Cited by 199Circadian rhythm and melatoninSleep and Wakefulness ResearchSleep and related disorders

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Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus

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Vadnie, Chelsea A., McClung, Colleen A.·2017·Neural Plasticity

DOI 10.1155/2017/1504507PMC PMC5694588

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Abstract

Circadian rhythm disturbances are a common symptom among individuals with mood disorders. The suprachiasmatic nucleus (SCN), in the ventral part of the anterior hypothalamus, orchestrates physiological and behavioral circadian rhythms. The SCN consists of self-sustaining oscillators and receives photic and nonphotic cues, which entrain the SCN to the external environment. In turn, through synaptic and hormonal mechanisms, the SCN can drive and synchronize circadian rhythms in extra-SCN brain regions and peripheral tissues. Thus, genetic or environmental perturbations of SCN rhythms could disrupt brain regions more closely related to mood regulation and cause mood disturbances. Here, we review clinical and preclinical studies that provide evidence both for and against a causal role for the SCN in mood disorders.

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Circadian rhythm disruption and mental health
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Authors: Vadnie, C. A., & McClung, C. A.
Affiliations: University of Pittsburgh (US)
Corresponding author: Vadnie, Chelsea A.
ORCID: Vadnie, Chelsea A.
McClung, Colleen A.
Venue: Neural Plasticity
Publisher: Wiley
Published: 2017
Volume: 2017
Pages: 1-28
ISSN: 1687-5443 (ISSN-L)
2090-5904
DOI: 10.1155/2017/1504507
PMC: PMC5694588
OpenAlex: W2767056255
Cited by: 199
References: 383
Citations by year: 2026: 13 · 2025: 20 · 2024: 25 · 2023: 23 · 2022: 31 · 2021: 29 · 2020: 29 · 2019: 13 · 2018: 15 · 2017: 1
FWCI: 1.92
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Neural Plasticity (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health (DA039865, DA023988, DA037636, MH106460, MH082876)
Pfizer (DA039865, DA023988, DA037636, MH106460, MH082876)
McKnight Foundation for Neuroscience (DA039865, DA023988, DA037636, MH106460, MH082876)
International Mental Health Research Organization (DA039865, DA023988, DA037636, MH106460, MH082876)
The Brain and Behavior Foundation (NARSAD) (DA039865, DA023988, DA037636, MH106460, MH082876)
National Institute on Drug Abuse (DA039865, DA023988, DA037636, MH106460, MH082876)
National Institute of Mental Health (DA039865, DA023988, DA037636, MH106460, MH082876)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords: circadian rhythm disruption, mood disorders, suprachiasmatic nucleus, circadian rhythm, mood regulation, circadian clock, hypothalamus
MeSH terms: Animals, Circadian Rhythm, Humans, Neural Pathways, Suprachiasmatic Nucleus, Mood Disorders

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Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus

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