Cited by 512Neuroendocrine regulation and behaviorStress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

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Social Deprivation of Neonatal, Adolescent, and Adult Rats Has Distinct Neurochemical and Behavioral Consequences

Hall, F. Scott·1998·Critical Reviews™ in Neurobiology

DOI 10.1615/critrevneurobiol.v12.i1-2.50

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Abstract

This review examines the consequences of social deprivation on brain chemistry and behavior on rats. Although social deprivation produces wide-ranging behavioral and neurochemical effects, it appears that these effects are determined by a number of factors, the most critical factor being the age or developmental stage during the period of deprivation. Roughly, the effects examined in this review may be separated into three major developmental stages and each is related to deprivation of specific types of social interaction: preweaning/neonatal, postweaning/adolescent, and adult. The effects of social deprivation during each of these stages appears to be neurochemically and behaviorally specific. However, much of the research to date has failed to examine deprivation during specific stages, often combining deprivation of different types. Nonetheless, these modifications of experience produce animals of differing phenotypes, which could be characterized as pathological in nature in many instances, and may model particular aspects of human psychopathologies or perhaps the propensity to develop those phenotypic features.

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Authors: Hall, F. S.
Affiliations: National Institute on Alcohol Abuse and Alcoholism (US)
Corresponding author: Hall, F. Scott
ORCID: Hall, F. Scott
Venue: Critical Reviews™ in Neurobiology
Publisher: Begell House
Published: 1998
Volume: 12
Issue: 1-2
Pages: 129-162
ISSN: 0892-0915 (ISSN-L)
DOI: 10.1615/critrevneurobiol.v12.i1-2.50
OpenAlex: W2127857578
Cited by: 512
References: 0
Citations by year: 2026: 7 · 2025: 8 · 2024: 10 · 2023: 15 · 2022: 15 · 2021: 17 · 2020: 13 · 2019: 20 · 2018: 14 · 2017: 17 · 2016: 20 · 2015: 23 · 2014: 19 · 2013: 27 · 2012: 31
FWCI: 24.21
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: social deprivation, social isolation, developmental stages, neurochemistry, behavioral effects, animal models of psychopathology
MeSH terms: Age Factors, Animals, Animals, Newborn, Behavior, Animal, Brain Chemistry, Critical Period, Psychological, Maternal Deprivation, Social Isolation, Rats

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Social Deprivation of Neonatal, Adolescent, and Adult Rats Has Distinct Neurochemical and Behavioral Consequences

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