eva–Maria Duerr, Manish K. Gala, Jingnan Li, Xiaobo Zhang, Michael A Zimmer, Othon Iliopoulos, Lawrence R. Zukerberg, Yutaka Kohgo et al. · 2005 · Nature Medicine
192. Density of immunogenic antigens does not explain the presence or absence of the T-cell–inflamed tumor microenvironment in melanoma
     Stefani Spranger, Jason J. Luke, Riyue Bao, Yuanyuan Zha, Kyle M. Hernandez, Li Yan, Alexander P. Gajewski, Jorge Andrade, Thomas F. Gajewski · 2016 · Proceedings of the National Academy of Sciences
193. Indoleamine 2,3-Dioxygenase Expression in Human Cancers: Clinical and Immunologic Perspectives
     Jessica Godin-Ethier, Laïla‐Aïcha Hanafi, Ciriaco A. Piccirillo, Réjean Lapointe · 2011 · Clinical Cancer Research
194. Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism
     Xu, Tao, Stewart, Kelly M., Wang, Xiaohu, Liu, Kai, Xie, Min, Ryu, Jae Kyu, Li, Ke, Ma, Tianhua, Wang, Haixia, Ni, Lu et al. · 2017 · Nature
195. HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma
     Qiu, Bo, Ackerman, Daniel, Sanchez, Danielle J., Li, Bo, Ochocki, Joshua D., Grazioli, Alison, Bobrovnikova-Marjon, Ekaterina, Diehl, J. Alan, Keith, Brian, Simon, M. Celeste · 2015 · Cancer Discovery
196. Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis
     Jamieson, Thomas, Clarke, Mairi, Steele, Colin W., Samuel, Michael S., Neumann, Jens, Jung, Andreas, Huels, David, Olson, Michael F., Das, Sudipto, Nibbs, Robert J.B. et al. · 2012 · Journal of Clinical Investigation
197. Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy
     Madhusudhanan Sukumar, Jie Liu, Gautam U. Mehta, Shashank J. Patel, Rahul Roychoudhuri, Joseph Garfield Crompton, Christopher Austin Klebanoff, Yun Ji, Peng Li, Zhiya Yu et al. · 2015 · Cell Metabolism
198. A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkers
     Philip A. Kramer, S. Ravi, B. Chacko, Michelle S. Johnson, V. Darley-Usmar · 2014 · Redox Biology
199. IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan
     Richard A. Metz, Sonja Rust, James B. DuHadaway, Mario R. Mautino, David H. Munn, Nicholas N. Vahanian, Charles J. Link, George C. Prendergast · 2012 · OncoImmunology
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