Regulation of life span by the gut microbiota in the short-lived African turquoise killifish
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Abstract
Gut bacteria occupy the interface between the organism and the external environment, contributing to homeostasis and disease. Yet, the causal role of the gut microbiota during host aging is largely unexplored. Here, using the African turquoise killifish (Nothobranchius furzeri), a naturally short-lived vertebrate, we show that the gut microbiota plays a key role in modulating vertebrate life span. Recolonizing the gut of middle-age individuals with bacteria from young donors resulted in life span extension and delayed behavioral decline. This intervention prevented the decrease in microbial diversity associated with host aging and maintained a young-like gut bacterial community, characterized by overrepresentation of the key genera Exiguobacterium, Planococcus, Propionigenium and Psychrobacter. Our findings demonstrate that the natural microbial gut community of young individuals can causally induce long-lasting beneficial systemic effects that lead to life span extension in a vertebrate model.
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The phenomenon of age-related gut microbiota change exists simultaneously in species such as Drosophila, fish, mice, rats, and humans.
“Moreover, this phenomenon exists simultaneously in species such as Drosophila,219 fish,220 mice,221 rats,222 and humans.223”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [220]
Transplantation of fecal matter from young donors into the gastrointestinal tract of middle-aged fish can effectively prolong lifespan and delay the onset of behavioral decline.
“Recent studies have revealed that the transplantation of fecal matter from young donors into the gastrointestinal tract of middle-aged fish can effectively prolong lifespan and delay the onset of behavioral decline,220”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [220]
An FMT study in the short-living killifish showed that exchange of microbial communities from young to old increased longevity in the older group.
“an intriguing FMT study in the short-living killifish showed that exchange of microbial communities from young to old increased longevity in the older group”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Smith et al., 2017
Changes in the aging intestinal microbiota can adversely affect host metabolism and immunity and are associated with development of cardiovascular, autoimmune, metabolic, and neurodegenerative disorders.
“These changes can adversely affect the host metabolism and immunity [25–27, 40, 64, 86, 110, 112, 118] and are associated with the development of cardiovascular, autoimmune, metabolic, and neurodegenerative disorders [17, 90, 122, 132].”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [110]
In the short-lived African killifish, transfer of young donor microbiota to aged individuals ameliorated behavioral decline and extended lifespan.
“In the short-lived African killifish, the transfer of young donor microbiota to aged individuals ameliorated behavioral decline and extended lifespan [110].”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [110]
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- Authors
- Smith, P., Willemsen, D., Popkes, M., Metge, F., Gandiwa, E., Reichard, M., & Valenzano, D. R.
- Affiliations
- Max Planck Institute for Biology of Ageing (DE)
- Chinhoyi University of Technology (ZW)
- Czech Academy of Sciences, Institute of Vertebrate Biology (CZ)
- University of Cologne (DE)
- Corresponding author
- Valenzano, Dario Riccardo
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2017-08-22
- Volume
- 6
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC5566455
- OpenAlex
- W2951096488
- Cited by
- 423
- References
- 82
- Citations by year
- 2026: 35 · 2025: 33 · 2024: 51 · 2023: 47 · 2022: 53 · 2021: 58 · 2020: 48 · 2019: 54 · 2018: 34 · 2017: 9
- FWCI
- 17.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- ASEP (submittedVersion, public-domain)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Czech Science Foundation (16-00291S)
- Max Planck Institute for Biology of Ageing (Open-access funding)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › Aquaculture disease management and microbiota
- Keywords
- gut microbiota, aging, lifespan extension, African turquoise killifish, Nothobranchius furzeri, microbial recolonization, microbial diversity, behavioral decline, Exiguobacterium, Psychrobacter, Planococcus
- MeSH terms
- Gastrointestinal Microbiome, Aging, Animals, Longevity, Fundulidae, Gastrointestinal Tract
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