The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Delayed Stabilization of Dendritic Spines in Fragile X Mice
Open accessAbstract
Fragile X syndrome (FXS) causes mental impairment and autism through transcriptional silencing of the Fmr1 gene, resulting in the loss of the RNA-binding protein fragile X mental retardation protein (FMRP). Cortical pyramidal neurons in affected individuals and Fmr1 knock-out (KO) mice have an increased density of dendritic spines. The mutant mice also show defects in synaptic and experience-dependent circuit plasticity, which are known to be mediated in part by dendritic spine dynamics. We used in vivo time-lapse imaging with two-photon microscopy through cranial windows in male and female neonatal mice to test the hypothesis that dynamics of dendritic protrusions are altered in KO mice during early postnatal development. We find that layer 2/3 neurons from wild-type mice exhibit a rapid decrease in dendritic spine dynamics during the first 2 postnatal weeks, as immature filopodia are replaced by mushroom spines. In contrast, KO mice show a developmental delay in the downregulation of spine turnover and in the transition from immature to mature spine subtypes. Blockade of metabotropic glutamate receptor (mGluR) signaling, which reverses some adult phenotypes of KO mice, accentuated this immature protrusion phenotype in KO mice. Thus, absence of FMRP delays spine stabilization and dysregulated mGluR signaling in FXS may partially normalize this early synaptic defect.
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“These experiments revealed that in our xenotransplantation assay, human cortical neurons show increasingly stable dendritic spine dynamics, comparable to juvenile mouse cortical neurons”
From Xenotransplanted human cortical neurons reveal species-specific development and functional integration into mouse visual circuits (2019) · cites this paper as Cruz-Martín et al., 2010
In the citing paper
“Fmr1 mutant mice have a significant delay in the stabilization of dendritic spines and in the maturation of thalamocortical and corticocortical synapses 94-98 , defects associated with a temporal shift in the critical period for sensory-induced plasticity across different cortical areas 94,97,99-101 .”
From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [95]
In the citing paper
“They also show a delayed maturation of spines [75]”
From Experience-dependent structural plasticity in the cortex (2011) · cites this paper as [75]
In the citing paper
“Both studies reveal a significant increase in spine turnover in the barrel cortex of Fmr1 KO mice.”
From Experience-dependent structural plasticity in the cortex (2011) · cites this paper as [75]
In the citing paper
“For example, spines on the apical dendrites of layer 2/3 pyramidal neurons in rodent barrel cortex exhibit gradually decreasing motility (elongation and shortening of spines) and turnover rate (defined as the total amount of gains and losses of spines) between postnatal day 7 and 24 (P7-24; Lendvai et al., 2000; Cruz-Martin et al., 2010).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Cruz-Martin et al., 2010
In the citing paper
“Nevertheless, spine density continuously increases over this period of time (Cruz-Martin et al., 2010).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Cruz-Martin et al., 2010
In the citing paper
“In vivo studies further showed that in such animals spine turnover increased in various cortical areas (Cruz-Martin et al., 2010; Pan et al., 2010; Padmashri et al., 2013), and neither whisker trimming nor motor learning could further alter spine dynamics (Pan et al., 2010; Padmashri et al., 2013).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Cruz-Martin et al., 2010
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Citations
Cites
Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,483
Experience-dependent structural synaptic plasticity in the mammalian brain
Holtmaat, A., & Svoboda, K. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2699 · Cited by 1,934
The mGluR theory of fragile X mental retardation
Bear, M. F., Huber, K. M., & Warren, S. T. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.04.009 · Cited by 1,580
Matsuzaki, M., Ellis-Davies, G. C. R., Nemoto, T., Miyashita, Y., Iino, M., & Kasai, H. (2001) · Nature Neuroscience · doi:10.1038/nn736 · Cited by 1,563 · cited 2×
“Previous work has established a strong correlation between protrusion size and synaptic strength (Matsuzaki et al., 2001; Zito et al., 2009), and modulating synaptic strength results in changes in spine volume (Lang et al.”
BackgroundImpaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Paylor, R. E., Wehner, J. M., & Tonegawa, S. (1992) · Science · doi:10.1126/science.1321493 · Cited by 1,366
Altered synaptic plasticity in a mouse model of fragile X mental retardation
Huber, K. M., Gallagher, S. M., Warren, S. T., & Bear, M. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122205699 · Cited by 1,349
ScanImage: Flexible software for operating laser scanning microscopes
Pologruto, T. A., Sabatini, B. L., & Svoboda, K. (2003) · BioMedical Engineering OnLine · doi:10.1186/1475-925x-2-13 · Cited by 1,300
Morphological Changes in Dendritic Spines Associated with Long-Term Synaptic Plasticity
Yuste, R., & Bonhoeffer, T. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1071 · Cited by 1,269
Migaud, M., Charlesworth, P., Dempster, M., Webster, L. C., Watabe, A. M., Makhinson, M., He, Y., Ramsay, M. F., Morris, R. G. M., Morrison, J. H., et al. (1998) · Nature · doi:10.1038/24790 · Cited by 1,160
Transient and persistent dendritic spines in the neocortex in vivo
Holtmaat, A. J. G. D., Trachtenberg, J. T., Wilbrecht, L., Shepherd, G. M., Zhang, X., Knott, G. W., & Svoboda, K. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.003 · Cited by 1,131
Fmr1 knockout mice: A model to study fragile X mental retardation
THEDUTCHBELGIANFRAGILEXCONSOR (1994) · Cell · doi:10.1016/0092-8674(94)90569-x · Cited by 1,108
Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function
Bassell, G. J., & Warren, S. T. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.004 · Cited by 1,051
Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits
Comery, T. A., Harris, J. B., Willems, P. J., Oostra, B. A., Irwin, S. A., Weiler, I. J., & Greenough, W. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5401 · Cited by 1,046
Electroporation and RNA interference in the rodent retina in vivo and in vitro
Matsuda, T., & Cepko, C. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2235688100 · Cited by 1,032
Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses
Zhou, Q., Homma, K. J., & Poo, M.-M. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.011 · Cited by 1,025
Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window
Holtmaat, A. J. D. G., Bonhoeffer, T., Chow, D. K., Chuckowree, J. A., Paola, V. D., Hofer, S. B., Hübener, M., Keck, T., Knott, G. W., Lee, W.-C. A., et al. (2009) · Nature Protocols · doi:10.1038/nprot.2009.89 · Cited by 1,023
Self-citationCorrection of Fragile X Syndrome in Mice
Dölen, G., Osterweil, E., Rao, B. S. S., Smith, G. B., Auerbach, B. D., Chattarji, S., & Bear, M. F. (2007) · Neuron · doi:10.1016/j.neuron.2007.12.001 · Cited by 979
Balancing Structure and Function at Hippocampal Dendritic Spines
Bourne, J. N., & Harris, K. M. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125646 · Cited by 916
Evidence for a Role of Dendritic Filopodia in Synaptogenesis and Spine Formation
Ziv, N. E., & Smith, S. J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80283-4 · Cited by 882
Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?
Fiala, J. C., Spacek, J., & Harris, K. M. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00158-3 · Cited by 811
Experience-dependent plasticity of dendritic spines in the developing rat barrel cortex in vivo
Lendvai, B., Stern, E. A., Chen, B., & Svoboda, K. (2000) · Nature · doi:10.1038/35009107 · Cited by 802
Efficient Gene Transfer into the Embryonic Mouse Brain Using in Vivo Electroporation
Saito, T., & Nakatsuji, N. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0439 · Cited by 772
Synaptogenesis Via Dendritic Filopodia in Developing Hippocampal Area CA1
Fiala, J. C., Feinberg, M., Popov, V., & Harris, K. M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-21-08900.1998 · Cited by 758
Dendritic Anomalies in Disorders Associated with Mental Retardation
Kaufmann, W. E. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.981 · Cited by 746
Genesis of dendritic spines: insights from ultrastructural and imaging studies
Yuste, R., & Bonhoeffer, T. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1300 · Cited by 657
Experience-dependent and cell-type-specific spine growth in the neocortex
Holtmaat, A., Wilbrecht, L., Knott, G. W., Welker, E., & Svoboda, K. (2006) · Nature · doi:10.1038/nature04783 · Cited by 631
Dendritic Spine Structural Anomalies in Fragile-X Mental Retardation Syndrome
Irwin, S. A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.1038 · Cited by 626
The Dynamics of Dendritic Structure in Developing Hippocampal Slices
Dailey, M. E., & Smith, S. J. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-09-02983.1996 · Cited by 611
Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression
Colledge, M., Snyder, E. M., Crozier, R. A., Soderling, J. A., Jin, Y., Langeberg, L. K., Lu, H., Bear, M. F., & Scott, J. D. (2003) · Neuron · doi:10.1016/s0896-6273(03)00687-1 · Cited by 567
(1994) · PubMed · Cited by 565
Abnormal Development of Dendritic Spines in FMR1 Knock-Out Mice
Nimchinsky, E. A., Oberlander, A. M., & Svoboda, K. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05139.2001 · Cited by 560
Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP
Yan, Q. J., Rammal, M., Tranfaglia, M., & Bauchwitz, R. P. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.06.004 · Cited by 521
Garber, K. B., Visootsak, J., & Warren, S. T. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.61 · Cited by 491
Glutamate Receptor Exocytosis and Spine Enlargement during Chemically Induced Long-Term Potentiation
Kopec, C. D., Li, B., Wei, W., Boehm, J., & Malinow, R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3918-05.2006 · Cited by 486
Cadherin Regulates Dendritic Spine Morphogenesis
Togashi, H., Abe, K., Mizoguchi, A., Takaoka, K., Chisaka, O., & Takeichi, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00748-1 · Cited by 485
From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome
Bagni, C., & Greenough, W. T. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1667 · Cited by 475
Muddashetty, R. S., Kelić, S., Gross, C., Xu, M., & Bassell, G. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0937-07.2007 · Cited by 421
A critical period for experience-dependent synaptic plasticity in rat barrel cortex
Fox, K. D. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-05-01826.1992 · Cited by 420
A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability
Zalfa, F., Eleuteri, B., Dickson, K. S., Mercaldo, V., Rubeis, S. D., di Penta, A., Tabolacci, E., Chiurazzi, P., Neri, G., Grant, S. G. N., et al. (2007) · Nature Neuroscience · doi:10.1038/nn1893 · Cited by 370
Adult fragile X syndrome: Clinico-neuropathologic findings
Rudelli, R. D., Brown, W. T., Wisniewski, K., Jenkins, E. C., Laure-Kamionowska, M., Connell, F., & Wisniewski, H. M. (1985) · Acta Neuropathologica · doi:10.1007/bf00687814 · Cited by 362
Bonhoeffer, T., & Yuste, R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00906-6 · Cited by 337
Early experience of tactile stimulation influences organization of somatic sensory cortex
Simons, D. J., & Land, P. W. (1987) · Nature · doi:10.1038/326694a0 · Cited by 319
Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice
de Vrij, F. M. S., Levenga, J., van der Linde, H. C., Koekkoek, S. K., De Zeeuw, C. I., Nelson, D. L., Oostra, B. A., & Willemsen, R. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.04.002 · Cited by 313
Rapid formation and remodeling of postsynaptic densities in developing dendrites
Marrs, G. S., Green, S. H., & Dailey, M. E. (2001) · Nature Neuroscience · doi:10.1038/nn717 · Cited by 311
Internally Mediated Developmental Desynchronization of Neocortical Network Activity
Golshani, P., Gonçalves, J. T., Khoshkhoo, S., Mostany, R., Smirnakis, S., & Portera-Cailliau, C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2012-09.2009 · Cited by 298
Self-citationDeficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome
Zhao, M.-G., Toyoda, H., Ko, S. W., Ding, H.-K., Wu, L.-J., & Zhuo, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1520-05.2005 · Cited by 296
Sparsification of neuronal activity in the visual cortex at eye-opening
Rochefort, N. L., Garaschuk, O., Milos, R., Narushima, M., Marandi, N., Pichler, B., Kovalchuk, Y., & Konnerth, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907660106 · Cited by 291
Structural abnormalities of the cerebral cortex in human chromosomal aberrations: a Golgi study
Marin-Padilla, M. (1972) · Brain Research · doi:10.1016/0006-8993(72)90324-1 · Cited by 290
Rapid Development and Plasticity of Layer 2/3 Maps in Rat Barrel Cortex In Vivo
Stern, E. A., Maravall, M., & Svoboda, K. (2001) · Neuron · doi:10.1016/s0896-6273(01)00360-9 · Cited by 282
Li, J., Pelletier, M. R., Perez-Velazquez, J. L., & Carlen, P. L. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.1085 · Cited by 275
Rapid functional maturation of nascent dendritic spines
Zito, K., Scheuss, V., Knott, G., Hill, T., & Svoboda, K. (2009) · Neuron · doi:10.1016/j.neuron.2008.10.054 · Cited by 272
Portera-Cailliau, C., Pan, D. T., & Yuste, R. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-18-07129.2003 · Cited by 269
Self-citationStability of dendritic spines and synaptic contacts is controlled by αN-catenin
Abe, K., Chisaka, O., Roy, F. M. V., & Takeichi, M. (2004) · Nature Neuroscience · doi:10.1038/nn1212 · Cited by 262
Antar, L. N., Li, C., Zhang, H., Carroll, R. C., & Bassell, G. J. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.02.001 · Cited by 259
Nakamoto, M., Nalavadi, V., Epstein, M. P., Narayanan, U., Bassell, G. J., & Warren, S. T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707484104 · Cited by 245
Lang, C., Barco, A., Zablow, L., Kandel, E. R., Siegelbaum, S. A., & Zakharenko, S. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407581101 · Cited by 245
Diverse Modes of Axon Elaboration in the Developing Neocortex
Portera-Cailliau, C., Weimer, R. M., De Paola, V., Caroni, P., & Svoboda, K. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030272 · Cited by 225
Self-citationEphB Receptors Couple Dendritic Filopodia Motility to Synapse Formation
Kayser, M. S., Nolt, M. J., & Dalva, M. B. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.007 · Cited by 212
Circuit and Plasticity Defects in the Developing Somatosensory Cortex of Fmr1 Knock-Out Mice
Bureau, I., Shepherd, G. M. G., & Svoboda, K. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1076-08.2008 · Cited by 201
Vanderklish, P. W., & Edelman, G. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032681099 · Cited by 200
Chuang, S.-C., Zhao, W., Bauchwitz, R., Yan, Q., Bianchi, R., & Wong, R. K. S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1777-05.2005 · Cited by 190
Meredith, R. M., Holmgren, C. D., Weidum, M., Burnashev, N., & Mansvelder, H. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.028 · Cited by 190
Pfeiffer, B. E., & Huber, K. M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0054-07.2007 · Cited by 189
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Mostany, R., & Portera‐Cailliau, C. (2008) · Journal of Visualized Experiments · doi:10.3791/680 · Cited by 182
Self-citationBAY36-7620: A Potent Non-Competitive mGlu1 Receptor Antagonist with Inverse Agonist Activity.
Carroll, F. Y., Stolle, A., Beart, P. M., Voerste, A. A. W., Brabet, I., Mauler, F., Joly, C., Antonicek, H., Bockaert, J., Müller, T. M., et al. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.5.965 · Cited by 171
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Löhmann, C., & Bonhoeffer, T. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.025 · Cited by 169
Tessier, C. R., & Broadie, K. S. (2008) · Development · doi:10.1242/dev.015867 · Cited by 147
Giuffrida, R., Musumeci, S., D'Antoni, S., Bonaccorso, C. M., Giuffrida-Stella, A. M., Oostra, B. A., & Catania, M. V. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0932-05.2005 · Cited by 141
De Rubeis, S., & Bagni, C. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.09.013 · Cited by 126
Absence of metabotropic glutamate receptor-mediated plasticity in the neocortex of fragile X mice
Wilson, B. M., & Cox, C. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610875104 · Cited by 121
Early Postnatal Plasticity in Neocortex of Fmr1 Knockout Mice
Desai, N. S., Casimiro, T. M., Gruber, S. M., & Vanderklish, P. W. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00221.2006 · Cited by 113
Ronesi, J. A., & Huber, K. M. (2008) · Science Signaling · doi:10.1126/stke.15pe6 · Cited by 107
Neurotrophin-Dependent Dendritic Filopodial Motility: A Convergence on PI3K Signaling
Luikart, B. W., Zhang, W., Wayman, G. A., Kwon, C. H., Westbrook, G. L., & Parada, L. F. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0195-08.2008 · Cited by 107
Maravall, M., Stern, E. A., & Svoboda, K. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00598.2003 · Cited by 99
Kawai, Y., & Senba, E. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960923)373:3 · Cited by 88
Dendritic spine plasticity—Current understanding from in vivo studies
Knott, G. W., & Holtmaat, A. J. D. G. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.01.002 · Cited by 86
A δ-Catenin Signaling Pathway Leading to Dendritic Protrusions
Abu-Elneel, K., Ochiishi, T., Medina, M., Remedi, M. V., Gastaldi, L., Cáceres, A., & Kosik, K. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804688200 · Cited by 59
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Mostany, R., & Portera‐Cailliau, C. (2008) · Journal of Visualized Experiments · doi:10.3791/680-v · Cited by 52
Self-citationDendritic Anomalies in Disorders Associated With Mental Retardation
Moser, H. W. (1999) · Developmental Neuropsychology · doi:10.1207/s15326942dn1603_18 · Cited by 28
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Portera‐Cailliau, C., & Yuste, R. (2001) · Revista de Neurología · doi:10.33588/rn.3312.2001338 · Cited by 28
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Metadata
- Authors
- Cruz-Martin, A., Crespo, M., & Portera-Cailliau, C.
- Affiliations
- Pediatrics and Genetics (US)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-06-09
- Volume
- 30
- Issue
- 23
- Pages
- 7793-7803
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2903441
- OpenAlex
- W2012010559
- Cited by
- 321
- References
- 80
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 14 · 2023: 15 · 2022: 18 · 2021: 24 · 2020: 25 · 2019: 19 · 2018: 18 · 2017: 24 · 2016: 27 · 2015: 23 · 2014: 34 · 2013: 28 · 2012: 16
- FWCI
- 12.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- FRAXA Research Foundation
- National Institutes of Health
- National Institute of General Medical Sciences
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD054453)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- fragile X syndrome, FMRP, Fmr1 knockout mice, spine dynamics, filopodia, mushroom spines, layer 2/3 pyramidal neurons, synaptic plasticity
- MeSH terms
- Animals, Animals, Newborn, Disease Models, Animal, Fragile X Syndrome, Male, Mice, Inbred C57BL, Pseudopodia, Pyridines, Receptors, Metabotropic Glutamate, Mice, Knockout, Excitatory Amino Acid Antagonists, Dendritic Spines, Mice, Fragile X Messenger Ribonucleoprotein 1, Fragile X Mental Retardation Protein
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