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Cited by 317Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGenetic and Kidney Cyst Diseases

The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.

Abdominal Fat Quantity and Distribution in Women with Polycystic Ovary Syndrome and Extent of Its Relation to Insulin Resistance

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Carmina, Enrico, Bucchieri, Salvo, Esposito, Antonella, Del Puente, Antonio, Mansueto, Pasquale, Orio, Francesco, Di Fede, Gaetana, Rini, GiovamBattista·2007·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2006-2725
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Abstract

CONTEXT: Increased abdominal fat has been linked to insulin resistance and increased cardiovascular risk. Because many patients with polycystic ovary syndrome (PCOS) present abdominal obesity, it may be the cause of insulin resistance in this disorder. SETTING: Fat quantity and distribution were evaluated by dual x-ray absorptiometry at the Departments of Clinical Medicine at the University of Palermo and the University of Naples, Italy. PATIENTS: A total of 110 patients with PCOS and 112 weight-matched controls were studied. Anthropometric data, blood glucose, serum insulin, and testosterone were evaluated. Total, trunk, and central abdominal fat quantity were measured by total-body dual x-ray absorptiometry. RESULTS: Compared with weight-matched controls, patients with PCOS had similar quantity of total and trunk fat but higher quantity of central abdominal fat. This difference was not observed when comparing obese PCOS and obese controls but depended on differences between overweight and normoweight patients and controls. All obese subjects, independently of having PCOS or not, had increased central abdominal fat. The same parameter was increased in 71% of overweight PCOS, 50% of overweight controls, and 30% of normoweight PCOS patients. PCOS patients with increased central abdominal fat had significantly higher (P < 0.01) insulin levels and significantly reduced (P < 0.01) insulin sensitivity than controls with similar quantities of central abdominal fat. Overweight PCOS patients with normal abdominal fat had significantly higher (P < 0.05) insulin levels and significantly reduced (P < 0.05) insulin sensitivity than overweight controls with normal abdominal fat. CONCLUSIONS: Most obese subjects, independent of being affected by PCOS, have an abdominal form of obesity. However, abdominal fat excess may not be the only determinant of insulin resistance in PCOS.

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  1. Zawadzki, 1992, Diagnostic criteria for polycystic ovary syndrome: towards a rational approach, In: Dunaif A, Givens JR, Haseltine FP, Merriam GR, eds. Polycystic ovary syndrome. Boston: Blackwell Scientific;, 377

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Metadata

Authors
Carmina, E., Bucchieri, S., Esposito, A., Del Puente, A., Mansueto, P., Orio, F., Di Fede, G., & Rini, G.
Affiliations
  • University of Palermo (IT)
  • Federico II University Hospital (IT)
  • Department of Clinical and Experimental Medicine (A.E., A.D.P.), Federico II University of Naples, 80131 Naples, Italy
  • University of Naples Federico II (IT)
  • Department of Clinical Medicine and Emerging Diseases (E.C., S.B., P.M., G.D.F., G.R.), University of Palermo, 90139 Palermo, Italy
Corresponding author
Rini, GiovamBattista
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2007-07-01
Volume
92
Issue
7
Pages
2500-2505
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2006-2725
OpenAlex
W2055594461
Cited by
317
References
38
Citations by year
2026: 8 · 2025: 10 · 2024: 9 · 2023: 18 · 2022: 17 · 2021: 18 · 2020: 23 · 2019: 15 · 2018: 16 · 2017: 15 · 2016: 20 · 2015: 22 · 2014: 22 · 2013: 15 · 2012: 23
FWCI
17.31
Type
journal article
Language
en
Open access
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS UniPA (University of Palermo) (submittedVersion, other-oa)
  • CINECA IRIS Institutial research information system (Parthenope University of Naples) (submittedVersion)
  • INFM-OAR (INFN Catania) (submittedVersion, cc-by)
  • Zenodo (CERN European Organization for Nuclear Research) (other-oa)
Funders
Università degli Studi di Palermo
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords
polycystic ovary syndrome, insulin resistance, abdominal fat, abdominal obesity, visceral fat, trunk fat, body fat distribution, obesity, insulin sensitivity, women
MeSH terms
Adult, Female, Humans, Insulin, Insulin Resistance, Obesity, Polycystic Ovary Syndrome, Absorptiometry, Photon, Abdominal Fat, Overweight

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