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Post-weaning social isolation alters anxiety-related behavior and neurochemical gene expression in the brain of male prairie voles
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The association between subjective social isolation and gene expression corresponds well to gene expression differences in animal models of social isolation, suggesting that a subjective sense of social connectedness is important for genomic expression and normal immunoregulation in humans.
“However, the association between subjective social isolation and gene expression corresponds well to gene expression differences in animal models of social isolation (e.g., [77–79]), suggesting that a subjective sense of social connectedness is important for genomic expression and normal immunoregulation in humans.”
From Loneliness matters: a theoretical and empirical review of consequences and mechanisms (2010) · cites this paper as [78]
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“Therefore, post-weaning social isolation is stressful, and this stress may alter neuroendocrine systems that modulate behavior in male prairie voles, as in other rodent species [3,21,47].”
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Metadata
- Authors
- Pan, Y., Liu, Y., Young, K. A., Zhang, Z., & Wang, Z.
- Affiliations
- Florida State University (US)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Wang, Zuoxin
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 454
- Issue
- 1
- Pages
- 67-71
- ISSN
- 0304-3940 (ISSN-L)
- PMC
- PMC2683268
- OpenAlex
- W2145436183
- Cited by
- 93
- References
- 11
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 9 · 2021: 6 · 2020: 5 · 2019: 8 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 6 · 2013: 10 · 2012: 11
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- U.S. Public Health Service (DAK02-23048, DAR01-19627, MHR01-58616)
- National Institute of Mental Health (R01MH058616)
- National Institute on Drug Abuse (K02DA023048, R01DA019627)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- social isolation, anxiety-like behavior, Microtus ochrogaster, vasopressin, oxytocin, corticotropin-releasing factor, tyrosine hydroxylase, paraventricular nucleus, gene expression, social monogamy, maternal separation, neuroendocrine regulation
- MeSH terms
- Animals, Anxiety, Autoradiography, Behavior, Animal, Brain, Corticotropin-Releasing Hormone, Arvicolinae, Male, Oxytocin, RNA, Messenger, Social Isolation, Stress, Psychological, Tyrosine 3-Monooxygenase, Vasopressins, Gene Expression
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