The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Environmental Enrichment Reverses the Effects of Maternal Separation on Stress Reactivity
Open accessAbstract
Postnatal maternal separation increases hypothalamic corticotropin-releasing factor (CRF) gene expression and hypothalamic-pituitary-adrenal (HPA) and behavioral responses to stress. We report here that environmental enrichment during the peripubertal period completely reverses the effects of maternal separation on both HPA and behavioral responses to stress, with no effect on CRF mRNA expression. We conclude that environmental enrichment leads to a functional reversal of the effects of maternal separation through compensation for, rather than reversal of, the neural effects of early life adversity.
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In the citing paper
“Environmental enrichment has been shown to successfully reverse several ELS-induced impairments in behavior, including learning and memory, anxiety, depressive-like behavior, and attention (Francis et al., 2002; Cui et al., 2006; Vivinetto et al., 2013; Zubedat et al., 2015; Koe et al., 2016).”
From Effects of Maternal Deprivation and Complex Housing on Rat Social Behavior in Adolescence and Adulthood (2018) · cites this paper as Francis et al., 2002
Experimental — accuracy not yet measuredIn the citing paper
“Studies in humans and animals models show that environmental enrichment can reduce or reverse some of the effects of deprivation, non-normative stimulation and even acute or chronic stress [122,123] at the behavioural and neural levels [109,[124][125][126].”
In the citing paper
“For example, Francis, Diorio, Plotsky, and Meaney (2002) demonstrated reversal of the effect of early stress associated with maternal separation during the neonatal period on the HPA response to stress, as indicated by corticosterone levels, and on learning and memory among rats receiving environmental enrichment.”
From Stress and the development of self-regulation in context (2010) · cites this paper as Francis, Diorio, Plotsky, and Meaney, 2002
In the citing paper
“Effects on corticosterone and behavior, however, could not be attributed to expected changes at the neural level in terms of primary processes that influence stress reactivity.”
From Stress and the development of self-regulation in context (2010) · cites this paper as Francis et al., 2002
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Citations
Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,501
Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170
Self-citationMeaney, M. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1161 · Cited by 2,708
Self-citationBrain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
Nongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat
Francis, D., Diorio, J., Liu, D., & Meaney, M. J. (1999) · Science · doi:10.1126/science.286.5442.1155 · Cited by 1,965
Self-citationJACOBSON, L., & SAPOLSKY, R. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-118 · Cited by 1,739
Plotsky, P. M., & Meaney, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90189-v · Cited by 1,638
Self-citationDiorio, D., Viau, V, & Meaney, M. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03839.1993 · Cited by 1,151
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Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429
Cognitive and affective development in adolescence
Steinberg, L. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.12.005 · Cited by 2,978
The neurobiology of stress and development.
Gunnar, M., & Quevedo, K. (2007) · Annual Review of Psychology · doi:10.1146/annurev.psych.58.110405.085605 · Cited by 2,011
Sensitive periods in the development of the brain and behavior
Knudsen, E. I. (2004) · Journal of Cognitive Neuroscience · doi:10.1162/0898929042304796 · Cited by 1,842
Enriched environments, experience-dependent plasticity and disorders of the nervous system
Nithianantharajah, J., & Hannan, A. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1970 · Cited by 1,771
Psychological well-being: evidence regarding its causes and consequences
Huppert, F. A. (2009) · Applied Psychology: Health and Well-Being · doi:10.1111/j.1758-0854.2009.01008.x · Cited by 1,583
Hensch, T. K. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144327 · Cited by 1,300
Psychobiology and molecular genetics of resilience
Feder, A., Nestler, E. J., & Charney, D. S. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2649 · Cited by 1,272
Early behavioral intervention, brain plasticity, and the prevention of autism spectrum disorder
Dawson, G. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000370 · Cited by 1,138
von Borell, E., Langbein, J., Desprès, G., Hansen, S., Leterrier, C., Marchant, J. N., Marchant-Forde, R. M., Minero, M., Möhr, E., Prunier, A., et al. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.01.007 · Cited by 973
Pubertal transitions in health
Patton, G. C., & Viner, R. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60366-3 · Cited by 940
Epigenetic mechanisms and the transgenerational effects of maternal care
Champagne, F. A. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.03.003 · Cited by 812
Kuzawa, C. W., & Sweet, E. (2008) · American Journal of Human Biology · doi:10.1002/ajhb.20822 · Cited by 699
A review of adversity, the amygdala and the hippocampus: a consideration of developmental timing
Tottenham, N. (2009) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.068.2009 · Cited by 651
Neurobiological and psychiatric consequences of child abuse and neglect
Heim, C., Shugart, M., Craighead, W. E., & Nemeroff, C. B. (2010) · Developmental Psychobiology · doi:10.1002/dev.20494 · Cited by 613
Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats
Aisa, B., Tordera, R. M., Lasheras, B., Río, J. D., & Ramírez, M. J. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.12.013 · Cited by 555
De Bellis, M. D. (2005) · Child Maltreatment · doi:10.1177/1077559505275116 · Cited by 531
Stress and the developing adolescent brain
Eiland, L. R., & Romeo, R. D. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.10.048 · Cited by 539
Early experience and the development of stress reactivity and regulation in children
Loman, M. M., & Gunnar, M. R. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.05.007 · Cited by 533
Animal models of major depression: drawbacks and challenges
Planchez, B., Surget, A., & Belzung, C. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-02084-y · Cited by 480
Sensitive periods of substance abuse: Early risk for the transition to dependence
Jordan, C. J., & Andersen, S. L. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2016.10.004 · Cited by 455
Treatment resistant depression: A multi-scale, systems biology approach
Akil, H., Gordon, J. A., Hen, R., Javitch, J. A., Mayberg, H. S., McEwen, B. S., Meaney, M. J., & Nestler, E. J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.019 · Cited by 463
Self-citationBlair, C. (2006) · Behavioral and Brain Sciences · doi:10.1017/s0140525x06009034 · Cited by 434
McLaughlin, K. A., Sheridan, M. A., Tibu, F., Fox, N. A., Zeanah, C. H., & Nelson, C. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1423363112 · Cited by 426
Environment and Brain Plasticity: Towards an Endogenous Pharmacotherapy
Sale, A., Berardi, N., & Maffei, L. (2014) · Physiological Reviews · doi:10.1152/physrev.00036.2012 · Cited by 402
Valence is a basic building block of emotional life
Barrett, L. F. (2005) · Journal of Research in Personality · doi:10.1016/j.jrp.2005.08.006 · Cited by 442
Millstein, R. A., & Holmes, A. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.05.003 · Cited by 406
Stress and the development of self-regulation in context
Blair, C. (2010) · Child Development Perspectives · doi:10.1111/j.1750-8606.2010.00145.x · Cited by 379
“The findings of Francis et al. (2002) and Bredy et al. (2003) indicate that the effects of enrichment as seen at the behavioral level are not necessarily mirrored in expected changes at the biological level (Fernandez-Teruel et al., 2002).”
BackgroundChampagne, F. A., & Meaney, M. J. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.6.1353 · Cited by 381
Self-citationStress and the adolescent brain
ROMEO, R. D., & McEWEN, B. S. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1376.022 · Cited by 379
Ladd, C. O., Huot, R. L., Thrivikraman, K. V., Nemeroff, C. B., & Plotsky, P. M. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.10.007 · Cited by 368
Self-citationGunnar, M. R., Frenn, K., Wewerka, S. S., & Van Ryzin, M. J. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.08.013 · Cited by 363
Environmental influence in the brain, human welfare and mental health
Tost, H., Champagne, F. A., & Meyer‐Lindenberg, A. (2015) · Nature Neuroscience · doi:10.1038/nn.4108 · Cited by 370
Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat
Szyf, M., Weaver, I. C. G., Champagne, F. A., Diorio, J., & Meaney, M. J. (2005) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2005.10.002 · Cited by 348
Self-citationExposure to postnatal depression predicts elevated cortisol in adolescent offspring
Halligan, S. L., Herbert, J., Goodyer, I. M., & Murray, L. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.09.013 · Cited by 362
Brenhouse, H. C., & Andersen, S. L. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.04.013 · Cited by 363
Morning cortisol Levels in preschool‐aged foster children: Differential effects of maltreatment type
Bruce, J., Fisher, P. A., Pears, K. C., & Levine, S. (2008) · Developmental Psychobiology · doi:10.1002/dev.20333 · Cited by 358
Social stress, therapeutics and drug abuse: Preclinical models of escalated and depressed intake
MICZEK, K., YAP, J., & COVINGTONIII, H. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.07.006 · Cited by 338
Stress, age, and immune function: toward a lifespan approach
Graham, J. E., Christian, L. M., & Kiecolt-Glaser, J. K. (2006) · Journal of Behavioral Medicine · doi:10.1007/s10865-006-9057-4 · Cited by 329
Gunnar, M. R., Fisher, P. A., & THE EARLY EXPERIENCE, S. (2006) · Development and Psychopathology · doi:10.1017/s0954579406060330 · Cited by 347
Andersen, S. L., & Teicher, M. H. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.09.009 · Cited by 326
Cameron, N. M., Champagne, F. A., Parent, C., Fish, E. W., Ozaki-Kuroda, K., & Meaney, M. J. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.022 · Cited by 320
Self-citationAdolescence: A central event in shaping stress reactivity
Romeo, R. D. (2010) · Developmental Psychobiology · doi:10.1002/dev.20437 · Cited by 344
Beijers, R., Buitelaar, J. K., & de Weerth, C. (2014) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-014-0566-3 · Cited by 354
Uchida, S., Hara, K., Kobayashi, A., Funato, H., Hobara, T., Otsuki, K., Yamagata, H., McEwen, B. S., & Watanabe, Y. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1436-10.2010 · Cited by 310
Morley‐Fletcher, S., Rea, M., Maccari, S., & Laviola, G. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03070.x · Cited by 373
Resilience to Chronic Stress Is Mediated by Hippocampal Brain-Derived Neurotrophic Factor
Taliaz, D., Loya, A., Gersner, R., Haramati, S., Chen, A., & Zangen, A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5725-10.2011 · Cited by 311
Laviola, G., Hannan, A. J., Macrì, S., Solinas, M., & Jaber, M. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.05.001 · Cited by 300
Cirulli, F., Berry, A., & Alleva, E. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00010-1 · Cited by 303
Fisher, P. A., Gunnar, M. R., Dozier, M., Bruce, J., & Pears, K. C. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1376.023 · Cited by 310
Stress Neurobiology and Developmental Psychopathology
Gunnar, M. R., & Vázquez, D. M. (2015) · Wiley eBooks · doi:10.1002/9780470939390.ch13 · Cited by 291
Recognizing resilience: Learning from the effects of stress on the brain
McEwen, B. S., Gray, J. D., & Nasca, C. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.09.001 · Cited by 292
Fox, C., Merali, Z., & Harrison, C. R. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.016 · Cited by 283
McCormick, C. M., Smith, C. L., & Mathews, I. Z. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.09.005 · Cited by 278
McCormick, C. M., Mathews, I. Z., Thomas, C., & Waters, P. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.06.003 · Cited by 276
Research Review: A neuroscience framework for pediatric anxiety disorders
Pine, D. S. (2007) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2007.01751.x · Cited by 288
Fontana, B. D., Mezzomo, N. J., Kalueff, A. V., & Rosemberg, D. B. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.10.004 · Cited by 289
Maternal neglect: oxytocin, dopamine and the neurobiology of attachment
Strathearn, L. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02228.x · Cited by 268
Understanding the potency of stressful early life experiences on brain and body function
McEwen, B. S. (2008) · Metabolism · doi:10.1016/j.metabol.2008.07.006 · Cited by 278
Neighborhood matters: divergent patterns of stress-induced plasticity across the brain
Chattarji, S., Tomar, A., Suvrathan, A., Ghosh, S., & Rahman, M. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4115 · Cited by 248
Early maternal separation: a rodent model of depression and a prevailing human condition
Vetulani, J. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71505-6 · Cited by 255
Macrı̀, S., & Würbel, H. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.015 · Cited by 258
Prevention and treatment of drug addiction by environmental enrichment
Solinas, M., Thiriet, N., Chauvet, C., & Jaber, M. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.08.002 · Cited by 270
Gunnar, M. R., & Quevedo, K. M. (2007) · Progress in Brain Research · doi:10.1016/s0079-6123(07)67010-1 · Cited by 199
Macrı̀, S., Mason, G. J., & Würbel, H. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03541.x · Cited by 245
The Neurobiological Toll of Child Abuse and Neglect
Neigh, G. N., Gillespie, C. F., & Nemeroff, C. B. (2009) · Trauma Violence & Abuse · doi:10.1177/1524838009339758 · Cited by 248
Gowland, R. L. (2015) · American Journal of Physical Anthropology · doi:10.1002/ajpa.22820 · Cited by 245
Mother and newborn baby: Mutual regulation of physiology and behavior— A selective review
Winberg, J. (2005) · Developmental Psychobiology · doi:10.1002/dev.20094 · Cited by 232
Hannan, A. J. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12102 · Cited by 240
Stress during development: Impact on neuroplasticity and relevance to psychopathology
Fumagalli, F., Molteni, R., Racagni, G., & Riva, M. A. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.01.002 · Cited by 226
How social experiences influence the brain
Champagne, F. A., & Curley, J. P. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.10.001 · Cited by 225
Cummings, E. M., & Valentino, K. (2015) · Wiley eBooks · doi:10.1002/9781118963418.childpsy115 · Cited by 214
Ford, J. D. (2005) · Psychiatric Annals · doi:10.3928/00485713-20050501-07 · Cited by 211
Gunnar, M. R., DePasquale, C. E., Reid, B. M., Donzella, B., & Miller, B. S. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1909699116 · Cited by 207
Arco, A. D., & Mora, F. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0243-8 · Cited by 211
Silk, J. S., Vanderbilt‐Adriance, E., Shaw, D. S., Forbes, E. E., Whalen, D. J., Ryan, N. D., & Dahl, R. E. (2007) · Development and Psychopathology · doi:10.1017/s0954579407000417 · Cited by 217
Kanitz, E., Tuchscherer, M., Puppe, B., Tuchscherer, A., & Stabenow, B. (2004) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(03)00085-0 · Cited by 200
Maternal separation alters drug intake patterns in adulthood in rats
Moffett, M. C., Vicentic, A., Kozel, M. A., Plotsky, P. M., Francis, D. D., & Kuhar, M. J. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.08.003 · Cited by 205
Self-citationSteinberg, L. D., Dahl, R. E., Keating, D. P., Kupfer, D. J., Masten, A. S., & Pine, D. S. (2015) · Wiley eBooks · doi:10.1002/9780470939390.ch18 · Cited by 202
Social influences on neurobiology and behavior: Epigenetic effects during development
Curley, J. P., Jensen, C. L., Rahia Mashoodh, A., & Champagne, F. A. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.06.005 · Cited by 205
Cellular and molecular mechanisms of immunomodulation in the brain through environmental enrichment
Singhal, G., Jaehne, E. J., Corrigan, F., & Baune, B. T. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00097 · Cited by 186
Epigenetic mechanisms mediating vulnerability and resilience to psychiatric disorders
Dudley, K. J., Li, X., Kobor, M. S., Kippin, T. E., & Bredy, T. W. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.12.016 · Cited by 180
Maternal separation produces lasting changes in cortisol and behavior in rhesus monkeys
Feng, X., Wang, L., Yang, S., Qin, D., Wang, J., Li, C., Lv, L., Ma, Y., & Hu, X. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010943108 · Cited by 185
Individual development and evolution: Experiential canalization of self-regulation.
Blair, C., & Raver, C. C. (2012) · Developmental Psychology · doi:10.1037/a0026472 · Cited by 190
Evolution and ontogeny of stress response to social challenges in the human child
FLINN, M. (2006) · Developmental Review · doi:10.1016/j.dr.2006.02.003 · Cited by 173
Early life stress in fathers improves behavioural flexibility in their offspring
Gapp, K., Soldado-Magraner, S., Álvarez-Sánchez, M., Bohacek, J., Vernaz, G., Shu, H., Franklin, T. B., Wolfer, D. P., & Mansuy, I. M. (2014) · Nature Communications · doi:10.1038/ncomms6466 · Cited by 170
Maniam, J., & Morris, M. J. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.10.013 · Cited by 173
A Systematic Review of the Valproic-Acid-Induced Rodent Model of Autism
Chaliha, D. R., Albrecht, M. A., Vaccarezza, M., Takechi, R., Lam, V., Al‐Salami, H., & Mamo, J. C. L. (2020) · Developmental Neuroscience · doi:10.1159/000509109 · Cited by 177
Del Arco, A., & Mora, F. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.04.011 · Cited by 163
Fabricius, K., Wörtwein, G., & Pakkenberg, B. (2008) · Brain Structure and Function · doi:10.1007/s00429-007-0169-6 · Cited by 171
Cicchetti, D., Rogosch, F. A., Toth, S. L., & Sturge-Apple, M. L. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000307 · Cited by 168
Priebe, K., Brake, W. G., Romeo, R. D., Sisti, H. M., Mueller, A., McEwen, B. S., & Francis, D. D. (2005) · Developmental Psychobiology · doi:10.1002/dev.20098 · Cited by 168
Self-citationPrimary parental preoccupation: circuits, genes, and the crucial role of the environment
Leckman, J. F., Feldman, R., Swain, J. E., Eicher, V. W., Thompson, N., & Mayes, L. C. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-003-0067-x · Cited by 176
Lajud, N., Roque, A., Cajero, M., Gutiérrez‐Ospina, G., & Torner, L. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.011 · Cited by 172
The impact of gestational stress and prenatal growth on emotional problems in offspring: a review
Rice, F. J., Jones, I. R., & Thapar, A. (2006) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2006.00895.x · Cited by 168
Trauma, Proximity, and Developmental Psychopathology: The Effects of War and Terrorism on Children
Pine, D. S., Costello, J. E., & Masten, A. S. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300814 · Cited by 169
The anxiolytic effect of environmental enrichment is mediated via amygdalar CRF receptor type 1
Sztainberg, Y., Kuperman, Y., Tsoory, M., Lebow, M., & Chen, A. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.151 · Cited by 164
Leuner, B., Glasper, E. R., & Gould, E. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.07.003 · Cited by 159
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Crespi, E. J., & Denver, R. J. (2004) · American Journal of Human Biology · doi:10.1002/ajhb.20098 · Cited by 153
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Metadata
- Authors
- Francis, D. D., Diorio, J., Plotsky, P. M., & Meaney, M. J.
- Affiliations
- Douglas Mental Health University Institute (CA)
- Emory University (US)
- ORCID
- Meaney, Michael J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-09-15
- Volume
- 22
- Issue
- 18
- Pages
- 7840-7843
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6758090
- OpenAlex
- W2144859742
- Cited by
- 663
- References
- 39
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 6 · 2023: 10 · 2022: 18 · 2021: 26 · 2020: 32 · 2019: 23 · 2018: 31 · 2017: 34 · 2016: 37 · 2015: 35 · 2014: 31 · 2013: 34 · 2012: 35
- FWCI
- 9.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- environmental enrichment, maternal separation, postpartum stress, stress reactivity, corticotropin-releasing factor, hypothalamic-pituitary-adrenal axis, childhood adversity, peripubertal period, behavioral stress response, neural compensation
- MeSH terms
- Animals, Appetitive Behavior, Behavior, Animal, Brain, Brain Chemistry, Corticotropin-Releasing Hormone, Exploratory Behavior, Handling, Psychological, Hypothalamo-Hypophyseal System, Maternal Deprivation, Pituitary-Adrenal System, Receptors, Glucocorticoid, RNA, Messenger, Social Environment, Stress, Physiological, In Situ Hybridization, Rats, Long-Evans, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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