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Cited by 179Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGenetic and Kidney Cyst Diseases

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Global Adiposity Rather Than Abnormal Regional Fat Distribution Characterizes Women with Polycystic Ovary Syndrome

Barber, Thomas M., Golding, Stephen J., Alvey, Christopher, Wass, John A. H., Karpe, Fredrik, Franks, Stephen, McCarthy, Mark I.·2008·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2007-2117
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Abstract

CONTEXT: Obesity-related predisposition to polycystic ovary syndrome (PCOS) could reflect overall adiposity and/or regional accumulation of abdominal visceral fat. OBJECTIVE: The objective of the study was to compare distributions of visceral, abdominal sc, and gluteofemoral sc adipose tissue in PCOS cases vs. control women. DESIGN: This was a cross-sectional study. SETTING AND PARTICIPANTS: Fat depot measurements from axial magnetic resonance imaging scans taken at anatomically predefined sites were compared between 22 body mass index (BMI)/fat mass-matched pairs of PCOS cases and controls; whole-group comparisons included 50 PCOS cases vs. 28 female controls. All subjects were of UK British/Irish origin. MAIN OUTCOME MEASURE(S): We measured cross-sectional areas of adipose tissue within visceral (mid-L4), abdominal (mid-L4) sc, and gluteofemoral (greater trochanteric and midfemoral) sc fat depots. Other measurements included fat mass, BMI, testosterone, SHBG, and homeostasis model assessment of insulin resistance (a measure of insulin sensitivity). Whole-group analyses were adjusted for fat mass and age. RESULTS: There were no significant differences in fat-depot measurements between BMI/fat mass-matched pairs of PCOS cases and controls: mid-L4 visceral (P=0.40), abdominal sc (P=0.22), gluteal sc (P=0.67), and midfemoral sc (P=0.37) depots. Whole-group comparisons gave similar results after adjustments for fat mass and age. Fasting serum insulin concentrations (P=0.03) and homeostasis model assessment of insulin resistance (P=0.03) were significantly higher in the PCOS group than BMI/fat mass-matched controls. CONCLUSIONS: PCOS cases and BMI/fat mass-matched control women are indistinguishable with respect to distribution of fat within visceral, abdominal sc, and gluteofemoral sc depots, despite significant differences in insulin resistance between these two groups.

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Metadata

Authors
Barber, T. M., Golding, S. J., Alvey, C., Wass, J. A. H., Karpe, F., Franks, S., & McCarthy, M. I.
Affiliations
  • Churchill Hospital (GB)
  • John Radcliffe Hospital (GB)
  • Imperial College London (GB)
Corresponding author
Barber, Thomas M.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2008-03-01
Volume
93
Issue
3
Pages
999-1004
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2007-2117
OpenAlex
W2168664376
Cited by
179
References
30
Citations by year
2026: 4 · 2025: 5 · 2024: 10 · 2023: 5 · 2022: 12 · 2021: 11 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 14 · 2016: 10 · 2015: 15 · 2014: 10 · 2013: 12 · 2012: 9
FWCI
11.74
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords
polycystic ovary syndrome, adiposity, regional fat distribution, visceral fat, subcutaneous abdominal fat, insulin resistance, obesity, women
MeSH terms
Adipose Tissue, Adolescent, Adult, Body Composition, Cross-Sectional Studies, Female, Humans, Middle Aged, Polycystic Ovary Syndrome, Adiposity

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