Cited by 57Dietary Effects on HealthGenetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Effects of Dietary Restriction on Adipose Mass and Biomarkers of Healthy Aging in Human

Open access
Lettieri-Barbato, Daniele, Giovannetti, Esmeralda, Aquilano, Katia·2016·Aging

Abstract

In developing countries the rise of obesity and obesity-related metabolic disorders, such as cardiovascular diseases and type 2 diabetes, reflects the changes in lifestyle habits and wrong dietary choices. Dietary restriction (DR) regimens have been shown to extend health span and lifespan in many animal models including primates. Identifying biomarkers predictive of clinical benefits of treatment is one of the primary goals of precision medicine. To monitor the clinical outcomes of DR interventions in humans, several biomarkers are commonly adopted. However, a validated link between the behaviors of such biomarkers and DR effects is lacking at present time. Through a systematic analysis of human intervention studies, we evaluated the effect size of DR (i.e. calorie restriction, very low calorie diet, intermittent fasting, alternate day fasting) on health-related biomarkers. We found that DR is effective in reducing total and visceral adipose mass and improving inflammatory cytokines profile and adiponectin/leptin ratio. By analysing the levels of canonical biomarkers of healthy aging, we also validated the changes of insulin, IGF-1 and IGFBP-1,2 to monitor DR effects. Collectively, we developed a useful platform to evaluate the human responses to dietary regimens low in calories.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.18632/aging.101122

Cites

88 of 88 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. [37]Borenstein M 2009 Introduction to meta-analysis Chichester, West Sussex, UK; Hoboken John Wiley & Sons
  2. [88]Higgins JP Green S Cochrane Collaboration 2008 Cochrane handbook for systematic reviews of interventions Chichester, West Sussex; Hoboken NJ Wiley-Blackwell

Cited by

Sorted by citations

Authors
Lettieri-Barbato, D., Giovannetti, E., & Aquilano, K.
Affiliations
  • Department of Biology, University of Rome Tor Vergata, Rome, Italy
  • University of Rome Tor Vergata (IT)
Venue
Aging
Published
2016-11-29
Volume
8
Issue
12
Pages
3341-3355
ISSN
1945-4589 (ISSN-L)
OpenAlex
W2559697180
Cited by
57
References
88
Citations by year
2026: 2 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 10 · 2020: 10 · 2019: 8 · 2018: 8 · 2017: 5
FWCI
0.82
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Aging (publishedVersion)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion, other-oa)
Funders
  • Ministero della Salute (GR-2011-02348047)
  • Università degli Studi di Roma Tor Vergata
Topics
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Keywords
dietary restriction, caloric restriction, very low calorie diet, intermittent fasting, alternate-day fasting, adipose mass, visceral adipose tissue, inflammation, adiponectin/leptin ratio, insulin, insulin-like growth factor I, IGFBP-1, IGFBP-2, obesity, type 2 diabetes, cardiovascular disease
MeSH terms
Adipose Tissue, Aging, Dehydroepiandrosterone, Gene Expression Regulation, Humans, Inflammation, Insulin, Insulin-Like Growth Factor I, Biomarkers, Cytokines, Protein Footprinting, Caloric Restriction, Adipokines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review