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The Influence of Body Fat Distribution on the Incidence of Diabetes Mellitus: 13.5 Years of Follow-up of the Participants in the Study of Men Born in 1913
Abstract
In a prospective study of risk factors for ischemic heart disease, 792 54-yr-old men selected by year of birth (1913) and residence in Göteborg, Sweden, agreed to attend for questioning and a number of anthropometric and other measurements in 1967. Thirteen and one-half years later, these baseline findings were reviewed in relation to the number of men who had subsequently developed diabetes mellitus. This analysis focused on the importance of abdominal adipose tissue distribution, measured as the waistto- hip circumference ratio, as a predictor for development of diabetes. Even when the confounding effect of body mass index, as a measure of the total body fat mass, was accounted for, the waist-to-hip ratio was positively and significantly associated with the risk for diabetes. These results from a prospective study strongly support previous cross-sectional findings indicating that not only the degree of obesity but also the localization of fat is a risk factor for diabetes.
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Alberti, K. G. M. M., Zimmet, P., & Shaw, J. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01858.x · Cited by 6,597
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961
Pathophysiology of human visceral obesity: an update
Tchernof, A., & Després, J.-P. (2013) · Physiological Reviews · doi:10.1152/physrev.00033.2011 · Cited by 2,583
Body Mass Index: Obesity, BMI, and Health A Critical Review
Nuttall, F. Q. (2015) · Nutrition Today · doi:10.1097/nt.0000000000000092 · Cited by 2,284
Ross, R., Neeland, I. J., Yamashita, S., Shai, I., Seidell, J., Magni, P., Santos, R. D., Arsenault, B., Cuevas, A., Hu, F. B., et al. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0310-7 · Cited by 1,966
Weyer, C., Bogardus, C., Mott, D. M., & Pratley, R. E. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7231 · Cited by 1,940
The Finnish Diabetes Prevention Study (DPS)
Lindström, J., Louheranta, A., Mannelin, M., Rastas, M., Salminen, V., Eriksson, J., Uusitupa, M., Tuomilehto, J., & for the Finnish Diabetes Prevention Study Group (2003) · Diabetes Care · doi:10.2337/diacare.26.12.3230 · Cited by 1,848
Amato, M. C., Giordano, C., Galia, M., Criscimanna, A., Vitabile, S., Midiri, M., Galluzzo, A., & for the AlkaMeSy Study Group (2010) · Diabetes Care · doi:10.2337/dc09-1825 · Cited by 1,751
Lillioja, S., Mott, D. M., Spraul, M., Ferraro, R., Foley, J. E., Ravussin, E., Knowler, W. C., Bennett, P. H., & Bogardus, C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292703 · Cited by 1,508
Body Fat Distribution and Risk of Cardiovascular Disease: An Update
Després, J.-P. (2012) · Circulation · doi:10.1161/circulationaha.111.067264 · Cited by 1,481
The role of estrogens in control of energy balance and glucose homeostasis
Mauvais-Jarvis, F., Clegg, D. J., & Hevener, A. L. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1055 · Cited by 1,329
Active Smoking and the Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis
Willi, C., Bodenmann, P., Ghali, W. A., Faris, P. D., & Cornuz, J. (2007) · JAMA · doi:10.1001/jama.298.22.2654 · Cited by 1,268
Validity of Self-Reported Waist and Hip Circumferences in Men and Women
Rimm, E. B., Stampfer, M. J., Colditz, G. A., Chute, C. G., Litin, L. B., & Willett, W. C. (1990) · Epidemiology · doi:10.1097/00001648-199011000-00009 · Cited by 1,015
Vazquez, G., Duval, S., Jacobs, D. R., & Silventoinen, K. (2007) · Epidemiologic Reviews · doi:10.1093/epirev/mxm008 · Cited by 976
Assessing Adiposity: A Scientific Statement From the American Heart Association
Cornier, M.-A., Després, J.-P., Davis, N., Grossniklaus, D. A., Klein, S., Lamarche, B., Lopez-Jimenez, F., Rao, G., St-Onge, M.-P., Towfighi, A., et al. (2011) · Circulation · doi:10.1161/cir.0b013e318233bc6a · Cited by 945
Ferrannini, E., Natali, A., Bell, P., Cavallo-Perin, P., Lalic, N., & Mingrone, G. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119628 · Cited by 898
Abdullah, A., Peeters, A., de Courten, M., & Stoelwinder, J. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2010.04.012 · Cited by 824
International Diabetes Federation: a consensus on Type 2 diabetes prevention
Alberti, K. G. M. M., Zimmet, P., & Shaw, J. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02157.x · Cited by 778
Relationships of generalized and regional adiposity to insulin sensitivity in men.
Abate, N., Garg, A., Peshock, R. M., Stray-Gundersen, J., & Grundy, S. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118083 · Cited by 759
(2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200007000-00024 · Cited by 604
Seidell, J. C., Björntorp, P., Sjöström, L., Kvist, H., & Sannerstedt, R. (1990) · Metabolism · doi:10.1016/0026-0495(90)90297-p · Cited by 567
Self-citationInsulin resistance is a characteristic feature of primary hypertension independent of obesity
Pollare, T., Lithell, H., & Berne, C. (1990) · Metabolism · doi:10.1016/0026-0495(90)90071-j · Cited by 530
Effect of Alcohol Consumption on Diabetes Mellitus: A Systematic Review
Howard, A. A., Arnsten, J. H., & Gourevitch, M. N. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-6-200403160-00011 · Cited by 526
Sex Differences in Body Composition
Bredella, M. A. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-70178-3_2 · Cited by 523
Visceral Obesity: A “Civilization Syndrome”
Björntorp, P. (1993) · Obesity Research · doi:10.1002/j.1550-8528.1993.tb00614.x · Cited by 483
Self-citationBMI Cut Points to Identify At-Risk Asian Americans for Type 2 Diabetes Screening
Hsu, W. C., Araneta, M. R. G., Kanaya, A. M., Chiang, J. L., & Fujimoto, W. (2015) · Diabetes Care · doi:10.2337/dc14-2391 · Cited by 500
Wei, M., Gaskill, S. P., Haffner, S. M., & Stern, M. P. (1997) · Obesity Research · doi:10.1002/j.1550-8528.1997.tb00278.x · Cited by 481
McLaughlin, T., Lamendola, C., Liu, A., & Abbasi, F. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0615 · Cited by 468
Body fat distribution, insulin resistance, and metabolic diseases
Björntorp, P. (1997) · Nutrition · doi:10.1016/s0899-9007(97)00191-3 · Cited by 470
Self-citationChurch, T. S., LaMonte, M. J., Barlow, C. E., & Blair, S. N. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.18.2114 · Cited by 445
Human Body Composition and the Epidemiology of Chronic Disease
Baumgartner, R. N., Heymsfield, S. B., & Roche, A. F. (1995) · Obesity Research · doi:10.1002/j.1550-8528.1995.tb00124.x · Cited by 413
Obesity and inflammation: the effects of weight loss
Forsythe, L. K., Wallace, J. M. W., & Livingstone, M. B. E. (2008) · Nutrition Research Reviews · doi:10.1017/s0954422408138732 · Cited by 381
LANDSBERG, L. (1986) · QJM: An International Journal of Medicine · doi:10.1093/oxfordjournals.qjmed.a068066 · Cited by 373
Point: Visceral Adiposity Is Causally Related to Insulin Resistance
Lebovitz, H. E., & Banerji, M. A. (2005) · Diabetes Care · doi:10.2337/diacare.28.9.2322 · Cited by 328
Sarcopenia and increased adipose tissue infiltration of muscle in elderly African American women
Song, M.-Y., Ruts, E., Kim, J., Janumala, I., Heymsfield, S., & Gallagher, D. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.874 · Cited by 324
Ohlson, L.-O., Larsson, B., Bj�rntorp, P., Eriksson, H., Sv�rdsudd, K., Welin, L., Tibblin, G., & Wilhelmsen, L. (1988) · Diabetologia · doi:10.1007/bf00277480 · Cited by 316
Self-citationLauenborg, J., Mathiesen, E., Hansen, T., Glümer, C., Jørgensen, T., Borch-Johnsen, K., Hornnes, P., Pedersen, O., & Damm, P. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1713 · Cited by 279
AGA technical review on obesity
Klein, S., Wadden, T., & Sugerman, H. J. (2002) · Gastroenterology · doi:10.1053/gast.2002.35514 · Cited by 274
Chan, D. C. (2003) · QJM · doi:10.1093/qjmed/hcg069 · Cited by 266
The Insulin Resistance—Dyslipidemic Syndrome of Visceral Obesity: Effect on Patients' Risk
Després, J. (1998) · Obesity Research · doi:10.1002/j.1550-8528.1998.tb00683.x · Cited by 261
Genetic and environmental determinants of non‐insulin‐dependent diabetes mellitus (NIDDM)
Hamman, R. F. (1992) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610080402 · Cited by 256
Obesity, insulin resistance and comorbidities? Mechanisms of association
Castro, A. V. B., Kolka, C. M., Kim, S. P., & Bergman, R. N. (2014) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/0004-2730000003223 · Cited by 254
Sexual differences in the control of energy homeostasis
Shi, H., Seeley, R. J., & Clegg, D. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.03.004 · Cited by 242
Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies
Giorgino, F., Laviola, L., & Eriksson, J. W. (2005) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2004.01385.x · Cited by 230
The epidemiology and natural history of NIDDM—lessons from the South Pacific
Zimmet, P., Dowse, G., Finch, C., Serjeantson, S., & King, H. (1990) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610060203 · Cited by 214
Depressive Symptoms and Change in Abdominal Obesity in Older Persons
Vogelzangs, N., Kritchevsky, S. B., Beekman, A. T. F., Newman, A. B., Satterfield, S., Simonsick, E. M., Yaffe, K., Harris, T. B., & Penninx, B. W. J. H. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.12.1386 · Cited by 200
Park, Y.-W., Heymsfield, S., & Gallagher, D. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801982 · Cited by 196
Reduced testosterone and adrenal C19 steroid levels in obese men
Tchernof, A., Després, J.-P., Bélanger, A., Dupont, A., Prud'homme, D., Moorjani, S., Lupien, P. J., & Labrie, F. (1995) · Metabolism · doi:10.1016/0026-0495(95)90060-8 · Cited by 175
Hewagalamulage, S. D., Lee, T. K., Clarke, I. J., & Henry, B. A. (2016) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2016.03.004 · Cited by 167
Winnick, J. J., Sherman, W. M., Habash, D. L., Stout, M. B., Failla, M. L., Belury, M. A., & Schuster, D. P. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1524 · Cited by 153
The Epidemiology of Central Fat Distribution in Relation to Disease
Pi-Sunyer, F. X. (2004) · Nutrition Reviews · doi:10.1111/j.1753-4887.2004.tb00081.x · Cited by 153
Armstrong, A., Jungbluth Rodriguez, K., Sabag, A., Mavros, Y., Parker, H. M., Keating, S. E., & Johnson, N. A. (2022) · Obesity Reviews · doi:10.1111/obr.13446 · Cited by 142
Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome
Kokosar, M., Benrick, A., Perfilyev, A., Fornes, R., Nilsson, E., Maliqueo, M., Behre, C. J., Sazonova, A., Ohlsson, C., Ling, C., et al. (2016) · Scientific Reports · doi:10.1038/srep22883 · Cited by 137
Samaras, K., Kelly, P. J., Chiano, M. N., Spector, T. D., & Campbell, L. V. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-11-199906010-00002 · Cited by 133
Nordhamn, K., Södergren, E., Olsson, E., Karlström, B., Vessby, B., & Berglund, L. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801216 · Cited by 131
Marti, B., Tuomilehto, J., Salomaa, V, Kartovaara, L., Korhonen, H. J., & Pietinen, P. (1991) · Journal of Epidemiology and Community Health · doi:10.1136/jech.45.2.131 · Cited by 129
A Twin Study of Sleep Duration and Body Mass Index
Watson, N. F., Buchwald, D., Vitiello, M. V., Noonan, C., & Goldberg, J. (2010) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27704 · Cited by 116
Do non-insulin-dependent diabetes mellitus and cardiovascular disease share common antecedents?
Stern, M. P. (1996) · Annals of Internal Medicine · doi:10.7326/0003-4819-124-1_part_2-199601011-00006 · Cited by 115
Perseghin, G., Scifo, P., Pagliato, E., Battezzati, A., Benedini, S., Soldini, L., Testolin, G., Del Maschio, A., & Luzi, L. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.7.7666 · Cited by 112
Impaired estrogen receptor action in the pathogenesis of the metabolic syndrome
Hevener, A. L., Clegg, D. J., & Mauvais-Jarvis, F. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.05.020 · Cited by 112
Surgical Management of Obesity: A Review of the Evidence Relating to the Health Benefits and Risks
Lara, M. D., Kothari, S. N., & Sugerman, H. J. (2005) · Treatments in Endocrinology · doi:10.2165/00024677-200504010-00006 · Cited by 107
The Effects of Exercise Training on Fat-Mass Loss in Obese Patients During Energy Intake Restriction
Hansen, D., Dendale, P., Berger, J., van Loon, L. J. C., & Meeusen, R. (2007) · Sports Medicine · doi:10.2165/00007256-200737010-00003 · Cited by 106
Echocardiographic Abnormalities in Normotensive Obese Patients: Relationship with Visceral Fat
Morricone, L., Malavazos, A. E., Coman, C., Donati, C., Hassan, T., & Caviezel, F. (2002) · Obesity Research · doi:10.1038/oby.2002.67 · Cited by 104
Importance of obesity for the metabolic abnormalities associated with an abdominal fat distribution
Landin, K., Krotkiewski, M., & Smith, U. (1989) · Metabolism · doi:10.1016/0026-0495(89)90219-9 · Cited by 91
Uusitupa, M. I. J. (1996) · Annals of Medicine · doi:10.3109/07853899608999106 · Cited by 91
Eliasson, M., Asplund, K., Nasic, S., & Rodu, B. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01344.x · Cited by 91
Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis
Shi, H., Strader, A. D., Sorrell, J. E., Chambers, J. B., Woods, S. C., & Seeley, R. J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00704.2007 · Cited by 85
Cardiorespiratory fitness and incident diabetes: the FIT (Henry Ford Exercise Testing) project.
Juraschek, S. P., Blaha, M. J., Blumenthal, R. S., Brawner, C., Qureshi, W., Keteyian, S. J., Schairer, J., Ehrman, J. K., & Al-Mallah, M. H. (2015) · Diabetes Care · doi:10.2337/dc14-2714 · Cited by 71
LANDIN, K., LÖNNROTH, P., KROTKIEWSKI, M., HOLM, G., & SMITH, U. (1990) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1990.tb01922.x · Cited by 70
Primary Prevention of Diabetes Mellitus
Zimmet, P. Z. (1988) · Diabetes Care · doi:10.2337/diacare.11.3.258 · Cited by 55
Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions
Wang, T., Zhou, D., & Hong, Z. (2025) · MedComm · doi:10.1002/mco2.70030 · Cited by 46
Islet dysfunction in obese women with impaired glucose tolerance
Larsson, H., & Ahrén, B. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90227-9 · Cited by 44
How effective are lifestyle changes in the prevention of type 2 diabetes mellitus?
Pi-Sunyer, F. X. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00287.x · Cited by 40
Shin, Y., Moon, J. H., Oh, T. J., Ahn, C. H., Moon, J. H., Choi, S. H., & Jang, H. C. (2022) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2021.0334 · Cited by 11
Metadata
- Authors
- Ohlson, L. O., Larsson, B., Svärdsudd, K., Welin, L., Eriksson, H., Wilhelmsen, L., Björntorp, P., & Tibblin, G.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1985-10-01
- Volume
- 34
- Issue
- 10
- Pages
- 1055-1058
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2125854867
- Cited by
- 1,020
- References
- 0
- FWCI
- 9.78
- Type
- journal article
- Language
- en
- Open access
- closed
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