Cited by 199Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and CancerCancer, Lipids, and Metabolism

The DOI matches its Crossref record; 305 of the 309 references it cites were found in a registry or an index.

The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues

Open access

Goetzman, Eric S., Prochownik, Edward V.·2018·Frontiers in Endocrinology

DOI 10.3389/fendo.2018.00129PMC PMC5907532

Open this paper in CoChat — free account Open PDF

Abstract

That cancer cells show patterns of metabolism different from normal cells has been known for over 50 years. Yet, it is only in the past decade or so that an appreciation of the benefits of these changes has begun to emerge. Altered cancer cell metabolism was initially attributed to defective mitochondria. However, we now realize that most cancers do not have mitochondrial mutations and that normal cells can transiently adopt cancer-like metabolism during periods of rapid proliferation. Indeed, an encompassing, albeit somewhat simplified, conceptual framework to explain both normal and cancer cell metabolism rests on several simple premises. First, the metabolic pathways used by cancer cells and their normal counterparts are the same. Second, normal quiescent cells use their metabolic pathways and the energy they generate largely to maintain cellular health and organelle turnover and, in some cases, to provide secreted products necessary for the survival of the intact organism. By contrast, undifferentiated cancer cells minimize the latter functions and devote their energy to producing the anabolic substrates necessary to maintain high rates of unremitting cellular proliferation. Third, as a result of the uncontrolled proliferation of cancer cells, a larger fraction of the metabolic intermediates normally used by quiescent cells purely as a source of energy are instead channeled into competing proliferation-focused and energy-consuming anabolic pathways. Fourth, cancer cell clones with the most plastic and rapidly adaptable metabolism will eventually outcompete their less well-adapted brethren during tumor progression and evolution. This attribute becomes increasingly important as tumors grow and as their individual cells compete in a constantly changing and inimical environment marked by nutrient, oxygen, and growth factor deficits. Here, we review some of the metabolic pathways whose importance has gained center stage for tumor growth, particularly those under the control of the c-Myc (Myc) oncoprotein. We discuss how these pathways differ functionally between quiescent and proliferating normal cells, how they are kidnapped and corrupted during the course of transformation, and consider potential therapeutic strategies that take advantage of common features of neoplastic and metabolic disorders.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3389/fendo.2018.00129

Cites

305 of 305 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
AMPK: a nutrient and energy sensor that maintains energy homeostasis
Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3311 · Cited by 4,602
Identification of c- MYC as a Target of the APC Pathway
He, T.-C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998) · Science · doi:10.1126/science.281.5382.1509 · Cited by 4,566
On Respiratory Impairment in Cancer Cells
Warburg, O. H. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,472
Otto Warburg's contributions to current concepts of cancer metabolism
Koppenol, W. H., Bounds, P. L., & Dang, C. V. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3038 · Cited by 3,427
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
Ward, P. S., & Thompson, C. B. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.014 · Cited by 3,233
Fundamentals of Cancer Metabolism
DeBerardinis, R. J., & Chandel, N. S. (2016) · Science Advances · doi:10.1126/sciadv.1600200 · Cited by 3,013
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E., & Chan, D. C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211046 · Cited by 2,601
Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor
Kelly, K., Cochran, B., Stiles, C. D., & Leder, P. (1983) · Cell · doi:10.1016/0092-8674(83)90092-2 · Cited by 2,227
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · cited 5×
“In addition to being at odds with the above-discussed role for Myc in the proliferation of fibroblasts and T-cells and numerous other cell types (154, 158, 191, 196, 203), these results also differ from studies in Drosophila and some cancer lines showing that cells expressing higher levels of Myc tend to outcompete th…”
BackgroundResultInfluential
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
Gao, P., Tchernyshyov, I., Chang, T.-C., Lee, Y.-S., Kita, K., Ochi, T., Zeller, K. I., De Marzo, A. M., Van Eyk, J. E., Mendell, J. T., et al. (2009) · Nature · doi:10.1038/nature07823 · Cited by 2,124
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001
Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis
Leist, M., Single, B., Castoldi, A. F., Kühnle, S., & Nicotera, P. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.8.1481 · Cited by 1,871
Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.
Dalla‐Favera, R., Bregni, M., Erikson, J., Patterson, D., Gallo, R. C., & Croce, C. M. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.24.7824 · Cited by 1,764
Reflecting on 25 years with MYC
Meyer, N., & Penn, L. Z. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2231 · Cited by 1,575
Hypoxia and the extracellular matrix: drivers of tumour metastasis
Gilkes, D. M., Semenza, G. L., & Wirtz, D. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3726 · Cited by 1,520
Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases
Chen, H., & Chan, D. C. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp326 · Cited by 1,506
Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.
Taub, R. A., Kirsch, I. R., Morton, C. C., Lenoir, G., Swan, D., Tronick, S. R., Aaronson, S. A., & Leder, P. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.24.7837 · Cited by 1,421
Liver regeneration
Michalopoulos, G. K. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21172 · Cited by 1,384
Induction of c-fos gene and protein by growth factors precedes activation of c-myc
Müller, R., Bravo, R., Burckhardt, J., & Curran, T. (1984) · Nature · doi:10.1038/312716a0 · Cited by 1,369
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
DeBerardinis, R. J., & Cheng, T. (2010) · Oncogene · doi:10.1038/onc.2009.358 · Cited by 1,365
Acidic extracellular microenvironment and cancer
Kato, Y., Ozawa, S., Miyamoto, C., Maehata, Y., Suzuki, A., Maeda, T., & Baba, Y. (2013) · Cancer Cell International · doi:10.1186/1475-2867-13-89 · Cited by 1,295
Cancer's Molecular Sweet Tooth and the Warburg Effect
Kim, J., & Dang, C. V. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1501 · Cited by 1,233
Fusion and fission: interlinked processes critical for mitochondrial health
Chan, D. C. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132529 · Cited by 1,196 · cited 2×
“Both fusion and fission can exert significant influence upon mitochondrial energy production and cell survival (176, 178, 179).”
Background
The c-Myc target gene network
Dang, C. V., O’Donnell, K. A., Zeller, K. I., Nguyen, T., Osthus, R. C., & Li, F. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.07.014 · Cited by 1,188
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
David, C. J., Chen, M., Assanah, M., Canoll, P., & Manley, J. L. (2010) · Nature · doi:10.1038/nature08697 · Cited by 1,179
MYC oncogenes and human neoplastic disease
Nesbit, C. E., Tersak, J. M., & Prochownik, E. V. (1999) · Oncogene · doi:10.1038/sj.onc.1202746 · Cited by 1,163
Self-citation
Transcriptional regulation and transformation by Myc proteins
Adhikary, S., & Eilers, M. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1703 · Cited by 1,157
Lactate: A Metabolic Key Player in Cancer
Hirschhaeuser, F., Sattler, U. G. A., & Mueller‐Klieser, W. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1457 · Cited by 1,093
c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth
Shim, H., Dolde, C., Lewis, B. C., Wu, C.-S., Dang, G., Jungmann, R. A., Dalla-Favera, R., & Dang, C. V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6658 · Cited by 1,092
P53 in survival, death and metabolic health: a lifeguard with a licence to kill.
Kruiswijk, F., Labuschagne, C. F., & Vousden, K. H. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4007 · Cited by 1,080
Links between metabolism and cancerPreprint
Dang, C. V. (2012) · Genes & Development · doi:10.1101/gad.189365.112 · Cited by 1,021
Brick by brick: metabolism and tumor cell growth
DeBerardinis, R. J., Sayed, N., Ditsworth, D., & Thompson, C. B. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.02.003 · Cited by 1,018
Hypoxia-Inducible Factors: Master Regulators of Cancer Progression
Schito, L., & Semenza, G. L. (2016) · Trends in Cancer · doi:10.1016/j.trecan.2016.10.016 · Cited by 962
MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities
Dang, C. V., Le, A., & Gao, P. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0889 · Cited by 959
MYC as a regulator of ribosome biogenesis and protein synthesis
van Riggelen, J., Yetil, A., & Felsher, D. W. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2819 · Cited by 956
Principles of biochemistry
(1994) · International Journal of Biochemistry · doi:10.1016/0020-711x(94)90020-5 · Cited by 941
Amplification and expression of the c-myc oncogene in human lung cancer cell lines
Little, C. D., Nau, M. M., Carney, D. N., Gazdar, A. F., & Minna, J. D. (1983) · Nature · doi:10.1038/306194a0 · Cited by 921
Structural Basis of Mitochondrial Tethering by Mitofusin Complexes
Koshiba, T., Detmer, S. A., Kaiser, J. T., Chen, H., McCaffery, J. M., & Chan, D. C. (2004) · Science · doi:10.1126/science.1099793 · Cited by 910
Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc
Osthus, R. C., Shim, H., Kim, S., Li, Q., Reddy, R., Mukherjee, M., Xu, Y., Wonsey, D. R., Lee, L. A., & Dang, C. V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000023200 · Cited by 876
Sequence-Specific DNA Binding by the c-Myc Protein
Blackwell, T. K., Kretzner, L., Blackwood, E. M., Eisenman, R. N., & Weintraub, H. M. (1990) · Science · doi:10.1126/science.2251503 · Cited by 863
Glutaminolysis: A Hallmark of Cancer Metabolism
Yang, L., Venneti, S., & Nagrath, D. (2017) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071516-044546 · Cited by 859
Modelling Myc inhibition as a cancer therapy
Soucek, L., Whitfield, J. R., Martins, C. P., Finch, A. J., Murphy, D. J., Sodir, N. M., Karnezis, A. N., Swigart, L. B., Nasi, S., & Evan, G. I. (2008) · Nature · doi:10.1038/nature07260 · Cited by 846
Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression
Li, Z., & Zhang, H. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2070-4 · Cited by 840
Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response
Monti, S. (2004) · Blood · doi:10.1182/blood-2004-07-2947 · Cited by 834
Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation
Carr, E. L., Kelman, A., Wu, G. S., Gopaul, R., Senkevitch, E., Aghvanyan, A., Turay, A. M., & Frauwirth, K. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903586 · Cited by 830
Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion
Coller, H. A., Grandori, C., Tamayo, P., Colbert, T., Lander, E. S., Eisenman, R. N., & Golub, T. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3260 · Cited by 823
The Mitochondrial Protein hFis1 Regulates Mitochondrial Fission in Mammalian Cells through an Interaction with the Dynamin-Like Protein DLP1
Yoon, Y., Krueger, E. W., Oswald, B. J., & McNiven, M. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5409-5420.2003 · Cited by 820
Respiratory active mitochondrial supercomplexes
Acín-Pérez, R., Fernández-Silva, P., Peleato, M. L., Pérez-Martos, A., & Enriquez, J. A. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.10.021 · Cited by 817
Mitochondrial Cristae: Where Beauty Meets Functionality
Cogliati, S., Enriquez, J. A., & Scorrano, L. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.01.001 · Cited by 816
Targeting the translation machinery in cancer
Bhat, M., Robichaud, N., Hulea, L., Sonenberg, N., Pelletier, J., & Topisirovic, I. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4505 · Cited by 799
Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
Hitosugi, T., Kang, S., Vander Heiden, M. G., Chung, T.-W., Elf, S., Lythgoe, K., Dong, S., Lonial, S., Wang, X., Chen, G. Z., et al. (2009) · Science Signaling · doi:10.1126/scisignal.2000431 · Cited by 784
Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.
Alitalo, K., Schwab, M., Lin, C. C., Varmus, H. E., & Bishop, J. M. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.6.1707 · Cited by 761
The randle cycle revisited: a new head for an old hat.
Hue, L., & Taegtmeyer, H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00093.2009 · Cited by 743
Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?
Fuchs, B. C., & Bode, B. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.04.005 · Cited by 717
The human c-myc oncogene: Structural consequences of translocation into the igh locus in Burkitt lymphoma
Battey, J., Moulding, C. T., Taub, R. A., Murphy, W., Stewart, T. A., Potter, H., Lenoir, G., & Leder, P. (1983) · Cell · doi:10.1016/0092-8674(83)90534-2 · Cited by 714
Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation
Campisi, J., Gray, H. E., Pardee, A. B., Dean, M. C., & Sonenshein, G. E. (1984) · Cell · doi:10.1016/0092-8674(84)90217-4 · Cited by 708
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
Yuneva, M., Zamboni, N., Oefner, P., Sachidanandam, R., & Lazebnik, Y. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200703099 · Cited by 690
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
Kim, J.-W., Gao, P., Liu, Y.-C., Semenza, G. L., & Dang, C. V. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00440-07 · Cited by 658
Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells
Heiden, M. G. V., Locasale, J. W., Swanson, K. D., Sharfi, H., Heffron, G. J., Amador‐Noguez, D., Christofk, H. R., Wagner, G., Rabinowitz, J. D., Asara, J. M., et al. (2010) · Science · doi:10.1126/science.1188015 · Cited by 648
Drosophila myc Regulates Cellular Growth during Development
Johnston, L. A., Prober, D. A., Edgar, B. A., Eisenman, R. N., & Gallant, P. (1999) · Cell · doi:10.1016/s0092-8674(00)81512-3 · Cited by 648
The mitochondrial pathways of apoptosis
Estaquier, J., Vallette, F., Vayssiere, J.-L., & Mignotte, B. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2869-1_7 · Cited by 637
Treatment of hereditary tyrosinaemia type I by inhibition of 4-hydroxyphenylpyruvate dioxygenase
LINDSTEDT, S. (1992) · The Lancet · doi:10.1016/0140-6736(92)92685-9 · Cited by 631
Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis
Li, F., Wang, Y., Zeller, K. I., Potter, J. J., Wonsey, D. R., O’Donnell, K. A., Kim, J., Yustein, J. T., Lee, L. A., & Dang, C. V. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.14.6225-6234.2005 · Cited by 615
Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line
Collins, S. J., & Groudine, M. T. (1982) · Nature · doi:10.1038/298679a0 · Cited by 613
Pyruvate kinase: Function, regulation and role in cancer
Israelsen, W. J., & Heiden, M. G. V. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.08.004 · Cited by 608
Stem cell metabolism in tissue development and aging
Shyh‐Chang, N., Daley, G. Q., & Cantley, L. C. (2013) · Development · doi:10.1242/dev.091777 · Cited by 602
Reductive carboxylation supports redox homeostasis during anchorage-independent growth
Jiang, L., Shestov, A. A., Swain, P., Yang, C., Parker, S. J., Wang, Q. A., Terada, L. S., Adams, N. D., McCabe, M. T., Pietrak, B., et al. (2016) · Nature · doi:10.1038/nature17393 · Cited by 582
Expression of myb, myc and fos proto-oncogenes during the differentiation of a murine myeloid leukaemia
Gonda, T. J., & Metcalf, D. (1984) · Nature · doi:10.1038/310249a0 · Cited by 570
Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex
Bowker-Kinley, M. M., DAVIS, I. W., Wu, P., HARRIS, A. R., & POPOV, M. K. (1998) · Biochemical Journal · doi:10.1042/bj3290191 · Cited by 567
Functional role for c-myc in mitogenic response to platelet-derived growth factor
Armelin, H. A., Armelin, M. C. S., Kelly, K., Stewart, T. A., Leder, P., Cochran, B., & Stiles, C. D. (1984) · Nature · doi:10.1038/310655a0 · Cited by 565
Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I
Overturf, K., Al-Dhalimy, M., Tanguay, R., Brantly, M., Ou, C.-N., Finegold, M., & Grompe, M. (1996) · Nature Genetics · doi:10.1038/ng0396-266 · Cited by 549
A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice.Preprint
Davis, A. C., Wims, M., Spotts, G. D., Hann, S., & Bradley, A. (1993) · Genes & Development · doi:10.1101/gad.7.4.671 · Cited by 544
Stoichiometry and compartmentation of NADH metabolism in Saccharomyces cerevisiae
Bakker, B. M., Overkamp, K. M., van Maris, A. J. A., Kötter, P., Luttik, M. A. H., van Dijken, J. P., & Pronk, J. T. (2001) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2001.tb00570.x · Cited by 540
Mitochondrial DNA copy number variation across human cancers
Reznik, E., Miller, M. L., Şenbabaoğlu, Y., Riaz, N., Sarungbam, J., Tickoo, S. K., Al‐Ahmadie, H. A., Lee, W., Seshan, V., Hakimi, A. A., et al. (2016) · eLife · doi:10.7554/elife.10769 · Cited by 530
PKM2, cancer metabolism, and the road ahead
Dayton, T. L., Jacks, T., & Vander Heiden, M. G. (2016) · The EMBO Reports · doi:10.15252/embr.201643300 · Cited by 515
Hypoxia Induces Production of L-2-Hydroxyglutarate
Intlekofer, A. M., Dematteo, R. G., Venneti, S., Finley, L. W. S., Lu, C., Judkins, A. R., Rustenburg, A. S., Grinaway, P. B., Chodera, J. D., Cross, J. R., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.023 · Cited by 513
Pathology of nonalcoholic fatty liver disease
Brunt, E. M. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.21 · Cited by 484
Constitutive c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitment
Coppola, J. A., & Cole, M. D. (1986) · Nature · doi:10.1038/320760a0 · Cited by 482
HIF-1 and HIF-2 Transcription Factors - Similar but Not Identical
Loboda, A., Jozkowicz, A., & Dulak, J. (2010) · Molecules and Cells · doi:10.1007/s10059-010-0067-2 · Cited by 477
Superoxide Radical and Iron Modulate Aconitase Activity in Mammalian Cells
Gardner, P. R., Raineri, I., Epstein, L. B., & White, C. W. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13399 · Cited by 469
MYC Deregulation in Primary Human Cancers
Kalkat, M., Melo, J. D., Hickman, K. A., Lourenco, C., Redel, C., Resetca, D., Tamachi, A., Tu, W. B., & Penn, L. Z. (2017) · Genes · doi:10.3390/genes8060151 · Cited by 469
An oligomer Complementary to c- myc mRNA Inhibits Proliferation of HL-60 Promyelocytic Cells and Induces Differentiation
Holt, J. T., Redner, R. L., & Nienhuis, A. W. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.2.963 · Cited by 468
Proline hydroxylation and gene expression
Kaelin, W. G. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133142 · Cited by 468
Hypertrophy and Unconventional Cell Division of Hepatocytes Underlie Liver Regeneration
Miyaoka, Y., Ebato, K., Kato, H., Arakawa, S., Shimizu, S., & Miyajima, A. (2012) · Current Biology · doi:10.1016/j.cub.2012.05.016 · Cited by 461
Glutaminolysis as a target for cancer therapy
Jin, L., Alesi, G. N., & Kang, S. (2016) · Oncogene · doi:10.1038/onc.2015.447 · Cited by 459
Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max
Amati, B. B., Dalton, S., Brooks, M. W., Littlewood, T. D., Evan, G. I., & Land, H. (1992) · Nature · doi:10.1038/359423a0 · Cited by 457
The mutation rate and cancer
Tomlinson, I. P. M., Novelli, M. R., & Bodmer, W. F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14800 · Cited by 457
Oxygen availability and metabolic adaptations
Nakazawa, M. S., Keith, B., & Simon, M. C. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.84 · Cited by 446
Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination.
Mateyak, M. K., Obaya, Á. J., Adachi, S., & Sedivy, J. M. (1997) · PubMed · Cited by 443
From Ancient Pathways to Aging Cells—Connecting Metabolism and Cellular Senescence
Wiley, C. D., & Campisi, J. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.010 · Cited by 440
The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues
Mráček, T., Drahota, Z., & Houštěk, J. (2012) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.11.014 · Cited by 438
c-Myc regulates mammalian body size by controlling cell number but not cell size
Trumpp, A., Refaeli, Y., Óskarsson, T., Gasser, S., Murphy, M., Martin, G. R., & Bishop, J. M. (2001) · Nature · doi:10.1038/414768a · Cited by 434
Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer
Liu, Y. (2006) · Prostate Cancer and Prostatic Diseases · doi:10.1038/sj.pcan.4500879 · Cited by 433
Lactate: mirror and motor of tumor malignancy
Walenta, S., & Mueller‐Klieser, W. (2004) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2004.04.004 · Cited by 432
Low molecular weight inhibitors of Myc–Max interaction and function
Yin, X., Giap, C., Lazo, J. S., & Prochownik, E. V. (2003) · Oncogene · doi:10.1038/sj.onc.1206641 · Cited by 426
Self-citation
An Overview of MYC and Its Interactome
Conacci-Sorrell, M., McFerrin, L., & Eisenman, R. N. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014357 · Cited by 408
Dynamic programming of CD8+ T lymphocyte responses
van Stipdonk, M. J. B., Hardenberg, G., Bijker, M. S., Lemmens, E. E., Droin, N. M., Green, D. R., & Schoenberger, S. P. (2003) · Nature Immunology · doi:10.1038/ni912 · Cited by 401
SDH mutations in cancer
Bardella, C., Pollard, P. J., & Tomlinson, I. (2011) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2011.07.003 · Cited by 395
Hepatic steatosis: Innocent bystander or guilty party?
Day, C. P., & James, O. (1998) · Hepatology · doi:10.1002/hep.510270601 · Cited by 395
ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation
Qing, G., Li, B., Vu, A., Skuli, N., Walton, Z. E., Liu, X., Mayes, P. A., Wise, D. R., Thompson, C. B., Maris, J. M., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.09.021 · Cited by 375
Expression of c-myc changes during differentiation of mouse erythroleukaemia cells
Lachman, H. M., & Skoultchi, A. I. (1984) · Nature · doi:10.1038/310592a0 · Cited by 368
The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells
Newsholme, E. A., Crabtree, B., & Ardawi, M. S. (1985) · Bioscience Reports · doi:10.1007/bf01116556 · Cited by 364
c-Myc enhances protein synthesis and cell size during B lymphocyte development
Iritani, B. M., & Eisenman, R. N. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13180 · Cited by 364
Mitochondrial Pathology and Glycolytic Shift during Proximal Tubule Atrophy after Ischemic AKI
Lan, R., Geng, H. Z., Singha, P. K., Saikumar, P., Böttinger, E. P., Weinberg, J. M., & Venkatachalam, M. A. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015020177 · Cited by 364
C-myc transcript is induced in rat liver at a very early stage of regeneration or by cycloheximide treatment
Makino, R., Hayashi, K., & Sügimura, T. (1984) · Nature · doi:10.1038/310697a0 · Cited by 361
Myc—Max—Mad: a transcription factor network controlling cell cycle progression, differentiation and death
Amati, B. B., & Land, H. (1994) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(94)90098-1 · Cited by 356
c-Myc in breast cancer.
Liao, D. J., & Dickson, R. B. (2000) · Endocrine Related Cancer · doi:10.1677/erc.0.0070143 · Cited by 350
Structures of mitochondrial oxidative phosphorylation supercomplexes and mechanisms for their stabilisation
Chaban, Y. L., Boekema, E. J., & Dudkina, N. V. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.10.004 · Cited by 349
Isocitrate dehydrogenase mutations in myeloid malignancies
Medeiros, B. C., Fathi, A. T., Dinardo, C. D., Pollyea, D. A., Chan, S. M., & Swords, R. T. (2016) · Leukemia · doi:10.1038/leu.2016.275 · Cited by 348
MYC and metabolism on the path to cancer
Hsieh, A. L., Walton, Z. E., Altman, B. J., Stine, Z. E., & Dang, C. V. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.08.003 · Cited by 347
THE SPECIFIC AMINO ACID REQUIREMENTS OF A HUMAN CARCINOMA CELL (STRAIN H E L A) IN TISSUE CULTURE
Eagle, H. (1955) · The Journal of Experimental Medicine · doi:10.1084/jem.102.1.37 · Cited by 336
c-Myc Regulates Cyclin D-Cdk4 and -Cdk6 Activity but Affects Cell Cycle Progression at Multiple Independent Points
Mateyak, M. K., Obaya, Á. J., & Sedivy, J. M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4672 · Cited by 333
Sleeping Beauty , a wide host-range transposon vector for genetic transformation in vertebrates 1 1Edited by J. Karn
Izsvák, Z., Ivics, Z., & Plasterk, R. H. A. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4047 · Cited by 332
Cellular myc oncogene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas.
Adams, J. M., Gerondakis, S., Webb, E., Corcoran, L. M., & Cory, S. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.7.1982 · Cited by 324
Activation of β-Catenin and Yap1 in Human Hepatoblastoma and Induction of Hepatocarcinogenesis in Mice
Tao, J., Calvisi, D. F., Ranganathan, S., Cigliano, A., Zhou, L., Singh, S., Jiang, L., Fan, B., Terracciano, L., Armeanu–Ebinger, S., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.05.004 · Cited by 317
Regulation of the activity of the pyruvate dehydrogenase complex
Harris, R. A., Bowker-Kinley, M. M., Huang, B., & Wu, P. (2002) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(01)00061-9 · Cited by 313
Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I
Grompe, M., Lindstedt, S., Al-Dhalimy, M., Kennaway, N. G., Papaconstantinou, J., Torres-Ramos, C. A., Ou, C.-N., & Finegold, M. (1995) · Nature Genetics · doi:10.1038/ng0895-453 · Cited by 312
Deregulated expression of c-myc by murine erythroleukaemia cells prevents differentiation
Prochownik, E. V., & Kukowska, J. (1986) · Nature · doi:10.1038/322848a0 · Cited by 310
Self-citation
Metabolic Pathway Alterations that Support Cell ProliferationPreprint
Heiden, M. G. V., Lunt, S. Y., Dayton, T. L., Fiske, B. P., Israelsen, W. J., Mattaini, K. R., Vokes, N. I., Stephanopoulos, G. N., Cantley, L. C., Metallo, C. M., et al. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2012.76.010900 · Cited by 309
Isolation and characterization of c-myc, a cellular homolog of the oncogene (v-myc) of avian myelocytomatosis virus strain 29
Vennström, B., Sheiness, D. K., Zabielski, J., & Bishop, J. M. (1982) · Journal of Virology · doi:10.1128/jvi.42.3.773-779.1982 · Cited by 307
Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity
Laurenti, E., Varnum-Finney, B., Wilson, A., Ferrero, I., Blanco-Bose, W. E., Ehninger, A., Knoepfler, P. S., Cheng, P.-F., MacDonald, H. R., Eisenman, R. N., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.005 · Cited by 305
Strategies to Inhibit Myc and Their Clinical Applicability
Whitfield, J. R., Beaulieu, M.-È., & Soucek, L. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00010 · Cited by 303
Metabolic reprogramming in glioblastoma: the influence of cancer metabolism on epigenetics and unanswered questions
Agnihotri, S., & Zadeh, G. M. (2015) · Neuro-Oncology · doi:10.1093/neuonc/nov125 · Cited by 302
Quantifying Reductive Carboxylation Flux of Glutamine to Lipid in a Brown Adipocyte Cell Line
Yoo, H., Antoniewicz, M. R., Stephanopoulos, G., & Kelleher, J. K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706494200 · Cited by 301
Inhibition of de novo palmitate synthesis by fatty acid synthase induces apoptosis in tumor cells by remodeling cell membranes, inhibiting signaling pathways, and reprogramming gene expression
Ventura, R., Mordec, K., Waszczuk, J., Wang, Z., Lai, J., Fridlib, M., Buckley, D., Kemble, G., & Heuer, T. S. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.06.020 · Cited by 301
Glutamine and Cancer
Souba, W. W. (1993) · Annals of Surgery · doi:10.1097/00000658-199312000-00004 · Cited by 294
Reduced Expression of MYC Increases Longevity and Enhances Healthspan
Hofmann, J. W., Zhao, X., De Cecco, M., Peterson, A. L., Pagliaroli, L., Manivannan, J., Hubbard, G. B., Ikeno, Y., Zhang, Y., Feng, B., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.016 · Cited by 293
Isocitrate dehydrogenase mutations in gliomas
Waitkus, M. S., Diplas, B. H., & Yan, H. (2015) · Neuro-Oncology · doi:10.1093/neuonc/nov136 · Cited by 292
A unique glucose-dependent apoptotic pathway induced by c-Myc
Shim, H., Chun, Y. S., Lewis, B. C., & Dang, C. V. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1511 · Cited by 286
Deregulated MYC expression induces dependence upon AMPK-related kinase 5
Liu, L., Ulbrich, J., Müller, J., Wüstefeld, T., Aeberhard, L., Kress, T. R., Muthalagu, N., Rycak, L., Rudalska, R., Moll, R., et al. (2012) · Nature · doi:10.1038/nature10927 · Cited by 285
Myc target genes
Grandori, C. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01025-6 · Cited by 285
Increased Uptake of Amino Acids and 2-Deoxy-D-Glucose by Virus-Transformed Cells in Culture
Isselbacher, K. J. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.3.585 · Cited by 276
Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology
Hahn, A. S., Parey, K., Bublitz, M., Mills, D. J., Zickermann, V., Vonck, J., Kühlbrandt, W., & Meier, T. W. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.037 · Cited by 273
The role of malonyl-coa in the coordination of fatty acid synthesis and oxidation in isolated rat hepatocytes.
McGarry, J., TAKABAYASHI, Y., & Foster, D. W. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34395-8 · Cited by 272
Enforced Expression of the c-myc Oncogene Inhibits Cell Differentiation by Precluding Entry into a Distinct Predifferentiation State in G0/G1
Freytag, S. O. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.4.1614 · Cited by 272
L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH
Intlekofer, A. M., Wang, B., Liu, H., Shah, H., Carmona-Fontaine, C., Rustenburg, A. S., Salah, S., Gunner, M. R., Chodera, J. D., Cross, J. R., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2307 · Cited by 268
Identification of c-myc responsive genes using rat cDNA microarray.
Guo, Q., Malek, R. L., Kim, H., Chiao, C., He, M., Ruffy, M., Sanka, K., Lee, N. H., Dang, C. V., & Liu, E. T. (2000) · PubMed · Cited by 265
The Mechanism of Naked DNA Uptake and Expression
Wolff, J. A., & Budker, V. G. (2005) · Advances in genetics · doi:10.1016/s0065-2660(05)54001-x · Cited by 260
Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells
Mannava, S., Grachtchouk, V., Wheeler, L. J., Im, M., Zhuang, D., Slavina, E. G., Mathews, C. K., Shewach, D. S., & Nikiforov, M. A. (2008) · Cell Cycle · doi:10.4161/cc.6390 · Cited by 257
Differential expression of the normal and of the translocated human c-myc oncogenes in B cells.
Nishikura, K., ar-Rushdi, A., Erikson, J., Watt, R. A., Rovera, G., & Croce, C. M. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.15.4822 · Cited by 256
Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc
Muncan, V., Sansom, O. J., Tertoolen, L. G. J., Phesse, T. J., Begthel, H., Sancho, E., Cole, A. M., Gregorieff, A., de Alborán, I. M., Clevers, H. C., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00821-06 · Cited by 249
Cancer metabolism: Key players in metabolic reprogramming
Soga, T. (2012) · Cancer Science · doi:10.1111/cas.12085 · Cited by 247
Turning on a Fuel Switch of Cancer: hnRNP Proteins Regulate Alternative Splicing of Pyruvate Kinase mRNA
Chen, M., Zhang, J., & Manley, J. L. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2513 · Cited by 242
Mysterious liaisons: the relationship between c-Myc and the cell cycle
Obaya, Á. J., Mateyak, M. K., & Sedivy, J. M. (1999) · Oncogene · doi:10.1038/sj.onc.1202749 · Cited by 242
The fatty acid chain elongation system of mammalian endoplasmic reticulum
Cinti, D. L., Cook, L. S., Nagi, M. N., & Suneja, S. K. (1992) · Progress in Lipid Research · doi:10.1016/0163-7827(92)90014-a · Cited by 241
Pyruvate Kinase M2: Multiple Faces for Conferring Benefits on Cancer Cells
Tamada, M., Suematsu, M., & Saya, H. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0859 · Cited by 238
myc Family Oncogenes in the Development of Normal and Neoplastic Cells
DePinho, R. A., Schreiber‐Agus, N., & Alt, F. W. (1991) · Advances in cancer research · doi:10.1016/s0065-230x(08)60994-x · Cited by 232
Lactate promotes glutamine uptake and metabolism in oxidative cancer cells
Pérez-Escuredo, J., Dadhich, R. K., Dhup, S., Cacace, A., Van Hée, V. F., De Saedeleer, C. J., Sboarina, M., Rodriguez, F., Fontenille, M.-J., Brisson, L., et al. (2016) · Cell Cycle · doi:10.1080/15384101.2015.1120930 · Cited by 231
Lactate Stimulates Fibroblast Expression of Hyaluronan and CD44: The Warburg Effect Revisited
Stern, R., Shuster, S., Neudecker, B. A., & Formby, B. (2002) · Experimental Cell Research · doi:10.1006/excr.2002.5508 · Cited by 230
The Warburg hypothesis fifty years later
Weinhouse, S. (1976) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf00284370 · Cited by 229
MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells
Zirath, H., Frenzel, A., Oliynyk, G., Segerström, L., Westermark, U., Larsson, K., Persson, M. M., Hultenby, K. R., Lehtiö, J., Einvik, C., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222404110 · Cited by 229
Dichloroacetate and cancer: New home for an orphan drug?
Kankotia, S., & Stacpoole, P. W. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.08.005 · Cited by 226
Mitochondrial transcription and its regulation in mammalian cells
Asin-Cayuela, J., & Gustafsson, C. M. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2007.01.003 · Cited by 223
MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
Wang, W., Wu, S.-P., Liu, J., Shi, Y., Huang, X. P., Zhang, Q.-B., & Yao, K. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1408 · Cited by 217
Fatty acid metabolism in breast cancer subtypes
Monaco, M. E. (2017) · Oncotarget · doi:10.18632/oncotarget.15494 · Cited by 216
Lipid metabolism in prostate cancer.
Wu, X., Daniels, G., Lee, P., & Monaco, M. E. (2014) · PubMed Central · Cited by 204
Mitochondrial fusion proteins: Dual regulators of morphology and metabolism
Antonio Zorzano, A., Liesa, M., Sebastián, D., Segalés, J., & Palacín, M. (2010) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2010.01.002 · Cited by 204
Isocitrate Dehydrogenase Mutation and ( R )-2-Hydroxyglutarate: From Basic Discovery to Therapeutics Development
Dang, L., & Su, S.-S. M. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061516-044732 · Cited by 204
Regulated Transcription of c-Ki- ras and c- myc During Compensatory Growth of Rat Liver
Goyette, M., Petropoulos, C. J., Shank, P. R., & Fausto, N. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.8.1493 · Cited by 201
A Functional Screen for Myc-Responsive Genes Reveals Serine Hydroxymethyltransferase, a Major Source of the One-Carbon Unit for Cell Metabolism
Nikiforov, M. A., Chandriani, S. J., O’Connell, B. C., Petrenko, O., Kotenko, I., Beavis, A. J., Sedivy, J. M., & Cole, M. D. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.16.5793-5800.2002 · Cited by 201
Mitochondrial Uncoupling: A Key Contributor to Reduced Cardiac Efficiency in Diabetes
Boudina, S., & Abel, E. D. (2006) · Physiology · doi:10.1152/physiol.00008.2006 · Cited by 199
Spatial and temporal pattern of cellular myc oncogene expression in developing human placenta: Implications for embryonic cell proliferation
Pfeifer‐Ohlsson, S., Goustin, A. S., Rydnert, J., Wahlström, T., Bjersing, L., Stéhelin, D., & OHLSSON, R. I. (1984) · Cell · doi:10.1016/0092-8674(84)90513-0 · Cited by 198
c-myc antisense transcripts accelerate differentiation and inhibit G1 progression in murine erythroleukemia cells.
Prochownik, E. V., Kukowska, J., & Rodgers, C. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.9.3683 · Cited by 192
Self-citation
Improved low molecular weight Myc-Max inhibitors
Wang, H., Hammoudeh, D. I., Follis, A. V., Reese, B. E., Lazo, J. S., Metallo, S. J., & Prochownik, E. V. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0005 · Cited by 191
Self-citation
Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo
Kim, S., Li, Q., Dang, C. V., & Lee, L. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200372597 · Cited by 187
Fibroblast lines expressing activated c-myc oncogenes are tumorigenic in nude mice and syngeneic animals
Keath, E. J., Caimi, P. G., & Cole, M. D. (1984) · Cell · doi:10.1016/0092-8674(84)90012-6 · Cited by 185
A role for c-Myc in the regulation of ribosomal RNA processing
Schlosser, I. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg794 · Cited by 183
Acute Myeloid Leukemia With IDH1 or IDH2 Mutation
Patel, K. P., Ravandi, F., Ma, D., Paladugu, A. V., Barkoh, B. A., Medeiros, L. J., & Luthra, R. (2010) · American Journal of Clinical Pathology · doi:10.1309/ajcpd7nr2rmnqdvf · Cited by 179
Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension
Piao, L. H., Fang, Y., Parikh, K. S., Ryan, J. J., Tóth, P. T., & Archer, S. L. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1064-7 · Cited by 179
c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle
Wang, H., Mannava, S., Grachtchouk, V., Zhuang, D., Soengas, M. S., Gudkov, A. V., Prochownik, E. V., & Nikiforov, M. A. (2007) · Oncogene · doi:10.1038/sj.onc.1210823 · Cited by 176
Self-citation
Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscle
Dirks, A. J., Hofer, T., Marzetti, E., Pahor, M., & Leeuwenburgh, C. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.03.002 · Cited by 169
Growth During the Cell Cycle
Mitchison, J. M. (2003) · International review of cytology · doi:10.1016/s0074-7696(03)01004-0 · Cited by 168
Supramolecular organization of protein complexes in the mitochondrial inner membrane
Vonck, J., & Schäfer, E. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.05.019 · Cited by 168
Oncogenes, ions, and phospholipids
Macara, I. G. (1985) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1985.248.1.c3 · Cited by 167
Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?
Hardie, D. G. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-3300 · Cited by 166
c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry
Morrish, F. M., Isern, N., Sadı́lek, M., Jeffrey, M., & Hockenbery, D. M. (2009) · Oncogene · doi:10.1038/onc.2009.112 · Cited by 165
ATP-dependent steps in apoptotic signal transduction.
Eguchi, Y., Srinivasan, A. N., Tomaselli, K. J., Shimizu, S., & Tsujimoto, Y. (1999) · PubMed · Cited by 164
Small-molecule inhibitors of the Myc oncoprotein
Fletcher, S., & Prochownik, E. V. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.03.005 · Cited by 160
Self-citation
MYC Controls Human Pluripotent Stem Cell Fate Decisions through Regulation of Metabolic Flux
Cliff, T. S., Wu, T., Boward, B., Yin, A., Yin, H., Glushka, J., Prestegaard, J. H., & Dalton, S. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.08.018 · Cited by 158
Oncogene-induced senescence results in marked metabolic and bioenergetic alterations
Quijano, C., Cao, L., Fergusson, M. M., Romero, H., Liu, J., Gutkind, S., Rovira, I. I., Mohney, R. P., Karoly, E. D., & Finkel, T. (2012) · Cell Cycle · doi:10.4161/cc.19800 · Cited by 155
Therapeutic Targeting of Myc
Prochownik, E. V., & Vogt, P. K. (2010) · Genes & Cancer · doi:10.1177/1947601910377494 · Cited by 154
Self-citation
Redox control of glutamine utilization in cancer
Alberghina, L., & Gaglio, D. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.513 · Cited by 150
c-Myc Is Required for the Formation of Intestinal Crypts but Dispensable for Homeostasis of the Adult Intestinal Epithelium
Bettess, M. D., Dubois, N. C., Murphy, M., Dubey, C., Roger, C., Robine, S., & Trumpp, A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.17.7868-7878.2005 · Cited by 149
Hepatic lipid droplet biology: Getting to the root of fatty liver
Mashek, D. G., Khan, S. A., Sathyanarayan, A., Ploeger, J. M., & Franklin, M. P. (2015) · Hepatology · doi:10.1002/hep.27839 · Cited by 149
The mitochondrial respiratory chain is a modulator of apoptosis
Kwong, J. Q., Henning, M. S., Starkov, A. A., & Manfredi, G. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704059 · Cited by 148
Myc Posttranscriptionally Induces HIF1 Protein and Target Gene Expression in Normal and Cancer Cells
Doe, M. R., Ascano, J. M., Kaur, M., & Cole, M. D. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-2371 · Cited by 146
Crosstalk between c‐Myc and ribosome in ribosomal biogenesis and cancer
Dai, M., & Lu, H. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21895 · Cited by 146
The Sleeping Beauty transposon system: a non-viral vector for gene therapy
Aronovich, E. L., McIvor, R. S., & Hackett, P. B. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr140 · Cited by 143
Energy Metabolism Plays a Critical Role in Stem Cell Maintenance and Differentiation
Hu, C., Fan, L., Cen, P., Chen, E., Jiang, Z., & Li, L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020253 · Cited by 143
Excess of free fatty acids as a cause of metabolic dysfunction in skeletal muscle
TUMOVA, J., ANDEL, M., & TRNKA, J. (2016) · Physiological Research · doi:10.33549/physiolres.932993 · Cited by 143 · cited 1×
“The Randle cycle refers to the reciprocal nature of mitochondrial rates of pyruvate oxidation and FAO (279, 280).”
Background
Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling
Nadtochiy, S. M., Schafer, X., Fu, D., Nehrke, K., Munger, J., & Brookes, P. S. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.738799 · Cited by 143
Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis
Nieminen, A. I., Eskelinen, V., Haikala, H. M., Tervonen, T. A., Yan, Y., Partanen, J. I., & Klefström, J. T. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208530110 · Cited by 142
Glycolysis and methylaminoisobutyrate uptake in rat-1 cells transfected with ras or myc oncogenes.
Racker, E., Resnick, R. J., & Feldman, R. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.11.3535 · Cited by 135
Mitochondrial respiratory gene expression is suppressed in many cancers
Reznik, E., Wang, Q., La, K., Schultz, N. D., & Sander, C. (2017) · eLife · doi:10.7554/elife.21592 · Cited by 133
Analysis of gene expression during myc oncogene-induced lymphomagenesis in the bursa of Fabricius
Neiman, P. E., Ruddell, A., Jasoni, C. L., Loring, G., Thomas, S., Brandvold, K. A., Lee, R.-M., Burnside, J., & Delrow, J. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111144898 · Cited by 129
The transport of glutamine into mammalian cells
John, D. M. (2006) · Frontiers in bioscience · doi:10.2741/2109 · Cited by 128

Flagged first, then by citations

4 of the 309 references couldn’t be matched to a known paper.

Sorted by citations

The metabolic signature of macrophage responses
Viola, A., Munari, F., Sánchez-Rodríguez, R., Scolaro, T., & Castegna, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01462 · Cited by 2,021
“Free fatty acids are subsequently transported into mitochondria, where they are converted by the FAO pathway into different products that continuously replenish the TCA cycle with acetylcoenzyme A, or the ETC through the generation of NADH and FADH2 (148).”
BackgroundInfluential
Regulation and metabolic functions of mTORC1 and mTORC2
Szwed, A., Kim, E., & Jacinto, E. (2021) · Physiological Reviews · doi:10.1152/physrev.00026.2020 · Cited by 855
Signaling pathways and targeted therapies for psoriasis
Guo, J., Zhang, H., Lin, W., Lu, L., Su, J., & Chen, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01655-6 · Cited by 489
“279 Prior metabolomic analyses have revealed an increased glutamate metabolism in patients with psoriasis, which is positively correlated with the PASI score.”
Background
The ERK and JNK pathways in the regulation of metabolic reprogramming
Papa, S., Choy, P. M., & Bubici, C. (2018) · Oncogene · doi:10.1038/s41388-018-0582-8 · Cited by 394
Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy
Carter, J. L., Hege-Hurrish, K., Yang, J., Kalpage, H. A., Su, Y., Edwards, H. J., Hüttemann, M., Taub, J. W., & Ge, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00361-x · Cited by 230

See all 199

Authors: Goetzman, E. S., & Prochownik, E. V.
Affiliations: Children's Hospital of Pittsburgh (US)
University of Pittsburgh (US)
Corresponding author: Prochownik, Edward V.
ORCID: Goetzman, Eric S.
Prochownik, Edward V.
Venue: Frontiers in Endocrinology
Publisher: Frontiers Media SA
Published: 2018-04-12
Volume: 9
Pages: 129-129
ISSN: 1664-2392 (ISSN-L)
DOI: 10.3389/fendo.2018.00129
PMC: PMC5907532
OpenAlex: W2797261189
Cited by: 199
References: 309
Citations by year: 2026: 14 · 2025: 20 · 2024: 28 · 2023: 23 · 2022: 33 · 2021: 26 · 2020: 32 · 2019: 17 · 2018: 6
FWCI: 2.10
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Frontiers in Endocrinology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health (CA174713, DK090242)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords: c-Myc, cancer metabolism, glycolysis, oxidative phosphorylation, glutaminolysis, fatty acid metabolism, tumor cell proliferation, metabolic reprogramming, tumor evolution, metabolic plasticity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks