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YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers
Open accessAbstract
YAP1 is a major effector of the Hippo pathway and a well-established oncogene. Elevated YAP1 activity due to mutations in Hippo pathway components or YAP1 amplification is observed in several types of human cancers. Here we investigated its genomic binding landscape in YAP1-activated cancer cells, as well as in non-transformed cells. We demonstrate that TEAD transcription factors mediate YAP1 chromatin-binding genome-wide, further explaining their dominant role as primary mediators of YAP1-transcriptional activity. Moreover, we show that YAP1 largely exerts its transcriptional control via distal enhancers that are marked by H3K27 acetylation and that YAP1 is necessary for this chromatin mark at bound enhancers and the activity of the associated genes. This work establishes YAP1-mediated transcriptional regulation at distal enhancers and provides an expanded set of target genes resulting in a fundamental source to study YAP1 function in a normal and cancer setting.
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“ChIP-seq and deepsequencing studies in cancer and normal cells showed that several YAP-binding regions also show a consensus motif for AP-1 transcriptional factors suggesting that YAP/TEAD and AP-1 cooperatively regulate target genes representing a cross-talk between YAP and JNK signalling (74,75).”
From A Tumour-Specific Molecular Network Promotes Tumour Growth in Drosophila by Enforcing a JNK-YKI Feedforward Loop (2023) · cites this paper as [74]
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“Third, YAP/TEAD bind distal regulatory elements to regulate transcription of target genes (73-75).”
From A Tumour-Specific Molecular Network Promotes Tumour Growth in Drosophila by Enforcing a JNK-YKI Feedforward Loop (2023) · cites this paper as [74]
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“Consistently, published ChIP-seq datasets34,38,39 reveal a similar phenomenon in human cancer cell lines (Figure S7F).”
From HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury (2025) · cites this paper as [38]
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Cites
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386
Cerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455
Differential expression analysis for sequence count data
Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581
Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M. J., Salzberg, S. L., Wold, B. J., & Pachter, L. (2010) · Nature Biotechnology · doi:10.1038/nbt.1621 · Cited by 15,556
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
Gao, J., Aksoy, B. A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S. O., Sun, Y., Jacobsen, A., Sinha, R., Larsson, E., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004088 · Cited by 15,160
The Human Genome Browser at UCSC
Kent, W. J., Sugnet, C. W., Furey, T. S., Roskin, K. M., Pringle, T. H., Zahler, A. M., & Haussler, A. D. (2002) · Genome Research · doi:10.1101/gr.229102 · Cited by 10,400
Histone H3K27ac separates active from poised enhancers and predicts developmental state
Creyghton, M. P., Cheng, A. W., Welstead, G. G., Kooistra, T., Carey, B. W., Steine, E. J., Hanna, J., Lodato, M. A., Frampton, G. M., Sharp, P. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016071107 · Cited by 4,302
Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes
Siepel, A., Bejerano, G., Pedersen, J. S., Hinrichs, A. S., Hou, M., Rosenbloom, K., Clawson, H., Spieth, J., Hillier, L. W., Richards, S., et al. (2005) · Genome Research · doi:10.1101/gr.3715005 · Cited by 3,971 · cited 1×
“We calculated the conservation rate of regions using the PhastCons 46 way placental mammals [94].”
MethodSystematic Localization of Common Disease-Associated Variation in Regulatory DNA
Maurano, M. T., Humbert, R., Rynes, E., Thurman, R. E., Haugen, E., Wang, H., Reynolds, A. P., Sandstrom, R., Qu, H., Brody, J., et al. (2012) · Science · doi:10.1126/science.1222794 · Cited by 3,716
Super-enhancers in the control of cell identity and disease
Hnisz, D., Abraham, B. J., Lee, T. I., Lau, A., Saint-André, V., Sigova, A. A., Hoke, H. A., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.09.053 · Cited by 3,662
Heintzman, N. D., Stuart, R. K., Hon, G., Fu, Y., Ching, C. W., Hawkins, R. D., Barrera, L. O., Van Calcar, S., Qu, C., Ching, K. A., et al. (2007) · Nature Genetics · doi:10.1038/ng1966 · Cited by 3,398 · cited 1×
“To gain further mechanistic insight into how YAP1 affects H3K27ac we performed ChIP-qPCR for p300, the major histone acetyltransferase that has been linked to enhancers [61, 62].”
MethodROCR: visualizing classifier performance in R
Sing, T., Sander, O., Beerenwinkel, N., & Lengauer, T. (2005) · Computer applications in the biosciences · doi:10.1093/bioinformatics/bti623 · Cited by 3,172
Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007) · Genes & Development · doi:10.1101/gad.1602907 · Cited by 3,092
The accessible chromatin landscape of the human genome
Thurman, R. E., Rynes, E., Humbert, R., Vierstra, J., Maurano, M. T., Haugen, E., Sheffield, N. C., Stergachis, A. B., Wang, H., Vernot, B., et al. (2012) · Nature · doi:10.1038/nature11232 · Cited by 2,679
MEME: discovering and analyzing DNA and protein sequence motifs
Bailey, T. L., Williams, N., Misleh, C., & Li, W. W. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl198 · Cited by 2,671
An atlas of active enhancers across human cell types and tissues
The FANTOM Consortium, Andersson, R., Gebhard, C., Miguel-Escalada, I., Hoof, I., Bornholdt, J., Boyd, M., Chen, Y., Zhao, X., Schmidl, C., et al. (2014) · Nature · doi:10.1038/nature12787 · Cited by 2,550
Histone modifications at human enhancers reflect global cell-type-specific gene expression
Heintzman, N. D., Hon, G. C., Hawkins, R. D., Kheradpour, P., Stark, A., Harp, L. F., Ye, Z., Lee, L. K., Stuart, R. K., Ching, C. W., et al. (2009) · Nature · doi:10.1038/nature07829 · Cited by 2,533
TEAD mediates YAP-dependent gene induction and growth control
Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Yu, J., Lin, J. D., Wang, C.-Y., Chinnaiyan, A. M., et al. (2008) · Genes & Development · doi:10.1101/gad.1664408 · Cited by 2,498
Elucidation of a universal size-control mechanism in Drosophila and mammals
Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, M. F., Anders, R. A., Maitra, A., & Pan, D. (2007) · Cell · doi:10.1016/j.cell.2007.07.019 · Cited by 2,370
The Hippo Signaling Pathway in Development and Cancer
Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.09.011 · Cited by 2,317
Weber, M., Hellmann, I., Stadler, M. B., Ramos, L., Pääbo, S., Rebhan, M., & Schübeler, D. (2007) · Nature Genetics · doi:10.1038/ng1990 · Cited by 2,297
Self-citationA unique chromatin signature uncovers early developmental enhancers in humans
Rada-Iglesias, A., Bajpai, R., Swigut, T., Brugmann, S. A., Flynn, R. A., & Wysocka, J. (2011) · Nature · doi:10.1038/nature09692 · Cited by 2,233
Transcription factors: from enhancer binding to developmental control
Spitz, F., & Furlong, E. E. M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3207 · Cited by 2,227
Huang, J., Wu, S., Barrera, J. A., Matthews, K. A., & Pan, D. (2005) · Cell · doi:10.1016/j.cell.2005.06.007 · Cited by 1,917
The Hippo pathway and human cancer
Harvey, K. F., Zhang, X., & Thomas, D. M. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3458 · Cited by 1,867
JASPAR: an open-access database for eukaryotic transcription factor binding profiles
Sandelin, A. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkh012 · Cited by 1,815
ChIP-seq accurately predicts tissue-specific activity of enhancers
Visel, A., Blow, M. J., Li, Z., Zhang, T., Akiyama, J. A., Holt, A., Plajzer-Frick, I., Shoukry, M., Wright, C., Chen, F., et al. (2009) · Nature · doi:10.1038/nature07730 · Cited by 1,639
DNA-Binding Specificities of Human Transcription Factors
Jolma, A., Yan, J., Whitington, T., Toivonen, J., Nitta, K. R., Rastas, P. M. A., Morgunova, E. Y., Enge, M., Taipale, M., Wei, G., et al. (2013) · Cell · doi:10.1016/j.cell.2012.12.009 · Cited by 1,262
YAP1 increases organ size and expands undifferentiated progenitor cells
Camargo, F. D., Gokhale, S., Johnnidis, J. B., Fu, D., Bell, G. W., Jaenisch, R., & Brummelkamp, T. R. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.039 · Cited by 1,252
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
Zhao, B., Tumaneng, K., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2303 · Cited by 1,205
The Hippo–YAP pathway in organ size control and tumorigenesis: an updated versionPreprint
Zhao, B., Li, L., Lei, Q., & Guan, K. (2010) · Genes & Development · doi:10.1101/gad.1909210 · Cited by 1,173
Distinct epigenomic landscapes of pluripotent and lineage-committed human cells
Hawkins, R. D., Hon, G. C., Lee, L. K., Ngo, Q., Lister, R., Pelizzola, M., Edsall, L. E., Kuan, S., Luu, Y., Klugman, S., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.03.018 · Cited by 806
Functional and Mechanistic Diversity of Distal Transcription Enhancers
Bulger, M., & Groudine, M. (2011) · Cell · doi:10.1016/j.cell.2011.01.024 · Cited by 803
Tumor Suppressor LATS1 Is a Negative Regulator of Oncogene YAP
Hao, Y., Chun, A., Cheung, K. J., Rashidi, B., & Yang, X. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m709037200 · Cited by 802
Hamaratoǧlu, F., Willecke, M., Kango‐Singh, M., Nolo, R. M., Hyun, E., Tao, C., Jafar‐Nejad, H., & Halder, G. A. (2005) · Nature Cell Biology · doi:10.1038/ncb1339 · Cited by 765
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiationPreprint
Lian, I., Kim, J., Okazawa, H., Zhao, J. J., Zhao, B., Yu, J., Chinnaiyan, A. M., Israel, M. A., Goldstein, L. S. B., Abujarour, R., et al. (2010) · Genes & Development · doi:10.1101/gad.1903310 · Cited by 762
KRAS and YAP1 Converge to Regulate EMT and Tumor Survival
Shao, D. D., Xue, W., Krall, E. B., Bhutkar, A., Piccioni, F., Wang, X., Schinzel, A. C., Sood, S., Rosenbluh, J., Kim, J. W., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.004 · Cited by 744
Vassilev, A., Kaneko, K. J., Shu, H., Zhao, Y., & DePamphilis, M. L. (2001) · Genes & Development · doi:10.1101/gad.888601 · Cited by 719
The Hippo signaling pathway in stem cell biology and cancer
Mo, J., Park, H. W., & Guan, K. (2014) · EMBO Reports · doi:10.15252/embr.201438638 · Cited by 701
The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain
Lamar, J. M., Stern, P., Liu, H., Schindler, J. W., Jiang, Z.-G., & Hynes, R. O. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212021109 · Cited by 673
Wu, S., Liu, Y., Zheng, Y., Dong, J., & Pan, D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.007 · Cited by 640
The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control
Zhang, L., Ren, F., Zhang, Q., Chen, Y., Wang, B., & Jiang, J. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.006 · Cited by 630
WikiPathways: building research communities on biological pathways
Kelder, T., van Iersel, M., Hanspers, K., Kutmon, M., Conklin, B. R., Evelo, C. T., & Pico, A. R. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr1074 · Cited by 521
Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state
Verfaillie, A., Imrichova, H., Atak, Z. K., Dewaele, M., Rambow, F., Hulselmans, G., Christiaens, V., Svetlichnyy, D., Luciani, F., Van den Mooter, L., et al. (2015) · Nature Communications · doi:10.1038/ncomms7683 · Cited by 489
Zhang, J., Ji, J., Yu, M., Overholtzer, M., Smolen, G. A., Wang, R., Brugge, J. S., Dyson, N. J., & Haber, D. A. (2009) · Nature Cell Biology · doi:10.1038/ncb1993 · Cited by 438
Zhang, H., Pasolli, H. A., & Fuchs, E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019603108 · Cited by 419
Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1
Xiao, J. H., Davidson, I., Matthes, H. W. D., Garnier, J., & Chambon, P. (1991) · Cell · doi:10.1016/0092-8674(91)90088-g · Cited by 419
Ota, M., & Sasaki, H. (2008) · Development · doi:10.1242/dev.027151 · Cited by 399
Kibra Is a Regulator of the Salvador/Warts/Hippo Signaling Network
Genevet, A., Wehr, M. C., Brain, R., Thompson, B. J., & Tapon, N. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.011 · Cited by 396
Characterization of a New Human Diploid Cell Strain, IMR-90
Nichols, W. W., Murphy, D. G., Cristofalo, V. J., Toji, L. H., Greene, A. E., & Dwight, S. (1977) · Science · doi:10.1126/science.841339 · Cited by 368
The Hippo-YAP signaling pathway and contact inhibition of growth
Gumbiner, B. M., & Kim, N. (2014) · Journal of Cell Science · doi:10.1242/jcs.140103 · Cited by 351
Wang, Y., Dong, Q., Zhang, Q., Li, Z., Wang, E., & Qiu, X. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01511.x · Cited by 341
Epigenomic Enhancer Profiling Defines a Signature of Colon Cancer
Akhtar‐Zaidi, B., Sallari, R. C., Corradin, O., Saiakhova, A., Bartels, C. F., Balasubramanian, D., Myeroff, L. L., Lutterbaugh, J., Jarrar, A., Kalady, M. F., et al. (2012) · Science · doi:10.1126/science.1217277 · Cited by 337
How to map billions of short reads onto genomes
Trapnell, C., & Salzberg, S. L. (2009) · Nature Biotechnology · doi:10.1038/nbt0509-455 · Cited by 322
Animal Transcription Networks as Highly Connected, Quantitative Continua
Biggin, M. D. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.09.008 · Cited by 308
Beyer, T. A., Weiss, A., Khomchuk, Y., Huang, K., Ogunjimi, A. A., Varelas, X., & Wrana, J. L. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.11.021 · Cited by 304
Davidson, I., Xiao, J. H., Rosales, R., Staub, A., & Chambon, P. (1988) · Cell · doi:10.1016/0092-8674(88)90108-0 · Cited by 281
Hippo Coactivator YAP1 Upregulates SOX9 and Endows Esophageal Cancer Cells with Stem-like Properties
Song, S., Ajani, J. A., Honjo, S., Maru, D. M., Chen, Q., Scott, A. W., Heallen, T. R., Xiao, L., Hofstetter, W. L., Weston, B. R., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3569 · Cited by 281
Mizuno, T., Murakami, H., Fujii, M., Ishiguro, F., Tanaka, I., Kondo, Y., Akatsuka, S., Toyokuni, S., Yokoi, K., Osada, H., et al. (2012) · Oncogene · doi:10.1038/onc.2012.5 · Cited by 278
LATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma
Murakami, H., Mizuno, T., Taniguchi, T., Fujii, M., Ishiguro, F., Fukui, T., Akatsuka, S., Horio, Y., Hida, T., Kondo, Y., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2164 · Cited by 260
Zhang, J., Smolen, G. A., & Haber, D. A. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6205 · Cited by 250
Del Re, D. P., Yang, Y., Nakano, N., Cho, J., Zhai, P., Yamamoto, T., Zhang, N., Yabuta, N., Nojima, H., Pan, D., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.436311 · Cited by 249
Gotea, V., Visel, A., Westlund, J. M., Nobrega, M. A., Pennacchio, L. A., & Ovcharenko, I. (2010) · Genome Research · doi:10.1101/gr.104471.109 · Cited by 248
AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma
Xu, M. Z., Chan, S. W., Liu, A., Wong, K. F., Fan, S., Chen, J., Poon, R. T. P., Zender, L., Lowe, S. W., Hong, W., et al. (2010) · Oncogene · doi:10.1038/onc.2010.504 · Cited by 228
Morikawa, Y., Zhang, M., Heallen, T. R., Leach, J. P., Tao, G., Xiao, Y., Bai, Y., Li, W., Willerson, J. T., & Martin, J. F. (2015) · Science Signaling · doi:10.1126/scisignal.2005781 · Cited by 227
TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors
Cebola, I., Rodríguez‐Seguí, S. A., Cho, C. H.-H., Bessa, J., Rovira, M., Luengo, M., Chhatriwala, M., Berry, A. A., Ponsa-Cobas, J., Maestro, M. A., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3160 · Cited by 218
SOX2 Regulates YAP1 to Maintain Stemness and Determine Cell Fate in the Osteo-Adipo Lineage
Seo, E., Basu-Roy, U., Gunaratne, P. H., Coarfa, C., Lim, D.-S., Basilico, C., & Mansukhani, A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.029 · Cited by 216
Methods and Statistics for Combining Motif Match Scores
Bailey, T. L., & Gribskov, M. (1998) · Journal of Computational Biology · doi:10.1089/cmb.1998.5.211 · Cited by 202
KIBRA Regulates Hippo Signaling Activity via Interactions with Large Tumor Suppressor Kinases
Xiao, L., Chen, Y., Ji, M., & Dong, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.173468 · Cited by 190
Tremblay, A. M., Missiaglia, E., Galli, G. G., Hettmer, S., Urcia, R., Carrara, M., Judson, R. N., Thway, K., Nadal, G., Selfe, J. L., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.05.029 · Cited by 178
Structural and functional analysis of the YAP-binding domain of human TEAD2
Tian, W., Yu, J., Tomchick, D. R., Pan, D., & Luo, X. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000293107 · Cited by 173
Xia, Y., Chang, T., Wang, Y., Liu, Y., Li, W., Li, M., & Fan, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091770 · Cited by 172
YAP/TEAD–Mediated Transcription Controls Cellular Senescence
Xie, Q., Chen, J., Han, F., Peng, S., Adams, U., Bai, Y., Huang, L., Li, J., Huang, J., Meng, S., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3793 · Cited by 172
Identification of β-catenin binding regions in colon cancer cells using ChIP-Seq
Bottomly, D., Kyler, S. L., McWeeney, S. K., & Yochum, G. S. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq363 · Cited by 160
Enhancers: Mechanisms of Action and Cell Specificity
Atchison, M. L. (1988) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.04.110188.001015 · Cited by 157
Genome-wide Association of Yorkie with Chromatin and Chromatin-Remodeling Complexes
Oh, H., Slattery, M., Ma, L., Crofts, A., White, K. P., Mann, R. S., & Irvine, K. D. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.008 · Cited by 145
Transcriptional enhancers in development and disease
Sakabe, N. J., Savic, D., & Nóbrega, M. A. (2012) · Genome biology · doi:10.1186/gb-2012-13-1-238 · Cited by 143
Integrating developmental signals: a Hippo in the (path)way
Mauviel, A., Nallet-Staub, F., & Varelas, X. (2011) · Oncogene · doi:10.1038/onc.2011.363 · Cited by 139
Anbanandam, A., Albarado, D. C., Nguyen, C. T. Y., Halder, G. A., Gao, X., & Veeraraghavan, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607171103 · Cited by 136
Jacquemin, P., Hwang, J.-J., MARTIAL, J. A., Dollé, P., & Davidson, I. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.36.21775 · Cited by 135
A computational pipeline for comparative ChIP-seq analyses
Bardet, A. F., He, Q., Zeitlinger, J., & Stark, A. (2011) · Nature Protocols · doi:10.1038/nprot.2011.420 · Cited by 118
Self-citationLiu, J.-Y., Li, Y.-H., Lin, H., Liao, Y.-J., Mai, S., Liu, Z.-W., Zhang, Z.-L., Jiang, L.-J., Zhang, J., Kung, H., et al. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-349 · Cited by 117
The mammalian Hippo pathway: regulation and function of YAP1 and TAZ
Kodaka, M., & Hata, Y. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1742-9 · Cited by 115
The Tyrosine Phosphatase PTPN14 Is a Negative Regulator of YAP Activity
Michaloglou, C., Lehmann, W., Martin, T., Delaunay, C., Hueber, A., Barys, L., Niu, H., Billy, É., Wartmann, M., Ito, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061916 · Cited by 94
Self-citationHalder, G. A., & Carroll, S. B. (2001) · Development · doi:10.1242/dev.128.17.3295 · Cited by 85
Clinical and prognostic significance of Yes-associated protein in colorectal cancer
Wang, Y., Xie, C., Li, Q., Xu, K., & Wang, E. (2013) · Tumor Biology · doi:10.1007/s13277-013-0751-x · Cited by 79
Qing, Y., Yin, F., Wang, W., Zheng, Y., Guo, P., Schozer, F., Deng, H., & Pan, D. (2014) · eLife · doi:10.7554/elife.02564 · Cited by 72
YAP1acts as oncogenic target of 11q22 amplification in multiple cancer subtypes
Lorenzetto, E., Brenca, M., Boeri, M., Verri, C., Piccinin, E., Gasparini, P., Facchinetti, F., Rossi, S., Salvatore, G., Massimino, M., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.1844 · Cited by 72
Song, M., Cheong, J., Kim, H., Noh, S. H., & Kim, H. (2012) · PubMed · Cited by 68
Hu, X., Xin, Y., Xiao, Y., & Zhao, J. (2014) · Pathology & Oncology Research · doi:10.1007/s12253-014-9757-y · Cited by 66
Mahajan, M., & Samuels, H. H. (2008) · Nuclear Receptor Signaling · doi:10.1621/nrs.06002 · Cited by 63
Transcription factor binding variation in the evolution of gene regulation
Dowell, R. D. (2010) · Trends in Genetics · doi:10.1016/j.tig.2010.08.005 · Cited by 61
Sikora-Wohlfeld, W., Ackermann, M., Christodoulou, E. G., Singaravelu, K., & Beyer, A. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003342 · Cited by 60
Identification of transcription factor binding sites from ChIP-seq data at high resolution
Bardet, A. F., Steinmann, J., Bafna, S., Knoblich, J. A., Zeitlinger, J., & Stark, A. (2013) · Bioinformatics · doi:10.1093/bioinformatics/btt470 · Cited by 59
Self-citationSchwarzer, W., & Spitz, F. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.03.014 · Cited by 52
Jiang, S., Desai, D. S., Khan, S., & Eberhardt, N. L. (2000) · DNA and Cell Biology · doi:10.1089/10445490050128430 · Cited by 47
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Metadata
- Authors
- Stein, C., Bardet, A. F., Roma, G., Bergling, S., Clay, I., Ruchti, A., Agarinis, C., Schmelzle, T., Bouwmeester, T., Schübeler, D., & Bauer, A.
- Affiliations
- Novartis (Switzerland) (CH)
- Friedrich Miescher Institute (CH)
- University of Basel (CH)
- Corresponding author
- Schübeler, Dirk
- Bauer, Andreas
- ORCID
- Venue
- PLOS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-08-21
- Volume
- 11
- Issue
- 8
- Pages
- e1005465
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- PMC
- PMC4546604
- OpenAlex
- W1539804860
- Cited by
- 414
- References
- 98
- Citations by year
- 2026: 26 · 2025: 26 · 2024: 53 · 2023: 52 · 2022: 42 · 2021: 52 · 2020: 42 · 2019: 38 · 2018: 33 · 2017: 29 · 2016: 17 · 2015: 2
- FWCI
- 14.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS Genetics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- European Commission (282510, 257082)
- SystemsX.ch
- FP7 Health (HEALTH-2010-257082, 282510)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- YAP, TEAD transcription factors, Hippo signaling pathway, enhancer activation, distal enhancers, H3K27 acetylation, chromatin binding, transcriptional regulation, oncogenes, cancer
- MeSH terms
- YAP-Signaling Proteins, TEA Domain Transcription Factors, Acetylation, Base Sequence, Binding Sites, DNA-Binding Proteins, Enhancer Elements, Genetic, Histones, Humans, Nuclear Proteins, Phosphoproteins, Protein Binding, Protein Processing, Post-Translational, Transcription Factors, Transcriptional Activation, Consensus Sequence, Cell Line, Tumor, Adaptor Proteins, Signal Transducing, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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