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Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways
Abstract
Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive immunoinflammatory mechanisms are involved. Inflammation is central at all stages of atherosclerosis. It is implicated in the formation of early fatty streaks, when the endothelium is activated and expresses chemokines and adhesion molecules leading to monocyte/lymphocyte recruitment and infiltration into the subendothelium. It also acts at the onset of adverse clinical vascular events, when activated cells within the plaque secrete matrix proteases that degrade extracellular matrix proteins and weaken the fibrous cap, leading to rupture and thrombus formation. Cells involved in the atherosclerotic process secrete and are activated by soluble factors, known as cytokines. Important recent advances in the comprehension of the mechanisms of atherosclerosis provided evidence that the immunoinflammatory response in atherosclerosis is modulated by regulatory pathways, in which the two anti-inflammatory cytokines interleukin-10 and transforming growth factor-β play a critical role. The purpose of this review is to bring together the current information concerning the role of cytokines in the development, progression, and complications of atherosclerosis. Specific emphasis is placed on the contribution of pro- and anti-inflammatory cytokines to pathogenic (innate and adaptive) and regulatory immunity in the context of atherosclerosis. Based on our current knowledge of the role of cytokines in atherosclerosis, we propose some novel therapeutic strategies to combat this disease. In addition, we discuss the potential of circulating cytokine levels as biomarkers of coronary artery disease.
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Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315
Grundy, S. M., Cleeman, J. I., Merz, C. N. B., Brewer, H. B., Clark, L. T., Hunninghake, D. B., Pasternak, R. C., Smith, S. C., & Stone, N. J. (2004) · Circulation · doi:10.1161/01.cir.0000133317.49796.0e · Cited by 6,902
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703
O'Leary, D. H., Polak, J. F., Kronmal, R. A., Manolio, T. A., Burke, G. L., & Wolfson, S. K. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901073400103 · Cited by 4,685
Cited by
Origin and physiological roles of inflammation
Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618
Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)
Berenbaum, F. (2013) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2012.11.012 · Cited by 1,718
Rajamäki, K., Lappalainen, J., Öörni, K., Välimäki, E., Matikainen, S., Kovanen, P. T., & Eklund, K. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011765 · Cited by 1,039
Inflammation in Atherosclerosis: From Vascular Biology to Biomarker Discovery and Risk Prediction
Packard, R. R. S., & Libby, P. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.097360 · Cited by 925
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554
Gylling, H., Plat, J., Turley, S., Ginsberg, H. N., Ellegård, L., Jessup, W., Jones, P. J., Lütjohann, D., Maerz, W., Masana, L., et al. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.11.043 · Cited by 529
Newby, A. C. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.173898 · Cited by 496
Role of Ion Channels and Transporters in Cell Migration
Schwab, A., Fabian, A., Hanley, P. J., & Stock, C. (2012) · Physiological Reviews · doi:10.1152/physrev.00018.2011 · Cited by 420
Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361
Cardilo‐Reis, L., Gruber, S., Schreier, S. M., Drechsler, M., Papac‐Milicevic, N., Weber, C., Wagner, O., Stangl, H., Soehnlein, O., & Binder, C. J. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201201374 · Cited by 292
Loneliness and stress-related inflammatory and neuroendocrine responses in older men and women
Hackett, R. A., Hamer, M., Endrighi, R., Brydon, L., & Steptoe, A. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.016 · Cited by 272
Anticytokine Agents: Targeting Interleukin Signaling Pathways for the Treatment of Atherothrombosis
Ridker, P. M. (2019) · Circulation Research · doi:10.1161/circresaha.118.313129 · Cited by 260
Nuts and novel biomarkers of cardiovascular disease
Ros, E. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.26736r · Cited by 266
Lactadherin Deficiency Leads to Apoptotic Cell Accumulation and Accelerated Atherosclerosis in Mice
Ait-Oufella, H., Kinugawa, K., Zoll, J., Simon, T., Boddaert, J., Heeneman, S., Blanc-Brude, O., Barateau, V., Potteaux, S., Merval, R., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.662080 · Cited by 255
Self-citationInnate and Adaptive Inflammation as a Therapeutic Target in Vascular Disease
Tousoulis, D., Psarros, C., Demosthenous, M., Patel, R., Antoniades, C., & Stefanadis, C. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.01.054 · Cited by 187
Macrophage heterogeneity in atherosclerotic plaques
Johnson, J. L., & Newby, A. C. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283309848 · Cited by 183
Mohty, D., Pibarot, P., Després, J.-P., Côté, C., Arsenault, B., Cartier, A., Cosnay, P., Couture, C., & Mathieu, P. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.154989 · Cited by 181
Iannantuoni, F., M. de Marañon, A., Diaz-Morales, N., Falcon, R., Bañuls, C., Abad-Jimenez, Z., Victor, V. M., Hernandez-Mijares, A., & Rovira-Llopis, S. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111814 · Cited by 166
Wolfs, I., Donners, M., & de Winther, M. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-05-0320 · Cited by 157
TREM2 macrophages induced by human lipids drive inflammation in acne lesions
Do, T. H., Ma, F., Andrade, P. R., Teles, R., de Andrade Silva, B. J., Hu, C., Espinoza, A., Hsu, J.-E., Cho, C.-S., Kim, M., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abo2787 · Cited by 139
“The lipid metabolic products from these foam cells have been shown to trigger proinflammatory cytokines, which amplify the inflammatory response (31).”
BackgroundIs the anti-inflammatory effect of regular exercise responsible for reduced cardiovascular disease?
Wilund, K. R. (2007) · Clinical Science · doi:10.1042/cs20060368 · Cited by 138
Rajaram, S., Connell, K. M., & Sabaté, J. (2010) · British Journal of Nutrition · doi:10.1017/s0007114509992480 · Cited by 134
Hallowell, R. W., Collins, S. L., Craig, J. M., Zhang, Y., Oh, M., Illei, P. B., Chan-Li, Y., Vigeland, C. L., Mitzner, W., Scott, A. L., et al. (2017) · Nature Communications · doi:10.1038/ncomms14208 · Cited by 129
miR-155 Regulated Inflammation Response by the SOCS1-STAT3-PDCD4 Axis in Atherogenesis
Ye, J., Guo, R., Shi, Y., Qi, F., Guo, C., & Yang, L. (2016) · Mediators of Inflammation · doi:10.1155/2016/8060182 · Cited by 127
Krysiak, R., & Okopien, B. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2986 · Cited by 117
Statin therapy modulates thickness and inflammatory profile of human epicardial adipose tissue
Parisi, V., Petraglia, L., D'Esposito, V., Cabaro, S., Rengo, G., Caruso, A., Grimaldi, M. G., Baldascino, F., De Bellis, A., Vitale, D., et al. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.06.106 · Cited by 114
Maternal high-fat diet impacts endothelial function in nonhuman primate offspring
Fan, L., Lindsley, S. R., Comstock, S. M., Takahashi, D. L., Evans, A. E., He, G.-W., Thornburg, K. L., & Grove, K. L. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.42 · Cited by 98
Aryal, B., Rotllan, N., Araldi, E., Ramírez, C. M., He, S., Chousterman, B. G., Fenn, A. M., Wanschel, A., Madrigal-Matute, J., Warrier, N., et al. (2016) · Nature Communications · doi:10.1038/ncomms12313 · Cited by 93
A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism
Seldin, M. M., Koplev, S., Rajbhandari, P., Vergnes, L., Rosenberg, G. M., Meng, Y., Pan, C., Phuong, T. M. N., Gharakhanian, R., Che, N., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.015 · Cited by 84
Johnson, J. L., Sala-Newby, G. B., Ismail, Y., Aguilera, C. M., & Newby, A. C. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.170548 · Cited by 68
Denollet, J., Vrints, C. J., & Conraads, V. M. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.10.015 · Cited by 58
Nagenborg, J., Goossens, P., Biessen, E. A. L., & Donners, M. M. P. C. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.10.005 · Cited by 50
Fu, H., Alabdullah, M., Großmann, J., Spieler, F., Abdosh, R., Lutz, V., Kalies, K., Knöpp, K., Rieckmann, M., Koch, S., et al. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-2109-9 · Cited by 51
Abdul Muneer, P. M., Alikunju, S., Mishra, V., Schuetz, H., Szlachetka, A. M., Burnham, E. L., & Haorah, J. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.02.014 · Cited by 33
Fong, L. Y., Ng, C. T., Zakaria, Z. A., Baharuldin, M. T. H., Arifah, A. K., Hakim, M. N., & Zuraini, A. (2015) · Phytotherapy Research · doi:10.1002/ptr.5404 · Cited by 33
Immune Complex Pathophysiology
NYDEGGER, U. E. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1398.009 · Cited by 31
Yanagisawa, N., Shimada, K., Miyazaki, T., Kume, A., Kitamura, Y., Sumiyoshi, K., Kiyanagi, T., Iesaki, T., Inoue, N., & Daida, H. (2008) · Lipids in Health and Disease · doi:10.1186/1476-511x-7-48 · Cited by 29
Puz, P., & Lasek–Bal, A. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.06.008 · Cited by 27
Spirulina and Herbal Combination on Metabolic Alterations of Cardiovascular Diseases (CVDs)
Pandey, R., & Singh, S. (2022) · International Journal of Research and Review · doi:10.52403/ijrr.20220334 · Cited by 6
Modeling Risk Factors and Confounding Effects in Stroke
McColl, B., Howells, D., Rothwell, N., & Denes, A. (2010) · Neuromethods · doi:10.1007/978-1-60761-750-1_9 · Cited by 3
Metadata
- Authors
- Tedgui, A., & Mallat, Z.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2006-04
- Volume
- 86
- Issue
- 2
- Pages
- 515-581
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2165463540
- Cited by
- 1,701
- References
- 52
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- closed
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