Cited by 1,256

The DOI matches its Crossref record; 530 of the 530 references it cites were found in a registry or an index.

Molecular Structure and Physiological Function of Chloride Channels

Jentsch, Thomas J., Stein, Valentin, Weinreich, Frank, Zdebik, Anselm A.·2002·Physiological Reviews

DOI 10.1152/physrev.00029.2001

Open this paper in CoChat — free account

Abstract

Cl−channels reside both in the plasma membrane and in intracellular organelles. Their functions range from ion homeostasis to cell volume regulation, transepithelial transport, and regulation of electrical excitability. Their physiological roles are impressively illustrated by various inherited diseases and knock-out mouse models. Thus the loss of distinct Cl−channels leads to an impairment of transepithelial transport in cystic fibrosis and Bartter's syndrome, to increased muscle excitability in myotonia congenita, to reduced endosomal acidification and impaired endocytosis in Dent's disease, and to impaired extracellular acidification by osteoclasts and osteopetrosis. The disruption of several Cl−channels in mice results in blindness. Several classes of Cl−channels have not yet been identified at the molecular level. Three molecularly distinct Cl−channel families (CLC, CFTR, and ligand-gated GABA and glycine receptors) are well established. Mutagenesis and functional studies have yielded considerable insights into their structure and function. Recently, the detailed structure of bacterial CLC proteins was determined by X-ray analysis of three-dimensional crystals. Nonetheless, they are less well understood than cation channels and show remarkably different biophysical and structural properties. Other gene families (CLIC or CLCA) were also reported to encode Cl−channels but are less well characterized. This review focuses on molecularly identified Cl−channels and their physiological roles.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1152/physrev.00029.2001

Cites

530 of 530 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
Riordan, J. R., Rommens, J. M., Kerem, B.-S., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.-L., et al. (1989) · Science · doi:10.1126/science.2475911 · Cited by 7,418
The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity
Doyle, D. A., Cabral, J. M., Pfuetzner, R. A., Kuo, A., Gulbis, J. M., Cohen, S. L., Chait, B. T., & MacKinnon, R. (1998) · Science · doi:10.1126/science.280.5360.69 · Cited by 6,807
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
Shimizu, S., Narita, M., Tsujimoto, Y., & Tsujimoto, Y. (1999) · Nature · doi:10.1038/20959 · Cited by 2,178
The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
Rivera, C., Voipio, J., Payne, J. A., Ruusuvuori, E., Lahtinen, H., Lamsa, K., Pirvola, U., Saarma, M., & Kaila, K. (1999) · Nature · doi:10.1038/16697 · Cited by 2,152
GABAA Receptor Channels
Macdonald, R. L., & Olsen, R. W. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.003033 · Cited by 1,975
Reconstitution of I KATP : An Inward Rectifier Subunit Plus the Sulfonylurea Receptor
Inagaki, N., Gonoi, T., Clement, J. P., Namba, N., Inazawa, J., Gonzalez, G., Aguilar-Bryan, L., Seino, S., & Bryan, J. (1995) · Science · doi:10.1126/science.270.5239.1166 · Cited by 1,709
Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family
Schofield, P. R., Darlison, M. G., Fujita, N., Burt, D. R., Stephenson, F. A., Rodriguez, H., Rhee, L. M., Ramachandran, J., Reale, V., Glencorse, T. A., et al. (1987) · Nature · doi:10.1038/328221a0 · Cited by 1,622
The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon
Wisden, W., Laurie, D., Monyer, H., & Seeburg, P. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-03-01040.1992 · Cited by 1,543
Inactivation of the sodium channel. I. Sodium current experiments.
Bezanilla, F., & Armstrong, C. M. (1977) · The Journal of general physiology · doi:10.1085/jgp.70.5.549 · Cited by 1,500
Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes.
Sieghart, W. (1995) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06840-1 · Cited by 1,301
Structural parts involved in activation and inactivation of the sodium channel
Stühmer, W., Conti, F., Suzuki, H., Wang, X., Noda, M., Yahagi, N., Kubo, H., & Numa, S. (1989) · Nature · doi:10.1038/339597a0 · Cited by 1,215
Mechanism of anion permeation through channels gated by glycine and gamma‐aminobutyric acid in mouse cultured spinal neurones.
Bormann, J., Hamill, O. P., & Sakmann, B. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016493 · Cited by 1,157
The distribution of thirteen GABAA receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development
Laurie, D., Wisden, W., & Seeburg, P. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04151.1992 · Cited by 1,143
Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity
Anderson, M. P., Gregory, R. J., Thompson, S., Souza, D. W., Paul, S., Mulligan, R. C., Smith, A. E., & Welsh, M. J. (1991) · Science · doi:10.1126/science.1712984 · Cited by 1,137
An excitatory amino-acid transporter with properties of a ligand-gated chloride channel
Fairman, W. A., Vandenberg, R. J., Arriza, J. L., Kavanaught, M. P., & Amara, S. G. (1995) · Nature · doi:10.1038/375599a0 · Cited by 1,131
GABA: an excitatory transmitter in early postnatal life
Cherubini, E., Gaiarsa, J. L., & Ben-Ari, Y. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90003-d · Cited by 1,108
CFTR as a cAMP-Dependent Regulator of Sodium Channels
Stutts, M. J., Canessa, C. M., Olsen, J. C., Hamrick, M., Cohn, J. A., Rossier, B. C., & Boucher, R. C. (1995) · Science · doi:10.1126/science.7543698 · Cited by 1,088
Human β-Defensin-1 Is a Salt-Sensitive Antibiotic in Lung That Is Inactivated in Cystic Fibrosis
Goldman, M. J., Anderson, G. M., Stolzenberg, E. D., Kari, U. P., Zasloff, M., & Wilson, J. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81895-4 · Cited by 1,080
GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis
LoTurco, J. J., Owens, D. F., Heath, M. J. S., Davis, M. B. E., & Kriegstein, A. R. (1995) · Neuron · doi:10.1016/0896-6273(95)90008-x · Cited by 1,064
Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors
Kaupmann, K., Huggel, K., Heid, J., Flor, P. J., Bischoff, S., Mickel, S. J., McMaster, G., Angst, C., Bittiger, H., Froestl, W., et al. (1997) · Nature · doi:10.1038/386239a0 · Cited by 1,029
An Endocytic Pathway Essential for Renal Uptake and Activation of the Steroid 25-(OH) Vitamin D3
Nykjaer, A., Dragun, D., Walther, D., Vorum, H., Jacobsen, C., Herz, J., Melsen, F., Christensen, E. I., & Willnow, T. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80655-8 · Cited by 1,027
Structure and Function of the CFTR Chloride Channel
SHEPPARD, D. N., & WELSH, M. J. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.s23 · Cited by 1,018
Acetylcholine receptor channel imaged in the open state
Unwin, N. (1995) · Nature · doi:10.1038/373037a0 · Cited by 999
Loss of the ClC-7 Chloride Channel Leads to Osteopetrosis in Mice and Man
Kornak, U., Kasper, D., Bösl, M. R., Kaiser, E., Schweizer, M., Schulz, A., Friedrich, W., Delling, G., & Jentsch, T. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00206-9 · Cited by 995
Self-citation
Primary Structure And Functional Expression of the 5HT 3 Receptor, A Serotonin-gated Ion Channel
Maricq, A. V., Peterson, A. S., Brake, A. J., Myers, R. M., & Julius, D. (1991) · Science · doi:10.1126/science.1718042 · Cited by 979
Inactivation of the sodium channel. II. Gating current experiments.
Armstrong, C. M., & Bezanilla, F. (1977) · The Journal of general physiology · doi:10.1085/jgp.70.5.567 · Cited by 959
Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)
Bear, C. E., Li, C., Kartner, N., Bridges, R. J., Jensen, T. J., Ramjeesingh, M., & Riordan, J. R. (1992) · Cell · doi:10.1016/0092-8674(92)90155-6 · Cited by 945
Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance
Arriza, J. L., Eliasof, S., Kavanaugh, M. P., & Amara, S. G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4155 · Cited by 912
Mechanism of calcium gating in small-conductance calcium-activated potassium channels
Xia, X.-M., Fakler, B., Rivard, A., Wayman, G., Johnson-Pais, T., Keen, J. E., Ishii, T., Hirschberg, B., Bond, C. T., Lutsenko, S., et al. (1998) · Nature · doi:10.1038/26758 · Cited by 871
Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III
Simon, D. B., Bindra, R. S., Mansfield, T. A., Nelson-Williams, C., Mendonca, E., Stone, R., Schurman, S., Nayir, A., Alpay, H., Bakkaloglu, A., et al. (1997) · Nature Genetics · doi:10.1038/ng1097-171 · Cited by 867
Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons
Takamori, S., Rhee, J. S., Rosenmund, C., & Jahn, R. (2000) · Nature · doi:10.1038/35025070 · Cited by 862
Postsynaptic clustering of major GABAA receptor subtypes requires the γ2 subunit and gephyrin
Essrich, C., Lorez, M., Benson, J. A., Fritschy, J.-M., & Lüscher, B. (1998) · Nature Neuroscience · doi:10.1038/2798 · Cited by 856
Neuronal KCNQ potassium channels:physislogy and role in disease
Jentsch, T. J. (2000) · Nature Reviews Neuroscience · doi:10.1038/35036198 · Cited by 849
Self-citation
Nicotinic Acetylcholine Receptor an 9 Å Resolution
Unwin, N. (1993) · Journal of Molecular Biology · doi:10.1006/jmbi.1993.1107 · Cited by 825
Uptake of Glutamate into Synaptic Vesicles by an Inorganic Phosphate Transporter
Bellocchio, E. E., Reimer, R. J., Fremeau, R. T., & Edwards, R. H. (2000) · Science · doi:10.1126/science.289.5481.957 · Cited by 802
GABAA, NMDA and AMPA receptors: a developmentally regulated 'ménage à trois'
Ben-Ari, Y. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01147-8 · Cited by 794
Long-term potentiation and functional synapse induction in developing hippocampus
Durand, G. M., Kovalchuk, Y., & Konnerth, A. (1996) · Nature · doi:10.1038/381071a0 · Cited by 789
Corelease of Two Fast Neurotransmitters at a Central Synapse
Jonas, P., Bischofberger, J., & Sandkühler, J. (1998) · Science · doi:10.1126/science.281.5375.419 · Cited by 784
Mutant GABAA receptor γ2-subunit in childhood absence epilepsy and febrile seizures
Wallace, R. H., Marini, C., Petrou, S., Harkin, L. A., Bowser, D. N., Panchal, R. G., Williams, D. A., Sutherland, G. R., Mulley, J. C., Scheffer, I. E., et al. (2001) · Nature Genetics · doi:10.1038/ng0501-49 · Cited by 781
First genetic evidence of GABAA receptor dysfunction in epilepsy: a mutation in the γ2-subunit gene
Baulac, S., Huberfeld, G., Gourfinkel-An, I., Mitropoulou, G., Beranger, A., Prud'homme, J.-F., Baulac, M., Brice, A., Bruzzone, R., & LeGuern, E. (2001) · Nature Genetics · doi:10.1038/ng0501-46 · Cited by 766
GABAA-receptor-associated protein links GABAA receptors and the cytoskeleton
Wang, H., Bedford, F. K., Brandon, N. J., Moss, S. J., & Olsen, R. W. (1999) · Nature · doi:10.1038/16264 · Cited by 732
A common molecular basis for three inherited kidney stone diseases
Lloyd, S. E., Pearce, S. H. S., Fisher, S. E., Steinmeyer, K., Schwappach, B., Scheinman, S. J., Harding, B., Bolino, A., Devoto, M., Goodyer, P., et al. (1996) · Nature · doi:10.1038/379445a0 · Cited by 724
Self-citation
Excitatory GABA Responses in Embryonic and Neonatal Cortical Slices Demonstrated by Gramicidin Perforated-Patch Recordings and Calcium Imaging
Owens, D. F., Boyce, L. H., Davis, M. B. E., & Kriegstein, A. R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-20-06414.1996 · Cited by 721
The Skeletal Muscle Chloride Channel in Dominant and Recessive Human Myotonia
Koch, M. C., Steinmeyer, K., Lorenz, C., Ricker, K., Wolf, F., Otto, M., Zoll, B., Lehmann-Horn, F., Grzeschik, K.-H., & Jentsch, T. J. (1992) · Science · doi:10.1126/science.1379744 · Cited by 714
Self-citation
Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis
Frattini, A., Orchard, P. J., Sobacchi, C., Giliani, S., Abinun, M., Mattsson, J. P., Keeling, D. J., Andersson, A.-K., Wallbrandt, P., Zecca, L., et al. (2000) · Nature Genetics · doi:10.1038/77131 · Cited by 674
Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel
Cheng, S. H., Rich, D. P., Marshall, J., Gregory, R. J., Welsh, M. J., & Smith, A. E. (1991) · Cell · doi:10.1016/0092-8674(91)90446-6 · Cited by 663
Volume expansion-sensing outward-rectifier Cl- channel: fresh start to the molecular identity and volume sensor
Okada, Y. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.3.c755 · Cited by 652
CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP
Schwiebert, E. M., Egan, M. E., Hwang, T.-H., Fulmer, S. B., Allen, S. S., Cutting, G. R., & Guggino, W. B. (1995) · Cell · doi:10.1016/s0092-8674(05)80011-x · Cited by 643
Electrophysiology of GABAA and GABAB receptor subtypes
Bormann, J. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90156-7 · Cited by 641
The ‘ABC’ of GABA receptors
Bormann, J. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01413-3 · Cited by 628
An update on GABAA receptors
Mehta, A. K., & Ticku, M. K. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00052-6 · Cited by 625
Disruption of KCC2 Reveals an Essential Role of K-Cl Cotransport Already in Early Synaptic Inhibition
Hübner, C. A., Stein, V., Hermans-Borgmeyer, I., Meyer, T., Ballanyi, K., & Jentsch, T. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00297-5 · Cited by 617
Self-citation
Cellular and molecular physiology of volume-sensitive anion channels
Strange, K., Emma, F., & Jackson, P. S. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.270.3.c711 · Cited by 610
A chloride channel widely expressed in epithelial and non-epithelial cells
Thiemann, A., Gründer, S., Pusch, M., & Jentsch, T. J. (1992) · Nature · doi:10.1038/356057a0 · Cited by 607
Self-citation
The Arabidopsis thaliana proton transporters, AtNhx1 and Avp1, can function in cation detoxification in yeast
Gaxiola, R. A., Rao, R., Sherman, A., Grisafi, P., Alper, S. L., & Fink, G. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1480 · Cited by 600
Barttin is a Cl- channel β-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion
Estévez, R., Boettger, T., Stein, V., Birkenhäger, R., Otto, E., Hildebrandt, F., & Jentsch, T. J. (2001) · Nature · doi:10.1038/35107099 · Cited by 583
Self-citation
Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation.
Boucher, R. C., Stutts, M. J., Knowles, M. R., Cantley, L., & Gatzy, J. T. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112708 · Cited by 575
Adaptive regulation of neuronal excitability by a voltage- independent potassium conductance
Brickley, S. G., Revilla, V., Cull-Candy, S. G., Wisden, W., & Farrant, M. (2001) · Nature · doi:10.1038/35051086 · Cited by 572
Altered Regulation of Airway Epithelial Cell Chloride Channels in Cystic Fibrosis
Frizzell, R. A., Rechkemmer, G., & Shoemaker, R. L. (1986) · Science · doi:10.1126/science.2425436 · Cited by 562
Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein
Valverde, M. A., DÍaz, M., Sepúlveda, F. V., Gill, D. R., Hyde, S. C., & Higgins, C. F. (1992) · Nature · doi:10.1038/355830a0 · Cited by 561
Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain.
Malosio, M. L., Marquèze-Pouey, B., Kuhse, J., & Betz, H. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07779.x · Cited by 552
ClC-5 Cl--channel disruption impairs endocytosis in a mouse model for Dent's disease
Piwon, N., Günther, W., Schwake, M., Bösl, M. R., & Jentsch, T. J. (2000) · Nature · doi:10.1038/35042597 · Cited by 551
Self-citation
Voltage-Gated Ion Channels and Hereditary Disease
Lehmann-Horn, F., & Jurkat-Rott, K. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1317 · Cited by 550
Maturation of a Central Glutamatergic Synapse
Wu, G.-Y., Malinow, R., & Cline, H. T. (1996) · Science · doi:10.1126/science.274.5289.972 · Cited by 546
Mutations in the α1 subunit of the inhibitory glycine receptor cause the dominant neurologic disorder, hyperekplexia
Shiang, R., Ryan, S. G., Zhu, Y.-Z., Hahn, A. F., O'Connell, P., & Wasmuth, J. J. (1993) · Nature Genetics · doi:10.1038/ng1293-351 · Cited by 543
Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure
Birkenhäger, R., Otto, E., Schürmann, M. J., Vollmer, M., Ruf, E.-M., Maier-Lutz, I., Beekmann, F., Fekete, A., Omran, H., Feldmann, D., et al. (2001) · Nature Genetics · doi:10.1038/ng752 · Cited by 539
Ion fluxes associated with excitatory amino acid transport
Wadiche, J. I., Amara, S. G., & Kavanaugh, M. P. (1995) · Neuron · doi:10.1016/0896-6273(95)90159-0 · Cited by 539
Cerebellar GABAA receptor selective for a behavioural alcohol antagonist
Lüddens, H., Pritchett, D. B., Köhler, M., Killisch, I., Keinänen, K., Monyer, H., Sprengel, R., & Seeburg, P. H. (1990) · Nature · doi:10.1038/346648a0 · Cited by 538
The structure of a domain common to archaebacteria and the homocystinuria disease protein
Bateman, A. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)30046-7 · Cited by 533
Nucleoside triphosphates are required to open the CFTR chloride channel
Anderson, M. P., Berger, H. A., Rich, D. P., Gregory, R. J., Smith, A. E., & Welsh, M. J. (1991) · Cell · doi:10.1016/0092-8674(91)90072-7 · Cited by 527
Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes
Jentsch, T. J., Steinmeyer, K., & Schwarz, G. (1990) · Nature · doi:10.1038/348510a0 · Cited by 518
Self-citation
Reconstitution in planar lipid bilayers of a voltage-dependent anion-selective channel obtained from paramecium mitochondria
Schein, S. J., Colombini, M., & Finkelstein, A. (1976) · The Journal of Membrane Biology · doi:10.1007/bf01869662 · Cited by 509
Disruption of ClC-3, a Chloride Channel Expressed on Synaptic Vesicles, Leads to a Loss of the Hippocampus
Stobrawa, S. M., Breiderhoff, T., Takamori, S., Engel, D., Schweizer, M., Zdebik, A. A., Bösl, M. R., Ruether, K., Jahn, H., Draguhn, A., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00189-1 · Cited by 508
Self-citation
Silent synapses during development of thalamocortical inputs
Isaac, J. T. R., Crair, M. C., Nicoll, R. A., & Malenka, R. C. (1997) · Neuron · doi:10.1016/s0896-6273(00)80267-6 · Cited by 507
A pharmacological study of the depression of spinal neurones by glycine and related amino acids
Curtis, D. R., H�sli, L., & Johnston, G. A. R. (1968) · Experimental Brain Research · doi:10.1007/bf00235443 · Cited by 505
Cystic fibrosis: a disease in electrolyte transport
Quinton, P. M. (1990) · The FASEB Journal · doi:10.1096/fasebj.4.10.2197151 · Cited by 504
Light microscope study of the coexistence of GABA‐like and glycine‐like immunoreactivities in the spinal cord of the rat
Todd, A. J., & Sullivan, A. C. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.902960312 · Cited by 500
Defective acidification of intracellular organelles in cystic fibrosis
Barasch, J., Kiss, B., Prince, A., Saiman, L., Gruenert, D., & AI-Awqati, Q. (1991) · Nature · doi:10.1038/352070a0 · Cited by 490
The diversity of GABAA receptors: Pharmacological and electrophysiological properties of GABAA channel subtypes
Hevers, W., & Lüddens, H. (1998) · Molecular Neurobiology · doi:10.1007/bf02741459 · Cited by 489
Stoichiometry and Assembly of a Recombinant GABAAReceptor Subtype
Tretter, V., Ehya, N., Fuchs, K., & Sieghart, W. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02728.1997 · Cited by 484
Mice devoid of γ-aminobutyrate type A receptor β3 subunit have epilepsy, cleft palate, and hypersensitive behavior
Homanics, G. E., DeLorey, T. M., Firestone, L. L., Quinlan, J. J., Handforth, A., Harrison, N. L., Krasowski, M. D., Rick, C. E. M., Korpi, E. R., Mäkelä, R., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4143 · Cited by 469
Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification
Li, Y.-P., Chen, W., Liang, Y., Li, E., & Stashenko, P. (1999) · Nature Genetics · doi:10.1038/70563 · Cited by 467
An Apical PDZ Protein Anchors the Cystic Fibrosis Transmembrane Conductance Regulator to the Cytoskeleton
Short, D. B., Trotter, K. W., Reczek, D., Kreda, S. M., Bretscher, A., Boucher, R. C., Stutts, M. J., & Milgram, S. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.31.19797 · Cited by 467
Mutations in CFTR associated with mild-disease-form CI- channels with altered pore properties
Sheppard, D. N., Rich, D. P., Ostedgaard, L. S., Gregory, R. J., Smith, A. E., & Welsh, M. J. (1993) · Nature · doi:10.1038/362160a0 · Cited by 467
A single histidine in GABAA receptors is essential for benzodiazepine agonist binding.
Wieland, H. A., Lüddens, H., & Seeburg, P. H. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45961-3 · Cited by 447
Role of CFTR in Airway Disease
PILEWSKI, J. M., & FRIZZELL, R. A. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.s215 · Cited by 447
Loss of Postsynaptic GABAAReceptor Clustering in Gephyrin-Deficient Mice
Kneussel, M., Brandstätter, J. H., Laube, B., Stahl, S., Müller, U., & Betz, H. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09289.1999 · Cited by 446
Molecular identification of a volume-regulated chloride channel
Duan, D., Winter, C., Cowley, S., Hume, J. R., & Horowitz, B. (1997) · Nature · doi:10.1038/37151 · Cited by 443
Megalin Knockout Mice as an Animal Model of Low Molecular Weight Proteinuria
Leheste, J.-R., Rolinski, B., Vorum, H., Hilpert, J., Nykjaer, A., Jacobsen, C., Aucouturier, P., Moskaug, J. Ø., Otto, A., Christensen, E. I., et al. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65238-8 · Cited by 443
Control of CFTR Channel Gating by Phosphorylation and Nucleotide Hydrolysis
GADSBY, D. C., & NAIRN, A. C. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.s77 · Cited by 443
CFTR Is a Conductance Regulator as well as a Chloride Channel
SCHWIEBERT, E. M., BENOS, D. J., EGAN, M. E., STUTTS, M. J., & GUGGINO, W. B. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.s145 · Cited by 442
Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors.
Günther, U., Benson, J., Benke, D., Fritschy, J. M., Reyes, G., Knoflach, F., Crestani, F., Aguzzi, A., Arigoni, M., Lang, Y., et al. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7749 · Cited by 441
Stoichiometry of a Recombinant GABAAReceptor
Chang, Y., Wang, R., Barot, S., & Weiss, D. S. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-17-05415.1996 · Cited by 440
Dual Requirement for Gephyrin in Glycine Receptor Clustering and Molybdoenzyme Activity
Feng, G., Tintrup, H., Kirsch, J., Nichol, M. C., Kuhse, J., Betz, H., & Sanes, J. R. (1998) · Science · doi:10.1126/science.282.5392.1321 · Cited by 438
Primary structure and functional expression of a developmentally regulated skeletal muscle chloride channel
Steinmeyer, K., Ortland, C., & Jentsch, T. J. (1991) · Nature · doi:10.1038/354301a0 · Cited by 437
Self-citation
The ABC of GABA receptors: a brief review
Chebib, M., & Johnston, G. A. R. (1999) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.1999.03151.x · Cited by 436
Stimulus‐secretion coupling: cytoplasmic calcium signals and the control of ion channels in exocrine acinar cells.
Petersen, O. H. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019028 · Cited by 436
ClC-5, the chloride channel mutated in Dent’s disease, colocalizes with the proton pump in endocytotically active kidney cells
Günther, W., Lüchow, A., Cluzeaud, F., Vandewalle, A., & Jentsch, T. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.8075 · Cited by 434
Self-citation
Another mechanism for creating diversity in gamma-aminobutyrate type A receptors: RNA splicing directs expression of two forms of gamma 2 phosphorylation site.
Whiting, P., McKernan, R. M., & Iversen, L. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9966 · Cited by 432
Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume
Gründer, S., Thiemann, A., Pusch, M., & Jentsch, T. J. (1992) · Nature · doi:10.1038/360759a0 · Cited by 428
Self-citation
Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina.
Cutting, G. R., Lu, L., O'Hara, B. F., Kasch, L. M., Montrose-Rafizadeh, C., Donovan, D. M., Shimada, S., Antonarakis, S. E., Guggino, W. B., & Uhl, G. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.7.2673 · Cited by 427
Defective regulation of outwardly rectifying Cl− channels by protein kinase A corrected by insertion of CFTR
Egan, M., Flotte, T., Afione, S., Solow, R., Zeitlin, P. L., Carter, B. J., & Guggino, W. B. (1992) · Nature · doi:10.1038/358581a0 · Cited by 426
Characteristics and physiological role of the Ca(2+)-activated Cl- conductance in smooth muscle
Large, W. A., & Wang, Q. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.2.c435 · Cited by 418
Identification of a gephyrin binding motif on the glycine receptor β subunit
Meyer, G., Kirsch, J., Betz, H., & Langosch, D. (1995) · Neuron · doi:10.1016/0896-6273(95)90145-0 · Cited by 416
Open-state substructure of single chloride channels from Torpedo electroplax
Miller, C. (1982) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1982.0140 · Cited by 414
Biosynthesis and Degradation of CFTR
KOPITO, R. R. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.s167 · Cited by 410
GABAB receptors and their significance in mammalian pharmacology
Bowery, N. (1989) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(89)90188-0 · Cited by 404
Ligand-gated ion channels in the brain: The amino acid receptor superfamily
Betz, H. (1990) · Neuron · doi:10.1016/0896-6273(90)90077-s · Cited by 398
Activation of multiple-conductance state chloride channels in spinal neurones by glycine and GABA
Hamill, O. P., Bormann, J., & Sakmann, B. (1983) · Nature · doi:10.1038/305805a0 · Cited by 396
Strychnine Binding Associated with Glycine Receptors of the Central Nervous System
Young, A. B., & Snyder, S. H. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.10.2832 · Cited by 388
Inactivation of muscle chloride channel by transposon insertion in myotonic mice
Steinmeyer, K., Klocke, R., Ortland, C., Gronemeier, M., Jockusch, H., GrÜnder, S., & Jentsch, T. J. (1991) · Nature · doi:10.1038/354304a0 · Cited by 386
Self-citation
Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer.
Langosch, D., Thomas, L., & Betz, H. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7394 · Cited by 384
Colocalization of GABA, glycine, and their receptors at synapses in the rat spinal cord
Todd, A., Watt, C., Spike, R., & Sieghart, W. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-03-00974.1996 · Cited by 379
Purification by affinity chromatography of the glycine receptor of rat spinal cord.
Pfeiffer, F., Graham, D., & Betz, H. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34082-1 · Cited by 374
Ubiquitination and Endocytosis of Plasma Membrane Proteins: Role of Nedd4/Rsp5p Family of Ubiquitin-Protein Ligases
Rotin, D., Staub, O., & Haguenauer-Tsapis, R. (2000) · The Journal of Membrane Biology · doi:10.1007/s002320001079 · Cited by 367
Distribution of glycine receptors at central synapses: an immunoelectron microscopy study.
Triller, A., Cluzeaud, F., Pfeiffer, F., Betz, H., & Korn, H. (1985) · The Journal of cell biology · doi:10.1083/jcb.101.2.683 · Cited by 361
Three types of calcium‐dependent channel in rat lacrimal glands.
Marty, A., Tan, Y. P., & Trautmann, A. (1984) · The Journal of Physiology · doi:10.1113/jphysiol.1984.sp015501 · Cited by 358
Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion
Pusch, M., Ludewig, U., Rehfeldt, A., & Jentsch, T. J. (1995) · Nature · doi:10.1038/373527a0 · Cited by 354
Self-citation
Pharmacology of GABA receptor CI− channels in rat retinal bipolar cells
Feigenspan, A., Wässle, H., & Bormann, J. (1993) · Nature · doi:10.1038/361159a0 · Cited by 350
Mutations in the a3 subunit of the vacuolar H+-ATPase cause infantile malignant osteopetrosis
Kornak, U. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.13.2059 · Cited by 347
Molecular and Functional Diversity of the Expanding GABA‐A Receptor Gene Family
WHITING, P. J., BONNERT, T. P., MCKERNAN, R. M., FARRAR, S., BOURDELLES, B. L., HEAVENS, R. P., SMITH, D. W., HEWSON, L., RIGBY, M. R., SIRINATHSINGHJI, D. J. S., et al. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11341.x · Cited by 345
Salmonella typhi uses CFTR to enter intestinal epithelial cells
Pier, G. B., Grout, M., Zaidi, T., Meluleni, G., Mueschenborn, S. S., Banting, G., Ratcliff, R., Evans, M. J., & Colledge, W. H. (1998) · Nature · doi:10.1038/30006 · Cited by 342
Spillover-Mediated Transmission at Inhibitory Synapses Promoted by High Affinity α6 Subunit GABAA Receptors and Glomerular Geometry
Rossi, D. J., & Hamann, M. (1998) · Neuron · doi:10.1016/s0896-6273(00)81016-8 · Cited by 339
Volume-sensitive anion channels mediate swelling-activated inositol and taurine efflux
Jackson, P. S., & Strange, K. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.265.6.c1489 · Cited by 338
Electrophysiological Study of a Novel Large Pore Formed by Bax and the Voltage-dependent Anion Channel That Is Permeable to Cytochrome c
Shimizu, S., Ide, T., Yanagida, T., & Tsujimoto, Y. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.12321 · Cited by 338
Phosphorylation fails to activate chloride channels from cystic fibrosis airway cells
Schoumacher, R. A., Shoemaker, R. L., Halm, D. R., Tallant, E. A., Wallace, R. W., & Frizzell, R. A. (1987) · Nature · doi:10.1038/330752a0 · Cited by 336
Structure and Regulation of Amiloride-Sensitive Sodium Channels
de la Rosa, D. A., Canessa, C. M., Fyfe, G. K., & Zhang, P. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.573 · Cited by 332
Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein
Gill, D. R., Hyde, S. C., Higgins, C. F., Valverde, M. A., Mintenig, G. M., & Sepúlveda, F. V. (1992) · Cell · doi:10.1016/0092-8674(92)90263-c · Cited by 329
Nonlinear amplification by calcium-dependent chloride channels in olfactory receptor cells
Lowe, G., & Gold, G. H. (1993) · Nature · doi:10.1038/366283a0 · Cited by 326
Cystic fibrosis transmembrane conductance regulator is an epithelial cell receptor for clearance of Pseudomonas aeruginosa from the lung
Pier, G. B., Grout, M., & Zaidi, T. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.22.12088 · Cited by 323
New mammalian chloride channel identified by expression cloning
Paulmichl, M., Li, Y., Wickman, K., Ackerman, M., Peralta, E., & Clapham, D. (1992) · Nature · doi:10.1038/356238a0 · Cited by 323
Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents.
Sheppard, D. N., & Welsh, M. J. (1992) · The Journal of general physiology · doi:10.1085/jgp.100.4.573 · Cited by 322
Functional correlation of fetal and adult forms of glycine receptors with developmental changes in inhibitory synaptic receptor channels
Takahashi, T., Momiyama, A., Hirai, K., Hishinuma, F., & Akagi, H. (1992) · Neuron · doi:10.1016/0896-6273(92)90073-m · Cited by 319
Ligand-Gated Ion Channel Subunit Partnerships: GABAAReceptor α6Subunit Gene Inactivation Inhibits δ Subunit Expression
Jones, A., Korpi, E. R., McKernan, R. M., Pelz, R., Nusser, Z., Mäkelä, R., Mellor, J. R., Pollard, S., Bahn, S., Stephenson, F. A., et al. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-04-01350.1997 · Cited by 318
Cloning and expression of a cDNA encoding a brain-specific Na(+)-dependent inorganic phosphate cotransporter.
Ni, B., Rosteck, P. R., Nadi, N. S., & Paul, S. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5607 · Cited by 316
Male germ cells and photoreceptors, both dependent on close cell–cell interactions, degenerate upon ClC-2 Cl− channel disruption
Bösl, M. R., Stein, V., Hübner, C., Zdebik, A. A., Jordt, S.-E., Mukhopadhyay, A. K., Davidoff, M. S., Holstein, A.-F., & Jentsch, T. J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.6.1289 · Cited by 316
Self-citation
Glycine and glycine receptor immunoreactivity in brain and spinal cord
van den Pol, A., & Gorcs, T. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-02-00472.1988 · Cited by 315
Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein
Prior, P., Schmitt, B., Grenningloh, G., Pribilla, I., Multhaup, G., Beyreuther, K., Maulet, Y., Werner, P., Langosch, D., Kirsch, J., et al. (1992) · Neuron · doi:10.1016/0896-6273(92)90136-2 · Cited by 313
Rates of Tectonometamorphic Processes from Rubidium and Strontium Isotopes in Garnet
Christensen, J. N., Rosenfeld, J. L., & DePaolo, D. J. (1989) · Science · doi:10.1126/science.244.4911.1465 · Cited by 312
Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis
Wang, S. S. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.20.2937 · Cited by 312
Niflumic and flufenamic acids are potent reversible blockers of Ca2(+)-activated Cl- channels in Xenopus oocytes.
White, M. M., & Aylwin, M. (1990) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10907-3 · Cited by 310
CFTR and outward rectifying chloride channels are distinct proteins with a regulatory relationship
Gabriel, S. E., Clarke, L. L., Boucher, R. C., & Stutts, M. J. (1993) · Nature · doi:10.1038/363263a0 · Cited by 307
Intra-renal and subcellular distribution of the human chloride channel, CLC-5, reveals a pathophysiological basis for Dent's disease
Devuyst, O. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.2.247 · Cited by 299
Glycine receptor: light microscopic autoradiographic localization with [3H]strychnine
Zarbin, M., Wamsley, J., & Kuhar, M. (1981) · The Journal of Neuroscience · doi:10.1523/jneurosci.01-05-00532.1981 · Cited by 297
Mutations in the Chloride Channel Gene CLCNKB as a Cause of Classic Bartter Syndrome
KONRAD, M., VOLLMER, M., LEMMINK, H. H., VAN DEN HEUVEL, L. P. W. J., JECK, N., VARGAS-POUSSOU, R., LAKINGS, A., RUF, R., DESCHE[Combining Circumflex Accent]NES, G., ANTIGNAC, C., et al. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1181449 · Cited by 289
Two highly homologous members of the ClC chloride channel family in both rat and human kidney.
Kieferle, S., Fong, P., Bens, M., Vandewalle, A., & Jentsch, T. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.6943 · Cited by 285
Self-citation
Molecular basis of Thomsen's disease (autosomal dominant myotonia congenita)
George, A. L., Crackower, M. A., Abdalla, J. A., Hudson, A. J., & Ebers, G. C. (1993) · Nature Genetics · doi:10.1038/ng0493-305 · Cited by 283
Pharmacology of CFTR Chloride Channel Activity
SCHULTZ, B. D., SINGH, A. K., DEVOR, D. C., & BRIDGES, R. J. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.s109 · Cited by 282
Cloning and Functional Expression of Rat CLC-5, a Chloride Channel Related to Kidney Disease
Steinmeyer, K., Schwappach, B., Bens, M., Vandewalle, A., & Jentsch, T. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.52.31172 · Cited by 282
Self-citation
The Glutathione Transferase Structural Family Includes a Nuclear Chloride Channel and a Ryanodine Receptor Calcium Release Channel Modulator
Dulhunty, A., Gage, P., Curtis, S., Chelvanayagam, G., & Board, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007874200 · Cited by 279
Two physically distinct pores in the dimeric CIC-0 chloride channel
Ludewig, U., Pusch, M., & Jentsch, T. J. (1996) · Nature · doi:10.1038/383340a0 · Cited by 279
Self-citation
The postsynaptic localization of the glycine receptor-associated protein gephyrin is regulated by the cytoskeleton
Kirsch, J., & Betz, H. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-06-04148.1995 · Cited by 276
The Synaptic VesicleCycle Revisited
Südhof, T. C. (2000) · Neuron · doi:10.1016/s0896-6273(00)00109-4 · Cited by 276
Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel
Matsumura, Y., Uchida, S., Kondo, Y., Miyazaki, H., Ko, S. B. H., Hayama, A., Morimoto, T., Liu, W., Arisawa, M., Sasaki, S., et al. (1999) · Nature Genetics · doi:10.1038/5036 · Cited by 276
A PDZ-interacting domain in CFTR is an apical membrane polarization signal
Moyer, B. D., Denton, J., Karlson, K. H., Reynolds, D., Wang, S., Mickle, J. E., Milewski, M., Cutting, G. R., Guggino, W. B., Li, M., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7453 · Cited by 275
Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes.
Grenningloh, G., Schmieden, V., Schofield, P. R., Seeburg, P. H., Siddique, T., Mohandas, T. K., Becker, C. M., & Betz, H. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08172.x · Cited by 274
The Two Nucleotide-binding Domains of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Have Distinct Functions in Controlling Channel Activity
Carson, M. R., Travis, S. M., & Welsh, M. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.4.1711 · Cited by 274
The 93-kDa glycine receptor-associated protein binds to tubulin.
Kirsch, J., Langosch, D., Prior, P., Littauer, U. Z., Schmitt, B., & Betz, H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54560-9 · Cited by 273
Neuronal domains in developing neocortex: Mechanisms of coactivation
Yuste, R., Nelson, D. A., Rubin, W. W., & Katz, L. C. (1995) · Neuron · doi:10.1016/0896-6273(95)90236-8 · Cited by 273
Mechanisms of GABA and glycine depolarization‐induced calcium transients in rat dorsal horn neurons.
Reichling, D. B., Kyrozis, A., Wang, J., & MacDermott, A. B. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020142 · Cited by 271
Development of Action Potential‐dependent and Independent Spontaneous GABAA Receptor‐mediated Currents in Granule Cells of Postnatal Rat Cerebellum
Wall, M. J., & Usowicz, M. M. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01630.x · Cited by 268
A functional role for the two-pore domain potassium channel TASK-1 in cerebellar granule neurons
Millar, J. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050012597 · Cited by 264
Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel.
Berger, H. A., Anderson, M. P., Gregory, R. J., Thompson, S., Howard, P. W., Maurer, R. A., Mulligan, R., Smith, A. E., & Welsh, M. J. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115450 · Cited by 259
Molecular dissection of gating in the ClC-2 chloride channel
Jordt, S.-E. (1997) · The EMBO Journal · doi:10.1093/emboj/16.7.1582 · Cited by 258
GABAc receptors
Bormann, J., & Feigenspan, A. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)98370-e · Cited by 258
Dimeric structure of single chloride channels from Torpedo electroplax.
Miller, C., & White, M. M. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.9.2772 · Cited by 257
Muscle chloride channels.
Bretag, A. H. (1987) · Physiological Reviews · doi:10.1152/physrev.1987.67.2.618 · Cited by 255
Calcium‐dependent chloride currents in isolated cells from rat lacrimal glands.
Evans, M. G., & Marty, A. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016229 · Cited by 253
Homodimeric architecture of a CIC-type chloride ion channel
Middleton, R. E., Pheasant, D. J., & Miller, C. (1996) · Nature · doi:10.1038/383337a0 · Cited by 250
Whole‐cell and single‐channel currents activated by GABA and glycine in granule cells of the rat cerebellum.
Kaneda, M., Farrant, M., & Cull-Candy, S. G. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020739 · Cited by 248
Activation of the epithelial Na+ channel (ENaC) requires CFTR Cl- channel function
Reddy, M. M., Light, M. J., & Quinton, P. M. (1999) · Nature · doi:10.1038/46297 · Cited by 246
GABAA/Benzodiazepine receptor heterogeneity: Neurophysiological implications
Lüddens, H., Korpi, E. R., & SEEBURG, P. H. (1995) · Neuropharmacology · doi:10.1016/0028-3908(94)00158-o · Cited by 245
Membrane changes in cells from myotonia patients.
Rüdel, R., & Lehmann-Horn, F. (1985) · Physiological Reviews · doi:10.1152/physrev.1985.65.2.310 · Cited by 244
Benzodiazepine-induced motor impairment linked to point mutation in cerebeilar GABAA receptor
Korpi, E. R., Kleingoor, C., Kettenmann, H., & Seeburg, P. H. (1993) · Nature · doi:10.1038/361356a0 · Cited by 244
Heteromultimeric CLC chloride channels with novel properties
Lorenz, C., Pusch, M., & Jentsch, T. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13362 · Cited by 243
Self-citation
A calcium‐activated chloride current generates the after‐depolarization of rat sensory neurones in culture.
Mayer, M. L. (1985) · The Journal of Physiology · doi:10.1113/jphysiol.1985.sp015740 · Cited by 243
Genomic Cloning, Molecular Characterization, and Functional Analysis of Human CLCA1, the First Human Member of the Family of Ca2+-Activated Cl−Channel Proteins
Gruber, A. D., Elble, R. C., Ji, H.-L., Schreur, K. D., Fuller, C. M., & Pauli, B. U. (1998) · Genomics · doi:10.1006/geno.1998.5562 · Cited by 243
Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and hetero-oligomers.
Bormann, J., Rundström, N., Betz, H., & Langosch, D. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06050.x · Cited by 241
Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla.
Uchida, S., Sasaki, S., Furukawa, T., Hiraoka, M., Imai, T., Hirata, Y., & Marumo, F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53545-6 · Cited by 240
GABAC receptors: relatively simple transmitter-gated ion channels?
Johnston, G. A. R. (1996) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(96)10038-9 · Cited by 239
Cloning and expression of the 58 kd β subunit of the inhibitory glycine receptor
Grenningloh, G., Pribilla, I., Prior, P., Multhaup, G., Beyreuther, K., Taleb, O., & Betz, H. (1990) · Neuron · doi:10.1016/0896-6273(90)90149-a · Cited by 235
Nonequilibrium gating and voltage dependence of the ClC-0 Cl- channel.
Chen, T. Y., & Miller, C. (1996) · The Journal of general physiology · doi:10.1085/jgp.108.4.237 · Cited by 231
Ca2+ sensitivity of volume‐regulatory K+ and Cl‐ channels in cultured human epithelial cells.
Hazama, A., & Okada, Y. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017229 · Cited by 230
Differential and transient expression of GABAA receptor alpha-subunit mRNAs in the developing rat CNS
Poulter, M., Barker, J., O'Carroll, A., Lolait, S., & Mahan, L. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-08-02888.1992 · Cited by 229
Immunocytochemical Localization of the GABACReceptor ρ Subunits in the Mammalian Retina
Enz, R., Brandstätter, J. H., Wässle, H., & Bormann, J. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-14-04479.1996 · Cited by 228
Alteration of GABAA Receptor Function Following Gene Transfer of the CLC-2 Chloride Channel
Staley, K., Smith, R., Schaack, J., Wilcox, C., & Jentsch, T. J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80186-5 · Cited by 227
Self-citation
gamma-Aminobutyric acid-containing terminals can be apposed to glycine receptors at central synapses
Triller, A., Cluzeaud, F., & Korn, H. (1987) · The Journal of cell biology · doi:10.1083/jcb.104.4.947 · Cited by 225
Cloning and expression of a protein kinase C-regulated chloride channel abundantly expressed in rat brain neuronal cells
Kawasaki, M., Uchida, S., Monkawa, T., Miyawaki, A., Mikoshiba, K., Marumo, F., & Sasaki, S. (1994) · Neuron · doi:10.1016/0896-6273(94)90215-1 · Cited by 225
Neuronal Ca2+-activated Cl− channels — homing in on an elusive channel species
Frings, S., Reuter, D., & Kleene, S. J. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00027-1 · Cited by 223
Properties of voltage‐gated chloride channels of the ClC gene family.
Jentsch, T. J., Günther, W., Pusch, M., & Schwappach, B. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020560 · Cited by 221
Self-citation
Multimeric structure of ClC-1 chloride channel revealed by mutations in dominant myotonia congenita (Thomsen).
Steinmeyer, K., Lorenz, C., Pusch, M., Koch, M. C., & Jentsch, T. J. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06315.x · Cited by 220
Self-citation
Kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture.
Macdonald, R. L., Rogers, C. J., & Twyman, R. E. (1989) · The Journal of Physiology · doi:10.1113/jphysiol.1989.sp017545 · Cited by 220
Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel
Lynch, J. W. (1997) · The EMBO Journal · doi:10.1093/emboj/16.1.110 · Cited by 219
Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms
Naren, A. P., Nelson, D. J., Xie, W., Jovov, B., Pevsner, J., Bennett, M. K., Benos, D. J., Quick, M. W., & Kirk, K. L. (1997) · Nature · doi:10.1038/36882 · Cited by 217
Anion Transport in Heart
Hume, J. R., Duan, D., Collier, M. L., Yamazaki, J., & Horowitz, B. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.31 · Cited by 216
Developmental Changes of Inhibitory Synaptic Currents in Cerebellar Granule Neurons: Role of GABAAReceptor α6 Subunit
Tia, S., Wang, J. F., Kotchabhakdi, N., & Vicini, S. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-11-03630.1996 · Cited by 214
E3KARP Mediates the Association of Ezrin and Protein Kinase A with the Cystic Fibrosis Transmembrane Conductance Regulator in Airway Cells
Sun, F., Hug, M. J., Lewarchik, C. M., Yun, C.-H. C., Bradbury, N. A., & Frizzell, R. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004961200 · Cited by 214
Characteristics of rabbit ClC-2 current expressed in Xenopus oocytes and its contribution to volume regulation
Furukawa, T., Ogura, T., Katayama, Y., & Hiraoka, M. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.2.c500 · Cited by 214
The amiloride-inhibitable Na+ conductance is reduced by the cystic fibrosis transmembrane conductance regulator in normal but not in cystic fibrosis airways.
Mall, M., Bleich, M., Greger, R., Schreiber, R., & Kunzelmann, K. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2729 · Cited by 211
Molecular Cloning and Expression of a Chloride Ion Channel of Cell Nuclei
Valenzuela, S. M., Martin, D. K., Por, S. B., Robbins, J. M., Warton, K., Bootcov, M. R., Schofield, P. R., Campbell, T. J., & Breit, S. N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.19.12575 · Cited by 210

Physiology of Microglia
Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547
The Retinal Pigment Epithelium in Visual Function
Strauss, O. (2005) · Physiological Reviews · doi:10.1152/physrev.00021.2004 · Cited by 2,828
Aromatic Rings in Chemical and Biological Recognition: Energetics and Structures
Salonen, L. M., Ellermann, M., & Diederich, F. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201007560 · Cited by 1,539
Physiology of cell volume regulation in vertebrates
Hoffmann, E. K., Lambert, I. H., & Pedersen, S. F. (2009) · Physiological Reviews · doi:10.1152/physrev.00037.2007 · Cited by 1,441
Gating the Selectivity Filter in ClC Chloride Channels
Dutzler, R., Campbell, E. B., & MacKinnon, R. (2003) · Science · doi:10.1126/science.1082708 · Cited by 727

See all 1,256

Authors: Jentsch, T. J., Stein, V., Weinreich, F., & Zdebik, A. A.
Venue: Physiological Reviews
Publisher: American Physiological Society
Published: 2002-04-01
Volume: 82
Issue: 2
Pages: 503-568
ISSN: 0031-9333 (ISSN-L)
1522-1210
DOI: 10.1152/physrev.00029.2001
OpenAlex: W2135426025
Cited by: 1,256
References: 530
FWCI: 5.74
Type: journal article
Language: en
Open access: closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

Molecular Structure and Physiological Function of Chloride Channels

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Metadata

Record

About these checks

Data sources