Effects of Dietary Restriction on Adipose Mass and Biomarkers of Healthy Aging in Human
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In developing countries the rise of obesity and obesity-related metabolic disorders, such as cardiovascular diseases and type 2 diabetes, reflects the changes in lifestyle habits and wrong dietary choices. Dietary restriction (DR) regimens have been shown to extend health span and lifespan in many animal models including primates. Identifying biomarkers predictive of clinical benefits of treatment is one of the primary goals of precision medicine. To monitor the clinical outcomes of DR interventions in humans, several biomarkers are commonly adopted. However, a validated link between the behaviors of such biomarkers and DR effects is lacking at present time. Through a systematic analysis of human intervention studies, we evaluated the effect size of DR (i.e. calorie restriction, very low calorie diet, intermittent fasting, alternate day fasting) on health-related biomarkers. We found that DR is effective in reducing total and visceral adipose mass and improving inflammatory cytokines profile and adiponectin/leptin ratio. By analysing the levels of canonical biomarkers of healthy aging, we also validated the changes of insulin, IGF-1 and IGFBP-1,2 to monitor DR effects. Collectively, we developed a useful platform to evaluate the human responses to dietary regimens low in calories.
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Meta-analysis has demonstrated that dietary restrictions decreased levels of circulating IGF-1 in humans.
“Meta-analysis has also demonstrated that dietary restrictions decreased levels of circulating IGF-1 in humans (213);”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [213]
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- Authors
- Lettieri-Barbato, D., Giovannetti, E., & Aquilano, K.
- Affiliations
- Department of Biology, University of Rome Tor Vergata, Rome, Italy
- University of Rome Tor Vergata (IT)
- ORCID
- Aquilano, Katia
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2016-11-29
- Volume
- 8
- Issue
- 12
- Pages
- 3341-3355
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC5270672
- OpenAlex
- W2559697180
- Cited by
- 57
- References
- 88
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 10 · 2020: 10 · 2019: 8 · 2018: 8 · 2017: 5
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- Aging (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion, other-oa)
- Funders
- Ministero della Salute (GR-2011-02348047)
- Università degli Studi di Roma Tor Vergata
- Topics
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- dietary restriction, caloric restriction, very low calorie diet, intermittent fasting, alternate-day fasting, adipose mass, visceral adipose tissue, inflammation, adiponectin/leptin ratio, insulin, insulin-like growth factor I, IGFBP-1, IGFBP-2, obesity, type 2 diabetes, cardiovascular disease
- MeSH terms
- Adipose Tissue, Aging, Dehydroepiandrosterone, Gene Expression Regulation, Humans, Inflammation, Insulin, Insulin-Like Growth Factor I, Biomarkers, Cytokines, Protein Footprinting, Caloric Restriction, Adipokines
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