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Cited by 567

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice

Open access
Howard, Jane K., Lord, Graham M., Matarese, Giuseppe, Vendetti, Silvia, Ghatei, Mohammad A., Ritter, Mary A., Lechler, Robert I., Bloom, Stephen R.·1999·Journal of Clinical Investigation
DOI 10.1172/jci6762
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Abstract

Thymic atrophy is a prominent feature of malnutrition. Forty-eight hours' starvation of normal mice reduced the total thymocyte count to 13% of that observed in freely fed controls, predominantly because of a diminution in the cortical CD4(+)CD8(+) thymocyte subpopulation. Prevention of the fasting-induced fall in the level of the adipocyte-derived hormone leptin by administering exogenous recombinant leptin protected mice from these starvation-induced thymic changes. The ob/ob mouse, which is unable to produce functional leptin because of a mutation in the obese gene, has impaired cellular immunity together with a marked reduction in the size and cellularity of the thymus. We found that ob/ob mice had a high level of thymocyte apoptosis resulting in a ratio of CD4(+)CD8(+) (cortical) to CD4(-)CD8(-) (precursor) thymocytes that was 4-fold lower than that observed in wild-type mice. Peripheral administration of recombinant leptin to ob/ob mice reduced thymocyte apoptosis and substantially increased both thymic cellularity and the CD4(+)CD8(+)/CD4(-)CD8(-) ratio. In contrast, a comparable weight loss in pair-fed PBS-treated ob/ob mice had no impact on thymocyte number. In vitro, leptin protected thymocytes from dexamethasone-induced apoptosis. These data indicate that reduced circulating leptin concentrations are pivotal in the pathogenesis of starvation-induced lymphoid atrophy.

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Metadata

Authors
Howard, J. K., Lord, G. M., Matarese, G., Vendetti, S., Ghatei, M. A., Ritter, M. A., Lechler, R. I., & Bloom, S. R.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1999-10-15
Volume
104
Issue
8
Pages
1051-1059
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci6762
OpenAlex
W2165345254
Cited by
567
References
6
FWCI
6.20
Type
journal article
Language
en
Open access
green

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