A TEST FOR CONCENTRATION OF ELECTROLYTES IN SWEAT IN CYSTIC FIBROSIS OF THE PANCREAS UTILIZING PILOCARPINE BY IONTOPHORESIS

Gibson, Lewis E.; Cooke, Robert E.

doi:10.1542/peds.23.3.545

Cited by 1,434Cystic Fibrosis Research AdvancesPancreatitis Pathology and TreatmentSalivary Gland Disorders and Functions

A TEST FOR CONCENTRATION OF ELECTROLYTES IN SWEAT IN CYSTIC FIBROSIS OF THE PANCREAS UTILIZING PILOCARPINE BY IONTOPHORESIS

Gibson, Lewis E., Cooke, Robert E.·1959·Pediatrics

DOI 10.1542/peds.23.3.545

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Abstract

A method of performing the test for chloride or sodium in the sweat of patients with cystic fibrosis of the pancreas is presented. It utilizes pilocarpine by iontophoresis and has the advantage of being both rapid and painless. Data are presented to show that the method is reliable.

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Crossref · 10.1542/peds.23.3.545

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Sweat testing has historically been used in applications ranging from medical diagnosis of cystic fibrosis and autonomic neuropathy to assessment of fluid and electrolyte balance in endurance athletes.
“Sweat testing has historically been used in applications ranging from medical diagnosis of cystic fibrosis and autonomic neuropathy to assessment of fluid and electrolyte balance in endurance athletes (6–10).”
From Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat (2019) · cites this paper as [6]
Sweat behaviors of only a few analytes, including ethanol and chloride, have been extensively investigated and related to blood concentrations or health status.
“Sweat behaviors of only a few analytes, including ethanol and chloride, have been extensively investigated and related to blood concentrations or health status (6, 8, 27, 35).”
From Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat (2019) · cites this paper as [6]
During iontophoresis, the cationic pilocarpine drug was delivered across the skin at the anode electrode.
“During the iontophoresis operation, the cationic pilocarpine drug was delivered across the skin at the anode electrode (Figure 1D).32”
From Noninvasive Alcohol Monitoring Using a Wearable Tattoo-Based Iontophoretic-Biosensing System (2016) · cites this paper as [32]
Pilocarpine can influence the electron shuttling activity of PB due to the vulnerability of PB against other positive ions in electrolytes.
“Pilocarpine is a large positively charged molecule, and the electron shuttling activity of PB can be influenced by pilocarpine due to the vulnerability of PB against other positive ions in electrolytes.32”
From Noninvasive Alcohol Monitoring Using a Wearable Tattoo-Based Iontophoretic-Biosensing System (2016) · cites this paper as [32]

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Background
Wearable Devices for Precision Medicine and Health State Monitoring
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Method
Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation
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“Spirometry was performed in all CF patients according to American Thoracic Society guidelines.67 Sweat chloride values were obtained by quantitative pilocarpine iontophoresis according to the standardized protocol of Gibson and Cooke.68 Five adult non-CF healthy volunteers underwent nasal brushing at each time at whic…”
Method
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BackgroundMethod
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Background
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Authors: Gibson, L. E., & Cooke, R. E.
Affiliations: Johns Hopkins University (US)
Venue: Pediatrics
Publisher: American Academy of Pediatrics (AAP)
Published: 1959-03-01
Volume: 23
Issue: 3
Pages: 545-549
ISSN: 0031-4005 (ISSN-L)
1098-4275
DOI: 10.1542/peds.23.3.545
OpenAlex: W1946951765
Cited by: 1,434
References: 0
Citations by year: 2026: 17 · 2025: 21 · 2024: 24 · 2023: 24 · 2022: 15 · 2021: 34 · 2020: 41 · 2019: 37 · 2018: 37 · 2017: 42 · 2016: 37 · 2015: 32 · 2014: 35 · 2013: 30 · 2012: 39
FWCI: 27.70
Type: journal article
Language: en
Open access: closed
Locations: PEDIATRICS (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
Health Sciences › Medicine › Physiology › Salivary Gland Disorders and Functions
Keywords: cystic fibrosis, sweat test, sweat electrolytes, chloride, sodium, pilocarpine, iontophoresis
MeSH terms: Chlorides, Cystic Fibrosis, Electrolytes, Humans, Iontophoresis, Pilocarpine, Sodium, Sodium, Dietary, Sweat

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A TEST FOR CONCENTRATION OF ELECTROLYTES IN SWEAT IN CYSTIC FIBROSIS OF THE PANCREAS UTILIZING PILOCARPINE BY IONTOPHORESIS

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