Cited by 1,251

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Proteobacteria: A Common Factor in Human Diseases

Open access

Rizzatti, G., Lopetuso, L. R., Gibiino, G., Binda, C., Gasbarrini, A.·2017·BioMed Research International

DOI 10.1155/2017/9351507

Open this paper in CoChat — free account

Abstract

Microbiota represents the entire microbial community present in the gut host. It serves several functions establishing a mutualistic relation with the host. Latest years have seen a burst in the number of studies focusing on this topic, in particular on intestinal diseases. In this scenario, Proteobacteria are one of the most abundant phyla, comprising several known human pathogens. This review highlights the latest findings on the role of Proteobacteria not only in intestinal but also in extraintestinal diseases. Indeed, an increasing amount of data identifies Proteobacteria as a possible microbial signature of disease. Several studies demonstrate an increased abundance of members belonging to this phylum in such conditions. Major evidences currently involve metabolic disorders and inflammatory bowel disease. However, more recent studies suggest a role also in lung diseases, such as asthma and chronic obstructive pulmonary disease, but evidences are still scant. Notably, all these conditions are sustained by various degree of inflammation, which thus represents a core aspect of Proteobacteria-related diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1155/2017/9351507

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762
Diagnosis and classification of diabetes mellitus
American Diabetes Association (2014) · Diabetes Care · doi:10.2337/dc14-s081 · Cited by 5,974
Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277
Bacterial evolution
Woese, C. R. (1987) · Microbiological Reviews · doi:10.1128/mr.51.2.221-271.1987 · Cited by 5,042 · cited 1×
“However, this grouping of bacteria was already been established by Woese in 1987 with the informal name of “purple bacteria and their relatives” [18].”
Background

Show all 32 references

Research works printed but not linked: 51

10.1016/j.mayocp.2013.10.011 · DOI · Paper page
10.1186/gb-2012-13-7-r60 · DOI · Paper page
10.1111/j.1462-2920.2011.02593.x · DOI
10.1097/MIB.0000000000000807 · DOI
10.1053/j.gastro.2008.10.080 · DOI · Paper page
10.1073/pnas.0706625104 · DOI · Paper page
10.1073/pnas.1000081107 · DOI · Paper page
10.1146/annurev-food-022811-101120 · DOI
10.1159/000111102 · DOI · Paper page
10.1097/MCG.0b013e31826ae849 · DOI
10.1099/00207713-38-3-321 · DOI · Paper page
1987, Clinical Microbiology Reviews, 51, 221, 10.1128/MMBR.51.2.221-271.1987 · DOI · Paper page
10.1007/s00125-017-4278-3 · DOI · Paper page
10.1155/2016/7353642 · DOI · Paper page
2017, Diabetes
2015, Journal of Diabetes and Obesity, 2, 1
10.2337/db06-1491 · DOI · Paper page
10.1038/ismej.2012.153 · DOI · Paper page
10.1096/fj.10-164921 · DOI · Paper page
10.1038/srep05922 · DOI · Paper page
10.1093/femsec/fiu002 · DOI · Paper page
10.1111/j.1462-2920.2006.01234.x · DOI
10.1111/jgh.13058 · DOI
10.1371/journal.pone.0054461 · DOI
10.1161/01.ATV.20.6.1417 · DOI
10.1073/pnas.1011383107 · DOI · Paper page
10.3389/fimmu.2017.00400 · DOI
10.1016/j.tibtech.2015.06.011 · DOI · Paper page
10.4161/gmic.26489 · DOI · Paper page
10.4049/jimmunol.1601410 · DOI
10.1016/j.bbi.2016.12.019 · DOI
10.1038/nrn3346 · DOI · Paper page
10.1038/nature10209 · DOI · Paper page
10.1053/j.gastro.2007.11.059 · DOI · Paper page
10.1016/j.chom.2007.09.013 · DOI · Paper page
10.1099/jmm.0.021170-0 · DOI
10.1128/JCM.01004-06 · DOI · Paper page
10.1038/ismej.2013.80 · DOI · Paper page
10.1016/j.freeradbiomed.2016.09.022 · DOI · Paper page
10.1016/j.mib.2017.07.003 · DOI · Paper page
10.1126/science.1232467 · DOI · Paper page
10.1126/science.aam9949 · DOI · Paper page
1999, Infection and Immunity, 67, 4499, 10.1128/IAI.67.9.4499-4509.1999 · DOI · Paper page
10.1002/ibd.20783 · DOI · Paper page
10.1186/s13073-014-0107-1 · DOI · Paper page
10.1038/cti.2017.6 · DOI · Paper page
10.1016/j.anai.2014.01.022 · DOI
10.1371/journal.pone.0008578 · DOI · Paper page
10.1016/j.jaci.2012.11.013 · DOI · Paper page
10.1371/journal.pone.0059260 · DOI · Paper page
10.1183/13993003.01406-2015 · DOI · Paper page

What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases
Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G. A. D., Gasbarrini, A., & Mele, M. C. (2019) · Microorganisms · doi:10.3390/microorganisms7010014 · Cited by 3,462
Self-citation
The Firmicutes/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients?
Magne, F., Gotteland, M., Gauthier, L., Zazueta, A., Pesoa, S., Navarrete, P., & Balamurugan, R. (2020) · Nutrients · doi:10.3390/nu12051474 · Cited by 2,335
The Gut Microbiome, Aging, and Longevity: A Systematic Review
Badal, V. D., Vaccariello, E. D., Murray, E. R., Yu, K. E., Knight, R., Jeste, D. V., & Nguyen, T. T. (2020) · Nutrients · doi:10.3390/nu12123759 · Cited by 551
Microbiota succession throughout life from the cradle to the grave
Martino, C., Dilmore, A. H., Burcham, Z. M., Metcalf, J. L., Jeste, D., & Knight, R. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00768-z · Cited by 275
Gut microbiota and metabolite alterations associated with reduced bone mineral density or bone metabolic indexes in postmenopausal osteoporosis
He, J., Xu, S., Zhang, B., Xiao, C., Chen, Z., Si, F., Fu, J., Lin, X., Zheng, G., Yu, G., et al. (2020) · Aging · doi:10.18632/aging.103168 · Cited by 258
Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified
Bruno, G., Zaccari, P., Rocco, G., Scalese, G., Panetta, C., Porowska, B., Pontone, S., & Severi, C. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i22.2706 · Cited by 258
Fatty acid diets: regulation of gut microbiota composition and obesity and its related metabolic dysbiosis
Machate, D. J., Figueiredo, P. S., Marcelino, G., Guimarães, R. D. C. A., Hiane, P. A., Bogo, D., Pinheiro, V. A. Z., Oliveira, L. C. S. D., & Pott, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114093 · Cited by 243
Environmental hotspots for antibiotic resistance genes
Kunhikannan, S., Thomas, C. J., Franks, A. E., Mahadevaiah, S., Kumar, S., & Petrovski, S. (2021) · MicrobiologyOpen · doi:10.1002/mbo3.1197 · Cited by 184
Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation
Lamas, B., Hernandez-Galan, L., Galipeau, H. J., Constante, M., Clarizio, A., Jury, J., Breyner, N. M., Caminero, A., Rueda, G., Hayes, C. L., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aba0624 · Cited by 179
Fecal microbiota transplantation in Parkinson's disease—A randomized repeat-dose, placebo-controlled clinical pilot study
DuPont, H. L., Suescun, J., Jiang, Z.-D., Brown, E. L., Essigmann, H. T., Alexander, A. S., DuPont, A. W., Iqbal, T., Utay, N. S., Newmark, M., et al. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1104759 · Cited by 162
Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study
BELLIKCI-KOYU, E., SARER-YUREKLI, B. P., AKYON, Y., AYDIN-KOSE, F., KARAGOZLU, C., OZGEN, A. G., BRINKMANN, A., NITSCHE, A., ERGUNAY, K., YILMAZ, E., et al. (2019) · Nutrients · doi:10.3390/nu11092089 · Cited by 144
“An association between the increased relative abundance of Proteobacteria and increased risk of cardio–metabolic disorders was suggested previously [66].”
Background
Interventional Influence of the Intestinal Microbiome Through Dietary Intervention and Bowel Cleansing Might Improve Motor Symptoms in Parkinson’s Disease
Hegelmaier, T., Lebbing, M., Duscha, A., Tomaske, L., Tönges, L., Holm, J. B., Bjørn Nielsen, H., Gatermann, S. G., Przuntek, H., & Haghikia, A. (2020) · Cells · doi:10.3390/cells9020376 · Cited by 118
A distinct gut microbiota composition in patients with ankylosing spondylitis is associated with increased levels of fecal calprotectin
Klingberg, E., Magnusson, M. K., Strid, H., Deminger, A., Ståhl, A., Sundin, J., Simrén, M., Carlsten, H., Öhman, L., & Forsblad-d’Elia, H. (2019) · Arthritis Research & Therapy · doi:10.1186/s13075-019-2018-4 · Cited by 101
Analysis of matched skin and gut microbiome of patients with vitiligo reveals deep skin dysbiosis: link with mitochondrial and immune changes
Bzioueche, H., Simonyté Sjödin, K., West, C. E., Khemis, A., Rocchi, S., Passeron, T., & Tulic, M. K. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.01.036 · Cited by 77
The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids
van Sadelhoff, J. H. J., Perez Pardo, P., Wu, J., Garssen, J., van Bergenhenegouwen, J., Hogenkamp, A., Hartog, A., & Kraneveld, A. D. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00247 · Cited by 71
Role of Dietary Defatted Rice Bran in the Modulation of Gut Microbiota in AOM/DSS-Induced Colitis-Associated Colorectal Cancer Rat Model
Tajasuwan, L., Kettawan, A., Rungruang, T., Wunjuntuk, K., & Prombutara, P. (2023) · Nutrients · doi:10.3390/nu15061528 · Cited by 49
Alterations in cecal microbiota and intestinal barrier function of laying hens fed on fluoride supplemented diets
Miao, L., Gong, Y., Li, H., Xie, C., Xu, Q., Dong, X., Elwan, H. A. M., & Zou, X. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110372 · Cited by 45
Interaction of Oral and Toothbrush Microbiota Affects Oral Cavity Health
Shang, Q., Gao, Y., Qin, T., Wang, S., Shi, Y., & Chen, T. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00017 · Cited by 39
Protective effect of gut microbiota restored by fecal microbiota transplantation in a sepsis model in juvenile mice
Han, Y. J., Kim, S., Shin, H., Kim, H. W., & Park, J. D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1451356 · Cited by 17
Functional evaluation of synbiotic combination of Kluyveromyces marxianus and Lentilactobacillus kefiri derived from milk kefir using multi-omics approaches
Lim, S. H., Mun, D., Ryu, S., Kang, M.-G., Kang, A., Lee, D. J., Seo, E., Son, S.-H., Kim, S., Jang, K. B., et al. (2025) · Current Research in Food Science · doi:10.1016/j.crfs.2025.101188 · Cited by 5
Adaptive changes in the gut microbiome during standard-of-care chemoradiotherapy for gynecologic cancers
El Alam, M. B., Sims, T. T., Kouzy, R., Biegert, G. W. G., Abi Jaoude, J., Karpinets, T. V., Yoshida-Court, K., Wu, X., Delgado Medrano, A. Y., Mezzari, M. P., et al. (2020) · doi:10.1101/2020.04.10.036426 · Cited by 41
DrugDomain 2.0: Comprehensive database of protein domains-ligands/drugs interactions across the whole Protein Data Bank
Medvedev, K. E., Schaeffer, R. D., & Grishin, N. V. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2025.09.018 · Cited by 1

Authors: Rizzatti, G., Lopetuso, L. R., Gibiino, G., Binda, C., & Gasbarrini, A.
Venue: BioMed Research International
Publisher: Wiley
Published: 2017
Volume: 2017
Pages: 1-7
ISSN: 1110-7243 (ISSN-L)
2314-6133
2314-6141
DOI: 10.1155/2017/9351507
OpenAlex: W2766754487
Cited by: 1,251
References: 32
FWCI: 17.47
Type: journal article
Language: en
Open access: hybrid
Licence: creativecommons.org/licenses/by/4.0/ (unspecified)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

Proteobacteria: A Common Factor in Human Diseases

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Metadata

Record

About these checks

Data sources