Prostaglandins and Inflammation

Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology

Funk, C. D. (2001) · Science · doi:10.1126/science.294.5548.1871 · Cited by 3,817

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525

Cyclooxygenases: Structural, cellular, and molecular biology

Smith, W. L., DeWitt, D. L., & Garavito, R. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.145 · Cited by 2,925

Points of control in inflammation

Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738

Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials

Rothwell, P. M., Wilson, M., Elwin, C.-E., Norrving, B., Algra, A., Warlow, C. P., & Meade, T. W. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61543-7 · Cited by 1,351

Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

Lehnardt, S., Massillon, L., Follett, P., Jensen, F. E., Ratan, R., Rosenberg, P. A., Volpe, J. J., & Vartanian, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432609100 · Cited by 1,052

Prostanoid Receptors: Subtypes and Signaling

Breyer, R. M., Bagdassarian, C. K., Myers, S. A., & Breyer, M. D. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.661 · Cited by 1,011

Prostaglandin E2 synthesis and secretion: The role of PGE2 synthases

Park, J. Y., Pillinger, M. H., & Abramson, S. B. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.01.016 · Cited by 793

Molecular Identification of Cytosolic Prostaglandin E2 Synthase That Is Functionally Coupled with Cyclooxygenase-1 in Immediate Prostaglandin E2Biosynthesis

Tanioka, T., Nakatani, Y., Semmyo, N., Murakami, M., & Kudo, I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003504200 · Cited by 708

Failure of Parturition in Mice Lacking the Prostaglandin F Receptor

Sugimoto, Y., Yamasaki, A., Segi, E., Tsuboi, K., Aze, Y., Nishimura, T., Oida, H., Yoshida, N., Tanaka, T., Katsuyama, M., et al. (1997) · Science · doi:10.1126/science.277.5326.681 · Cited by 608

In situ click chemistry generation of cyclooxygenase-2 inhibitors

Bhardwaj, A., Kaur, J., Wuest, M., & Wuest, F. (2017) · Nature Communications · doi:10.1038/s41467-016-0009-6 · Cited by 7,448

Atherosclerosis

Libby, P., Buring, J. E., Badimon, L., Hansson, G. K., Deanfield, J., Bittencourt, M. S., Tokgözoğlu, L., & Lewis, E. F. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0106-z · Cited by 3,211

From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.

Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206

Effects of extended-release niacin with laropiprant in high-risk patients

The HPS2-THRIVE Collaborative Group (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1300955 · Cited by 1,668

Eicosanoid storm in infection and inflammation

Dennis, E. A., & Norris, P. C. (2015) · Nature Reviews Immunology · doi:10.1038/nri3859 · Cited by 1,517

Decoding cell death signals in liver inflammation

Brenner, C., Galluzzi, L., Kepp, O., & Kroemer, G. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.03.033 · Cited by 1,022

The Potential Benefits of Red Beetroot Supplementation in Health and Disease

Clifford, T., Howatson, G., West, D., & Stevenson, E. (2015) · Nutrients · doi:10.3390/nu7042801 · Cited by 635

Functions of ROS in Macrophages and Antimicrobial Immunity

Herb, M., & Schramm, M. (2021) · Antioxidants · doi:10.3390/antiox10020313 · Cited by 633

Kaempferol and inflammation: from chemistry to medicine

Devi, K. P., Malar, D. S., Nabavi, S. F., Sureda, A., Xiao, J., Nabavi, S. M., & Daglia, M. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.05.002 · Cited by 619

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

Minhas, P. S., Latif-Hernandez, A., McReynolds, M. R., Durairaj, A. S., Wang, Q., Rubin, A., Joshi, A. U., He, J. Q., Gauba, E., Liu, L., et al. (2021) · Nature · doi:10.1038/s41586-020-03160-0 · Cited by 526

Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise

Yin, F. (2023) · The FEBS Journal · doi:10.1111/febs.16344 · Cited by 441

Bioactive Lipids and Chronic Inflammation: Managing the Fire Within

Chiurchiù, V., Leuti, A., & Maccarrone, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00038 · Cited by 427

Stress, sex hormones, inflammation, and major depressive disorder: Extending Social Signal Transduction Theory of Depression to account for sex differences in mood disorders

Slavich, G. M., & Sacher, J. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05326-9 · Cited by 383

Advanced glycation end-products produced systemically and by macrophages: A common contributor to inflammation and degenerative diseases

Byun, K., Yoo, Y., Son, M., Lee, J., Jeong, G.-B., Park, Y. M., Salekdeh, G. H., & Lee, B. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.030 · Cited by 357

Molecular pharmacology of inflammation: Medicinal plants as anti-inflammatory agents

Tasneem, S., Liu, B., Li, B., Choudhary, M. I., & Wang, W. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2018.11.001 · Cited by 358

Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response

Osorio, F. G., Bárcena, C., Soria-Valles, C., Ramsay, A. J., de Carlos, F., Cobo, J., Fueyo, A., Freije, J. M. P., & López-Otín, C. (2012) · Genes & Development · doi:10.1101/gad.197954.112 · Cited by 276

Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Gastroprotective NSAIDs on the Gastrointestinal Tract: A Narrative Review

Sohail, R., Mathew, M., Patel, K. K., Reddy, S. A., Haider, Z., Naria, M., Habib, A., Abdin, Z. U., Razzaq Chaudhry, W., & Akbar, A. (2023) · Cureus · doi:10.7759/cureus.37080 · Cited by 239

Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination

Zirngibl, M., Assinck, P., Sizov, A., Caprariello, A. V., & Plemel, J. R. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00538-8 · Cited by 233

Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength

Palla, A. R., Ravichandran, M., Wang, Y. X., Alexandrova, L., Yang, A. V., Kraft, P., Holbrook, C. A., Schürch, C. M., Ho, A. T. V., & Blau, H. M. (2021) · Science · doi:10.1126/science.abc8059 · Cited by 232

TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function

Rustenhoven, J., Aalderink, M., Scotter, E. L., Oldfield, R. L., Bergin, P. S., Mee, E. W., Graham, E. S., Faull, R. L. M., Curtis, M. A., Park, T. I.-H., et al. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0503-0 · Cited by 201

Immunologic and endocrine functions of adipose tissue: implications for kidney disease

Zhu, Q., & Scherer, P. E. (2018) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.157 · Cited by 200

Cell fate coordinates mechano-osmotic forces in intestinal crypt formation

Yang, Q., Xue, S.-L., Chan, C. J., Rempfler, M., Vischi, D., Maurer-Gutierrez, F., Hiiragi, T., Hannezo, E., & Liberali, P. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00700-2 · Cited by 183

Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis

Wiley, C. D., Sharma, R., Davis, S. S., Lopez-Dominguez, J. A., Mitchell, K. P., Wiley, S., Alimirah, F., Kim, D. E., Payne, T., Rosko, A., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.03.008 · Cited by 173

Biological effects of red beetroot and betalains: A review

Hadipour, E., Taleghani, A., Tayarani‐Najaran, N., & Tayarani‐Najaran, Z. (2020) · Phytotherapy Research · doi:10.1002/ptr.6653 · Cited by 165

Phenotypic modulation of macrophages in response to plaque lipids

Adamson, S., & Leitinger, N. (2011) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32834a97e4 · Cited by 154

Pharmaceutical compounds in aquatic environments-occurrence, fate and bioremediation prospective

Fernandes, J. P., Almeida, C. M. R., Salgado, M. A., Carvalho, M. F., & Mucha, A. P. (2021) · Toxics · doi:10.3390/toxics9100257 · Cited by 154

A systematic review of the effect of Centella asiatica on wound healing

Arribas-López, E., Zand, N., Ojo, O., Snowden, M. J., & Kochhar, T. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19063266 · Cited by 143

Tracking neuroinflammation in Alzheimer’s disease: the role of positron emission tomography imaging

Zimmer, E. R., Leuzy, A., Benedet, A. L., Breitner, J., Gauthier, S., & Rosa-Neto, P. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-120 · Cited by 121

Bioactive products formed in humans from fish oils

Skarke, C., Alamuddin, N., Lawson, J. A., Li, X., Ferguson, J. F., Reilly, M. P., & FitzGerald, G. A. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m060392 · Cited by 109

Prostaglandin E 2 as a Regulator of Immunity to Pathogens

Martínez-Colón, G. J., & Moore, B. B. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.12.008 · Cited by 109

A Synopsis of the Associations of Oxidative Stress, ROS, and Antioxidants with Diabetes Mellitus

Black, H. S. (2022) · Antioxidants · doi:10.3390/antiox11102003 · Cited by 103

Curcumin analogues and derivatives with anti-proliferative and anti-inflammatory activity: Structural characteristics and molecular targets

Chainoglou, E., & Hadjipavlou-Litina, D. (2019) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2019.1614560 · Cited by 92

Consumption of analgesics before a marathon and the incidence of cardiovascular, gastrointestinal and renal problems: a cohort study

Küster, M., Renner, B., Oppel, P., Niederweis, U., & Brune, K. (2013) · BMJ Open · doi:10.1136/bmjopen-2012-002090 · Cited by 88

Targeting Opioid-Induced Hyperalgesia in Clinical Treatment: Neurobiological Considerations

Arout, C. A., Edens, E., Petrakis, I. L., & Sofuoglu, M. (2015) · CNS Drugs · doi:10.1007/s40263-015-0255-x · Cited by 80

Functional multi-organelle units control inflammatory lipid metabolism of macrophages

Zimmermann, J. A., Lucht, K., Stecher, M., Badhan, C., Glaser, K. M., Epple, M. W., Koch, L. R., Deboutte, W., Manke, T., Ebnet, K., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01457-0 · Cited by 79

Mangiferin from Pueraria tuberosa reduces inflammation via inactivation of NLRP3 inflammasome

Bulugonda, R. K., kumar, K. A., Gangappa, D., Beeda, H., Philip, G. H., Muralidhara Rao, D., & Faisal, S. M. (2017) · Scientific Reports · doi:10.1038/srep42683 · Cited by 74

Atf3 negatively regulates Ptgs2/Cox2 expression during acute inflammation

Hellmann, J., Tang, Y., Zhang, M. J., Hai, T., Bhatnagar, A., Srivastava, S., & Spite, M. (2015) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2015.01.001 · Cited by 74

Filifactor alocis : Recent Insights and Advances

Aja, E., Mangar, M., Fletcher, H. M., & Mishra, A. (2021) · Journal of Dental Research · doi:10.1177/00220345211000656 · Cited by 70

Anti-inflammatory activity of betalains: A comprehensive review

Moreno-Ley, C. M., Osorio-Revilla, G., Hernández-Martínez, D. M., Ramos-Monroy, O. A., & Gallardo-Velázquez, T. (2021) · Human Nutrition & Metabolism · doi:10.1016/j.hnm.2021.200126 · Cited by 70

Complement receptor-mediated phagocytosis induces proinflammatory cytokine production in murine macrophages

Acharya, D., Li, X. R. (., Heineman, R. E.-S., & Harrison, R. E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03049 · Cited by 66

Identification of novel mechanisms involved in generating localized vulvodynia pain

Falsetta, M. L., Foster, D. C., Woeller, C. F., Pollock, S. J., Bonham, A. D., Haidaris, C. G., Stodgell, C. J., & Phipps, R. P. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.02.002 · Cited by 69

From environmental adaptation to host survival: Attributes that mediate pathogenicity of Candida auris

Allert, S., Schulz, D., Kämmer, P., Großmann, P., Wolf, T., Schäuble, S., Panagiotou, G., Brunke, S., & Hube, B. (2022) · Virulence · doi:10.1080/21505594.2022.2026037 · Cited by 66

New insights in lipid metabolism: potential therapeutic targets for the treatment of Alzheimer’s disease

Cao, Y., Zhao, L.-W., Chen, Z.-X., & Li, S.-H. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1430465 · Cited by 65

Polar lipidomic profile shows Chlorococcum amblystomatis as a promising source of value-added lipids

Conde, T. A., Couto, D., Melo, T., Costa, M., Silva, J., Domingues, M. R., & Domingues, P. (2021) · Scientific Reports · doi:10.1038/s41598-021-83455-y · Cited by 58

Partial loss of endothelial nitric oxide leads to increased cerebrovascular beta amyloid

Austin, S. A., & Katusic, Z. S. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18822474 · Cited by 52

The electrophile responsive proteome: Integrating proteomics and lipidomics with cellular function

Higdon, A. N., Landar, A., Barnes, S., & Darley-Usmar, V. M. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4523 · Cited by 51

Red Beetroot and Its By-Products: A Comprehensive Review of Phytochemicals, Extraction Methods, Health Benefits, and Applications

Stoica, F., Râpeanu, G., Rațu, R. N., Stănciuc, N., Croitoru, C., Țopa, D., & Jităreanu, G. (2025) · Agriculture · doi:10.3390/agriculture15030270 · Cited by 52

Nicotinamide Mononucleotide Alleviates LPS-Induced Inflammation and Oxidative Stress via Decreasing COX-2 Expression in Macrophages

Liu, J., Zong, Z., Zhang, W., Chen, Y., Wang, X., Shen, J., Yang, C., Liu, X., & Deng, H. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.702107 · Cited by 48

Cannflavins—From plant to patient: A scoping review

Erridge, S., Mangal, N., Salazar, O., Pacchetti, B., & Sodergren, M. H. (2020) · Fitoterapia · doi:10.1016/j.fitote.2020.104712 · Cited by 45

Ten years of proteomics in multiple sclerosis

Farias, A. S., Pradella, F., Schmitt, A., Santos, L. M. B., & Martins‐de‐Souza, D. (2014) · PROTEOMICS · doi:10.1002/pmic.201300268 · Cited by 40

Impact of Age-, Cancer- and Treatment-Driven Inflammation on T Cell Function and Immunotherapy

Quinn, K. M., Kartikasari, A. E. R., Cooke, R. E., Koldej, R. M., Ritchie, D. S., & Plebanski, M. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.5mr0520-466r · Cited by 31

Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells

Jeong, K., Jung, J., Kim, J., & Kang, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020556 · Cited by 30

The Role of Snake Venom Proteins in Inducing Inflammation Post-Envenomation: An Overview on Mechanistic Insights and Treatment Strategies

Rao, S., Reghu, N., Nair, B. G., & Vanuopadath, M. (2024) · Toxins · doi:10.3390/toxins16120519 · Cited by 30

Dynamics of action of a Lys-49 and an Asp-49 PLA2s on inflammasome NLRP3 activation in murine macrophages

Boeno, C. N., Paloschi, M. V., Lopes, J. A., Souza Silva, M. D., Evangelista, J. R., dos Reis, V. P., da S. Setúbal, S., Soares, A. M., & Zuliani, J. P. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109194 · Cited by 24

Effect of the dietary intake of melatonin- and hydroxytyrosol-rich wines by healthy female volunteers on the systemic lipidomic-related oxylipins

Marhuenda, J., Medina, S., Martínez-Hernández, P., Arina, S., Zafrilla, P., Mulero, J., Oger, C., Galano, J.-M., Durand, T., Solana, A., et al. (2017) · Food Funct. · doi:10.1039/c7fo01081h · Cited by 22

The effectiveness of nonsteroidal anti-inflammatory drugs and acetaminophen in reduce the risk of amyotrophic lateral sclerosis? A meta-analysis

Chang, M. C., Kwak, S. G., Park, J.-S., & Park, D. (2020) · Scientific Reports · doi:10.1038/s41598-020-71813-1 · Cited by 17

The lipid paradox in neuroprogressive disorders: Causes and consequences

Morris, G., Berk, M., Walder, K., O’Neil, A., Maes, M., & Puri, B. K. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.017 · Cited by 17

Inhibition of Inflammatory Responses by Centella asiatica via Suppression of IRAK1-TAK1 in Mouse Macrophages

Cho, Y.-C., Vuong, H. L., Ha, J., Lee, S., Park, J., Wibow, A. E., & Cho, S. (2020) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x20500548 · Cited by 15

Structure and post-translational modification of the prostaglandin transporter

Yu, P., Orlando, M. A., & Orlando, B. J. (2025) · Communications Biology · doi:10.1038/s42003-025-08510-0 · Cited by 3